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Does sex alter the relationship between CYP2B6 variation, hydroxybupropion concentration and bupropion-aided smoking cessation in African Americans? A moderated mediation analysis.

Addiction (Abingdon, England)

Chenoweth MJ, Peng AR, Zhu AZX, Cox LS, Nollen NL, Ahluwalia JS, Benowitz NL, Knight J, Swardfager W, Tyndale RF.
PMID: 34791718
Addiction. 2021 Nov 17; doi: 10.1111/add.15742. Epub 2021 Nov 17.

BACKGROUND AND AIMS: CYP2B6, a genetically variable enzyme, converts bupropion to its active metabolite hydroxybupropion. CYP2B6 activity and bupropion-aided cessation differ between women and men. The aim of this study was to determine whether genetically normal (versus reduced) CYP2B6...

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Chenoweth MJ, Peng AR, Zhu AZX, et al. Does sex alter the relationship between CYP2B6 variation, hydroxybupropion concentration and bupropion-aided smoking cessation in African Americans? A moderated mediation analysis. Addiction. 2021;doi: 10.1111/add.15742.
Chenoweth, M. J., Peng, A. R., Zhu, A. Z. X., Cox, L. S., Nollen, N. L., Ahluwalia, J. S., Benowitz, N. L., Knight, J., Swardfager, W., & Tyndale, R. F. (2021). Does sex alter the relationship between CYP2B6 variation, hydroxybupropion concentration and bupropion-aided smoking cessation in African Americans? A moderated mediation analysis. Addiction (Abingdon, England), . https://doi.org/10.1111/add.15742
Chenoweth, Meghan J, et al. "Does sex alter the relationship between CYP2B6 variation, hydroxybupropion concentration and bupropion-aided smoking cessation in African Americans? A moderated mediation analysis." Addiction (Abingdon, England) vol. (2021). doi: https://doi.org/10.1111/add.15742
Chenoweth MJ, Peng AR, Zhu AZX, Cox LS, Nollen NL, Ahluwalia JS, Benowitz NL, Knight J, Swardfager W, Tyndale RF. Does sex alter the relationship between CYP2B6 variation, hydroxybupropion concentration and bupropion-aided smoking cessation in African Americans? A moderated mediation analysis. Addiction. 2021 Nov 17; doi: 10.1111/add.15742. Epub 2021 Nov 17. PMID: 34791718.
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Reappraising Choice in Addiction: Novel Conceptualizations and Treatments for Tobacco Use Disorder.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco

Palmer AM, Toll BA, Carpenter MJ, Donny EC, Hatsukami DK, Rojewski AM, Smith TT, Sofuoglu M, Thrul J, Benowitz NL.
PMID: 34270729
Nicotine Tob Res. 2022 Jan 01;24(1):3-9. doi: 10.1093/ntr/ntab148.

The introduction of alternative nicotine and tobacco products (such as e-cigarettes, heat-not-burn devices, nicotine pouches) warrants an updated framework from which to conceptualize tobacco use disorder (TUD). The following review provides considerations for TUD within the context of novel...

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Palmer AM, Toll BA, Carpenter MJ, et al. Reappraising Choice in Addiction: Novel Conceptualizations and Treatments for Tobacco Use Disorder. Nicotine Tob Res. 2022;24(1):3-9doi: 10.1093/ntr/ntab148.
Palmer, A. M., Toll, B. A., Carpenter, M. J., Donny, E. C., Hatsukami, D. K., Rojewski, A. M., Smith, T. T., Sofuoglu, M., Thrul, J., & Benowitz, N. L. (2022). Reappraising Choice in Addiction: Novel Conceptualizations and Treatments for Tobacco Use Disorder. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 24(1), 3-9. https://doi.org/10.1093/ntr/ntab148
Palmer, Amanda M, et al. "Reappraising Choice in Addiction: Novel Conceptualizations and Treatments for Tobacco Use Disorder." Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco vol. 24,1 (2022): 3-9. doi: https://doi.org/10.1093/ntr/ntab148
Palmer AM, Toll BA, Carpenter MJ, Donny EC, Hatsukami DK, Rojewski AM, Smith TT, Sofuoglu M, Thrul J, Benowitz NL. Reappraising Choice in Addiction: Novel Conceptualizations and Treatments for Tobacco Use Disorder. Nicotine Tob Res. 2022 Jan 01;24(1):3-9. doi: 10.1093/ntr/ntab148. PMID: 34270729.
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Nicotine delivery and cigarette equivalents from vaping a JUULpod.

Tobacco control

Prochaska JJ, Vogel EA, Benowitz N.
PMID: 33762429
Tob Control. 2021 Mar 24; doi: 10.1136/tobaccocontrol-2020-056367. Epub 2021 Mar 24.

With patented nicotine salt technology, JUUL dominates the e-cigarette market. We reviewed studies of JUUL's nicotine pharmacokinetic profile and studies quantifying nicotine in a JUULpod, emitted in the aerosol and absorbed by users. Examined in eight studies, JUUL's peak...

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Prochaska JJ, Vogel EA, Benowitz N. Nicotine delivery and cigarette equivalents from vaping a JUULpod. Tob Control. 2021;doi: 10.1136/tobaccocontrol-2020-056367.
Prochaska, J. J., Vogel, E. A., & Benowitz, N. (2021). Nicotine delivery and cigarette equivalents from vaping a JUULpod. Tobacco control, . https://doi.org/10.1136/tobaccocontrol-2020-056367
Prochaska, Judith J, et al. "Nicotine delivery and cigarette equivalents from vaping a JUULpod." Tobacco control vol. (2021). doi: https://doi.org/10.1136/tobaccocontrol-2020-056367
Prochaska JJ, Vogel EA, Benowitz N. Nicotine delivery and cigarette equivalents from vaping a JUULpod. Tob Control. 2021 Mar 24; doi: 10.1136/tobaccocontrol-2020-056367. Epub 2021 Mar 24. PMID: 33762429; PMCID: PMC8460696.
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Effect of race and glucuronidation rates on the relationship between nicotine metabolite ratio and nicotine clearance.

Pharmacogenetics and genomics

Liakoni E, Tyndale RF, Jacob P, Dempsey DA, Addo N, Benowitz NL.
PMID: 33675323
Pharmacogenet Genomics. 2021 Jul 01;31(5):97-107. doi: 10.1097/FPC.0000000000000427.

OBJECTIVES: To investigate if the nicotine metabolite ratio (NMR, the ratio of nicotine metabolites 3'-hydroxycotinine/cotinine) is a reliable phenotypic biomarker for nicotine clearance across races, and as a function of differences in the rate of nicotine, cotinine and 3'-hydroxycotinine...

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Liakoni E, Tyndale RF, Jacob P, et al. Effect of race and glucuronidation rates on the relationship between nicotine metabolite ratio and nicotine clearance. Pharmacogenet Genomics. 2021;31(5):97-107doi: 10.1097/FPC.0000000000000427.
Liakoni, E., Tyndale, R. F., Jacob, P., Dempsey, D. A., Addo, N., & Benowitz, N. L. (2021). Effect of race and glucuronidation rates on the relationship between nicotine metabolite ratio and nicotine clearance. Pharmacogenetics and genomics, 31(5), 97-107. https://doi.org/10.1097/FPC.0000000000000427
Liakoni, Evangelia, et al. "Effect of race and glucuronidation rates on the relationship between nicotine metabolite ratio and nicotine clearance." Pharmacogenetics and genomics vol. 31,5 (2021): 97-107. doi: https://doi.org/10.1097/FPC.0000000000000427
Liakoni E, Tyndale RF, Jacob P, Dempsey DA, Addo N, Benowitz NL. Effect of race and glucuronidation rates on the relationship between nicotine metabolite ratio and nicotine clearance. Pharmacogenet Genomics. 2021 Jul 01;31(5):97-107. doi: 10.1097/FPC.0000000000000427. PMID: 33675323; PMCID: PMC8184575.
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Determination of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone (NNK) arising from tobacco smoke in airborne particulate matter.

Environment international

Aquilina NJ, Havel CM, Harrison RM, Ho KF, Benowitz NL, Jacob Iii P.
PMID: 34991253
Environ Int. 2022 Jan;158:106992. doi: 10.1016/j.envint.2021.106992. Epub 2021 Nov 19.

The most important tobacco-specific nitrosamine found in cigarette smoke and formed in ageing smoke after cigarettes are extinguished is 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). It is formed from nitrosation of nicotine, under particular conditions both in indoor and outdoor environments. NNK has...

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Aquilina NJ, Havel CM, Harrison RM, et al. Determination of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone (NNK) arising from tobacco smoke in airborne particulate matter. Environ Int. 2021;158:106992doi: 10.1016/j.envint.2021.106992.
Aquilina, N. J., Havel, C. M., Harrison, R. M., Ho, K. F., Benowitz, N. L., & Jacob Iii, P. (2022). Determination of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone (NNK) arising from tobacco smoke in airborne particulate matter. Environment international, 158106992. https://doi.org/10.1016/j.envint.2021.106992
Aquilina, Noel J, et al. "Determination of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone (NNK) arising from tobacco smoke in airborne particulate matter." Environment international vol. 158 (2022): 106992. doi: https://doi.org/10.1016/j.envint.2021.106992
Aquilina NJ, Havel CM, Harrison RM, Ho KF, Benowitz NL, Jacob Iii P. Determination of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone (NNK) arising from tobacco smoke in airborne particulate matter. Environ Int. 2022 Jan;158:106992. doi: 10.1016/j.envint.2021.106992. Epub 2021 Nov 19. PMID: 34991253.
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Post-transcriptional regulation of GAP-43 rnRNA levels during neuronal differentiation and nerve regeneration.

Molecular and cellular neurosciences

Perrone-Bizzozero NI, Neve RL, Irwin N, Lewis S, Fischer I, Benowitz LI.
PMID: 19912825
Mol Cell Neurosci. 1991 Oct;2(5):402-9. doi: 10.1016/1044-7431(91)90027-l.

The expression of GAP-43 is a well-characterized correlate of the growth and reorganization of neural connections. Although the expression of this protein is known to depend on the levels of the mRNA, the mechanisms that control the latter are...

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Perrone-Bizzozero NI, Neve RL, Irwin N, et al. Post-transcriptional regulation of GAP-43 rnRNA levels during neuronal differentiation and nerve regeneration. Mol Cell Neurosci. 1991;2(5):402-9doi: 10.1016/1044-7431(91)90027-l.
Perrone-Bizzozero, N. I., Neve, R. L., Irwin, N., Lewis, S., Fischer, I., & Benowitz, L. I. (1991). Post-transcriptional regulation of GAP-43 rnRNA levels during neuronal differentiation and nerve regeneration. Molecular and cellular neurosciences, 2(5), 402-9. https://doi.org/10.1016/1044-7431(91)90027-l
Perrone-Bizzozero, N I, et al. "Post-transcriptional regulation of GAP-43 rnRNA levels during neuronal differentiation and nerve regeneration." Molecular and cellular neurosciences vol. 2,5 (1991): 402-9. doi: https://doi.org/10.1016/1044-7431(91)90027-l
Perrone-Bizzozero NI, Neve RL, Irwin N, Lewis S, Fischer I, Benowitz LI. Post-transcriptional regulation of GAP-43 rnRNA levels during neuronal differentiation and nerve regeneration. Mol Cell Neurosci. 1991 Oct;2(5):402-9. doi: 10.1016/1044-7431(91)90027-l. PMID: 19912825.
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Correlates of NNAL levels among nondaily and daily smokers in the college student population.

Current biomarker findings

Berg CJ, Schauer GL, Ahluwalia JS, Benowitz NL.
PMID: 24298447
Curr Biomark Find. 2012 Oct 15;2012(2). doi: 10.2147/CBF.S34642.

INTRODUCTION: Recent simultaneous increases in nondaily smoking and decreases in daily smoking make the identification of nondaily smokers through biomarker measures as well as the relationship of biomarker levels to smoking behaviors important topics. However, little is known about...

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Berg CJ, Schauer GL, Ahluwalia JS, et al. Correlates of NNAL levels among nondaily and daily smokers in the college student population. Curr Biomark Find. 2012;2012(2)doi: 10.2147/CBF.S34642.
Berg, C. J., Schauer, G. L., Ahluwalia, J. S., & Benowitz, N. L. (2012). Correlates of NNAL levels among nondaily and daily smokers in the college student population. Current biomarker findings, 2012(2), . https://doi.org/10.2147/CBF.S34642
Berg, Carla J, et al. "Correlates of NNAL levels among nondaily and daily smokers in the college student population." Current biomarker findings vol. 2012,2 (2012). doi: https://doi.org/10.2147/CBF.S34642
Berg CJ, Schauer GL, Ahluwalia JS, Benowitz NL. Correlates of NNAL levels among nondaily and daily smokers in the college student population. Curr Biomark Find. 2012 Oct 15;2012(2). doi: 10.2147/CBF.S34642. PMID: 24298447; PMCID: PMC3843970.
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Gender differences in the pharmacology of nicotine addiction.

Addiction biology

Benowitz NL, Hatsukami D.
PMID: 26735114
Addict Biol. 1998 Oct;3(4):383-404. doi: 10.1080/13556219871930.

Smoking rates have declined in recent years less rapidly in women than in men. More adolescent girls than boys are currently smoking. Quitting smoking is reported in many studies to be more difficult in women than in men. These...

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Benowitz NL, Hatsukami D. Gender differences in the pharmacology of nicotine addiction. Addict Biol. 1998;3(4):383-404doi: 10.1080/13556219871930.
Benowitz, N. L., & Hatsukami, D. (1998). Gender differences in the pharmacology of nicotine addiction. Addiction biology, 3(4), 383-404. https://doi.org/10.1080/13556219871930
Benowitz, N L, and Hatsukami, D. "Gender differences in the pharmacology of nicotine addiction." Addiction biology vol. 3,4 (1998): 383-404. doi: https://doi.org/10.1080/13556219871930
Benowitz NL, Hatsukami D. Gender differences in the pharmacology of nicotine addiction. Addict Biol. 1998 Oct;3(4):383-404. doi: 10.1080/13556219871930. PMID: 26735114.
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Tunneling Nanotubes and Gap Junctions-Their Role in Long-Range Intercellular Communication during Development, Health, and Disease Conditions.

Frontiers in molecular neuroscience

Ariazi J, Benowitz A, De Biasi V, Den Boer ML, Cherqui S, Cui H, Douillet N, Eugenin EA, Favre D, Goodman S, Gousset K, Hanein D, Israel DI, Kimura S, Kirkpatrick RB, Kuhn N, Jeong C, Lou E, Mailliard R, Maio S, Okafo G, Osswald M, Pasquier J, Polak R, Pradel G, de Rooij B, Schaeffer P, Skeberdis VA, Smith IF, Tanveer A, Volkmann N, Wu Z, Zurzolo C.
PMID: 29089870
Front Mol Neurosci. 2017 Oct 17;10:333. doi: 10.3389/fnmol.2017.00333. eCollection 2017.

Cell-to-cell communication is essential for the organization, coordination, and development of cellular networks and multi-cellular systems. Intercellular communication is mediated by soluble factors (including growth factors, neurotransmitters, and cytokines/chemokines), gap junctions, exosomes and recently described tunneling nanotubes (TNTs). It...

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Ariazi J, Benowitz A, De Biasi V, et al. Tunneling Nanotubes and Gap Junctions-Their Role in Long-Range Intercellular Communication during Development, Health, and Disease Conditions. Front Mol Neurosci. 2017;10:333doi: 10.3389/fnmol.2017.00333.
Ariazi, J., Benowitz, A., De Biasi, V., Den Boer, M. L., Cherqui, S., Cui, H., Douillet, N., Eugenin, E. A., Favre, D., Goodman, S., Gousset, K., Hanein, D., Israel, D. I., Kimura, S., Kirkpatrick, R. B., Kuhn, N., Jeong, C., Lou, E., Mailliard, R., Maio, S., Okafo, G., Osswald, M., Pasquier, J., Polak, R., Pradel, G., de Rooij, B., Schaeffer, P., Skeberdis, V. A., Smith, I. F., Tanveer, A., Volkmann, N., Wu, Z., & Zurzolo, C. (2017). Tunneling Nanotubes and Gap Junctions-Their Role in Long-Range Intercellular Communication during Development, Health, and Disease Conditions. Frontiers in molecular neuroscience, 10333. https://doi.org/10.3389/fnmol.2017.00333
Ariazi, Jennifer, et al. "Tunneling Nanotubes and Gap Junctions-Their Role in Long-Range Intercellular Communication during Development, Health, and Disease Conditions." Frontiers in molecular neuroscience vol. 10 (2017): 333. doi: https://doi.org/10.3389/fnmol.2017.00333
Ariazi J, Benowitz A, De Biasi V, Den Boer ML, Cherqui S, Cui H, Douillet N, Eugenin EA, Favre D, Goodman S, Gousset K, Hanein D, Israel DI, Kimura S, Kirkpatrick RB, Kuhn N, Jeong C, Lou E, Mailliard R, Maio S, Okafo G, Osswald M, Pasquier J, Polak R, Pradel G, de Rooij B, Schaeffer P, Skeberdis VA, Smith IF, Tanveer A, Volkmann N, Wu Z, Zurzolo C. Tunneling Nanotubes and Gap Junctions-Their Role in Long-Range Intercellular Communication during Development, Health, and Disease Conditions. Front Mol Neurosci. 2017 Oct 17;10:333. doi: 10.3389/fnmol.2017.00333. eCollection 2017. PMID: 29089870; PMCID: PMC5651011.
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Nicotine Replacement, Topography, and Smoking Phenotypes of E-cigarettes.

Tobacco regulatory science

Strasser AA, Souprountchouk V, Kaufmann A, Blazekovic S, Leone F, Benowitz NL, Schnoll RA.
PMID: 27942543
Tob Regul Sci. 2016 Oct;2(4):352-362. doi: 10.18001/TRS.2.4.7.

OBJECTIVES: Little is known about the degree of nicotine replacement across first-generation e-cigarette brands, how e-cigarettes are used, and if there is variation across brands in relevant smoking phenotypes. The objective of this project was to collect data that...

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Strasser AA, Souprountchouk V, Kaufmann A, et al. Nicotine Replacement, Topography, and Smoking Phenotypes of E-cigarettes. Tob Regul Sci. 2016;2(4):352-362doi: 10.18001/TRS.2.4.7.
Strasser, A. A., Souprountchouk, V., Kaufmann, A., Blazekovic, S., Leone, F., Benowitz, N. L., & Schnoll, R. A. (2016). Nicotine Replacement, Topography, and Smoking Phenotypes of E-cigarettes. Tobacco regulatory science, 2(4), 352-362. https://doi.org/10.18001/TRS.2.4.7
Strasser, Andrew A, et al. "Nicotine Replacement, Topography, and Smoking Phenotypes of E-cigarettes." Tobacco regulatory science vol. 2,4 (2016): 352-362. doi: https://doi.org/10.18001/TRS.2.4.7
Strasser AA, Souprountchouk V, Kaufmann A, Blazekovic S, Leone F, Benowitz NL, Schnoll RA. Nicotine Replacement, Topography, and Smoking Phenotypes of E-cigarettes. Tob Regul Sci. 2016 Oct;2(4):352-362. doi: 10.18001/TRS.2.4.7. PMID: 27942543; PMCID: PMC5142626.
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Tobacco-free Nicotine - New Name, Same Scheme?.

The New England journal of medicine

Cwalina SN, McConnell R, Benowitz NL, Barrington-Trimis JL.
PMID: 34919358
N Engl J Med. 2021 Dec 18; doi: 10.1056/NEJMp2111159. Epub 2021 Dec 18.

No abstract available.

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Cwalina SN, McConnell R, Benowitz NL, et al. Tobacco-free Nicotine - New Name, Same Scheme?. N Engl J Med. 2021;doi: 10.1056/NEJMp2111159.
Cwalina, S. N., McConnell, R., Benowitz, N. L., & Barrington-Trimis, J. L. (2021). Tobacco-free Nicotine - New Name, Same Scheme?. The New England journal of medicine, . https://doi.org/10.1056/NEJMp2111159
Cwalina, Sam N, et al. "Tobacco-free Nicotine - New Name, Same Scheme?." The New England journal of medicine vol. (2021). doi: https://doi.org/10.1056/NEJMp2111159
Cwalina SN, McConnell R, Benowitz NL, Barrington-Trimis JL. Tobacco-free Nicotine - New Name, Same Scheme?. N Engl J Med. 2021 Dec 18; doi: 10.1056/NEJMp2111159. Epub 2021 Dec 18. PMID: 34919358.
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Nicotine and Anatabine Exposure from Very Low Nicotine Content Cigarettes.

Tobacco regulatory science

Denlinger RL, Smith TT, Murphy SE, Koopmeiners JS, Benowitz NL, Hatsukami DK, Pacek LR, Colino C, Cwalina SN, Donny EC.
PMID: 29600258
Tob Regul Sci. 2016 Apr;2(2):186-203. doi: 10.18001/TRS.2.2.9.

OBJECTIVES: Research using very low nicotine content (VLNC) cigarettes has shown that participants underreport use of non-study cigarettes. Biomarkers of nicotine exposure could be used to verify compliance with VLNC cigarettes. This study aimed to characterize biomarkers of exposure...

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Denlinger RL, Smith TT, Murphy SE, et al. Nicotine and Anatabine Exposure from Very Low Nicotine Content Cigarettes. Tob Regul Sci. 2016;2(2):186-203doi: 10.18001/TRS.2.2.9.
Denlinger, R. L., Smith, T. T., Murphy, S. E., Koopmeiners, J. S., Benowitz, N. L., Hatsukami, D. K., Pacek, L. R., Colino, C., Cwalina, S. N., & Donny, E. C. (2016). Nicotine and Anatabine Exposure from Very Low Nicotine Content Cigarettes. Tobacco regulatory science, 2(2), 186-203. https://doi.org/10.18001/TRS.2.2.9
Denlinger, Rachel L, et al. "Nicotine and Anatabine Exposure from Very Low Nicotine Content Cigarettes." Tobacco regulatory science vol. 2,2 (2016): 186-203. doi: https://doi.org/10.18001/TRS.2.2.9
Denlinger RL, Smith TT, Murphy SE, Koopmeiners JS, Benowitz NL, Hatsukami DK, Pacek LR, Colino C, Cwalina SN, Donny EC. Nicotine and Anatabine Exposure from Very Low Nicotine Content Cigarettes. Tob Regul Sci. 2016 Apr;2(2):186-203. doi: 10.18001/TRS.2.2.9. PMID: 29600258; PMCID: PMC5870904.
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Showing 25 to 36 of 64 entries