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Showing 5989 to 5999 of 5999 entries
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High level nitrosamines in rat faeces with colorectal cancer determined by a sensitive GC-MS method.

Journal of pharmaceutical and biomedical analysis

Zhao ZX, Chen SZ, Xia ZL, Bin Xu Y, Zhang LL, Tian SM, Fan Q.
PMID: 34998074
J Pharm Biomed Anal. 2022 Jan 03;210:114576. doi: 10.1016/j.jpba.2021.114576. Epub 2022 Jan 03.

N-nitrosamines (NAs) are common toxic substances that have a strong correlation with many human diseases, such as liver damage and cancer. However, there is a lack of studies on methods involving the detection of NAs in biological samples, possibly...

Changes of plasma nitric oxide, endothelin-1, and blood coagulation following intravitreal conbercept.

Scientific reports

Yi QY, Chen LS, Shen Y, Liao YH, Wang YY, Yang J, Jin Y, Cheng L.
PMID: 34903819
Sci Rep. 2021 Dec 13;11(1):23885. doi: 10.1038/s41598-021-03335-3.

Intravitreal anti-VEGF (anti-vascular endothelial growth factor) biologics have revolutionized the pharmacological management of chorioretinal diseases. However, the systemic adverse events such as stroke or bleeding are the concerns for many patients and physicians. The mechanism to develop these side...

Transcranial direct-current stimulation protects against cerebral ischemia-reperfusion injury through regulating Cezanne-dependent signaling.

Experimental neurology

Cheng J, Fan YQ, Jiang HX, Chen SF, Chen J, Liao XY, Zou YY, Lan HY, Cui Y, Chen ZB, Chen QX, Wan Q.
PMID: 34324860
Exp Neurol. 2021 Nov;345:113818. doi: 10.1016/j.expneurol.2021.113818. Epub 2021 Jul 27.

Transcranial direct-current stimulation (tDCS) is proved safe and shows therapeutic effect in cerebral ischemic stroke in clinical trials. But the underlying molecular mechanisms remain unclear. Here we show that tDCS treatment reduces the infarct volume after rat cerebral ischemia-reperfusion...

Predicting transcription factor binding sites using DNA shape features based on shared hybrid deep learning architecture.

Molecular therapy. Nucleic acids

Wang S, Zhang Q, Shen Z, He Y, Chen ZH, Li J, Huang DS.
PMID: 33767912
Mol Ther Nucleic Acids. 2021 Feb 18;24:154-163. doi: 10.1016/j.omtn.2021.02.014. eCollection 2021 Jun 04.

The study of transcriptional regulation is still difficult yet fundamental in molecular biology research. Recent research has shown that the double helix structure of nucleotides plays an important role in improving the accuracy and interpretability of transcription factor binding...

Atypical presentations of idiopathic intracranial hypertension.

Taiwan journal of ophthalmology

Chen BS, Newman NJ, Biousse V.
PMID: 33767953
Taiwan J Ophthalmol. 2020 Dec 02;11(1):25-38. doi: 10.4103/tjo.tjo_69_20. eCollection 2021.

Idiopathic intracranial hypertension (IIH) is a disorder of unknown etiology that results in isolated raised intracranial pressure. Classic symptoms and signs of IIH include headache, papilledema, diplopia from sixth nerve palsy and divergence insufficiency, and pulsatile tinnitus. Atypical presentations...

TARBP2 Suppresses Ubiquitin-Proteasomal Degradation of HIF-1α in Breast Cancer.

International journal of molecular sciences

Li JN, Chen PS, Chiu CF, Lyu YJ, Lo C, Tsai LW, Wang MY.
PMID: 35008634
Int J Mol Sci. 2021 Dec 24;23(1). doi: 10.3390/ijms23010208.

TAR (HIV-1) RNA binding protein 2 (TARBP2) is an RNA-binding protein participating in cytoplasmic microRNA processing. Emerging evidence has shown the oncogenic role of TARBP2 in promoting cancer progression, making it an unfavorable prognosis marker for breast cancer. Hypoxia...

Testing the concept of hypervalency: charge density analysis of K2SO4.

Inorganic chemistry

Schmøkel MS, Cenedese S, Overgaard J, Jørgensen MR, Chen YS, Gatti C, Stalke D, Iversen BB.
PMID: 22834961
Inorg Chem. 2012 Aug 06;51(15):8607-16. doi: 10.1021/ic301372m. Epub 2012 Jul 26.

One of the most basic concepts in chemical bonding theory is the octet rule, which was introduced by Lewis in 1916, but later challenged by Pauling to explain the bonding of third-row elements. In the third row, the central...

NAMPT promotes hepatitis B virus replication and liver cancer cell proliferation through the regulation of aerobic glycolysis.

Oncology letters

Guo HJ, Li HY, Chen ZH, Zhou WJ, Li JJ, Zhang JY, Wang J, Luo XY, Zeng T, Shi Z, Mo CF.
PMID: 33777213
Oncol Lett. 2021 May;21(5):390. doi: 10.3892/ol.2021.12651. Epub 2021 Mar 18.

Nicotinamide phosphoribosyltransferase (NAMPT) is a critical rate-limiting enzyme involved in NAD synthesis that has been shown to contribute to the progression of liver cancer. However, the potential role and mechanism of NAMPT in hepatitis B virus (HBV)-associated liver cancer...

Well-written but misplaced: a response to Barrett's comment.

The International journal on drug policy

Chen JS.
PMID: 22417825
Int J Drug Policy. 2012 May;23(3):187. doi: 10.1016/j.drugpo.2012.02.004. Epub 2012 Mar 13.

No abstract available.

Automated Urine Particle Analyzer UF-1000i Can Pre-Estimate the Treatment Response of Women's Uncomplicated Urinary Tract Infections to Antibiotics.

Urology journal

Shei-Dei Yang S, Chen YS, Yang CC, Chang SJ.
PMID: 34431075
Urol J. 2021 Aug 25; doi: 10.22037/uj.v18i.6514. Epub 2021 Aug 25.

PURPOSE: To evaluate the ability of bacterial scatter diagrams generated from the automated urine particle analyzer (UF-1000i, Sysmex, Kobe, Japan) in pre-estimate the treatment efficacy of oral cefalexin in treating women with uncomplicated urinary tract infection (uUTI).MATERIALS AND METHODS:...

High Baseline C-Reactive Protein Level Can Predict the Occurrence of the Jarisch-Herxheimer Reaction in Patients with Active Syphilis.

Infection and drug resistance

Tseng YT, Chou PY, Tai MH, Dai CY, Lee SS, Chen YS, Tsai HC, Chen YH.
PMID: 34898992
Infect Drug Resist. 2021 Dec 02;14:5121-5129. doi: 10.2147/IDR.S335121. eCollection 2021.

BACKGROUND: The Jarisch-Herxheimer reaction (JHR) is an inflammatory reaction that can occur after treatment for syphilis. The mechanism of JHR is unknown. The level of C-reactive protein (CRP) increases during infection and inflammation. We hypothesized that CRP may be...

Showing 5989 to 5999 of 5999 entries