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Showing 649 to 654 of 654 entries
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Long-Term Safety and Efficacy of the Anti-Mucosal Addressin Cell Adhesion Molecule-1 Monoclonal Antibody Ontamalimab (SHP647) for the Treatment of Crohn's Disease: The OPERA II Study.

Inflammatory bowel diseases

D'Haens GR, Reinisch W, Lee SD, Tarabar D, Louis E, Kłopocka M, Klaus J, Schreiber S, Il Park D, Hébuterne X, Nagy P, Cataldi F, Martin SW, Nayak S, Banerjee A, Gorelick KJ, Sandborn WJ.
PMID: 34427633
Inflamm Bowel Dis. 2021 Aug 24; doi: 10.1093/ibd/izab215. Epub 2021 Aug 24.

BACKGROUND: Patients with Crohn's disease (CD) experience intestinal inflammation. Ontamalimab (SHP647), a fully human immunoglobulin G2 monoclonal antibody against mucosal addressin cell adhesion molecule-1, is a potential novel CD treatment. OPERA II, a multicenter, open-label, phase 2 extension study,...

Early Echocardiographic and Cardiac MRI Findings in Multisystem Inflammatory Syndrome in Children.

Journal of clinical medicine

Sirico D, Basso A, Reffo E, Cavaliere A, Castaldi B, Sabatino J, Meneghel A, Martini G, Da Dalt L, Zulian F, Di Salvo G.
PMID: 34362141
J Clin Med. 2021 Jul 29;10(15). doi: 10.3390/jcm10153360.

Multisystem Inflammatory Syndrome in Children (MIS-C) is a known severe condition affecting children previously exposed to SARS-CoV-2. The aim of our study was to describe the early cardiac abnormalities in patients with MIS-C, evaluated by speckle tracking echocardiography (STE)...

Glucose control in home-isolated adults with type 1 diabetes affected by COVID-19 using continuous glucose monitoring.

Journal of endocrinological investigation

Longo M, Scappaticcio L, Petrizzo M, Castaldo F, Sarnataro A, Forestiere D, Caiazzo F, Bellastella G, Maiorino MI, Capuano A, Esposito K.
PMID: 34482534
J Endocrinol Invest. 2021 Sep 05; doi: 10.1007/s40618-021-01669-3. Epub 2021 Sep 05.

PURPOSE: This study is aimed at evaluating changes in metrics of glucose control in home-isolated patients with type 1 diabetes and COVID-19 using a continuous glucose monitoring (CGM) system.METHODS: We included adults aged 18-45 years with type 1 diabetes,...

Social Inferences in Agenesis of the Corpus Callosum and Autism: Semantic Analysis and Topic Modeling.

Journal of autism and developmental disorders

Renteria-Vazquez T, Brown WS, Kang C, Graves M, Castelli F, Paul LK.
PMID: 33768420
J Autism Dev Disord. 2021 Mar 25; doi: 10.1007/s10803-021-04957-2. Epub 2021 Mar 25.

Impoverished capacity for social inference is one of several symptoms that are common to both agenesis of the corpus callosum (AgCC) and Autism Spectrum Disorder (ASD). This research compared the ability of 14 adults with AgCC, 13 high-functioning adults...

The cascade of care of HIV after one year of follow-up in a cohort of HIV-positive adult patients in three health settings of Morrumbene in rural Mozambique.

Tropical medicine & international health : TM & IH

Magro P, Cerini C, da Gloria A, Tembe S, Castelli F, Tomasoni LR.
PMID: 34455661
Trop Med Int Health. 2021 Nov;26(11):1503-1511. doi: 10.1111/tmi.13671. Epub 2021 Sep 12.

OBJECTIVE: To assess the state of the retention in care of HIV patients in three health settings in Morrumbene, a rural district of Inhambane Province, Mozambique. We evaluated potential factors associated with early loss to follow-up (LTFU), retention in...

Alternative poly-adenylation modulates α1-antitrypsin expression in chronic obstructive pulmonary disease.

PLoS genetics

Lackey L, Coria A, Ghosh AJ, Grayeski P, Hatfield A, Shankar V, Platig J, Xu Z, Ramos SBV, Silverman EK, Ortega VE, Cho MH, Hersh CP, Hobbs BD, Castaldi P, Laederach A.
PMID: 34784346
PLoS Genet. 2021 Nov 16;17(11):e1009912. doi: 10.1371/journal.pgen.1009912. eCollection 2021 Nov.

α1-anti-trypsin (A1AT), encoded by SERPINA1, is a neutrophil elastase inhibitor that controls the inflammatory response in the lung. Severe A1AT deficiency increases risk for Chronic Obstructive Pulmonary Disease (COPD), however, the role of A1AT in COPD in non-deficient individuals...

Showing 649 to 654 of 654 entries