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Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pK a Polar Moiety.

ACS medicinal chemistry letters

Ndubaku CO, Crawford JJ, Drobnick J, Aliagas I, Campbell D, Dong P, Dornan LM, Duron S, Epler J, Gazzard L, Heise CE, Hoeflich KP, Jakubiak D, La H, Lee W, Lin B, Lyssikatos JP, Maksimoska J, Marmorstein R, Murray LJ, O'Brien T, Oh A, Ramaswamy S, Wang W, Zhao X, Zhong Y, Blackwood E, Rudolph J.
PMID: 26713112
ACS Med Chem Lett. 2015 Oct 31;6(12):1241-6. doi: 10.1021/acsmedchemlett.5b00398. eCollection 2015 Dec 10.

Signaling pathways intersecting with the p21-activated kinases (PAKs) play important roles in tumorigenesis and cancer progression. By recognizing that the limitations of FRAX1036 (1) were chiefly associated with the highly basic amine it contained, we devised a mitigation strategy...

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Ndubaku CO, Crawford JJ, Drobnick J, et al. Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pK a Polar Moiety. ACS Med Chem Lett. 2015;6(12):1241-6doi: 10.1021/acsmedchemlett.5b00398.
Ndubaku, C. O., Crawford, J. J., Drobnick, J., Aliagas, I., Campbell, D., Dong, P., Dornan, L. M., Duron, S., Epler, J., Gazzard, L., Heise, C. E., Hoeflich, K. P., Jakubiak, D., La, H., Lee, W., Lin, B., Lyssikatos, J. P., Maksimoska, J., Marmorstein, R., Murray, L. J., O'Brien, T., Oh, A., Ramaswamy, S., Wang, W., Zhao, X., Zhong, Y., Blackwood, E., & Rudolph, J. (2015). Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pK a Polar Moiety. ACS medicinal chemistry letters, 6(12), 1241-6. https://doi.org/10.1021/acsmedchemlett.5b00398
Ndubaku, Chudi O, et al. "Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pK a Polar Moiety." ACS medicinal chemistry letters vol. 6,12 (2015): 1241-6. doi: https://doi.org/10.1021/acsmedchemlett.5b00398
Ndubaku CO, Crawford JJ, Drobnick J, Aliagas I, Campbell D, Dong P, Dornan LM, Duron S, Epler J, Gazzard L, Heise CE, Hoeflich KP, Jakubiak D, La H, Lee W, Lin B, Lyssikatos JP, Maksimoska J, Marmorstein R, Murray LJ, O'Brien T, Oh A, Ramaswamy S, Wang W, Zhao X, Zhong Y, Blackwood E, Rudolph J. Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pK a Polar Moiety. ACS Med Chem Lett. 2015 Oct 31;6(12):1241-6. doi: 10.1021/acsmedchemlett.5b00398. eCollection 2015 Dec 10. PMID: 26713112; PMCID: PMC4677365.
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Cost-Effectiveness Of Everolimus Plus Reduced Tacrolimus In De Novo Liver-Recipients In The Italian Setting.

Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research

Bianic F, Campbell R, De SP, Roccia A, Gregson G.
PMID: 27200771
Value Health. 2014 Nov;17(7):A367. doi: 10.1016/j.jval.2014.08.824. Epub 2014 Oct 26.

No abstract available.

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Bianic F, Campbell R, De SP, et al. Cost-Effectiveness Of Everolimus Plus Reduced Tacrolimus In De Novo Liver-Recipients In The Italian Setting. Value Health. 2014;17(7):A367doi: 10.1016/j.jval.2014.08.824.
Bianic, F., Campbell, R., De, S. P., Roccia, A., & Gregson, G. (2014). Cost-Effectiveness Of Everolimus Plus Reduced Tacrolimus In De Novo Liver-Recipients In The Italian Setting. Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research, 17(7), A367. https://doi.org/10.1016/j.jval.2014.08.824
Bianic, F, et al. "Cost-Effectiveness Of Everolimus Plus Reduced Tacrolimus In De Novo Liver-Recipients In The Italian Setting." Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research vol. 17,7 (2014): A367. doi: https://doi.org/10.1016/j.jval.2014.08.824
Bianic F, Campbell R, De SP, Roccia A, Gregson G. Cost-Effectiveness Of Everolimus Plus Reduced Tacrolimus In De Novo Liver-Recipients In The Italian Setting. Value Health. 2014 Nov;17(7):A367. doi: 10.1016/j.jval.2014.08.824. Epub 2014 Oct 26. PMID: 27200771.
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Incorporation of label from radioactive uridine into the stylar nucleic acids of Lilium longiflorum thunb. as affected by heat, 6-methylpurine and actinomycin D.

TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik

Campbell RJ, Ascher PD.
PMID: 24414758
Theor Appl Genet. 1976 Sep;47(5):215-26. doi: 10.1007/BF00284391.

5-(3)H-uridine injected into the stylar canal of detached lily stigma-styles was taken up initially into the rapidly-labeled-RNA of the nucleic acid profile of a methylated albumin kieselguhr (MAK) column but with increasing time was found in all portions of...

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Campbell RJ, Ascher PD. Incorporation of label from radioactive uridine into the stylar nucleic acids of Lilium longiflorum thunb. as affected by heat, 6-methylpurine and actinomycin D. Theor Appl Genet. 1976;47(5):215-26doi: 10.1007/BF00284391.
Campbell, R. J., & Ascher, P. D. (1976). Incorporation of label from radioactive uridine into the stylar nucleic acids of Lilium longiflorum thunb. as affected by heat, 6-methylpurine and actinomycin D. TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 47(5), 215-26. https://doi.org/10.1007/BF00284391
Campbell, R J, and Ascher, P D. "Incorporation of label from radioactive uridine into the stylar nucleic acids of Lilium longiflorum thunb. as affected by heat, 6-methylpurine and actinomycin D." TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik vol. 47,5 (1976): 215-26. doi: https://doi.org/10.1007/BF00284391
Campbell RJ, Ascher PD. Incorporation of label from radioactive uridine into the stylar nucleic acids of Lilium longiflorum thunb. as affected by heat, 6-methylpurine and actinomycin D. Theor Appl Genet. 1976 Sep;47(5):215-26. doi: 10.1007/BF00284391. PMID: 24414758.
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Insulin therapy and dietary adjustments to normalize glycemia and prevent nocturnal hypoglycemia after evening exercise in type 1 diabetes: a randomized controlled trial.

BMJ open diabetes research & care

Campbell MD, Walker M, Bracken RM, Turner D, Stevenson EJ, Gonzalez JT, Shaw JA, West DJ.
PMID: 26019878
BMJ Open Diabetes Res Care. 2015 May 12;3(1):e000085. doi: 10.1136/bmjdrc-2015-000085. eCollection 2015.

INTRODUCTION: Evening-time exercise is a frequent cause of severe hypoglycemia in type 1 diabetes, fear of which deters participation in regular exercise. Recommendations for normalizing glycemia around exercise consist of prandial adjustments to bolus insulin therapy and food composition,...

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Campbell MD, Walker M, Bracken RM, et al. Insulin therapy and dietary adjustments to normalize glycemia and prevent nocturnal hypoglycemia after evening exercise in type 1 diabetes: a randomized controlled trial. BMJ Open Diabetes Res Care. 2015;3(1):e000085doi: 10.1136/bmjdrc-2015-000085.
Campbell, M. D., Walker, M., Bracken, R. M., Turner, D., Stevenson, E. J., Gonzalez, J. T., Shaw, J. A., & West, D. J. (2015). Insulin therapy and dietary adjustments to normalize glycemia and prevent nocturnal hypoglycemia after evening exercise in type 1 diabetes: a randomized controlled trial. BMJ open diabetes research & care, 3(1), e000085. https://doi.org/10.1136/bmjdrc-2015-000085
Campbell, Matthew D, et al. "Insulin therapy and dietary adjustments to normalize glycemia and prevent nocturnal hypoglycemia after evening exercise in type 1 diabetes: a randomized controlled trial." BMJ open diabetes research & care vol. 3,1 (2015): e000085. doi: https://doi.org/10.1136/bmjdrc-2015-000085
Campbell MD, Walker M, Bracken RM, Turner D, Stevenson EJ, Gonzalez JT, Shaw JA, West DJ. Insulin therapy and dietary adjustments to normalize glycemia and prevent nocturnal hypoglycemia after evening exercise in type 1 diabetes: a randomized controlled trial. BMJ Open Diabetes Res Care. 2015 May 12;3(1):e000085. doi: 10.1136/bmjdrc-2015-000085. eCollection 2015. PMID: 26019878; PMCID: PMC4442134.
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General Physical Description of the Behavior of Oppositely Charged Polyelectrolyte/Surfactant Mixtures at the Air/Water Interface.

Langmuir : the ACS journal of surfaces and colloids

Varga I, Campbell RA.
PMID: 28493707
Langmuir. 2017 Jun 13;33(23):5915-5924. doi: 10.1021/acs.langmuir.7b01288. Epub 2017 May 26.

This work reports a unifying general physical description of the behavior of oppositely charged polyelectrolyte/surfactant mixtures at the air/water interface in terms of equilibrium vs nonequilibrium extremes. The poly(diallyldimethylammonium chloride)/sodium dodecyl sulfate system with added NaCl at two different...

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Varga I, Campbell RA. General Physical Description of the Behavior of Oppositely Charged Polyelectrolyte/Surfactant Mixtures at the Air/Water Interface. Langmuir. 2017;33(23):5915-5924doi: 10.1021/acs.langmuir.7b01288.
Varga, I., & Campbell, R. A. (2017). General Physical Description of the Behavior of Oppositely Charged Polyelectrolyte/Surfactant Mixtures at the Air/Water Interface. Langmuir : the ACS journal of surfaces and colloids, 33(23), 5915-5924. https://doi.org/10.1021/acs.langmuir.7b01288
Varga, Imre, and Campbell, Richard A. "General Physical Description of the Behavior of Oppositely Charged Polyelectrolyte/Surfactant Mixtures at the Air/Water Interface." Langmuir : the ACS journal of surfaces and colloids vol. 33,23 (2017): 5915-5924. doi: https://doi.org/10.1021/acs.langmuir.7b01288
Varga I, Campbell RA. General Physical Description of the Behavior of Oppositely Charged Polyelectrolyte/Surfactant Mixtures at the Air/Water Interface. Langmuir. 2017 Jun 13;33(23):5915-5924. doi: 10.1021/acs.langmuir.7b01288. Epub 2017 May 26. PMID: 28493707.
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Primary care physicians' perceived barriers and facilitators to conservative care for older adults with chronic kidney disease: design of a mixed methods study.

Canadian journal of kidney health and disease

Tam-Tham H, Hemmelgarn B, Campbell D, Thomas C, Quinn R, Fruetel K, King-Shier K.
PMID: 27047667
Can J Kidney Health Dis. 2016 Apr 04;3:17. doi: 10.1186/s40697-016-0110-0. eCollection 2016.

BACKGROUND: Guideline committees have identified the need for research to inform the provision of conservative care for older adults with stage 5 chronic kidney disease (CKD) who have a high burden of comorbidity or functional impairment. We will use...

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Tam-Tham H, Hemmelgarn B, Campbell D, et al. Primary care physicians' perceived barriers and facilitators to conservative care for older adults with chronic kidney disease: design of a mixed methods study. Can J Kidney Health Dis. 2016;3:17doi: 10.1186/s40697-016-0110-0.
Tam-Tham, H., Hemmelgarn, B., Campbell, D., Thomas, C., Quinn, R., Fruetel, K., & King-Shier, K. (2016). Primary care physicians' perceived barriers and facilitators to conservative care for older adults with chronic kidney disease: design of a mixed methods study. Canadian journal of kidney health and disease, 317. https://doi.org/10.1186/s40697-016-0110-0
Tam-Tham, Helen, et al. "Primary care physicians' perceived barriers and facilitators to conservative care for older adults with chronic kidney disease: design of a mixed methods study." Canadian journal of kidney health and disease vol. 3 (2016): 17. doi: https://doi.org/10.1186/s40697-016-0110-0
Tam-Tham H, Hemmelgarn B, Campbell D, Thomas C, Quinn R, Fruetel K, King-Shier K. Primary care physicians' perceived barriers and facilitators to conservative care for older adults with chronic kidney disease: design of a mixed methods study. Can J Kidney Health Dis. 2016 Apr 04;3:17. doi: 10.1186/s40697-016-0110-0. eCollection 2016. PMID: 27047667; PMCID: PMC4819283.
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Ancestry Matters: Patrilineage Growth and Extinction.

American sociological review

Song X, Campbell CD, Lee JZ.
PMID: 27041745
Am Sociol Rev. 2015 Jun;80(3):574-602. doi: 10.1177/0003122415576516. Epub 2015 May 31.

Patrilineality, the organization of kinship, inheritance, and other key social processes based on patrilineal male descent, has been a salient feature of social organization in China and many other societies for centuries. Because continuity or growth of the patrilineage...

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Song X, Campbell CD, Lee JZ. Ancestry Matters: Patrilineage Growth and Extinction. Am Sociol Rev. 2015;80(3):574-602doi: 10.1177/0003122415576516.
Song, X., Campbell, C. D., & Lee, J. Z. (2015). Ancestry Matters: Patrilineage Growth and Extinction. American sociological review, 80(3), 574-602. https://doi.org/10.1177/0003122415576516
Song, Xi, et al. "Ancestry Matters: Patrilineage Growth and Extinction." American sociological review vol. 80,3 (2015): 574-602. doi: https://doi.org/10.1177/0003122415576516
Song X, Campbell CD, Lee JZ. Ancestry Matters: Patrilineage Growth and Extinction. Am Sociol Rev. 2015 Jun;80(3):574-602. doi: 10.1177/0003122415576516. Epub 2015 May 31. PMID: 27041745; PMCID: PMC4813328.
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Molecular Breast Imaging using Synthetic Projections from High-Purity Germanium Detectors: A Simulation Study.

IEEE transactions on radiation and plasma medical sciences

Campbell D, Peterson T.
PMID: 28989990
IEEE Trans Radiat Plasma Med Sci. 2017 Sep;1(5):405-415. doi: 10.1109/TRPMS.2017.2725310. Epub 2017 Jul 11.

High-Purity Germanium (HPGe) gamma cameras are an emerging technology for Molecular Breast Imaging (MBI) due to their 2D lateral spatial resolution, depth-of-interaction (DOI) estimation, and superb energy resolution. In this simulation study, we investigate the potential imaging performance of...

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Campbell D, Peterson T. Molecular Breast Imaging using Synthetic Projections from High-Purity Germanium Detectors: A Simulation Study. IEEE Trans Radiat Plasma Med Sci. 2017;1(5):405-415doi: 10.1109/TRPMS.2017.2725310.
Campbell, D., & Peterson, T. (2017). Molecular Breast Imaging using Synthetic Projections from High-Purity Germanium Detectors: A Simulation Study. IEEE transactions on radiation and plasma medical sciences, 1(5), 405-415. https://doi.org/10.1109/TRPMS.2017.2725310
Campbell, Desmond, and Peterson, Todd. "Molecular Breast Imaging using Synthetic Projections from High-Purity Germanium Detectors: A Simulation Study." IEEE transactions on radiation and plasma medical sciences vol. 1,5 (2017): 405-415. doi: https://doi.org/10.1109/TRPMS.2017.2725310
Campbell D, Peterson T. Molecular Breast Imaging using Synthetic Projections from High-Purity Germanium Detectors: A Simulation Study. IEEE Trans Radiat Plasma Med Sci. 2017 Sep;1(5):405-415. doi: 10.1109/TRPMS.2017.2725310. Epub 2017 Jul 11. PMID: 28989990; PMCID: PMC5629019.
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Methods for topography artifacts compensation in scanning thermal microscopy.

Ultramicroscopy

Martinek J, Klapetek P, Campbell AC.
PMID: 25942752
Ultramicroscopy. 2015 Aug;155:55-61. doi: 10.1016/j.ultramic.2015.04.011. Epub 2015 Apr 25.

Thermal conductivity contrast images in scanning thermal microscopy (SThM) are often distorted by artifacts related to local sample topography. This is pronounced on samples with sharp topographic features, on rough samples and while using larger probes, for example, Wollaston...

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Martinek J, Klapetek P, Campbell AC. Methods for topography artifacts compensation in scanning thermal microscopy. Ultramicroscopy. 2015;155:55-61doi: 10.1016/j.ultramic.2015.04.011.
Martinek, J., Klapetek, P., & Campbell, A. C. (2015). Methods for topography artifacts compensation in scanning thermal microscopy. Ultramicroscopy, 15555-61. https://doi.org/10.1016/j.ultramic.2015.04.011
Martinek, Jan, et al. "Methods for topography artifacts compensation in scanning thermal microscopy." Ultramicroscopy vol. 155 (2015): 55-61. doi: https://doi.org/10.1016/j.ultramic.2015.04.011
Martinek J, Klapetek P, Campbell AC. Methods for topography artifacts compensation in scanning thermal microscopy. Ultramicroscopy. 2015 Aug;155:55-61. doi: 10.1016/j.ultramic.2015.04.011. Epub 2015 Apr 25. PMID: 25942752.
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Multifocal but non-disseminated phaeohyphomycosis in a healthy man via a unique mechanism: Ejection from motor vehicle accident into a vegetable field in Afghanistan resulting in multiple contaminated skin wounds.

Journal of cutaneous pathology

Malakzai MO, Sahak JG, Campbell R, Abobakar M, Hoogestraat DR, SenGupta DJ, Bryan A, Gardner JM.
PMID: 28349548
J Cutan Pathol. 2017 Jul;44(7):620-624. doi: 10.1111/cup.12942. Epub 2017 Apr 25.

A 20-year-old male presented with multiple subcutaneous nodules on the head, neck, chest and oral cavity. FNA and biopsy showed pigmented fungal hyphae diagnostic of multifocal phaeohyphomycosis, found to be Exophiala spinifera by molecular diagnostics. The presentation initially raised...

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Malakzai MO, Sahak JG, Campbell R, et al. Multifocal but non-disseminated phaeohyphomycosis in a healthy man via a unique mechanism: Ejection from motor vehicle accident into a vegetable field in Afghanistan resulting in multiple contaminated skin wounds. J Cutan Pathol. 2017;44(7):620-624doi: 10.1111/cup.12942.
Malakzai, M. O., Sahak, J. G., Campbell, R., Abobakar, M., Hoogestraat, D. R., SenGupta, D. J., Bryan, A., & Gardner, J. M. (2017). Multifocal but non-disseminated phaeohyphomycosis in a healthy man via a unique mechanism: Ejection from motor vehicle accident into a vegetable field in Afghanistan resulting in multiple contaminated skin wounds. Journal of cutaneous pathology, 44(7), 620-624. https://doi.org/10.1111/cup.12942
Malakzai, M Omer, et al. "Multifocal but non-disseminated phaeohyphomycosis in a healthy man via a unique mechanism: Ejection from motor vehicle accident into a vegetable field in Afghanistan resulting in multiple contaminated skin wounds." Journal of cutaneous pathology vol. 44,7 (2017): 620-624. doi: https://doi.org/10.1111/cup.12942
Malakzai MO, Sahak JG, Campbell R, Abobakar M, Hoogestraat DR, SenGupta DJ, Bryan A, Gardner JM. Multifocal but non-disseminated phaeohyphomycosis in a healthy man via a unique mechanism: Ejection from motor vehicle accident into a vegetable field in Afghanistan resulting in multiple contaminated skin wounds. J Cutan Pathol. 2017 Jul;44(7):620-624. doi: 10.1111/cup.12942. Epub 2017 Apr 25. PMID: 28349548.
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Locating and applying sociological theories of risk-taking to develop public health interventions for adolescents.

Health sociology review : the journal of the Health Section of the Australian Sociological Association

Pound P, Campbell R.
PMID: 25999784
Health Sociol Rev. 2015 Jan 02;24(1):64-80. doi: 10.1080/14461242.2015.1008537. Epub 2015 Apr 01.

Sociological theories seldom inform public health interventions at the community level. The reasons for this are unclear but may include difficulties in finding, understanding or operationalising theories. We conducted a study to explore the feasibility of locating sociological theories...

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Pound P, Campbell R. Locating and applying sociological theories of risk-taking to develop public health interventions for adolescents. Health Sociol Rev. 2015;24(1):64-80doi: 10.1080/14461242.2015.1008537.
Pound, P., & Campbell, R. (2015). Locating and applying sociological theories of risk-taking to develop public health interventions for adolescents. Health sociology review : the journal of the Health Section of the Australian Sociological Association, 24(1), 64-80. https://doi.org/10.1080/14461242.2015.1008537
Pound, Pandora, and Campbell, Rona. "Locating and applying sociological theories of risk-taking to develop public health interventions for adolescents." Health sociology review : the journal of the Health Section of the Australian Sociological Association vol. 24,1 (2015): 64-80. doi: https://doi.org/10.1080/14461242.2015.1008537
Pound P, Campbell R. Locating and applying sociological theories of risk-taking to develop public health interventions for adolescents. Health Sociol Rev. 2015 Jan 02;24(1):64-80. doi: 10.1080/14461242.2015.1008537. Epub 2015 Apr 01. PMID: 25999784; PMCID: PMC4409085.
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Microbial Biomass and Community Structure in a Sequence of Soils with Increasing Fertility and Changing Land Use.

Microbial ecology

Yao H, He Z, Wilson MJ, Campbell CD.
PMID: 11080380
Microb Ecol. 2000 Aug;40(3):223-237. doi: 10.1007/s002480000053.

The microbial biomass and community structure of eight Chinese red soils with different fertility and land use history was investigated. Two community based microbiological measurements, namely, community level physiological profiling (CLPP) using Biolog sole C source utilization tests and...

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Yao H, He Z, Wilson MJ, et al. Microbial Biomass and Community Structure in a Sequence of Soils with Increasing Fertility and Changing Land Use. Microb Ecol. 2000;40(3):223-237doi: 10.1007/s002480000053.
Yao, H., He, Z., Wilson, M. J., & Campbell, C. D. (2000). Microbial Biomass and Community Structure in a Sequence of Soils with Increasing Fertility and Changing Land Use. Microbial ecology, 40(3), 223-237. https://doi.org/10.1007/s002480000053
Yao, et al. "Microbial Biomass and Community Structure in a Sequence of Soils with Increasing Fertility and Changing Land Use." Microbial ecology vol. 40,3 (2000): 223-237. doi: https://doi.org/10.1007/s002480000053
Yao H, He Z, Wilson MJ, Campbell CD. Microbial Biomass and Community Structure in a Sequence of Soils with Increasing Fertility and Changing Land Use. Microb Ecol. 2000 Aug;40(3):223-237. doi: 10.1007/s002480000053. PMID: 11080380.
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Showing 13 to 24 of 973 entries