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The α-tocopherol-derived long-chain metabolite α-13'-COOH mediates endotoxin tolerance and modulates the inflammatory response via MAPK and NFκB pathways.

Free radical biology & medicine

Schubert M, Kluge S, Brunner E, Pace S, Birringer M, Werz O, Lorkowski S.
PMID: 34848369
Free Radic Biol Med. 2021 Nov 27;178:83-96. doi: 10.1016/j.freeradbiomed.2021.11.032. Epub 2021 Nov 27.

SCOPE: The long-chain metabolites of (LCM) vitamin E are proposed as the active regulatory metabolites of vitamin E providing, with their anti-inflammatory properties, an explanatory approach for the inconsistent effects of vitamin E on inflammatory-driven diseases. We examined the...

BOB.1/OBF.1 is required during B-cell ontogeny for B-cell differentiation and germinal center function.

European journal of immunology

Betzler AC, Fiedler K, Hoffmann TK, Fehling HJ, Wirth T, Brunner C.
PMID: 34918350
Eur J Immunol. 2021 Dec 08; doi: 10.1002/eji.202149333. Epub 2021 Dec 08.

BOB.1/OBF.1 is a lymphocyte-specific transcriptional co-activator of octamer-dependent transcription. It regulates the expression of genes important for lymphocyte physiology together with the Oct-1 and Oct-2 transcription factors. So far, BOB.1/OBF.1 has been studied in conventional knockout mice, whereby a...

Quantum nonlocality does not imply entanglement distillability.

Physical review letters

Vértesi T, Brunner N.
PMID: 22400720
Phys Rev Lett. 2012 Jan 20;108(3):030403. doi: 10.1103/PhysRevLett.108.030403. Epub 2012 Jan 19.

Entanglement and nonlocality are both fundamental aspects of quantum theory, and play a prominent role in quantum information science. The exact relation between entanglement and nonlocality is, however, still poorly understood. Here we make progress in this direction by...

Differences sustained between diffuse and limited forms of juvenile systemic sclerosis in expanded international cohort. www.juvenile-scleroderma.com.

Arthritis care & research

Foeldvari I, Klotsche J, Kasapcopur O, Adrovic A, Terreri MT, Sakamoto AP, Stanevicha V, Sztajnbok F, Anton J, Feldman B, Alexeeva E, Katsicas M, Smith V, Avcin T, Marrani E, Kostik M, Lehman T, Sifuentes-Giraldo WA, Vasquez-Canizares N, Appenzeller S, Janarthanan M, Moll M, Nemcova D, Patwardhan A, Santos MJ, Sawhney S, Schonenberg-Meinema D, Battagliotti C, Berntson L, Bica B, Brunner J, Costa-Reis P, Eleftheriou D, Harel L, Horneff G, Kaiser D, Kallinich T, Lazarevic D, Minden K, Nielsen S, Nuruzzaman F, Uziel Y, Helmus N, Torok KS.
PMID: 33787070
Arthritis Care Res (Hoboken). 2021 Mar 30; doi: 10.1002/acr.24609. Epub 2021 Mar 30.

OBJECTIVES: To evaluate the baseline clinical characteristics of juvenile systemic sclerosis (jSSc) patients in the international Juvenile SSc Inception Cohort (jSScC), compare these characteristics between the classically defined diffuse (dcjSSc) and limited cutaneous (lcjSSc) subtypes, and among those with...

Showing 1141 to 1144 of 1144 entries