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Showing 217 to 228 of 228 entries
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Process monitoring of polysaccharide deketalization for vaccine bioconjugation development using in situ analytical methodology.

Journal of pharmaceutical and biomedical analysis

Lomont JP, Ralbovsky NM, Guza C, Saha-Shah A, Burzynski J, Konietzko J, Wang SC, McHugh PM, Mangion I, Smith JP.
PMID: 34929570
J Pharm Biomed Anal. 2021 Dec 11;209:114533. doi: 10.1016/j.jpba.2021.114533. Epub 2021 Dec 11.

Pneumococcal conjugate vaccines (PCVs) are formed by bioconjugation of a carrier protein to the purified capsular polysaccharide (Ps) from multiple serological strains of Streptococcus pneumoniae. The associated bioconjugation chemistry relies on initial selective modifications to the Ps backbone structure....

Utilizing in situ spectroscopic tools to monitor ketal deprotection processes.

International journal of pharmaceutics

Ralbovsky NM, Lomont JP, Ruccolo S, Konietzko J, McHugh PM, Wang SC, Mangion I, Smith JP.
PMID: 34848366
Int J Pharm. 2021 Nov 27;611:121324. doi: 10.1016/j.ijpharm.2021.121324. Epub 2021 Nov 27.

The use of protection groups to shield a functional group during a synthesis is employed throughout many reactions and organic syntheses. The role of a protection group can be vital to the success of a reaction, as well as...

Utilizing in situ spectroscopic tools to monitor ketal deprotection processes.

International journal of pharmaceutics

Ralbovsky NM, Lomont JP, Ruccolo S, Konietzko J, McHugh PM, Wang SC, Mangion I, Smith JP.
PMID: 34848366
Int J Pharm. 2021 Nov 27;611:121324. doi: 10.1016/j.ijpharm.2021.121324. Epub 2021 Nov 27.

The use of protection groups to shield a functional group during a synthesis is employed throughout many reactions and organic syntheses. The role of a protection group can be vital to the success of a reaction, as well as...

Utilizing in situ spectroscopic tools to monitor ketal deprotection processes.

International journal of pharmaceutics

Ralbovsky NM, Lomont JP, Ruccolo S, Konietzko J, McHugh PM, Wang SC, Mangion I, Smith JP.
PMID: 34848366
Int J Pharm. 2021 Nov 27;611:121324. doi: 10.1016/j.ijpharm.2021.121324. Epub 2021 Nov 27.

The use of protection groups to shield a functional group during a synthesis is employed throughout many reactions and organic syntheses. The role of a protection group can be vital to the success of a reaction, as well as...

Utilizing in situ spectroscopic tools to monitor ketal deprotection processes.

International journal of pharmaceutics

Ralbovsky NM, Lomont JP, Ruccolo S, Konietzko J, McHugh PM, Wang SC, Mangion I, Smith JP.
PMID: 34848366
Int J Pharm. 2022 Jan 05;611:121324. doi: 10.1016/j.ijpharm.2021.121324. Epub 2021 Nov 27.

The use of protection groups to shield a functional group during a synthesis is employed throughout many reactions and organic syntheses. The role of a protection group can be vital to the success of a reaction, as well as...

Splenectomy for primary immune thrombocytopenia revisited in the era of thrombopoietin receptor agonists: New insights for an old treatment.

American journal of hematology

Mageau A, Terriou L, Ebbo M, Souchaud-Debouverie O, Orvain C, Graveleau J, Lega JC, Ruivard M, Viallard JF, Cheze S, Dossier A, Bonnotte B, Perlat A, Gobert D, Costedoat-Chalumeau N, Jeandel PY, Dernoncourt A, Michel M, Godeau B, Comont T.
PMID: 34661954
Am J Hematol. 2021 Oct 18; doi: 10.1002/ajh.26378. Epub 2021 Oct 18.

Although splenectomy is still considered the most effective curative treatment for immune thrombocytopenia (ITP), its use has significantly declined in the last decade, especially since the approval of thrombopoietin receptor agonists (TPO-RAs). The main objective of the study was...

A descriptive study of IgG4-related disease in children and young adults.

Autoimmunity reviews

de Sainte Marie B, Ebbo M, Grados A, Rebours V, Reumaux H, Briantais A, Urbina D, Cury J, Morel N, Lhote F, Rohmer B, Lazaro E, Agbo-Kpati KP, Deroux A, Domont F, Delacroix I, Lavigne C, Perlat A, Kahn JE, Godeau B, Hamidou M, Launay D, Bader-Meunier B, Schleinitz N.
PMID: 34995766
Autoimmun Rev. 2022 Jan 04;21(4):103035. doi: 10.1016/j.autrev.2022.103035. Epub 2022 Jan 04.

No abstract available.

Lignin-First Monomers to Catechol: Rational Cleavage of C-O and C-C Bonds over Zeolites.

ChemSusChem

Wu X, Liao Y, Bomon J, Tian G, Bai ST, Van Aelst K, Zhang Q, Vermandel W, Wambacq B, Maes BUW, Yu J, Sels BF.
PMID: 34927813
ChemSusChem. 2021 Dec 20; doi: 10.1002/cssc.202102248. Epub 2021 Dec 20.

We report a catalytic route to synthesize bio-renewable catechol from softwood derived lignin-first monomers. This process concept consists of two steps: 1) O -demethylation of 4- n -propylguaiacol (4-PG) over acidic Beta zeolites in hot pressurized liquid water delivering...

Deep Proteomic Analysis on Biobanked Paraffine-Archived Melanoma with Prognostic/Predictive Biomarker Read-Out.

Cancers

Szadai L, Velasquez E, Szeitz B, Almeida NP, Domont G, Betancourt LH, Gil J, Marko-Varga M, Oskolas H, Jánosi ÁJ, Boyano-Adánez MDC, Kemény L, Baldetorp B, Malm J, Horvatovich P, Szász AM, Németh IB, Marko-Varga G.
PMID: 34885218
Cancers (Basel). 2021 Dec 03;13(23). doi: 10.3390/cancers13236105.

The discovery of novel protein biomarkers in melanoma is crucial. Our introduction of formalin-fixed paraffin-embedded (FFPE) tumor protocol provides new opportunities to understand the progression of melanoma and open the possibility to screen thousands of FFPE samples deposited in...

A descriptive study of IgG4-related disease in children and young adults.

Autoimmunity reviews

de Sainte Marie B, Ebbo M, Grados A, Rebours V, Reumaux H, Briantais A, Urbina D, Cury J, Morel N, Lhote F, Rohmer B, Lazaro E, Agbo-Kpati KP, Deroux A, Domont F, Delacroix I, Lavigne C, Perlat A, Kahn JE, Godeau B, Hamidou M, Launay D, Bader-Meunier B, Schleinitz N.
PMID: 34995766
Autoimmun Rev. 2022 Jan 04;21(4):103035. doi: 10.1016/j.autrev.2022.103035. Epub 2022 Jan 04.

No abstract available.

COVID-19 outcomes in patients with inflammatory rheumatic and musculoskeletal diseases treated with rituximab: a cohort study.

The Lancet. Rheumatology

Avouac J, Drumez E, Hachulla E, Seror R, Georgin-Lavialle S, El Mahou S, Pertuiset E, Pham T, Marotte H, Servettaz A, Domont F, Chazerain P, Devaux M, Claudepierre P, Langlois V, Mekinian A, Maria ATJ, Banneville B, Fautrel B, Pouchot J, Thomas T, Flipo RM, Richez C.
PMID: 33786454
Lancet Rheumatol. 2021 Jun;3(6):e419-e426. doi: 10.1016/S2665-9913(21)00059-X. Epub 2021 Mar 25.

BACKGROUND: Various observations have suggested that the course of COVID-19 might be less favourable in patients with inflammatory rheumatic and musculoskeletal diseases receiving rituximab compared with those not receiving rituximab. We aimed to investigate whether treatment with rituximab is...

Deep Proteomic Analysis on Biobanked Paraffine-Archived Melanoma with Prognostic/Predictive Biomarker Read-Out.

Cancers

Szadai L, Velasquez E, Szeitz B, Almeida NP, Domont G, Betancourt LH, Gil J, Marko-Varga M, Oskolas H, Jánosi ÁJ, Boyano-Adánez MDC, Kemény L, Baldetorp B, Malm J, Horvatovich P, Szász AM, Németh IB, Marko-Varga G.
PMID: 34885218
Cancers (Basel). 2021 Dec 03;13(23). doi: 10.3390/cancers13236105.

The discovery of novel protein biomarkers in melanoma is crucial. Our introduction of formalin-fixed paraffin-embedded (FFPE) tumor protocol provides new opportunities to understand the progression of melanoma and open the possibility to screen thousands of FFPE samples deposited in...

Showing 217 to 228 of 228 entries