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Showing 13 to 24 of 36 entries
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Correction: Quality of life under extended continuous versus intermittent adjuvant letrozole in lymph node-positive, early breast cancer patients: the SOLE randomised phase 3 trial.

British journal of cancer

Ribi K, Luo W, Colleoni M, Karlsson P, Chirgwin J, Aebi S, Jerusalem G, Neven P, Di Lauro V, Gomez HL, Ruhstaller T, Abdi E, Biganzoli L, Müller B, Barbeaux A, Graas MP, Rabaglio M, Francis PA, Foukakis T, Pagani O, Graiff C, Vorobiof D, Maibach R, Di Leo A, Gelber RD, Goldhirsch A, Coates AS, Regan MM, Bernhard J.
PMID: 31949268
Br J Cancer. 2020 Mar;122(7):1119. doi: 10.1038/s41416-019-0709-x.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Molecular differentiation of Panax notoginseng grown under different conditions by internal extractive electrospray ionization mass spectrometry and multivariate analysis.

Phytochemistry

Zhang X, Chen ZY, Qiu ZD, Liu M, Xu J, Lai CJ, Frankevich V, Chingin K.
PMID: 34839132
Phytochemistry. 2021 Nov 26;194:113030. doi: 10.1016/j.phytochem.2021.113030. Epub 2021 Nov 26.

Panax notoginseng is a highly valuable and widely used herb in traditional Chinese medicine. The quality and efficacy of Panax notoginseng grown under different conditions can greatly vary due to the differences in chemical composition. The analysis of chemical...

Detection of diethyl phthalate in perfumes by extractive electrospray ionization mass spectrometry.

Analytical chemistry

Chingin K, Chen H, Gamez G, Zhu L, Zenobi R.
PMID: 19063675
Anal Chem. 2009 Jan 01;81(1):123-9. doi: 10.1021/ac801572d.

Recent findings suggest that long-term exposure to diethyl phthalate (DEP), one of the widely used phthalate esters, can lead to serious health problems. Most perfumes contain non-negligible amounts of DEP. Rapid and sensitive detection of DEP in perfumes is...

Analysis of the charge exchange between the human body and ground: evaluation of "earthing" from an electrical perspective.

Journal of chiropractic medicine

Chamberlin K, Smith W, Chirgwin C, Appasani S, Rioux P.
PMID: 25435837
J Chiropr Med. 2014 Dec;13(4):239-46. doi: 10.1016/j.jcm.2014.10.001.

OBJECTIVE: The purpose of this study was to investigate "earthing" from an electrical perspective through measurement and analysis of the naturally occurring electron flow between the human body or a control and ground as this relates to the magnitude...

The other 96%: Can neglected sources of fitness variation offer new insights into adaptation to global change?.

Evolutionary applications

Chirgwin E, Marshall DJ, Sgrò CM, Monro K.
PMID: 28250811
Evol Appl. 2016 Dec 20;10(3):267-275. doi: 10.1111/eva.12447. eCollection 2017 Mar.

Mounting research considers whether populations may adapt to global change based on additive genetic variance in fitness. Yet selection acts on phenotypes, not additive genetic variance alone, meaning that persistence and evolutionary potential in the near term, at least,...

Correction to: Direct Analysis of Aqueous Solutions and Untreated Biological Samples Using Nanoelectrospray Ionization Mass Spectrometry with Pipette Tip in Series with High-Ohmic Resistor as Ion Source.

Journal of the American Society for Mass Spectrometry

Rahman MM, Wu D, Chingin K.
PMID: 30949968
J Am Soc Mass Spectrom. 2019 Jul;30(7):1337. doi: 10.1007/s13361-019-02188-5.

Md. Matiur Rahman's name was incorrect in the original publication of this article.

Navigating facilitated regulatory pathways during a disease X pandemic.

NPJ vaccines

Simpson S, Chakrabarti A, Robinson D, Chirgwin K, Lumpkin M.
PMID: 33110630
NPJ Vaccines. 2020 Oct 23;5:101. doi: 10.1038/s41541-020-00249-5. eCollection 2020.

In 2018, the Bill and Melinda Gates Foundation convened over thirty subject matter experts in clinical development, manufacturing, and regulatory assessment to determine how the development and approval of medical countermeasures could be accelerated in the event of Disease...

Chemical Profiling of Bulk Alloys Using Micro-Electrochemical Probe Mass Spectrometry.

Analytical chemistry

Xu J, Zhong D, Chingin K, Song L, Chen H.
PMID: 31055916
Anal Chem. 2019 Jul 02;91(13):8304-8309. doi: 10.1021/acs.analchem.9b01056. Epub 2019 May 14.

Micro-electrochemical probe mass spectrometry (μECP-MS) is demonstrated as a method for the direct profiling of chemical composition of bulk alloy samples without tedious sample pretreatment. The spatial distribution of Zn and Cu components of a Cu/Zn alloy sample was...

Halofuginone inhibits TGF-β/BMP signaling and in combination with zoledronic acid enhances inhibition of breast cancer bone metastasis.

Oncotarget

Juárez P, Fournier PGJ, Mohammad KS, McKenna RC, Davis HW, Peng XH, Niewolna M, Mauviel A, Chirgwin JM, Guise TA.
PMID: 29156807
Oncotarget. 2017 Sep 23;8(49):86447-86462. doi: 10.18632/oncotarget.21200. eCollection 2017 Oct 17.

More efficient therapies that target multiple molecular mechanisms are needed for the treatment of incurable bone metastases. Halofuginone is a plant alkaloid-derivative with antiangiogenic and antiproliferative effects. Here we demonstrate that halofuginone is an effective therapy for the treatment...

Fragmentation of benzylpyridinium "thermometer" ions and its effect on the accuracy of internal energy calibration.

Journal of the American Society for Mass Spectrometry

Barylyuk KV, Chingin K, Balabin RM, Zenobi R.
PMID: 19879774
J Am Soc Mass Spectrom. 2010 Jan;21(1):172-7. doi: 10.1016/j.jasms.2009.09.023. Epub 2009 Oct 06.

Electrospray ionization mass spectrometry (ESI-MS) is a powerful analytical method to study biomolecules and noncovalent complexes. The prerequisite for their intact observation is soft ionization. In ESI, the internal energy of ions is primarily influenced by collisional activation in...

Mass spectrometry imaging for visualizing organic analytes in food.

Mass spectrometry reviews

Handberg E, Chingin K, Wang N, Dai X, Chen H.
PMID: 24687728
Mass Spectrom Rev. 2015 Nov-Dec;34(6):641-58. doi: 10.1002/mas.21424. Epub 2014 Mar 28.

The demand for rapid chemical imaging of food products steadily increases. Mass spectrometry (MS) is featured by excellent molecular specificity of analysis and is, therefore, a very attractive method for chemical profiling. MS for food imaging has increased significantly...

Applications of direct analysis in real time mass spectrometry in food analysis: A review.

Rapid communications in mass spectrometry : RCM

Zhang X, Ren X, Chingin K.
PMID: 33277776
Rapid Commun Mass Spectrom. 2021 Mar 30;35(6):e9013. doi: 10.1002/rcm.9013.

RATIONALE: Direct analysis in real time (DART) combined with mass spectrometry (MS) detection has become one of the most broadly used analytical approaches for the direct molecular characterization of food samples with regard to their chemical quality, safety, origin,...

Showing 13 to 24 of 36 entries