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Showing 25 to 36 of 276 entries
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Inhibition of APE1/Ref-1 Redox Signaling Alleviates Intestinal Dysfunction and Damage to Myenteric Neurons in a Mouse Model of Spontaneous Chronic Colitis.

Inflammatory bowel diseases

Sahakian L, Filippone RT, Stavely R, Robinson AM, Yan XS, Abalo R, Eri R, Bornstein JC, Kelley MR, Nurgali K.
PMID: 32618996
Inflamm Bowel Dis. 2021 Feb 16;27(3):388-406. doi: 10.1093/ibd/izaa161.

BACKGROUND: Inflammatory bowel disease (IBD) associates with damage to the enteric nervous system (ENS), leading to gastrointestinal (GI) dysfunction. Oxidative stress is important for the pathophysiology of inflammation-induced enteric neuropathy and GI dysfunction. Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) is...

Effects of Dimensions of Root-End Fillings and Peripheral Root Dentine on the Healing Outcome of Apical Surgery.

European endodontic journal

Von Arx T, Marwik E, Bornstein MM.
PMID: 32161887
Eur Endod J. 2019 Jul 18;4(2):49-56. doi: 10.14744/eej.2019.76376. eCollection 2019.

OBJECTIVE: The objective of this study was to assess dimensions of root-end fillings (REFs), as well as peripheral root dentine (PRD) and their effects on the healing outcome of apical surgery.METHODS: Cone beam computed tomography (CBCT) scans were utilized...

Spatiotemporal Mapping Reveals Regional Gastrointestinal Dysfunction in mdx Dystrophic Mice Ameliorated by Oral L-arginine Supplementation.

Journal of neurogastroenterology and motility

Swiderski K, Bindon R, Trieu J, Naim T, Schokman S, Swaminathan M, Leembruggen AJL, Hill-Yardin EL, Koopman R, Bornstein JC, Lynch GS.
PMID: 31715094
J Neurogastroenterol Motil. 2020 Jan 30;26(1):133-146. doi: 10.5056/jnm19029.

BACKGROUND/AIMS: Patients with Duchenne muscular dystrophy exhibit significant, ongoing impairments in gastrointestinal (GI) function likely resulting from dysregulated nitric oxide production. Compounds increasing neuronal nitric oxide synthase expression and/or activity could improve GI dysfunction and enhance quality of life...

DNA methylation-based surrogates of plasma proteins are associated with Parkinson's disease risk.

Journal of the neurological sciences

Fu KA, Paul KC, Lu AT, Horvath S, Keener AM, Bordelon Y, Bronstein JM, Ritz B.
PMID: 34768133
J Neurol Sci. 2021 Dec 15;431:120046. doi: 10.1016/j.jns.2021.120046. Epub 2021 Nov 03.

BACKGROUND: The epigenome may reflect Parkinson's disease (PD) risk, which serves as a point of convergence of genetic and environmental risk factors. Here, we investigate whether blood DNA methylation (DNAm) markers are associated with PD risk.METHODS: We selected 12...

CCR5-Δ32 polymorphism: a possible protective factor for post-stroke depressive symptoms.

Journal of psychiatry & neuroscience : JPN

Tene O, Hallevi H, Molad J, Usher S, Seyman E, Bornstein NM, Shenhar-Tsarfaty S, Ben Assayag E.
PMID: 34291627
J Psychiatry Neurosci. 2021 Jul 22;46(4):E431-E440. doi: 10.1503/jpn.200197.

BACKGROUND: A naturally occurring loss-of-function mutation in the gene for C-C chemokine receptor type 5 (CCR5-Δ32) has recently been reported as a protective factor in post-stroke motor and cognitive recovery. We sought to examine whether this mutation also prevented...

Histologic Outcomes With Vedolizumab Versus Adalimumab in Ulcerative Colitis: Results From An Efficacy and Safety Study of Vedolizumab Intravenous Compared to Adalimumab Subcutaneous in Participants With Ulcerative Colitis (VARSITY).

Gastroenterology

Peyrin-Biroulet L, Loftus EV, Colombel JF, Danese S, Rogers R, Bornstein JD, Chen J, Schreiber S, Sands BE, Lirio RA.
PMID: 34144047
Gastroenterology. 2021 Oct;161(4):1156-1167.e3. doi: 10.1053/j.gastro.2021.06.015. Epub 2021 Jun 16.

BACKGROUND AND AIMS: VARSITY (An Efficacy and Safety Study of Vedolizumab Intravenous [IV] Compared to Adalimumab Subcutaneous [SC] in Participants With Ulcerative Colitis) showed superior clinical remission and endoscopic improvement in ulcerative colitis with vedolizumab vs adalimumab. This analysis...

Selective Continuous Positive Airway Pressure Withdrawal With Supplemental Oxygen During Slow-Wave Sleep as a Method of Dissociating Sleep Fragmentation and Intermittent Hypoxemia-Related Sleep Disruption in Obstructive Sleep Apnea.

Frontiers in physiology

Mullins AE, Parekh A, Kam K, Castillo B, Roberts ZJ, Fakhoury A, Valencia DI, Schoenholz R, Tolbert TM, Bronstein JZ, Mooney AM, Burschtin OE, Rapoport DM, Ayappa I, Varga AW.
PMID: 34880775
Front Physiol. 2021 Nov 22;12:750516. doi: 10.3389/fphys.2021.750516. eCollection 2021.

Obstructive sleep apnea (OSA) is considered to impair memory processing and increase the expression of amyloid-β (Aβ) and risk for Alzheimer's disease (AD). Given the evidence that slow-wave sleep (SWS) is important in both memory and Aβ metabolism, a...

Transient fetal hypertrichosis - Three cases.

European journal of obstetrics, gynecology, and reproductive biology

Bronshtein M, Hac NT, Gover A, Khatib N.
PMID: 34942554
Eur J Obstet Gynecol Reprod Biol. 2021 Dec 15;269:1-2. doi: 10.1016/j.ejogrb.2021.12.008. Epub 2021 Dec 15.

We Summarize a three cases of transient fetal hypertrichosis in low risk preganant women. Hypertrichosis has been previously associated with over 140 different syndromes (OMIM); however this finding is rarely described in prenatal ultrasound. In this study we describe...

A critical analysis and commentary on Moscona's 'Citation analysis of the highest-cited articles on developmental dysplasia of the hip'.

Journal of pediatric orthopedics. Part B

Bondar K, Mattingly L, Herrington T, Massel DH, Bernstein JM, Carvajal JA.
PMID: 34848670
J Pediatr Orthop B. 2022 Jan 01;31(1):e108-e110. doi: 10.1097/BPB.0000000000000918.

No abstract available.

The contribution of potentially modifiable risk factors to acute ischemic stroke burden - Comparing young and older adults.

Preventive medicine

Libruder C, Ram A, Hershkovitz Y, Karolinsky D, Tanne D, Bornstein NM, Zucker I.
PMID: 34954243
Prev Med. 2021 Dec 24;155:106933. doi: 10.1016/j.ypmed.2021.106933. Epub 2021 Dec 24.

Stroke is a leading cause of death and disability. In order to estimate the contribution of five modifiable risk factors to acute ischemic stroke (AIS) incidence in Israel, we conducted a case-control study based on first AIS cases aged...

Meeting the unmet needs of clinicians from AI systems showcased for cardiology with deep-learning-based ECG analysis.

Proceedings of the National Academy of Sciences of the United States of America

Elul Y, Rosenberg AA, Schuster A, Bronstein AM, Yaniv Y.
PMID: 34099565
Proc Natl Acad Sci U S A. 2021 Jun 15;118(24). doi: 10.1073/pnas.2020620118.

Despite their great promise, artificial intelligence (AI) systems have yet to become ubiquitous in the daily practice of medicine largely due to several crucial unmet needs of healthcare practitioners. These include lack of explanations in clinically meaningful terms, handling...

The contribution of potentially modifiable risk factors to acute ischemic stroke burden - Comparing young and older adults.

Preventive medicine

Libruder C, Ram A, Hershkovitz Y, Karolinsky D, Tanne D, Bornstein NM, Zucker I.
PMID: 34954243
Prev Med. 2021 Dec 23;106933. doi: 10.1016/j.ypmed.2021.106933. Epub 2021 Dec 23.

Stroke is a leading cause of death and disability. In order to estimate the contribution of five modifiable risk factors to acute ischemic stroke (AIS) incidence in Israel, we conducted a case-control study based on first AIS cases aged...

Showing 25 to 36 of 276 entries