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Showing 253 to 257 of 257 entries
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Clinical and biological aspects of myeloid leukemia in Down syndrome.

Leukemia

Boucher AC, Caldwell KJ, Crispino JD, Flerlage JE.
PMID: 34518645
Leukemia. 2021 Dec;35(12):3352-3360. doi: 10.1038/s41375-021-01414-y. Epub 2021 Sep 13.

Children with Down syndrome are at an elevated risk of leukemia, especially myeloid leukemia (ML-DS). This malignancy is frequently preceded by transient abnormal myelopoiesis (TAM), which is self-limited expansion of fetal liver-derived megakaryocyte progenitors. An array of international studies...

Early literacy training among medical students.

The clinical teacher

Dunlap M, Walker B, Nguyen C, Gerth K, Garbe MC, Caldwell A.
PMID: 34313383
Clin Teach. 2021 Dec;18(6):602-606. doi: 10.1111/tct.13402. Epub 2021 Jul 27.

BACKGROUND: The American Academy of Pediatrics regards literacy promotion as essential. Medical professionals are in a key position to promote children's early literacy, however this requires knowledge of existing literacy programmes. This study describes medical student training, awareness, experiences,...

Amelioration of Alzheimer's disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow.

Nature biomedical engineering

Xie C, Zhuang XX, Niu Z, Ai R, Lautrup S, Zheng S, Jiang Y, Han R, Gupta TS, Cao S, Lagartos-Donate MJ, Cai CZ, Xie LM, Caponio D, Wang WW, Schmauck-Medina T, Zhang J, Wang HL, Lou G, Xiao X, Zheng W, Palikaras K, Yang G, Caldwell KA, Caldwell GA, Shen HM, Nilsen H, Lu JH, Fang EF.
PMID: 34992270
Nat Biomed Eng. 2022 Jan 06; doi: 10.1038/s41551-021-00819-5. Epub 2022 Jan 06.

A reduced removal of dysfunctional mitochondria is common to aging and age-related neurodegenerative pathologies such as Alzheimer's disease (AD). Strategies for treating such impaired mitophagy would benefit from the identification of mitophagy modulators. Here we report the combined use...

Screening for Pancreatic Ductal Adenocarcinoma: Are We Asking the Impossible?-Response.

Cancer prevention research (Philadelphia, Pa.)

Caldwell KE, Hammill CW.
PMID: 34607878
Cancer Prev Res (Phila). 2021 Oct;14(10):975-976. doi: 10.1158/1940-6207.CAPR-21-0257.

No abstract available.

AIRE in context: Leveraging chromatin plasticity to trigger ectopic gene expression.

Immunological reviews

Kaiser C, Bradu A, Gamble N, Caldwell JA, Koh AS.
PMID: 34545959
Immunol Rev. 2022 Jan;305(1):59-76. doi: 10.1111/imr.13026. Epub 2021 Sep 20.

The emergence of antigen receptor diversity in clonotypic lymphocytes drove the evolution of a novel gene, Aire, that enabled the adaptive immune system to discriminate foreign invaders from self-constituents. AIRE functions in the epithelial cells of the thymus to...

Showing 253 to 257 of 257 entries