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Showing 25 to 36 of 307 entries
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Somatic Accumulation of GluA1-AMPA Receptors Leads to Selective Cognitive Impairments in Mice.

Frontiers in molecular neuroscience

Bannerman DM, Borchardt T, Jensen V, Rozov A, Haj-Yasein NN, Burnashev N, Zamanillo D, Bus T, Grube I, Adelmann G, Rawlins JNP, Sprengel R.
PMID: 29988555
Front Mol Neurosci. 2018 Jun 25;11:199. doi: 10.3389/fnmol.2018.00199. eCollection 2018.

The GluA1 subunit of the L-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) plays a crucial, but highly selective, role in cognitive function. Here we analyzed AMPAR expression, AMPAR distribution and spatial learning in mice (

Author Correction: The landscape of genomic alterations across childhood cancers.

Nature

Gröbner SN, Worst BC, Weischenfeldt J, Buchhalter I, Kleinheinz K, Rudneva VA, Johann PD, Balasubramanian GP, Segura-Wang M, Brabetz S, Bender S, Hutter B, Sturm D, Pfaff E, Hübschmann D, Zipprich G, Heinold M, Eils J, Lawerenz C, Erkek S, Lambo S, Waszak S, Blattmann C, Borkhardt A, Kuhlen M, Eggert A, Fulda S, Gessler M, Wegert J, Kappler R, Baumhoer D, Burdach S, Kirschner-Schwabe R, Kontny U, Kulozik AE, Lohmann D, Hettmer S, Eckert C, Bielack S, Nathrath M, Niemeyer C, Richter GH, Schulte J, Siebert R, Westermann F, Molenaar JJ, Vassal G, Witt H, Burkhardt B, Kratz CP, Witt O, van Tilburg CM, Kramm CM, Fleischhack G, Dirksen U, Rutkowski S, Frühwald M, von Hoff K, Wolf S, Klingebiel T, Koscielniak E, Landgraf P, Koster J, Resnick AC, Zhang J, Liu Y, Zhou X, Waanders AJ, Zwijnenburg DA, Raman P, Brors B, Weber UD, Northcott PA, Pajtler KW, Kool M, Piro RM, Korbel JO, Schlesner M, Eils R, Jones DTW, Lichter P, Chavez L, Zapatka M, Pfister SM.
PMID: 29875405
Nature. 2018 Jul;559(7714):E10. doi: 10.1038/s41586-018-0167-2.

In this Article, author Benedikt Brors was erroneously associated with affiliation number '8' (Department of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, Tennessee, USA); the author's two other affiliations (affiliations '3' and '7', both at the German Cancer...

Oxa Analogues of Nexturastat A Demonstrate Improved HDAC6 Selectivity and Superior Antileukaemia Activity.

ChemMedChem

Pflieger M, Sönnichsen M, Horstick-Muche N, Yang J, Schliehe-Diecks J, Schöler A, Borkhardt A, Hamacher A, Kassack MU, Hansen FK, Bhatia S, Kurz T.
PMID: 33629513
ChemMedChem. 2021 Jun 07;16(11):1798-1803. doi: 10.1002/cmdc.202001011. Epub 2021 Mar 25.

The acetylome is important for maintaining the homeostasis of cells. Abnormal changes can result in the pathogenesis of immunological or neurological diseases, and degeneration can promote the manifestation of cancer. In particular, pharmacological intervention in the acetylome with pan-histone...

Evaluation of Methods for Inoculating Dry Powder Foods with .

Journal of food protection

Wiertzema JR, Borchardt C, Beckstrom AK, Dev K, Chen P, Chen C, Vickers Z, Feirtag J, Lee L, Ruan R, Baumler DJ.
PMID: 31135183
J Food Prot. 2019 May 28;1082-1088. doi: 10.4315/0362-028X.JFP-18-284. Epub 2019 May 28.

No abstract available.

Mechanochemically-Assisted Synthesis of Polyimides.

ChemSusChem

Rensch T, Fabig S, Grätz S, Borchardt L.
PMID: 34731534
ChemSusChem. 2022 Jan 10;15(1):e202101975. doi: 10.1002/cssc.202101975. Epub 2021 Dec 06.

Polyimides were obtained in 99 % yield in under 1 h through the "beat and heat" approach, involving solvent-free vibrational ball milling and a thermal treatment step. The influence of a plethora of additives was explored, such as Lewis...

A Customized Screening Tool Approach for the Development of a Self-Nanoemulsifying Drug Delivery System (SNEDDS).

AAPS PharmSciTech

Schmied FP, Bernhardt A, Engel A, Klein S.
PMID: 34961897
AAPS PharmSciTech. 2021 Dec 27;23(1):39. doi: 10.1208/s12249-021-02176-7.

The present study focused on establishing a novel, (pre-)screening approach that enables the development of promising performing self-nanoemulsifying drug delivery systems (SNEDDSs) with a limited number of experiments. The strategic approach was based on first identifying appropriate excipients (oils/lipids,...

Intracellular Amplifiers of Reactive Oxygen Species Affecting Mitochondria as Radiosensitizers.

Cancers

Xu HG, Reshetnikov V, Wondrak M, Eckhardt L, Kunz-Schughart LA, Janko C, Tietze R, Alexiou C, Borchardt H, Aigner A, Gong W, Schmitt M, Sellner L, Daum S, Özkan HG, Mokhir A.
PMID: 35008371
Cancers (Basel). 2021 Dec 31;14(1). doi: 10.3390/cancers14010208.

Radiotherapy (RT) efficacy can be improved by using radiosensitizers, i.e., drugs enhancing the effect of ionizing radiation (IR). One of the side effects of RT includes damage of normal tissue in close proximity to the treated tumor. This problem...

Retention Forces of Monolithic CAD/CAM Crowns Adhesively Cemented to Titanium Base Abutments-Effect of Saliva Contamination Followed by Cleaning of the Titanium Bond Surface.

Materials (Basel, Switzerland)

Burkhardt F, Pitta J, Fehmer V, Mojon P, Sailer I.
PMID: 34207110
Materials (Basel). 2021 Jun 18;14(12). doi: 10.3390/ma14123375.

The aim of this study was to investigate the effects of saliva contamination and the cleaning of the bond surface of titanium base (ti-base) abutments on the bonding stability and retention force values. The bond surface of the ti-base...

Chromosomal risk classification in high hyperdiploid acute lymphocytic leukaemia: the beginning of a new chapter.

The Lancet. Haematology

Borkhardt A, Haas OA.
PMID: 34971585
Lancet Haematol. 2022 Jan;9(1):e9. doi: 10.1016/S2352-3026(21)00348-3.

No abstract available.

The SPEER: an interprofessional team behavior rubric to optimize geriatric clinical care.

Gerontology & geriatrics education

Bhattacharya SB, Sabata D, Gibbs H, Jernigan S, Marchello N, Zwahlen D, Yang FM, Bhattacharya RK, Burkhardt C.
PMID: 34872460
Gerontol Geriatr Educ. 2021 Dec 07;1-13. doi: 10.1080/02701960.2021.2002854. Epub 2021 Dec 07.

Geriatric patients with complex health care needs can benefit from interprofessional (IP) care; however, a major gap in health professional education is determining how to prepare future providers for IP collaboration. Effective IP team behavior assessment tools are needed...

Development of a physiologically relevant and easily scalable LUHMES cell-based model of G2019S LRRK2-driven Parkinson's disease.

Disease models & mechanisms

Calamini B, Geyer N, Huss-Braun N, Bernhardt A, Harsany V, Rival P, Cindhuchao M, Hoffmann D, Gratzer S.
PMID: 34114604
Dis Model Mech. 2021 Jun 01;14(6). doi: 10.1242/dmm.048017. Epub 2021 Jun 11.

Parkinson's disease (PD) is a fatal neurodegenerative disorder that is primarily caused by the degeneration and loss of dopaminergic neurons of the substantia nigra in the ventral midbrain. Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common...

The influence of QTL allelic diversity on QTL detection in multi-parent populations: a simulation study in sugar beet.

BMC genomic data

Garin V, Wimmer V, Borchardt D, Malosetti M, van Eeuwijk F.
PMID: 33568071
BMC Genom Data. 2021 Feb 03;22(1):4. doi: 10.1186/s12863-021-00960-9.

BACKGROUND: Multi-parent populations (MPPs) are important resources for studying plant genetic architecture and detecting quantitative trait loci (QTLs). In MPPs, the QTL effects can show various levels of allelic diversity, which can be an important factor influencing the detection...

Showing 25 to 36 of 307 entries