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Showing 13 to 24 of 34 entries
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Molecular underpinnings of cancer in ulcerative colitis.

Current opinion in gastroenterology

Brentnall TA.
PMID: 15699896
Curr Opin Gastroenterol. 2003 Jan;19(1):64-8. doi: 10.1097/00001574-200301000-00011.

Ulcerative colitis (UC) is a chronic inflammatory disease of the colon that can lead to cancer. Patients with UC have approximately 20% lifetime risk of colon cancer, with the risk increasing with the duration of disease. Why some patients...

The impact of using weight estimated from mammographic images .

Proceedings of SPIE--the International Society for Optical Engineering

Nair KP, Harkness EF, Gadde S, Lim YY, Maxwell AJ, Moschidis E, Foden P, Cuzick J, Brentnall A, Evans DG, Howell A, Astley SM.
PMID: 34925706
Proc SPIE Int Soc Opt Eng. 2017 Mar 03;10134. doi: 10.1117/12.2255619. eCollection 2017 Mar 03.

Personalised breast screening requires assessment of individual risk of breast cancer, of which one contributory factor is weight. Self-reported weight has been used for this purpose, but may be unreliable. We explore the use of volume of fat in...

Risk Models for Breast Cancer and Their Validation.

Statistical science : a review journal of the Institute of Mathematical Statistics

Brentnall AR, Cuzick J.
PMID: 32226220
Stat Sci. 2020 Mar 03;35(1):14-30. doi: 10.1214/19-STS729.

Strategies to prevent cancer and diagnose it early when it is most treatable are needed to reduce the public health burden from rising disease incidence. Risk assessment is playing an increasingly important role in targeting individuals in need of...

Systemic Proteome Alterations Linked to Early Stage Pancreatic Cancer in Diabetic Patients.

Cancers

Peng H, Pan S, Yan Y, Brand RE, Petersen GM, Chari ST, Lai LA, Eng JK, Brentnall TA, Chen R.
PMID: 32545216
Cancers (Basel). 2020 Jun 11;12(6). doi: 10.3390/cancers12061534.

BACKGROUND: Diabetes is a risk factor associated with pancreatic ductal adenocarcinoma (PDAC), and new adult-onset diabetes can be an early sign of pancreatic malignancy. Development of blood-based biomarkers to identify diabetic patients who warrant imaging tests for cancer detection...

Evaluation of a novel universal robotic surgery virtual reality simulation proficiency index that will allow comparisons of users across any virtual reality simulation curriculum.

Surgical endoscopy

Simmonds C, Brentnall M, Lenihan J.
PMID: 34231063
Surg Endosc. 2021 Oct;35(10):5867-5875. doi: 10.1007/s00464-021-08609-5. Epub 2021 Jul 06.

STUDY OBJECTIVE: Evaluate a universal proficiency metric for Robotic Surgery Virtual Reality (VR) simulation that will allow comparison of all users across any VR curriculum.DESIGN: Retrospective analysis of VR Simulation metrics.SETTING: Two training institutions.PATIENTS OR PARTICIPANTS: Residents, fellows and...

Dynamic tracking of microvascular hemoglobin content for continuous perfusion monitoring in the intensive care unit: pilot feasibility study.

Journal of clinical monitoring and computing

Mendelson AA, Rajaram A, Bainbridge D, Lawrence KS, Bentall T, Sharpe M, Diop M, Ellis CG.
PMID: 33104968
J Clin Monit Comput. 2021 Dec;35(6):1453-1465. doi: 10.1007/s10877-020-00611-x. Epub 2020 Oct 26.

PURPOSE: There is a need for bedside methods to monitor oxygen delivery in the microcirculation. Near-infrared spectroscopy commonly measures tissue oxygen saturation, but does not reflect the time-dependent variability of microvascular hemoglobin content (MHC) that attempts to match oxygen...

The importance of ethnicity: Are breast cancer polygenic risk scores ready for women who are not of White European origin?.

International journal of cancer

Evans DG, van Veen EM, Byers H, Roberts E, Howell A, Howell SJ, Harkness EF, Brentnall A, Cuzick J, Newman WG.
PMID: 34460111
Int J Cancer. 2022 Jan 01;150(1):73-79. doi: 10.1002/ijc.33782. Epub 2021 Sep 07.

Polygenic risk scores (PRS) for disease risk stratification show great promise for application in general populations, but most are based on data from individuals of White European origin. We assessed two well validated PRS (SNP18, SNP143) in the Predicting-Risk-of-Cancer-At-Screening...

Proteome heterogeneity and malignancy detection in pancreatic cyst fluids.

Clinical and translational medicine

Pan S, Brand RE, Lai LA, Dawson DW, Donahue TR, Kim S, Khalaf NI, Othman MO, Fisher WE, Bronner MP, Simeone DM, Brentnall TA, Chen R.
PMID: 34459141
Clin Transl Med. 2021 Aug;11(8):e506. doi: 10.1002/ctm2.506.

No abstract available.

Insoluble derivatives of polynucleotide-phosphorylase.

FEBS letters

Smith JC, Stratford IJ, Hutchinson DW, Brentnall HJ.
PMID: 11947104
FEBS Lett. 1973 Mar 01;30(2):246-248. doi: 10.1016/0014-5793(73)80662-3.

No abstract available.

Proteome heterogeneity and malignancy detection in pancreatic cyst fluids.

Clinical and translational medicine

Pan S, Brand RE, Lai LA, Dawson DW, Donahue TR, Kim S, Khalaf NI, Othman MO, Fisher WE, Bronner MP, Simeone DM, Brentnall TA, Chen R.
PMID: 34459141
Clin Transl Med. 2021 Aug;11(8):e506. doi: 10.1002/ctm2.506.

No abstract available.

Arabidopsis Glutathione Transferases U24 and U25 Exhibit a Range of Detoxification Activities with the Environmental Pollutant and Explosive, 2,4,6-Trinitrotoluene.

Plant physiology

Gunning V, Tzafestas K, Sparrow H, Johnston EJ, Brentnall AS, Potts JR, Rylott EL, Bruce NC.
PMID: 24733884
Plant Physiol. 2014 Jun;165(2):854-865. doi: 10.1104/pp.114.237180. Epub 2014 Apr 14.

The explosive 2,4,6-trinitrotoluene (TNT) is a major worldwide military pollutant. The presence of this toxic and highly persistent pollutant, particularly at military sites and former manufacturing facilities, presents various health and environmental concerns. Due to the chemically resistant structure...

Final Results of the Prospective FH02 Mammographic Surveillance Study of Women Aged 35-39 at Increased Familial Risk of Breast Cancer.

EClinicalMedicine

Evans DG, Thomas S, Caunt J, Burch A, Brentnall AR, Roberts L, Howell A, Wilson M, Fox R, Hillier S, Sibbering DM, Moss S, Wallis MG, Eccles DM, Duffy S.
PMID: 31008449
EClinicalMedicine. 2019 Jan;7:39-46. doi: 10.1016/j.eclinm.2019.01.005.

BACKGROUND: Many women who are at increased risk of breast cancer due to a mother or sister diagnosed with breast cancer aged under 40 do not currently qualify for surveillance before 40 years of age. There are almost no...

Showing 13 to 24 of 34 entries