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Showing 25 to 34 of 34 entries
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BTK inhibition sensitizes acute lymphoblastic leukemia to asparaginase by suppressing the amino acid response pathway.

Blood

Butler M, van Ingen Schenau DS, Yu J, Jenni S, Dobay MP, Hagelaar R, Vervoort BMT, Tee TM, Hoff FW, Meijerink JP, Kornblau SM, Bornhauser B, Bourquin JP, Kuiper RP, van der Meer LT, van Leeuwen FN.
PMID: 34280258
Blood. 2021 Dec 09;138(23):2383-2395. doi: 10.1182/blood.2021011787.

Asparaginase (ASNase) therapy has been a mainstay of acute lymphoblastic leukemia (ALL) protocols for decades and shows promise in the treatment of a variety of other cancers. To improve the efficacy of ASNase treatment, we used a CRISPR/Cas9-based screen...

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Butler M, van Ingen Schenau DS, Yu J, et al. BTK inhibition sensitizes acute lymphoblastic leukemia to asparaginase by suppressing the amino acid response pathway. Blood. 2021;138(23):2383-2395doi: 10.1182/blood.2021011787.
Butler, M., van Ingen Schenau, D. S., Yu, J., Jenni, S., Dobay, M. P., Hagelaar, R., Vervoort, B. M. T., Tee, T. M., Hoff, F. W., Meijerink, J. P., Kornblau, S. M., Bornhauser, B., Bourquin, J. P., Kuiper, R. P., van der Meer, L. T., & van Leeuwen, F. N. (2021). BTK inhibition sensitizes acute lymphoblastic leukemia to asparaginase by suppressing the amino acid response pathway. Blood, 138(23), 2383-2395. https://doi.org/10.1182/blood.2021011787
Butler, Miriam, et al. "BTK inhibition sensitizes acute lymphoblastic leukemia to asparaginase by suppressing the amino acid response pathway." Blood vol. 138,23 (2021): 2383-2395. doi: https://doi.org/10.1182/blood.2021011787
Butler M, van Ingen Schenau DS, Yu J, Jenni S, Dobay MP, Hagelaar R, Vervoort BMT, Tee TM, Hoff FW, Meijerink JP, Kornblau SM, Bornhauser B, Bourquin JP, Kuiper RP, van der Meer LT, van Leeuwen FN. BTK inhibition sensitizes acute lymphoblastic leukemia to asparaginase by suppressing the amino acid response pathway. Blood. 2021 Dec 09;138(23):2383-2395. doi: 10.1182/blood.2021011787. PMID: 34280258.
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14q32 rearrangements deregulating BCL11B mark a distinct subgroup of T-lymphoid and myeloid immature acute leukemia.

Blood

Di Giacomo D, La Starza R, Gorello P, Pellanera F, Kalender Atak Z, De Keersmaecker K, Pierini V, Harrison CJ, Arniani S, Moretti M, Testoni N, De Santis G, Roti G, Matteucci C, Bassan R, Vandenberghe P, Aerts S, Cools J, Bornhauser B, Bourquin JP, Piazza R, Mecucci C.
PMID: 33876209
Blood. 2021 Sep 02;138(9):773-784. doi: 10.1182/blood.2020010510.

Acute leukemias (ALs) of ambiguous lineage are a heterogeneous group of high-risk leukemias characterized by coexpression of myeloid and lymphoid markers. In this study, we identified a distinct subgroup of immature acute leukemias characterized by a broadly variable phenotype,...

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Di Giacomo D, La Starza R, Gorello P, et al. 14q32 rearrangements deregulating BCL11B mark a distinct subgroup of T-lymphoid and myeloid immature acute leukemia. Blood. 2021;138(9):773-784doi: 10.1182/blood.2020010510.
Di Giacomo, D., La Starza, R., Gorello, P., Pellanera, F., Kalender Atak, Z., De Keersmaecker, K., Pierini, V., Harrison, C. J., Arniani, S., Moretti, M., Testoni, N., De Santis, G., Roti, G., Matteucci, C., Bassan, R., Vandenberghe, P., Aerts, S., Cools, J., Bornhauser, B., Bourquin, J. P., Piazza, R., & Mecucci, C. (2021). 14q32 rearrangements deregulating BCL11B mark a distinct subgroup of T-lymphoid and myeloid immature acute leukemia. Blood, 138(9), 773-784. https://doi.org/10.1182/blood.2020010510
Di Giacomo, Danika, et al. "14q32 rearrangements deregulating BCL11B mark a distinct subgroup of T-lymphoid and myeloid immature acute leukemia." Blood vol. 138,9 (2021): 773-784. doi: https://doi.org/10.1182/blood.2020010510
Di Giacomo D, La Starza R, Gorello P, Pellanera F, Kalender Atak Z, De Keersmaecker K, Pierini V, Harrison CJ, Arniani S, Moretti M, Testoni N, De Santis G, Roti G, Matteucci C, Bassan R, Vandenberghe P, Aerts S, Cools J, Bornhauser B, Bourquin JP, Piazza R, Mecucci C. 14q32 rearrangements deregulating BCL11B mark a distinct subgroup of T-lymphoid and myeloid immature acute leukemia. Blood. 2021 Sep 02;138(9):773-784. doi: 10.1182/blood.2020010510. PMID: 33876209; PMCID: PMC8513670.
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Long-term VTE treatment with rivaroxaban: Results from the DRESDEN NOAC REGISTRY.

Thrombosis research

Marten S, Naue C, Tittl L, Bornhauser M, Beyer-Westendorf J.
PMID: 34808410
Thromb Res. 2021 Nov 16;208:181-189. doi: 10.1016/j.thromres.2021.11.006. Epub 2021 Nov 16.

Data on long-term effectiveness and safety of venous thromboembolism (VTE) treatment with rivaroxaban are scarce and not available from randomized clinical trials. To supplement the positive results of phase III VTE treatment trials with rivaroxaban, we used data from...

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Marten S, Naue C, Tittl L, et al. Long-term VTE treatment with rivaroxaban: Results from the DRESDEN NOAC REGISTRY. Thromb Res. 2021;208:181-189doi: 10.1016/j.thromres.2021.11.006.
Marten, S., Naue, C., Tittl, L., Bornhauser, M., & Beyer-Westendorf, J. (2021). Long-term VTE treatment with rivaroxaban: Results from the DRESDEN NOAC REGISTRY. Thrombosis research, 208181-189. https://doi.org/10.1016/j.thromres.2021.11.006
Marten, Sandra, et al. "Long-term VTE treatment with rivaroxaban: Results from the DRESDEN NOAC REGISTRY." Thrombosis research vol. 208 (2021): 181-189. doi: https://doi.org/10.1016/j.thromres.2021.11.006
Marten S, Naue C, Tittl L, Bornhauser M, Beyer-Westendorf J. Long-term VTE treatment with rivaroxaban: Results from the DRESDEN NOAC REGISTRY. Thromb Res. 2021 Nov 16;208:181-189. doi: 10.1016/j.thromres.2021.11.006. Epub 2021 Nov 16. PMID: 34808410.
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A Hopeful Leap Forward by Multicentric Cooperation for Precision-Based Therapy for Very Resistant, Relapsed, or Refractory Childhood Leukemia.

Cancer discovery

Bornhauser BC, Bourquin JP.
PMID: 34078660
Cancer Discov. 2021 Jun;11(6):1322-1323. doi: 10.1158/2159-8290.CD-21-0258.

Pikman and colleagues report the results of a multicentric prospective clinical trial of the leukemia precision-based therapy (LEAP) consortium that combines identification of targetable lesions in drug-resistant childhood leukemia, tiered based on evidence for genomic lesions and drug target,...

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Bornhauser BC, Bourquin JP. A Hopeful Leap Forward by Multicentric Cooperation for Precision-Based Therapy for Very Resistant, Relapsed, or Refractory Childhood Leukemia. Cancer Discov. 2021;11(6):1322-1323doi: 10.1158/2159-8290.CD-21-0258.
Bornhauser, B. C., & Bourquin, J. P. (2021). A Hopeful Leap Forward by Multicentric Cooperation for Precision-Based Therapy for Very Resistant, Relapsed, or Refractory Childhood Leukemia. Cancer discovery, 11(6), 1322-1323. https://doi.org/10.1158/2159-8290.CD-21-0258
Bornhauser, Beat C, and Bourquin, Jean-Pierre. "A Hopeful Leap Forward by Multicentric Cooperation for Precision-Based Therapy for Very Resistant, Relapsed, or Refractory Childhood Leukemia." Cancer discovery vol. 11,6 (2021): 1322-1323. doi: https://doi.org/10.1158/2159-8290.CD-21-0258
Bornhauser BC, Bourquin JP. A Hopeful Leap Forward by Multicentric Cooperation for Precision-Based Therapy for Very Resistant, Relapsed, or Refractory Childhood Leukemia. Cancer Discov. 2021 Jun;11(6):1322-1323. doi: 10.1158/2159-8290.CD-21-0258. PMID: 34078660.
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Perturbation-facilitated detection of the first quintet-quintet band in C2.

The Journal of chemical physics

Bornhauser P, Marquardt R, Gourlaouen C, Knopp G, Beck M, Gerber T, van Bokhoven JA, Radi PP.
PMID: 25747087
J Chem Phys. 2015 Mar 07;142(9):094313. doi: 10.1063/1.4913925.

The first high-spin transition in C2 (1 (5)Πu - 1 (5)Πg) is observed by perturbation-facilitated optical-optical double resonance spectroscopy. The experiment is performed by applying unfolded two-color resonant four-wave mixing. C2 radicals in the initial a (3)Πu, v =...

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Bornhauser P, Marquardt R, Gourlaouen C, et al. Perturbation-facilitated detection of the first quintet-quintet band in C2. J Chem Phys. 2015;142(9):094313doi: 10.1063/1.4913925.
Bornhauser, P., Marquardt, R., Gourlaouen, C., Knopp, G., Beck, M., Gerber, T., van Bokhoven, J. A., & Radi, P. P. (2015). Perturbation-facilitated detection of the first quintet-quintet band in C2. The Journal of chemical physics, 142(9), 094313. https://doi.org/10.1063/1.4913925
Bornhauser, P, et al. "Perturbation-facilitated detection of the first quintet-quintet band in C2." The Journal of chemical physics vol. 142,9 (2015): 094313. doi: https://doi.org/10.1063/1.4913925
Bornhauser P, Marquardt R, Gourlaouen C, Knopp G, Beck M, Gerber T, van Bokhoven JA, Radi PP. Perturbation-facilitated detection of the first quintet-quintet band in C2. J Chem Phys. 2015 Mar 07;142(9):094313. doi: 10.1063/1.4913925. PMID: 25747087.
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Perturbation facilitated two-color four-wave-mixing spectroscopy of C3.

The Journal of chemical physics

Sych Y, Bornhauser P, Knopp G, Liu Y, Gerber T, Marquardt R, Radi PP.
PMID: 24160506
J Chem Phys. 2013 Oct 21;139(15):154203. doi: 10.1063/1.4825198.

Perturbation-facilitated two-color resonant four-wave-mixing spectroscopy is realized to access the (dark) triplet manifold of the C3 molecule from the singlet X̃(1)Σg (+) ground state. The inherent nonlinear signal dependence and coherence of the technique result in a favorable detection...

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Sych Y, Bornhauser P, Knopp G, et al. Perturbation facilitated two-color four-wave-mixing spectroscopy of C3. J Chem Phys. 2013;139(15):154203doi: 10.1063/1.4825198.
Sych, Y., Bornhauser, P., Knopp, G., Liu, Y., Gerber, T., Marquardt, R., & Radi, P. P. (2013). Perturbation facilitated two-color four-wave-mixing spectroscopy of C3. The Journal of chemical physics, 139(15), 154203. https://doi.org/10.1063/1.4825198
Sych, Y, et al. "Perturbation facilitated two-color four-wave-mixing spectroscopy of C3." The Journal of chemical physics vol. 139,15 (2013): 154203. doi: https://doi.org/10.1063/1.4825198
Sych Y, Bornhauser P, Knopp G, Liu Y, Gerber T, Marquardt R, Radi PP. Perturbation facilitated two-color four-wave-mixing spectroscopy of C3. J Chem Phys. 2013 Oct 21;139(15):154203. doi: 10.1063/1.4825198. PMID: 24160506.
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Spectroscopic disentanglement of the quantum states of highly excited Cu.

Nature communications

Beck M, Bornhauser P, Visser B, Knopp G, Bokhoven JAV, Radi PP.
PMID: 31332175
Nat Commun. 2019 Jul 22;10(1):3270. doi: 10.1038/s41467-019-11156-2.

Transition metals, characterised by their partially filled d orbitals, provide the basis for many of the most relevant processes in chemistry, biology, and physics. Embedded as single atoms or in small clusters, they give rise to exceptional optical, chemical,...

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Beck M, Bornhauser P, Visser B, et al. Spectroscopic disentanglement of the quantum states of highly excited Cu. Nat Commun. 2019;10(1):3270doi: 10.1038/s41467-019-11156-2.
Beck, M., Bornhauser, P., Visser, B., Knopp, G., Bokhoven, J. A. V., & Radi, P. P. (2019). Spectroscopic disentanglement of the quantum states of highly excited Cu. Nature communications, 10(1), 3270. https://doi.org/10.1038/s41467-019-11156-2
Beck, M, et al. "Spectroscopic disentanglement of the quantum states of highly excited Cu." Nature communications vol. 10,1 (2019): 3270. doi: https://doi.org/10.1038/s41467-019-11156-2
Beck M, Bornhauser P, Visser B, Knopp G, Bokhoven JAV, Radi PP. Spectroscopic disentanglement of the quantum states of highly excited Cu. Nat Commun. 2019 Jul 22;10(1):3270. doi: 10.1038/s41467-019-11156-2. PMID: 31332175; PMCID: PMC6646321.
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Prevalence of diabetic nephropathy in Type 2 Diabetes Mellitus in rural communities of Guanajuato, Mexico. Effect after 6 months of Telmisartan treatment.

Journal of clinical & translational endocrinology

Zenteno-Castillo P, Muñoz-López DB, Merino-Reyes B, Vega-Sánchez Á, Preciado-Puga M, González-Yebra AL, Kornhauser C.
PMID: 29159116
J Clin Transl Endocrinol. 2015 Aug 18;2(4):125-128. doi: 10.1016/j.jcte.2015.08.001. eCollection 2015 Dec.

OBJECTIVE: To determine the prevalence of Diabetic Nephropathy (DN) in patients with type 2 Diabetes Mellitus (T2DM) with over 5 years of evolution in rural communities of Guanajuato, Mexico, and evaluate the effects of an ARB treatment over 6...

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Zenteno-Castillo P, Muñoz-López DB, Merino-Reyes B, et al. Prevalence of diabetic nephropathy in Type 2 Diabetes Mellitus in rural communities of Guanajuato, Mexico. Effect after 6 months of Telmisartan treatment. J Clin Transl Endocrinol. 2015;2(4):125-128doi: 10.1016/j.jcte.2015.08.001.
Zenteno-Castillo, P., Muñoz-López, D. B., Merino-Reyes, B., Vega-Sánchez, �. �., Preciado-Puga, M., González-Yebra, A. L., & Kornhauser, C. (2015). Prevalence of diabetic nephropathy in Type 2 Diabetes Mellitus in rural communities of Guanajuato, Mexico. Effect after 6 months of Telmisartan treatment. Journal of clinical & translational endocrinology, 2(4), 125-128. https://doi.org/10.1016/j.jcte.2015.08.001
Zenteno-Castillo, Priscyla, et al. "Prevalence of diabetic nephropathy in Type 2 Diabetes Mellitus in rural communities of Guanajuato, Mexico. Effect after 6 months of Telmisartan treatment." Journal of clinical & translational endocrinology vol. 2,4 (2015): 125-128. doi: https://doi.org/10.1016/j.jcte.2015.08.001
Zenteno-Castillo P, Muñoz-López DB, Merino-Reyes B, Vega-Sánchez Á, Preciado-Puga M, González-Yebra AL, Kornhauser C. Prevalence of diabetic nephropathy in Type 2 Diabetes Mellitus in rural communities of Guanajuato, Mexico. Effect after 6 months of Telmisartan treatment. J Clin Transl Endocrinol. 2015 Aug 18;2(4):125-128. doi: 10.1016/j.jcte.2015.08.001. eCollection 2015 Dec. PMID: 29159116; PMCID: PMC5685013.
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Clonal dynamics in pediatric B-cell precursor acute lymphoblastic leukemia with very early relapse.

Pediatric blood & cancer

Antić Ž, Yu J, Bornhauser BC, Lelieveld SH, van der Ham CG, van Reijmersdal SV, Morgado L, Elitzur S, Bourquin JP, Cazzaniga G, Eckert C, Camós M, Sutton R, Cavé H, Moorman AV, Sonneveld E, Geurts van Kessel A, van Leeuwen FN, Hoogerbrugge PM, Waanders E, Kuiper RP.
PMID: 34597466
Pediatr Blood Cancer. 2022 Jan;69(1):e29361. doi: 10.1002/pbc.29361. Epub 2021 Oct 01.

INTRODUCTION: One-quarter of the relapses in children with B-cell precursor acute lymphoblastic leukemia (BCP-ALL) occur very early (within 18 months, before completion of treatment), and prognosis in these patients is worse compared to cases that relapse after treatment has...

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Antić Ž, Yu J, Bornhauser BC, et al. Clonal dynamics in pediatric B-cell precursor acute lymphoblastic leukemia with very early relapse. Pediatr Blood Cancer. 2021;69(1):e29361doi: 10.1002/pbc.29361.
Antić, �. �., Yu, J., Bornhauser, B. C., Lelieveld, S. H., van der Ham, C. G., van Reijmersdal, S. V., Morgado, L., Elitzur, S., Bourquin, J. P., Cazzaniga, G., Eckert, C., Camós, M., Sutton, R., Cavé, H., Moorman, A. V., Sonneveld, E., Geurts van Kessel, A., van Leeuwen, F. N., Hoogerbrugge, P. M., Waanders, E., & Kuiper, R. P. (2022). Clonal dynamics in pediatric B-cell precursor acute lymphoblastic leukemia with very early relapse. Pediatric blood & cancer, 69(1), e29361. https://doi.org/10.1002/pbc.29361
Antić, Željko, et al. "Clonal dynamics in pediatric B-cell precursor acute lymphoblastic leukemia with very early relapse." Pediatric blood & cancer vol. 69,1 (2022): e29361. doi: https://doi.org/10.1002/pbc.29361
Antić Ž, Yu J, Bornhauser BC, Lelieveld SH, van der Ham CG, van Reijmersdal SV, Morgado L, Elitzur S, Bourquin JP, Cazzaniga G, Eckert C, Camós M, Sutton R, Cavé H, Moorman AV, Sonneveld E, Geurts van Kessel A, van Leeuwen FN, Hoogerbrugge PM, Waanders E, Kuiper RP. Clonal dynamics in pediatric B-cell precursor acute lymphoblastic leukemia with very early relapse. Pediatr Blood Cancer. 2022 Jan;69(1):e29361. doi: 10.1002/pbc.29361. Epub 2021 Oct 01. PMID: 34597466.
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BTK inhibition sensitizes acute lymphoblastic leukemia to asparaginase by suppressing the amino acid response pathway.

Blood

Butler M, van Ingen Schenau DS, Yu J, Jenni S, Dobay MP, Hagelaar R, Vervoort BMT, Tee TM, Hoff FW, Meijerink JP, Kornblau SM, Bornhauser B, Bourquin JP, Kuiper RP, van der Meer LT, van Leeuwen FN.
PMID: 34280258
Blood. 2021 Dec 09;138(23):2383-2395. doi: 10.1182/blood.2021011787.

Asparaginase (ASNase) therapy has been a mainstay of acute lymphoblastic leukemia (ALL) protocols for decades and shows promise in the treatment of a variety of other cancers. To improve the efficacy of ASNase treatment, we used a CRISPR/Cas9-based screen...

Cite
Butler M, van Ingen Schenau DS, Yu J, et al. BTK inhibition sensitizes acute lymphoblastic leukemia to asparaginase by suppressing the amino acid response pathway. Blood. 2021;138(23):2383-2395doi: 10.1182/blood.2021011787.
Butler, M., van Ingen Schenau, D. S., Yu, J., Jenni, S., Dobay, M. P., Hagelaar, R., Vervoort, B. M. T., Tee, T. M., Hoff, F. W., Meijerink, J. P., Kornblau, S. M., Bornhauser, B., Bourquin, J. P., Kuiper, R. P., van der Meer, L. T., & van Leeuwen, F. N. (2021). BTK inhibition sensitizes acute lymphoblastic leukemia to asparaginase by suppressing the amino acid response pathway. Blood, 138(23), 2383-2395. https://doi.org/10.1182/blood.2021011787
Butler, Miriam, et al. "BTK inhibition sensitizes acute lymphoblastic leukemia to asparaginase by suppressing the amino acid response pathway." Blood vol. 138,23 (2021): 2383-2395. doi: https://doi.org/10.1182/blood.2021011787
Butler M, van Ingen Schenau DS, Yu J, Jenni S, Dobay MP, Hagelaar R, Vervoort BMT, Tee TM, Hoff FW, Meijerink JP, Kornblau SM, Bornhauser B, Bourquin JP, Kuiper RP, van der Meer LT, van Leeuwen FN. BTK inhibition sensitizes acute lymphoblastic leukemia to asparaginase by suppressing the amino acid response pathway. Blood. 2021 Dec 09;138(23):2383-2395. doi: 10.1182/blood.2021011787. PMID: 34280258.
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Showing 25 to 34 of 34 entries