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Showing 253 to 264 of 264 entries
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Vertical Inheritance Facilitates Interspecies Diversification in Biosynthetic Gene Clusters and Specialized Metabolites.

mBio

Chase AB, Sweeney D, Muskat MN, Guillén-Matus DG, Jensen PR.
PMID: 34809466
mBio. 2021 Nov 23;e0270021. doi: 10.1128/mBio.02700-21. Epub 2021 Nov 23.

While specialized metabolites are thought to mediate ecological interactions, the evolutionary processes driving chemical diversification, particularly among closely related lineages, remain poorly understood. Here, we examine the evolutionary dynamics governing the distribution of natural product biosynthetic gene clusters (BGCs)...

Teaching Critical Appraisal Through the Lens of Study Design in Journal Club.

Journal of the Endocrine Society

Hendrickson CD.
PMID: 34258489
J Endocr Soc. 2021 Apr 19;5(8):bvab072. doi: 10.1210/jendso/bvab072. eCollection 2021 Aug 01.

Training in endocrinology presents a major challenge: How to both develop a fellow's medical knowledge and teach that fellow to independently increase that fund of knowledge as a future endocrinologist. Journal clubs hold a traditional role in teaching the...

Volume of frail patients predicts outcome in frail patients after cardiac surgery.

The Journal of thoracic and cardiovascular surgery

Goel NJ, Iyengar A, Kelly JJ, Han JJ, Brown CR, Desai ND.
PMID: 32563575
J Thorac Cardiovasc Surg. 2022 Jan;163(1):151-160.e6. doi: 10.1016/j.jtcvs.2020.04.097. Epub 2020 May 04.

OBJECTIVE: Recent data from major noncardiac surgery suggest that outcomes in frail patients are better predicted by a hospital's volume of frail patients specifically, rather than overall surgical volume. We sought to evaluate this "frailty volume-frailty outcome relationship" in...

High-Fiber, Whole-Food Dietary Intervention Alters the Human Gut Microbiome but Not Fecal Short-Chain Fatty Acids.

mSystems

Oliver A, Chase AB, Weihe C, Orchanian SB, Riedel SF, Hendrickson CL, Lay M, Sewall JM, Martiny JBH, Whiteson K.
PMID: 33727392
mSystems. 2021 Mar 16;6(2). doi: 10.1128/mSystems.00115-21.

Dietary shifts can have a direct impact on the gut microbiome by preferentially selecting for microbes capable of utilizing the various dietary nutrients. The intake of dietary fiber has decreased precipitously in the last century, while consumption of processed...

[Re(CO).

Dalton transactions (Cambridge, England : 2003)

Case DR, Spear A, Henwood AF, Nanao M, Dampf S, Korter TM, Gunnlaugsson T, Zubieta J, Doyle RP.
PMID: 33660719
Dalton Trans. 2021 Mar 16;50(10):3479-3486. doi: 10.1039/d0dt04116e.

A rhenium(i) naphthalimide complex [Re(CO)3(5-PAN)Cl] (Re(5-PAN); 5-PAN = 1-(1,10-phenanthroline)-4-nitro-naphthalimide) was synthesized, characterized, and evaluated as a photocatalyst for CO2 reduction. Characterization included use of MALDI-ToF mass spectrometry, FT-IR, RAMAN, 1H and 13C NMR, elemental analysis, electronic absorption and emission...

Development of Persistent Opioid Use After Cardiac Surgery.

JAMA cardiology

Brown CR, Chen Z, Khurshan F, Groeneveld PW, Desai ND.
PMID: 32584934
JAMA Cardiol. 2020 Aug 01;5(8):889-896. doi: 10.1001/jamacardio.2020.1445.

IMPORTANCE: The overuse of opioids for acute pain management has led to an epidemic of persistent opioid use.OBJECTIVE: To determine the proportion of opioid-naive patients who develop persistent opioid use after cardiac surgery and investigate the association between the...

Integrative Neuroinformatics for Precision Prognostication and Personalized Therapeutics in Moderate and Severe Traumatic Brain Injury.

Frontiers in neurology

Zeiler FA, Iturria-Medina Y, Thelin EP, Gomez A, Shankar JJ, Ko JH, Figley CR, Wright GEB, Anderson CM.
PMID: 34557154
Front Neurol. 2021 Sep 07;12:729184. doi: 10.3389/fneur.2021.729184. eCollection 2021.

Despite changes in guideline-based management of moderate/severe traumatic brain injury (TBI) over the preceding decades, little impact on mortality and morbidity have been seen. This argues against the "one-treatment fits all" approach to such management strategies. With this, some...

Immune-Mediated Renal Diseases: A Team-Based Learning Module for Preclinical Medical Students.

MedEdPORTAL : the journal of teaching and learning resources

Beckler MD, Chase AJ.
PMID: 34970632
MedEdPORTAL. 2021 Dec 16;17:11206. doi: 10.15766/mep_2374-8265.11206. eCollection 2021.

INTRODUCTION: The underlying immune mechanisms of renal diseases are complex, and medical students benefit from learning these complexities in the setting of team-based learning (TBL), where they can apply foundational immunologic concepts to clinical problems.METHODS: This immune-mediated renal disease...

Curb Your Enthusiasm.

The Annals of thoracic surgery

Brown CR, Cevasco M.
PMID: 33524344
Ann Thorac Surg. 2021 Oct;112(4):1217. doi: 10.1016/j.athoracsur.2020.12.053. Epub 2021 Jan 29.

No abstract available.

A role for translational regulation by S6 kinase and a downstream target in inflammatory pain.

British journal of pharmacology

de la Peña JB, Kunder N, Lou TF, Chase R, Stanowick A, Barragan-Iglesias P, Pancrazio JJ, Campbell ZT.
PMID: 34355805
Br J Pharmacol. 2021 Dec;178(23):4675-4690. doi: 10.1111/bph.15646. Epub 2021 Sep 12.

BACKGROUND AND PURPOSE: Translational controls pervade neurobiology. Nociceptors play an integral role in the detection and propagation of pain signals. Nociceptors can undergo persistent changes in their intrinsic excitability. Pharmacological disruption of nascent protein synthesis diminishes acute and chronic...

Indoor Human Localization and Gait Analysis using Machine Learning for In-home Health Monitoring.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

Hahm KS, Chase AS, Dwyer B, Anthony BW.
PMID: 34892682
Annu Int Conf IEEE Eng Med Biol Soc. 2021 Nov;2021:6859-6862. doi: 10.1109/EMBC46164.2021.9630761.

Homes equipped with ambient sensors can measure physiological signals correlated with the resident's health without requiring a wearable device. Gait characteristics may reveal physical imbalances or recognize changes in cognitive health. In this paper, we use the physical interactions...

Corrigendum: Intrarenal Renin Angiotensin System Imbalance During Postnatal Life Is Associated With Increased Microvascular Density in the Mature Kidney.

Frontiers in physiology

Dalmasso C, Chade AR, Mendez M, Giani JF, Bix GJ, Chen KC, Loria AS.
PMID: 33329067
Front Physiol. 2020 Nov 16;11:615022. doi: 10.3389/fphys.2020.615022. eCollection 2020.

[This corrects the article DOI: 10.3389/fphys.2020.01046.].

Showing 253 to 264 of 264 entries