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Showing 13 to 24 of 26 entries
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Single-Nucleotide Polymorphisms (SNP) Mining and Their Effect on the Tridimensional Protein Structure Prediction in a Set of Immunity-Related Expressed Sequence Tags (EST) in Atlantic Salmon (.

Frontiers in genetics

Vallejos-Vidal E, Reyes-Cerpa S, Rivas-Pardo JA, Maisey K, Yáñez JM, Valenzuela H, Cea PA, Castro-Fernandez V, Tort L, Sandino AM, Imarai M, Reyes-López FE.
PMID: 32174954
Front Genet. 2020 Feb 27;10:1406. doi: 10.3389/fgene.2019.01406. eCollection 2019.

Single-nucleotide polymorphisms (SNPs) are single genetic code variations considered one of the most common forms of nucleotide modifications. Such SNPs can be located in genes associated to immune response and, therefore, they may have direct implications over the phenotype...

The Promising Role of miR-21 as a Cancer Biomarker and Its Importance in RNA-Based Therapeutics.

Molecular therapy. Nucleic acids

Bautista-Sánchez D, Arriaga-Canon C, Pedroza-Torres A, De La Rosa-Velázquez IA, González-Barrios R, Contreras-Espinosa L, Montiel-Manríquez R, Castro-Hernández C, Fragoso-Ontiveros V, Álvarez-Gómez RM, Herrera LA.
PMID: 32244168
Mol Ther Nucleic Acids. 2020 Jun 05;20:409-420. doi: 10.1016/j.omtn.2020.03.003. Epub 2020 Mar 13.

MicroRNAs are small noncoding transcripts that posttranscriptionally regulate gene expression via base-pairing complementarity. Their role in cancer can be related to tumor suppression or oncogenic function. Moreover, they have been linked to processes recognized as hallmarks of cancer, such...

AC electrified jets in a flow-focusing device: Jet length scaling.

Biomicrofluidics

Castro-Hernández E, García-Sánchez P, Alzaga-Gimeno J, Tan SH, Baret JC, Ramos A.
PMID: 27375826
Biomicrofluidics. 2016 Jun 15;10(4):043504. doi: 10.1063/1.4954194. eCollection 2016 Jul.

We use a microfluidic flow-focusing device with integrated electrodes for controlling the production of water-in-oil drops. In a previous work, we reported that very long jets can be formed upon application of AC fields. We now study in detail...

Structural and Kinetic Insights Into the Molecular Basis of Salt Tolerance of the Short-Chain Glucose-6-Phosphate Dehydrogenase From .

Frontiers in microbiology

Fuentes-Ugarte N, Herrera SM, Maturana P, Castro-Fernandez V, Guixé V.
PMID: 34650535
Front Microbiol. 2021 Sep 28;12:730429. doi: 10.3389/fmicb.2021.730429. eCollection 2021.

Halophilic enzymes need high salt concentrations for activity and stability and are considered a promising source for biotechnological applications. The model study for haloadaptation has been proteins from the

ADP-Dependent Kinases From the Archaeal Order .

Frontiers in microbiology

Gonzalez-Ordenes F, Cea PA, Fuentes-Ugarte N, Muñoz SM, Zamora RA, Leonardo D, Garratt RC, Castro-Fernandez V, Guixé V.
PMID: 29997580
Front Microbiol. 2018 Jun 26;9:1305. doi: 10.3389/fmicb.2018.01305. eCollection 2018.

Halophilic organisms inhabit hypersaline environments where the extreme ionic conditions and osmotic pressure have driven the evolution of molecular adaptation mechanisms. Understanding such mechanisms is limited by the common difficulties encountered in cultivating such organisms. Within the

Vulnerability of mesostriatal dopaminergic neurons in Parkinson's disease.

Frontiers in neuroanatomy

González-Hernández T, Cruz-Muros I, Afonso-Oramas D, Salas-Hernandez J, Castro-Hernandez J.
PMID: 21079748
Front Neuroanat. 2010 Oct 20;4:140. doi: 10.3389/fnana.2010.00140. eCollection 2010.

The term vulnerability was first associated with the midbrain dopaminergic neurons 85 years ago, before they were identified as monoaminergic neurons, when Foix and Nicolesco (1925) reported the loss of neuromelanin containing neurons in the midbrain of patients with...

Prognostic Significance of the MAD1L1 1673 G: A Polymorphism in Ovarian Adenocarcinomas.

Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion

Bandala-Jacques A, Hernández-Cruz IA, Castro-Hernández C, Díaz-Chávez J, Arriaga-Canon C, Barquet-Muñoz SA, Prada-Ortega DG, Cantú-de León D, Herrera LA.
PMID: 32488223
Rev Invest Clin. 2020 May 07;73(3). Epub 2020 May 07.

BACKGROUND: Ovarian cancer is the most lethal gynecologic cancer. Although most patients respond adequately to the first-line therapy, up to 85% experience a recurrence of disease, which carries a poor prognosis. Mitotic arrest deficiency 1 is a protein that...

Thermo/pH Responsive Star and Linear Copolymers Containing a Cholic Acid-Derived Monomer, .

Polymers

Castro-Hernández A, Cortez-Lemus NA.
PMID: 31717987
Polymers (Basel). 2019 Nov 11;11(11). doi: 10.3390/polym11111859.

In this work three CTAs trithiocarbonate-type were synthesized-bifunctional (with PEG), trifunctional (with glycerol), and tetrafunctional (PERT)-and used in the controlled polymerization of 2-(acryloyloxy)ethyl cholate (CAE) via reversible addition-fragmentation chain transfer (RAFT) polymerization. The resulting macroCTAs containing a cholic acid-derived...

Landscape of Germline Genetic Variants in AGT, MGMT, and TP53 in Mexican Adult Patients with Astrocytoma.

Cellular and molecular neurobiology

Carlos-Escalante JA, Gómez-Flores-Ramos L, Bian X, Perdomo-Pantoja A, de Andrade KC, Mejía-Pérez SI, Cacho-Díaz B, González-Barrios R, Reynoso-Noverón N, Soto-Reyes E, Sánchez-Correa TE, Guerra-Calderas L, Yan C, Chen Q, Castro-Hernández C, Vidal-Millán S, Taja-Chayeb L, Gutiérrez O, Álvarez-Gómez RM, Gómez-Amador JL, Ostrosky-Wegman P, Mohar-Betancourt A, Herrera-Montalvo LA, Corona T, Meerzaman D, Wegman-Ostrosky T.
PMID: 32535722
Cell Mol Neurobiol. 2021 Aug;41(6):1285-1297. doi: 10.1007/s10571-020-00901-7. Epub 2020 Jun 13.

Astrocytoma is the most common type of primary brain tumor. The risk factors for astrocytoma are poorly understood; however, germline genetic variants account for 25% of the risk of developing gliomas. In this study, we assessed the risk of...

ATP-Dependent Chromatin Remodeling During Cortical Neurogenesis.

Frontiers in neuroscience

Sokpor G, Castro-Hernandez R, Rosenbusch J, Staiger JF, Tuoc T.
PMID: 29686607
Front Neurosci. 2018 Apr 09;12:226. doi: 10.3389/fnins.2018.00226. eCollection 2018.

The generation of individual neurons (neurogenesis) during cortical development occurs in discrete steps that are subtly regulated and orchestrated to ensure normal histogenesis and function of the cortex. Notably, various gene expression programs are known to critically drive many...

Chromatin Remodeling BAF155 Subunit Regulates the Genesis of Basal Progenitors in Developing Cortex.

iScience

Narayanan R, Pham L, Kerimoglu C, Watanabe T, Castro Hernandez R, Sokpor G, Ulmke PA, Kiszka KA, Tonchev AB, Rosenbusch J, Seong RH, Teichmann U, Frahm J, Fischer A, Bonn S, Stoykova A, Staiger JF, Tuoc T.
PMID: 30240734
iScience. 2018 Jun 29;4:109-126. doi: 10.1016/j.isci.2018.05.014. Epub 2018 May 23.

The abundance of basal progenitors (BPs), basal radial glia progenitors (bRGs) and basal intermediate progenitors (bIPs), in primate brain has been correlated to the high degree of cortical folding. Here we examined the role of BAF155, a subunit of...

The epigenetic factor BORIS (CTCFL) controls the androgen receptor regulatory network in ovarian cancer.

Oncogenesis

Salgado-Albarrán M, González-Barrios R, Guerra-Calderas L, Alcaraz N, Estefanía Sánchez-Correa T, Castro-Hernández C, Sánchez-Pérez Y, Aréchaga-Ocampo E, García-Carrancá A, Cantú de León D, Herrera LA, Baumbach J, Soto-Reyes E.
PMID: 31406110
Oncogenesis. 2019 Aug 12;8(8):41. doi: 10.1038/s41389-019-0150-2.

The identification of prognostic biomarkers is a priority for patients suffering from high-grade serous ovarian cancer (SOC), which accounts for >70% of ovarian cancer (OC) deaths. Meanwhile, borderline ovarian cancer (BOC) is a low malignancy tumor and usually patients...

Showing 13 to 24 of 26 entries