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Synthesis and evaluation of bifunctional PTP4A3 phosphatase inhibitors activating the ER stress pathway.

Bioorganic & medicinal chemistry letters

Rastelli EJ, Sannino S, Hart DJ, Sharlow ER, Lazo JS, Brodsky JL, Wipf P.
PMID: 34089839
Bioorg Med Chem Lett. 2021 Aug 15;46:128167. doi: 10.1016/j.bmcl.2021.128167. Epub 2021 Jun 02.

We developed JMS-053, a potent inhibitor of the dual specificity phosphatase PTP4A3 that is potentially suitable for cancer therapy. Due to the emerging role of the unfolded protein response (UPR) in cancer pathology, we sought to identify derivatives that...

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Rastelli EJ, Sannino S, Hart DJ, et al. Synthesis and evaluation of bifunctional PTP4A3 phosphatase inhibitors activating the ER stress pathway. Bioorg Med Chem Lett. 2021;46:128167doi: 10.1016/j.bmcl.2021.128167.
Rastelli, E. J., Sannino, S., Hart, D. J., Sharlow, E. R., Lazo, J. S., Brodsky, J. L., & Wipf, P. (2021). Synthesis and evaluation of bifunctional PTP4A3 phosphatase inhibitors activating the ER stress pathway. Bioorganic & medicinal chemistry letters, 46128167. https://doi.org/10.1016/j.bmcl.2021.128167
Rastelli, Ettore J, et al. "Synthesis and evaluation of bifunctional PTP4A3 phosphatase inhibitors activating the ER stress pathway." Bioorganic & medicinal chemistry letters vol. 46 (2021): 128167. doi: https://doi.org/10.1016/j.bmcl.2021.128167
Rastelli EJ, Sannino S, Hart DJ, Sharlow ER, Lazo JS, Brodsky JL, Wipf P. Synthesis and evaluation of bifunctional PTP4A3 phosphatase inhibitors activating the ER stress pathway. Bioorg Med Chem Lett. 2021 Aug 15;46:128167. doi: 10.1016/j.bmcl.2021.128167. Epub 2021 Jun 02. PMID: 34089839.
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Senescent Tissue-Resident Mesenchymal Stromal Cells Are an Internal Source of Inflammation in Human Osteoarthritic Cartilage.

Frontiers in cell and developmental biology

Liu W, Brodsky AS, Feng M, Liu Y, Ding J, Jayasuriya CT, Chen Q, Situmorang M, Sitorus M.
PMID: 34552931
Front Cell Dev Biol. 2021 Sep 06;9:725071. doi: 10.3389/fcell.2021.725071. eCollection 2021.

Human osteoarthritic cartilage contains not only chondrocytes (OACs), but also mesenchymal stromal cells (OA-MSCs), whose abundance increases during osteoarthritis (OA). However, it is not clear how OA-MSC contributes to OA pathogenesis. Here, we show that aging OA-MSC plays an...

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Liu W, Brodsky AS, Feng M, et al. Senescent Tissue-Resident Mesenchymal Stromal Cells Are an Internal Source of Inflammation in Human Osteoarthritic Cartilage. Front Cell Dev Biol. 2021;9:725071doi: 10.3389/fcell.2021.725071.
Liu, W., Brodsky, A. S., Feng, M., Liu, Y., Ding, J., Jayasuriya, C. T., Chen, Q., Situmorang, M., & Sitorus, M. (2021). Senescent Tissue-Resident Mesenchymal Stromal Cells Are an Internal Source of Inflammation in Human Osteoarthritic Cartilage. Frontiers in cell and developmental biology, 9725071. https://doi.org/10.3389/fcell.2021.725071
Liu, Wenguang, et al. "Senescent Tissue-Resident Mesenchymal Stromal Cells Are an Internal Source of Inflammation in Human Osteoarthritic Cartilage." Frontiers in cell and developmental biology vol. 9 (2021): 725071. doi: https://doi.org/10.3389/fcell.2021.725071
Liu W, Brodsky AS, Feng M, Liu Y, Ding J, Jayasuriya CT, Chen Q, Situmorang M, Sitorus M. Senescent Tissue-Resident Mesenchymal Stromal Cells Are an Internal Source of Inflammation in Human Osteoarthritic Cartilage. Front Cell Dev Biol. 2021 Sep 06;9:725071. doi: 10.3389/fcell.2021.725071. eCollection 2021. PMID: 34552931; PMCID: PMC8450518.
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Effects of Vitamin D Supplementation on Insulin Sensitivity and Secretion in Prediabetes.

The Journal of clinical endocrinology and metabolism

Rasouli N, Brodsky IG, Chatterjee R, Kim SH, Pratley RE, Staten MA, Pittas AG.
PMID: 34473295
J Clin Endocrinol Metab. 2022 Jan 01;107(1):230-240. doi: 10.1210/clinem/dgab649.

CONTEXT: Vitamin D regulates glucose homeostasis pathways, but effects of vitamin D supplementation on β-cell function remain unclear.OBJECTIVE: To investigate the effects of vitamin D3 supplementation on insulin sensitivity and β-cell function.METHODS: This is a prespecified secondary analysis of...

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Rasouli N, Brodsky IG, Chatterjee R, et al. Effects of Vitamin D Supplementation on Insulin Sensitivity and Secretion in Prediabetes. J Clin Endocrinol Metab. 2022;107(1):230-240doi: 10.1210/clinem/dgab649.
Rasouli, N., Brodsky, I. G., Chatterjee, R., Kim, S. H., Pratley, R. E., Staten, M. A., Pittas, A. G. (2022). Effects of Vitamin D Supplementation on Insulin Sensitivity and Secretion in Prediabetes. The Journal of clinical endocrinology and metabolism, 107(1), 230-240. https://doi.org/10.1210/clinem/dgab649
Rasouli, Neda, et al. "Effects of Vitamin D Supplementation on Insulin Sensitivity and Secretion in Prediabetes." The Journal of clinical endocrinology and metabolism vol. 107,1 (2022): 230-240. doi: https://doi.org/10.1210/clinem/dgab649
Rasouli N, Brodsky IG, Chatterjee R, Kim SH, Pratley RE, Staten MA, Pittas AG. Effects of Vitamin D Supplementation on Insulin Sensitivity and Secretion in Prediabetes. J Clin Endocrinol Metab. 2022 Jan 01;107(1):230-240. doi: 10.1210/clinem/dgab649. PMID: 34473295; PMCID: PMC8684490.
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In Memoriam: Peter Hartmann (1946-2020), publisher, colleague, and friend.

Traffic (Copenhagen, Denmark)

Brodsky FM, Parham P.
PMID: 32981140
Traffic. 2020 Dec;21(12):749-750. doi: 10.1111/tra.12767. Epub 2020 Oct 11.

No abstract available.

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Brodsky FM, Parham P. In Memoriam: Peter Hartmann (1946-2020), publisher, colleague, and friend. Traffic. 2020;21(12):749-750doi: 10.1111/tra.12767.
Brodsky, F. M., & Parham, P. (2020). In Memoriam: Peter Hartmann (1946-2020), publisher, colleague, and friend. Traffic (Copenhagen, Denmark), 21(12), 749-750. https://doi.org/10.1111/tra.12767
Brodsky, Frances M, and Parham, Peter. "In Memoriam: Peter Hartmann (1946-2020), publisher, colleague, and friend." Traffic (Copenhagen, Denmark) vol. 21,12 (2020): 749-750. doi: https://doi.org/10.1111/tra.12767
Brodsky FM, Parham P. In Memoriam: Peter Hartmann (1946-2020), publisher, colleague, and friend. Traffic. 2020 Dec;21(12):749-750. doi: 10.1111/tra.12767. Epub 2020 Oct 11. PMID: 32981140.
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Trauma-Focused Mitigation Testimony in Capital Sentencing Hearings.

The journal of the American Academy of Psychiatry and the Law

Goldenson J, Brodsky SL.
PMID: 34789500
J Am Acad Psychiatry Law. 2021 Nov 17; doi: 10.29158/JAAPL.210090-21. Epub 2021 Nov 17.

When capital trials of convicted defendants reach the sentencing phase, forensic mental health experts often testify as part of mitigation evidence. Three aspects of such testimony hold particular promise. First, developmental traumas in the lives of the defendants are...

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Goldenson J, Brodsky SL. Trauma-Focused Mitigation Testimony in Capital Sentencing Hearings. J Am Acad Psychiatry Law. 2021;doi: 10.29158/JAAPL.210090-21.
Goldenson, J., & Brodsky, S. L. (2021). Trauma-Focused Mitigation Testimony in Capital Sentencing Hearings. The journal of the American Academy of Psychiatry and the Law, . https://doi.org/10.29158/JAAPL.210090-21
Goldenson, Julie, and Brodsky, Stanley L. "Trauma-Focused Mitigation Testimony in Capital Sentencing Hearings." The journal of the American Academy of Psychiatry and the Law vol. (2021). doi: https://doi.org/10.29158/JAAPL.210090-21
Goldenson J, Brodsky SL. Trauma-Focused Mitigation Testimony in Capital Sentencing Hearings. J Am Acad Psychiatry Law. 2021 Nov 17; doi: 10.29158/JAAPL.210090-21. Epub 2021 Nov 17. PMID: 34789500.
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Antagonistic regulation controls clathrin-mediated endocytosis: AP2 adaptor facilitation vs restraint from clathrin light chains.

Cells & development

Redlingshöfer L, Brodsky FM.
PMID: 34182181
Cells Dev. 2021 Jun 25;203714. doi: 10.1016/j.cdev.2021.203714. Epub 2021 Jun 25.

Orchestration of a complex network of protein interactions drives clathrin-mediated endocytosis (CME). A central role for the AP2 adaptor complex beyond cargo recognition and clathrin recruitment has emerged in recent years. It is now apparent that AP2 serves as...

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Redlingshöfer L, Brodsky FM. Antagonistic regulation controls clathrin-mediated endocytosis: AP2 adaptor facilitation vs restraint from clathrin light chains. Cells Dev. 2021;203714doi: 10.1016/j.cdev.2021.203714.
Redlingshöfer, L., & Brodsky, F. M. (2021). Antagonistic regulation controls clathrin-mediated endocytosis: AP2 adaptor facilitation vs restraint from clathrin light chains. Cells & development, 203714. https://doi.org/10.1016/j.cdev.2021.203714
Redlingshöfer, Lisa, and Brodsky, Frances M. "Antagonistic regulation controls clathrin-mediated endocytosis: AP2 adaptor facilitation vs restraint from clathrin light chains." Cells & development vol. (2021): 203714. doi: https://doi.org/10.1016/j.cdev.2021.203714
Redlingshöfer L, Brodsky FM. Antagonistic regulation controls clathrin-mediated endocytosis: AP2 adaptor facilitation vs restraint from clathrin light chains. Cells Dev. 2021 Jun 25;203714. doi: 10.1016/j.cdev.2021.203714. Epub 2021 Jun 25. PMID: 34182181.
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Pain at the Cochlear Implant Site Requiring Device Removal in Pediatric Patients.

The Laryngoscope

Shearer AE, Wang A, Lawton M, Lachenauer C, Brodsky JR, Poe D, Kenna M, Licameli G.
PMID: 34981837
Laryngoscope. 2022 Jan 04; doi: 10.1002/lary.29993. Epub 2022 Jan 04.

OBJECTIVES: Idiopathic pain at the cochlear implant (CI) site outside of the immediate postoperative period is an uncommon occurrence but may necessitate device explantation. Our objective was to describe the clinical course for pediatric patients with CI site pain...

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Shearer AE, Wang A, Lawton M, et al. Pain at the Cochlear Implant Site Requiring Device Removal in Pediatric Patients. Laryngoscope. 2022;doi: 10.1002/lary.29993.
Shearer, A. E., Wang, A., Lawton, M., Lachenauer, C., Brodsky, J. R., Poe, D., Kenna, M., & Licameli, G. (2022). Pain at the Cochlear Implant Site Requiring Device Removal in Pediatric Patients. The Laryngoscope, . https://doi.org/10.1002/lary.29993
Shearer, A Eliot, et al. "Pain at the Cochlear Implant Site Requiring Device Removal in Pediatric Patients." The Laryngoscope vol. (2022). doi: https://doi.org/10.1002/lary.29993
Shearer AE, Wang A, Lawton M, Lachenauer C, Brodsky JR, Poe D, Kenna M, Licameli G. Pain at the Cochlear Implant Site Requiring Device Removal in Pediatric Patients. Laryngoscope. 2022 Jan 04; doi: 10.1002/lary.29993. Epub 2022 Jan 04. PMID: 34981837.
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Yolk-shell nanocrystal@ZIF-8 nanostructures for gas-phase heterogeneous catalysis with selectivity control.

Journal of the American Chemical Society

Kuo CH, Tang Y, Chou LY, Sneed BT, Brodsky CN, Zhao Z, Tsung CK.
PMID: 22901021
J Am Chem Soc. 2012 Sep 05;134(35):14345-8. doi: 10.1021/ja306869j. Epub 2012 Aug 27.

A general synthetic strategy for yolk-shell nanocrystal@ZIF-8 nanostructures has been developed. The yolk-shell nanostructures possess the functions of nanoparticle cores, microporous shells, and a cavity in between, which offer great potential in heterogeneous catalysis. The synthetic strategy involved first...

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Kuo CH, Tang Y, Chou LY, et al. Yolk-shell nanocrystal@ZIF-8 nanostructures for gas-phase heterogeneous catalysis with selectivity control. J Am Chem Soc. 2012;134(35):14345-8doi: 10.1021/ja306869j.
Kuo, C. H., Tang, Y., Chou, L. Y., Sneed, B. T., Brodsky, C. N., Zhao, Z., & Tsung, C. K. (2012). Yolk-shell nanocrystal@ZIF-8 nanostructures for gas-phase heterogeneous catalysis with selectivity control. Journal of the American Chemical Society, 134(35), 14345-8. https://doi.org/10.1021/ja306869j
Kuo, Chun-Hong, et al. "Yolk-shell nanocrystal@ZIF-8 nanostructures for gas-phase heterogeneous catalysis with selectivity control." Journal of the American Chemical Society vol. 134,35 (2012): 14345-8. doi: https://doi.org/10.1021/ja306869j
Kuo CH, Tang Y, Chou LY, Sneed BT, Brodsky CN, Zhao Z, Tsung CK. Yolk-shell nanocrystal@ZIF-8 nanostructures for gas-phase heterogeneous catalysis with selectivity control. J Am Chem Soc. 2012 Sep 05;134(35):14345-8. doi: 10.1021/ja306869j. Epub 2012 Aug 27. PMID: 22901021.
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Swimming with tympanostomy tubes: the controversy continues.

Archives of otolaryngology--head & neck surgery

Brodsky L.
PMID: 11115297
Arch Otolaryngol Head Neck Surg. 2000 Dec;126(12):1509. doi: 10.1001/archotol.126.12.1509.

No abstract available.

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Brodsky L. Swimming with tympanostomy tubes: the controversy continues. Arch Otolaryngol Head Neck Surg. 2000;126(12):1509doi: 10.1001/archotol.126.12.1509.
Brodsky, L. (2000). Swimming with tympanostomy tubes: the controversy continues. Archives of otolaryngology--head & neck surgery, 126(12), 1509. https://doi.org/10.1001/archotol.126.12.1509
Brodsky. "Swimming with tympanostomy tubes: the controversy continues." Archives of otolaryngology--head & neck surgery vol. 126,12 (2000): 1509. doi: https://doi.org/10.1001/archotol.126.12.1509
Brodsky L. Swimming with tympanostomy tubes: the controversy continues. Arch Otolaryngol Head Neck Surg. 2000 Dec;126(12):1509. doi: 10.1001/archotol.126.12.1509. PMID: 11115297.
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A social view of the psychiatric consultation. The medical view and the social view.

Psychosomatics

Brodsky CM.
PMID: 6047741
Psychosomatics. 1967 Mar-Apr;8(2):61-8. doi: 10.1016/S0033-3182(67)72024-1.

No abstract available.

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Brodsky CM. A social view of the psychiatric consultation. The medical view and the social view. Psychosomatics. 1967;8(2):61-8doi: 10.1016/S0033-3182(67)72024-1.
Brodsky, C. M. (1967). A social view of the psychiatric consultation. The medical view and the social view. Psychosomatics, 8(2), 61-8. https://doi.org/10.1016/S0033-3182(67)72024-1
Brodsky, C M. "A social view of the psychiatric consultation. The medical view and the social view." Psychosomatics vol. 8,2 (1967): 61-8. doi: https://doi.org/10.1016/S0033-3182(67)72024-1
Brodsky CM. A social view of the psychiatric consultation. The medical view and the social view. Psychosomatics. 1967 Mar-Apr;8(2):61-8. doi: 10.1016/S0033-3182(67)72024-1. PMID: 6047741.
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Training of policemen in emotional control and awareness.

The American psychologist

Danish SJ, Brodsky SL.
PMID: 5434642
Am Psychol. 1970 Apr;25(4):368-9. doi: 10.1037/h0029496.

No abstract available.

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Danish SJ, Brodsky SL. Training of policemen in emotional control and awareness. Am Psychol. 1970;25(4):368-9doi: 10.1037/h0029496.
Danish, S. J., & Brodsky, S. L. (1970). Training of policemen in emotional control and awareness. The American psychologist, 25(4), 368-9. https://doi.org/10.1037/h0029496
Danish, S J, and Brodsky, S L. "Training of policemen in emotional control and awareness." The American psychologist vol. 25,4 (1970): 368-9. doi: https://doi.org/10.1037/h0029496
Danish SJ, Brodsky SL. Training of policemen in emotional control and awareness. Am Psychol. 1970 Apr;25(4):368-9. doi: 10.1037/h0029496. PMID: 5434642.
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Daily measurement of slow slip from low-frequency earthquakes is consistent with ordinary earthquake scaling.

Science advances

Frank WB, Brodsky EE.
PMID: 31616786
Sci Adv. 2019 Oct 02;5(10):eaaw9386. doi: 10.1126/sciadv.aaw9386. eCollection 2019 Oct.

Slow slip transients on faults can last from seconds to months and stitch together the earthquake cycle. However, no single geophysical instrument is able to observe the full range of slow slip because of bandwidth limitations. Here, we connect...

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Frank WB, Brodsky EE. Daily measurement of slow slip from low-frequency earthquakes is consistent with ordinary earthquake scaling. Sci Adv. 2019;5(10):eaaw9386doi: 10.1126/sciadv.aaw9386.
Frank, W. B., & Brodsky, E. E. (2019). Daily measurement of slow slip from low-frequency earthquakes is consistent with ordinary earthquake scaling. Science advances, 5(10), eaaw9386. https://doi.org/10.1126/sciadv.aaw9386
Frank, William B, and Brodsky, Emily E. "Daily measurement of slow slip from low-frequency earthquakes is consistent with ordinary earthquake scaling." Science advances vol. 5,10 (2019): eaaw9386. doi: https://doi.org/10.1126/sciadv.aaw9386
Frank WB, Brodsky EE. Daily measurement of slow slip from low-frequency earthquakes is consistent with ordinary earthquake scaling. Sci Adv. 2019 Oct 02;5(10):eaaw9386. doi: 10.1126/sciadv.aaw9386. eCollection 2019 Oct. PMID: 31616786; PMCID: PMC6774729.
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Showing 25 to 36 of 178 entries