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Showing 25 to 36 of 43 entries
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Post-stenotic Recirculating Flow May Cause Hemodynamic Perforator Infarction.

Journal of stroke

Kim BJ, Ha H, Huh HK, Kim GB, Kim JS, Kim N, Lee SJ, Kang DW, Kwon SU.
PMID: 26687122
J Stroke. 2016 Jan;18(1):66-72. doi: 10.5853/jos.2015.01445. Epub 2015 Dec 17.

BACKGROUND AND PURPOSE: The primary mechanism underlying paramedian pontine infarction (PPI) is atheroma obliterating the perforators. Here, we encountered a patient with PPI in the post-stenotic area of basilar artery (BA) without a plaque, shown by high-resolution magnetic resonance...

Age-Related Vascular Changes Affect Turbulence in Aortic Blood Flow.

Frontiers in physiology

Ha H, Ziegler M, Welander M, Bjarnegård N, Carlhäll CJ, Lindenberger M, Länne T, Ebbers T, Dyverfeldt P.
PMID: 29422871
Front Physiol. 2018 Jan 25;9:36. doi: 10.3389/fphys.2018.00036. eCollection 2018.

Turbulent blood flow is implicated in the pathogenesis of several aortic diseases but the extent and degree of turbulent blood flow in the normal aorta is unknown. We aimed to quantify the extent and degree of turbulece in the...

Mitochondria function associated genes contribute to Parkinson's Disease risk and later age at onset.

NPJ Parkinson's disease

Billingsley KJ, Barbosa IA, Bandrés-Ciga S, Quinn JP, Bubb VJ, Deshpande C, Botia JA, Reynolds RH, Zhang D, Simpson MA, Blauwendraat C, Gan-Or Z, Gibbs JR, Nalls MA, Singleton A, Ryten M, Koks S.
PMID: 31123700
NPJ Parkinsons Dis. 2019 May 22;5:8. doi: 10.1038/s41531-019-0080-x. eCollection 2019.

Mitochondrial dysfunction has been implicated in the etiology of monogenic Parkinson's disease (PD). Yet the role that mitochondrial processes play in the most common form of the disease; sporadic PD, is yet to be fully established. Here, we comprehensively...

Correlation between nitric oxide synthase activity and reduced glutathione level in human and murine endothelial cells.

Amino acids

Ghigo D, Geromin D, Franchino C, Todde R, Priotto C, Costamagna C, Arese M, Garbarino G, Pescarmona GP, Bosia A.
PMID: 24178542
Amino Acids. 1996 Sep;10(3):277-81. doi: 10.1007/BF00807330.

The synthesis of nitric oxide (NO), detected as citrulline production, in human (HUVEC) and murine (tEnd.1) endothelial cells correlated with intracellular GSH. tEnd.1, which exhibited an intracellular GSH level 2.5-fold higher than HUVEC, showed a citrulline production (basally and...

Frontiers in bioengineering and biotechnology

Ha H, Huh HK, Park KJ, Dyverfeldt P, Ebbers T, Kim DH, Yang DH.
PMID: 34950643
Front Bioeng Biotechnol. 2021 Dec 07;9:774954. doi: 10.3389/fbioe.2021.774954. eCollection 2021.

Imaging hemodynamics play an important role in the diagnosis of abnormal blood flow due to vascular and valvular diseases as well as in monitoring the recovery of normal blood flow after surgical or interventional treatment. Recently, characterization of turbulent...

NF-kB related transgene expression in mouse tibial cranial muscle after pDNA injection followed or not by electrotransfer.

Biochimica et biophysica acta

Mahindhoratep S, Bouda HA, El Shafey N, Scherman D, Kichler A, Pichon Ch, Midoux P, Mignet N, Bureau MF.
PMID: 24973564
Biochim Biophys Acta. 2014 Nov;1840(11):3257-63. doi: 10.1016/j.bbagen.2014.06.013. Epub 2014 Jun 26.

BACKGROUND: When activated, NF-κB can promote the nuclear import and transcription of DNA possessing NF-κB consensus sequences. Here, we investigated whether NF-κB is involved in the plasmid electrotransfer process.METHODS: Mouse tibial cranial muscles were transfected with plasmids encoding luciferase...

Nitric oxide donor doxorubicins accumulate into Doxorubicin-resistant human colon cancer cells inducing cytotoxicity.

ACS medicinal chemistry letters

Chegaev K, Riganti C, Lazzarato L, Rolando B, Guglielmo S, Campia I, Fruttero R, Bosia A, Gasco A.
PMID: 24900337
ACS Med Chem Lett. 2011 Apr 04;2(7):494-7. doi: 10.1021/ml100302t. eCollection 2011 Jul 14.

Products 4 and 5, obtained by conjugation of doxorubicin with nitric oxide (NO) donor nitrooxy and phenylsulfonyl furoxan moieties, respectively, accumulate in doxorubicin-resistant human colon cancer cells (HT29-dx), inducing high cytotoxicity. This behavior parallels the ability of the compounds...

A genetic link between risk for Alzheimer's disease and severe COVID-19 outcomes via the OAS1 gene.

Brain : a journal of neurology

Magusali N, Graham AC, Piers TM, Panichnantakul P, Yaman U, Shoai M, Reynolds RH, Botia JA, Brookes KJ, Guetta-Baranes T, Bellou E, Bayram S, Sokolova D, Ryten M, Sala Frigerio C, Escott-Price V, Morgan K, Pocock JM, Hardy J, Salih DA.
PMID: 34619763
Brain. 2021 Dec 31;144(12):3727-3741. doi: 10.1093/brain/awab337.

Recently, we reported oligoadenylate synthetase 1 (OAS1) contributed to the risk of Alzheimer's disease, by its enrichment in transcriptional networks expressed by microglia. However, the function of OAS1 within microglia was not known. Using genotyping from 1313 individuals with...

Social skills and psycho-social functioning in early adolescence: a three-year follow-up.

International journal of adolescent medicine and health

Bijstra JO, Jackson S, Bosma HA.
PMID: 22912217
Int J Adolesc Med Health. 2011 May 18;8(4):221-34. doi: 10.1515/IJAMH.1995.8.4.221.

No abstract available.

OmicsOne: associate omics data with phenotypes in one-click.

Clinical proteomics

Zhang H, Ao M, Boja A, Schnaubelt M, Hu Y.
PMID: 34895137
Clin Proteomics. 2021 Dec 11;18(1):29. doi: 10.1186/s12014-021-09334-w.

BACKGROUND: The rapid advancements of high throughput "omics" technologies have brought a massive amount of data to process during and after experiments. Multi-omic analysis facilitates a deeper interrogation of a dataset and the discovery of interesting genes, proteins, lipids,...

Engineering Bioactive Dimeric Transcription Factor Analogs via Palladium Rebound Reagents.

Journal of the American Chemical Society

Jbara M, Pomplun S, Schissel CK, Hawken SW, Boija A, Klein I, Rodriguez J, Buchwald SL, Pentelute BL.
PMID: 34289685
J Am Chem Soc. 2021 Aug 04;143(30):11788-11798. doi: 10.1021/jacs.1c05666. Epub 2021 Jul 22.

Transcription factors (TF), such as Myc, are proteins implicated in disease pathogenesis, with dysregulation of Myc expression in 50% of all human cancers. Still, targeting Myc remains a challenge due to the lack of small molecule binding pockets in...

Retrieval of proximally migrated double J ureteric stents in children using goose neck snare.

Journal of Indian Association of Pediatric Surgeons

Jayakumar S, Marjan M, Wong K, Bolia A, Ninan GK.
PMID: 22279356
J Indian Assoc Pediatr Surg. 2012 Jan;17(1):6-8. doi: 10.4103/0971-9261.91078.

PURPOSE: Proximal migration of the ureteric double J stent is a rare but known complication. We describe three cases where a minimally invasive technique for retrieval of displaced double J stents using Amplatz(™) goose-neck snare was successful.MATERIALS AND METHODS:...

Showing 25 to 36 of 43 entries