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Showing 25 to 36 of 221 entries
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Curcumin Delivery on Metal-Organic Frameworks: The Effect of the Metal Center on Pharmacokinetics within the M-MOF-74 Family.

ACS applied bio materials

Lawson S, Newport K, Pederniera N, Rownaghi AA, Rezaei F.
PMID: 35014426
ACS Appl Bio Mater. 2021 Apr 19;4(4):3423-3432. doi: 10.1021/acsabm.1c00009. Epub 2021 Mar 12.

Metal-organic frameworks (MOFs) have gained considerable attention as drug delivery platforms over the past decade owing to their tunable physiochemical properties, biodiversity, and capability to encapsulate sizable active compound loadings. Nevertheless, many fundamental properties pertaining to MOFs' pharmacokinetic performances...

Comparison of Clinical and Social Characteristics of Canadian Youth Living With Type 1 and Type 2 Diabetes.

Canadian journal of diabetes

Carino M, Elia Y, Sellers E, Curtis J, McGavock J, Scholey J, Hamilton J, Clarson C, Pinto T, Hadjiyannakis S, Mertens L, Samaan MC, Ho J, Nour M, Panagiotopoulos C, Jetha M, Gabbs M, Mahmud FH, Wicklow B, Dart A.
PMID: 33714663
Can J Diabetes. 2021 Jul;45(5):428-435. doi: 10.1016/j.jcjd.2021.01.008. Epub 2021 Jan 22.

OBJECTIVES: Our aim in this study was to describe the clinical and social characteristics of 2 Canadian cohorts of adolescents with diabetes.METHODS: Participants from the Improving renal Complications in Adolescents with type 2 diabetes through REsearch (iCARE) study (n=322)...

Mixing Mg-MOF-74 with Zn-MOF-74: A Facile Pathway of Controlling the Pharmacokinetic Release Rate of Curcumin.

ACS applied bio materials

Lawson S, Siemers A, Kostlenick J, Al-Naddaf Q, Newport K, Rownaghi AA, Rezaei F.
PMID: 35006987
ACS Appl Bio Mater. 2021 Sep 20;4(9):6874-6880. doi: 10.1021/acsabm.1c00585. Epub 2021 Aug 11.

Recently, metal-organic frameworks (MOFs) have been widely employed as potential drug-delivery platforms; however, most studies have focused on the initial aspects of material development and have made little progress toward using MOFs as a means of controlling the pharmacokinetic...

Clinical predictors of driving simulator performance in drivers with multiple sclerosis.

Multiple sclerosis (Houndmills, Basingstoke, England)

Krasniuk S, Classen S, Morrow SA, Alvarez L, He W, Srinivasan S, Monahan M.
PMID: 33565905
Mult Scler. 2021 Nov;27(13):2085-2092. doi: 10.1177/1352458521992507. Epub 2021 Feb 10.

BACKGROUND: Drivers with multiple sclerosis (MS) may experience visual-cognitive impairment that affects their fitness to drive. Due to limitations associated with the on-road assessment, an alternative assessment that measures driving performance is warranted. Whether clinical indicators of on-road outcomes...

Fear of hypoglycemia in children with type 1 diabetes and their parents: Effect of pump therapy and continuous glucose monitoring with option of low glucose suspend in the CGM TIME trial.

Pediatric diabetes

Verbeeten KC, Perez Trejo ME, Tang K, Chan J, Courtney JM, Bradley BJ, McAssey K, Clarson C, Kirsch S, Curtis JR, Mahmud FH, Richardson C, Cooper T, Lawson ML.
PMID: 33179818
Pediatr Diabetes. 2021 Mar;22(2):288-293. doi: 10.1111/pedi.13150. Epub 2020 Nov 27.

To determine if pump therapy with continuous glucose monitoring offering low glucose suspend (LGS) decreases fear of hypoglycemia among children with type 1 diabetes and their parents. The CGM TIME trial is a multicenter randomized controlled trial that enrolled...

An Integrative Review on Teen Distracted Driving for Model Program Development.

Frontiers in public health

Classen S, Winter SM, Brown C, Morgan-Daniel J, Medhizadah S, Agarwal N.
PMID: 31131271
Front Public Health. 2019 May 03;7:111. doi: 10.3389/fpubh.2019.00111. eCollection 2019.

Distracted driving, especially driver inattention, is associated with high levels of crash-related fatalities and injury. Teen novice drivers are one of the groups most likely to drive distracted and to suffer its consequences. Teens have a higher risk of...

Rates and timing of short-term complications following operative treatment of tibial shaft fractures.

OTA international : the open access journal of orthopaedic trauma

Upfill-Brown A, Hwang R, Clarkson S, Brodke D, Devana S, Mayer E, Kelley B, Arshi A, Lee C.
PMID: 34765906
OTA Int. 2021 Nov 03;4(4):e158. doi: 10.1097/OI9.0000000000000158. eCollection 2021 Dec.

INTRODUCTION: Tibial shaft fractures are a relatively common injury in orthopaedic surgery, with management options including intramedullary nail (IMN) fixation or open reduction internal fixation (ORIF) with plate osteosynthesis. Using a large national database, we sought to compare the...

Corneal Lesion Characterized by Optical Coherence Tomography Assists in the Diagnosis of Epidermolysis Bullosa in a Two-Week-Old Neonate.

Cornea

Williamson J, Chan S, Clapson K, Shah S.
PMID: 34743104
Cornea. 2022 Feb 01;41(2):e1. doi: 10.1097/ICO.0000000000002929.

No abstract available.

Stress cardiomyopathy as a cause of reverse redistribution with Tc-99m tetrofosmin regadenoson-rest myocardial perfusion imaging.

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

Joseph L, Clarkson S, Heindl B, Iskandrian AE, Hage FG.
PMID: 34409573
J Nucl Cardiol. 2021 Aug 18; doi: 10.1007/s12350-021-02754-z. Epub 2021 Aug 18.

No abstract available.

Combined Ibuprofen and Curcumin Delivery Using Mg-MOF-74 as a Single Nanocarrier.

ACS applied bio materials

Lawson S, Rownaghi AA, Rezaei F.
PMID: 35014812
ACS Appl Bio Mater. 2022 Jan 17;5(1):265-271. doi: 10.1021/acsabm.1c01067. Epub 2021 Dec 27.

Metal-organic frameworks (MOFs) have been extensively used as drug delivery platforms because of their considerable textural properties and physiochemical tunability. However, most medicinal treatments often administer multiple therapeutic pharmaceuticals simultaneously and combined drug delivery over a single MOF carrier...

Exploiting Chromosomal Instability of PTEN-Deficient Triple-Negative Breast Cancer Cell Lines for the Sensitization against PARP1 Inhibition in a Replication-Dependent Manner.

Cancers

Rieckhoff J, Meyer F, Classen S, Zielinski A, Riepen B, Wikman H, Petersen C, Rothkamm K, Borgmann K, Parplys AC.
PMID: 33003585
Cancers (Basel). 2020 Sep 29;12(10). doi: 10.3390/cancers12102809.

Chromosomal instability (CIN) is an emerging hallmark of cancer and its role in therapeutic responses has been increasingly attracting the attention of the research community. To target the vulnerability of tumors with high CIN, it is important to identify...

Psychological Flexibility Among Competitive Athletes: A Psychometric Investigation of a New Scale.

Frontiers in sports and active living

Johles L, Gustafsson H, Jansson-Fröjmark M, Classon C, Hasselqvist J, Lundgren T.
PMID: 33345099
Front Sports Act Living. 2020 Sep 18;2:110. doi: 10.3389/fspor.2020.00110. eCollection 2020.

There is increasing interest in applying acceptance and mindfulness interventions among athletes. However, there is a lack of sport-specific psychometrically evaluated scales to measure the impact of these interventions. The present study describes the development of a measure: the...

Showing 25 to 36 of 221 entries