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Showing 3565 to 3567 of 3567 entries
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Widespread introgression across a phylogeny of 155 Drosophila genomes.

Current biology : CB

Suvorov A, Kim BY, Wang J, Armstrong EE, Peede D, D'Agostino ERR, Price DK, Waddell P, Lang M, Courtier-Orgogozo V, David JR, Petrov D, Matute DR, Schrider DR, Comeault AA.
PMID: 34788634
Curr Biol. 2022 Jan 10;32(1):111-123.e5. doi: 10.1016/j.cub.2021.10.052. Epub 2021 Nov 16.

Genome-scale sequence data have invigorated the study of hybridization and introgression, particularly in animals. However, outside of a few notable cases, we lack systematic tests for introgression at a larger phylogenetic scale across entire clades. Here, we leverage 155...

Tumor density is associated with response to endobronchial ultrasound-guided transbronchial needle injection of cisplatin.

Journal of thoracic disease

Kinsey CM, San José Estépar R, Bates JHT, Cole BF, Washko G, Jantz M, Mehta H.
PMID: 33145055
J Thorac Dis. 2020 Sep;12(9):4825-4832. doi: 10.21037/jtd-20-674.

BACKGROUND: Endobronchial ultrasound-guided transbronchial needle injection of cisplatin (EBUS-TBNI cisplatin) is a therapeutic option for patients with recurrent lung cancer. However, the tumor characteristics that influence the distribution of the agent following intratumoral delivery remain largely unknown.METHODS: We performed...

Positive allosteric modulation of the mu-opioid receptor produces analgesia with reduced side effects.

Proceedings of the National Academy of Sciences of the United States of America

Kandasamy R, Hillhouse TM, Livingston KE, Kochan KE, Meurice C, Eans SO, Li MH, White AD, Roques BP, McLaughlin JP, Ingram SL, Burford NT, Alt A, Traynor JR.
PMID: 33846240
Proc Natl Acad Sci U S A. 2021 Apr 20;118(16). doi: 10.1073/pnas.2000017118.

Positive allosteric modulators (PAMs) of the mu-opioid receptor (MOR) have been hypothesized as potentially safer analgesics than traditional opioid drugs. This is based on the idea that PAMs will promote the action of endogenous opioid peptides while preserving their...

Showing 3565 to 3567 of 3567 entries