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Showing 2521 to 2525 of 2525 entries
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Analysis of independent cohorts of outbred CFW mice reveals novel loci for behavioral and physiological traits and identifies factors determining reproducibility.

G3 (Bethesda, Md.)

Zou J, Gopalakrishnan S, Parker CC, Nicod J, Mott R, Cai N, Lionikas A, Davies RW, Palmer AA, Flint J.
PMID: 34791208
G3 (Bethesda). 2021 Nov 13; doi: 10.1093/g3journal/jkab394. Epub 2021 Nov 13.

Combining samples for genetic association is standard practice in human genetic analysis of complex traits, but is rarely undertaken in rodent genetics. Here, using 23 phenotypes and genotypes from two independent laboratories, we obtained a sample size of 3,076...

Challenges in Veterinary Vaccine Development.

Methods in molecular biology (Clifton, N.J.)

Thomas S, Abraham A, Rodríguez-Mallon A, Unajak S, Bannantine JP.
PMID: 34816396
Methods Mol Biol. 2022;2411:3-34. doi: 10.1007/978-1-0716-1888-2_1.

Animals provide food and clothing in addition to other value-added products. Changes in diet and lifestyle have increased the consumption and the use of animal products. Infectious diseases in animals are a major threat to global animal health and...

Next-Generation Sequencing of 487 Esophageal Adenocarcinomas Reveals Independently Prognostic Genomic Driver Alterations and Pathways.

Clinical cancer research : an official journal of the American Association for Cancer Research

Sihag S, Nussenzweig SC, Walch HS, Hsu M, Tan KS, Sanchez-Vega F, Chatila WK, De La Torre SA, Patel A, Janjigian YY, Maron S, Ku GY, Tang LH, Hechtman J, Shah PM, Wu AJ, Jones DR, Molena D, Solit DB, Schultz N, Berger MF.
PMID: 33795256
Clin Cancer Res. 2021 Jun 15;27(12):3491-3498. doi: 10.1158/1078-0432.CCR-20-4707. Epub 2021 Apr 01.

PURPOSE: To delineate recurrent oncogenic driver alterations and dysregulated pathways in esophageal adenocarcinoma and to assess their prognostic value.EXPERIMENTAL DESIGN: We analyzed a large cohort of patients with lower esophageal and junctional adenocarcinoma, prospectively sequenced by MSK-IMPACT with high-quality...

Genome-wide association study of problematic opioid prescription use in 132,113 23andMe research participants of European ancestry.

Molecular psychiatry

Sanchez-Roige S, Fontanillas P, Jennings MV, Bianchi SB, Huang Y, Hatoum AS, Sealock J, Davis LK, Elson SL, Palmer AA.
PMID: 34728798
Mol Psychiatry. 2021 Nov;26(11):6209-6217. doi: 10.1038/s41380-021-01335-3. Epub 2021 Nov 02.

The growing prevalence of opioid use disorder (OUD) constitutes an urgent health crisis. Ample evidence indicates that risk for OUD is heritable. As a surrogate (or proxy) for OUD, we explored the genetic basis of using prescription opioids 'not...

A randomized controlled trial to optimize patient's selection for endovascular treatment in acute ischemic stroke (SELECT2): Study protocol.

International journal of stroke : official journal of the International Stroke Society

Sarraj A, Hassan AE, Abraham M, Ribo M, Blackburn S, Chen M, Hussain MS, Pereira VM, Ortega-Gutierrez S, Sitton C, Lavori PW, Cai C, Rahbar M, Pujara D, Shaker F, Lansberg MG, Campbell B, Grotta JC, Albers GW.
PMID: 34282987
Int J Stroke. 2021 Dec 15;17474930211035032. doi: 10.1177/17474930211035032. Epub 2021 Dec 15.

RATIONALE: Randomized evidence for endovascular thrombectomy safety and efficacy in patients with large core strokes is lacking.AIMS: To demonstrate endovascular thrombectomy efficacy and safety in patients with large core on non-contrast CT or perfusion imaging (CT/MR) and determine if...

Showing 2521 to 2525 of 2525 entries