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Showing 13 to 24 of 26 entries
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Risk factors and outcome of pulmonary aspergillosis in critically ill coronavirus disease 2019 patients-a multinational observational study by the European Confederation of Medical Mycology.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

Prattes J, Wauters J, Giacobbe DR, Salmanton-García J, Maertens J, Bourgeois M, Reynders M, Rutsaert L, Van Regenmortel N, Lormans P, Feys S, Reisinger AC, Cornely OA, Lahmer T, Valerio M, Delhaes L, Jabeen K, Steinmann J, Chamula M, Bassetti M, Hatzl S, Rautemaa-Richardson R, Koehler P, Lagrou K, Hoenigl M.
PMID: 34454093
Clin Microbiol Infect. 2021 Aug 26; doi: 10.1016/j.cmi.2021.08.014. Epub 2021 Aug 26.

OBJECTIVES: Coronavirus disease 2019 (COVID-19) -associated pulmonary aspergillosis (CAPA) has emerged as a complication in critically ill COVID-19 patients. The objectives of this multinational study were to determine the prevalence of CAPA in patients with COVID-19 in intensive care...

Intra-uterine effects on adult muscle strength.

Early human development

Garay JL, Barreira TV, Wang Q, Brutsaert TD.
PMID: 34717155
Early Hum Dev. 2021 Dec;163:105490. doi: 10.1016/j.earlhumdev.2021.105490. Epub 2021 Oct 20.

BACKGROUND: Maternal behaviors and exposures affect fetal growth and development. Smoking, malnutrition, sedentary behavior, and stress can each lead to fetal programming and intra-uterine growth restriction. As a result, tissue development may be impaired. Problems with muscle formation can...

Size at birth and accelerometer-measured physical activity or sedentary behavior in healthy term-born adults.

American journal of human biology : the official journal of the Human Biology Council

Garay JL, Barreira TV, Wang Q, Brutsaert TD.
PMID: 34978113
Am J Hum Biol. 2022 Jan 02;e23717. doi: 10.1002/ajhb.23717. Epub 2022 Jan 02.

The present study investigated the relationship between birth size and activity patterns. One hundred and twenty-four adults wore accelerometers for 7 days. Birth weight was adjusted for gestational age (AdjBW). The overall association between time spent in MVPA/day and...

Does digoxin therapy affect outcome in patients with diastolic heart failure?.

Nature clinical practice. Cardiovascular medicine

Brutsaert DL.
PMID: 17245399
Nat Clin Pract Cardiovasc Med. 2007 Feb;4(2):70-1. doi: 10.1038/ncpcardio0765.

No abstract available.

Effect of developmental and ancestral high altitude exposure on chest morphology and pulmonary function in Andean and European/North American natives.

American journal of human biology : the official journal of the Human Biology Council

Brutsaert TD, Soria R, Caceres E, Spielvogel H, Haas JD.
PMID: 11533958
Am J Hum Biol. 1999;11(3):383-395. doi: 10.1002/(SICI)1520-6300(1999)11:3<383::AID-AJHB9>3.0.CO;2-X.

Chest depth, chest width, forced vital capacity (FVC), and forced expiratory volume (FEV1) were measured in 170 adult males differing by ancestral (genetic) and developmental exposure to high altitude (HA). A complete migrant study design was used to study...

Heart failure: an epidemic of the XXIst century?.

Bulletin et memoires de l'Academie royale de medecine de Belgique

Brutsaert D.
PMID: 18075050
Bull Mem Acad R Med Belg. 2007;162(3):203-5; discussion 205-6.

No abstract available.

Cardiac Remodeling: Endothelial Cells Have More to Say Than Just NO.

Frontiers in physiology

Segers VFM, Brutsaert DL, De Keulenaer GW.
PMID: 29695980
Front Physiol. 2018 Apr 11;9:382. doi: 10.3389/fphys.2018.00382. eCollection 2018.

The heart is a highly structured organ consisting of different cell types, including myocytes, endothelial cells, fibroblasts, stem cells, and inflammatory cells. This pluricellularity provides the opportunity of intercellular communication within the organ, with subsequent optimization of its function....

DNA Methylation Changes Are Associated With an Incremental Ascent to High Altitude.

Frontiers in genetics

Childebayeva A, Harman T, Weinstein J, Goodrich JM, Dolinoy DC, Day TA, Bigham AW, Brutsaert TD.
PMID: 31737045
Front Genet. 2019 Oct 29;10:1062. doi: 10.3389/fgene.2019.01062. eCollection 2019.

Genetic and nongenetic factors are involved in the individual ability to physiologically acclimatize to high-altitude hypoxia through processes that include increased heart rate and ventilation. High-altitude acclimatization is thought to have a genetic component, yet it is unclear if...

Genome-Wide Epigenetic Signatures of Adaptive Developmental Plasticity in the Andes.

Genome biology and evolution

Childebayeva A, Goodrich JM, Leon-Velarde F, Rivera-Chira M, Kiyamu M, Brutsaert TD, Dolinoy DC, Bigham AW.
PMID: 33185669
Genome Biol Evol. 2021 Feb 03;13(2). doi: 10.1093/gbe/evaa239.

High-altitude adaptation is a classic example of natural selection operating on the human genome. Physiological and genetic adaptations have been documented in populations with a history of living at high altitude. However, the role of epigenetic gene regulation, including...

COVID-19-associated invasive pulmonary aspergillosis.

Annals of intensive care

Rutsaert L, Steinfort N, Van Hunsel T, Bomans P, Naesens R, Mertes H, Dits H, Van Regenmortel N.
PMID: 32488446
Ann Intensive Care. 2020 Jun 01;10(1):71. doi: 10.1186/s13613-020-00686-4.

No abstract available.

Genome-Wide DNA Methylation Changes Associated With High-Altitude Acclimatization During an Everest Base Camp Trek.

Frontiers in physiology

Childebayeva A, Harman T, Weinstein J, Day T, Brutsaert TD, Bigham AW.
PMID: 34262470
Front Physiol. 2021 Jun 28;12:660906. doi: 10.3389/fphys.2021.660906. eCollection 2021.

The individual physiological response to high-altitude hypoxia involves both genetic and non-genetic factors, including epigenetic modifications. Epigenetic changes in hypoxia factor pathway (HIF) genes are associated with high-altitude acclimatization. However, genome-wide epigenetic changes that are associated with short-term hypoxia...

The effects of high altitude ascent on splenic contraction and the diving response during voluntary apnoea.

Experimental physiology

Holmström PK, Bird JD, Thrall SF, Kalker A, Herrington BA, Soriano JE, Mann LM, Rampuri ZH, Brutsaert TD, Karlsson Ø, Sherpa MT, Schagatay EKA, Day TA.
PMID: 32893898
Exp Physiol. 2021 Jan;106(1):160-174. doi: 10.1113/EP088571. Epub 2020 Oct 28.

NEW FINDINGS: What is the central question of this study? What is the relative contribution of a putative tonic splenic contraction to the haematological acclimatization process during high altitude ascent in native lowlanders? What is the main finding and...

Showing 13 to 24 of 26 entries