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Mepolizumab improves sino-nasal symptoms and asthma control in severe eosinophilic asthma patients with chronic rhinosinusitis and nasal polyps: a 12-month real-life study.

Therapeutic advances in respiratory disease

Detoraki A, Tremante E, D'Amato M, Calabrese C, Casella C, Maniscalco M, Poto R, Brancaccio R, Boccia M, Martino M, Imperatore C, Spadaro G.
PMID: 33910399
Ther Adv Respir Dis. 2021 Jan-Dec;15:17534666211009398. doi: 10.1177/17534666211009398.

BACKGROUND: Severe eosinophilic asthma is frequently associated to chronic rhinosinusitis and nasal polyposis (CRSwNP) that contribute to poor asthma control. Mepolizumab is an anti-IL-5 monoclonal antibody, approved for the treatment of severe eosinophilic asthma. A limited number of studies...

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Detoraki A, Tremante E, D'Amato M, et al. Mepolizumab improves sino-nasal symptoms and asthma control in severe eosinophilic asthma patients with chronic rhinosinusitis and nasal polyps: a 12-month real-life study. Ther Adv Respir Dis. 2021;15:17534666211009398doi: 10.1177/17534666211009398.
Detoraki, A., Tremante, E., D'Amato, M., Calabrese, C., Casella, C., Maniscalco, M., Poto, R., Brancaccio, R., Boccia, M., Martino, M., Imperatore, C., & Spadaro, G. (2021). Mepolizumab improves sino-nasal symptoms and asthma control in severe eosinophilic asthma patients with chronic rhinosinusitis and nasal polyps: a 12-month real-life study. Therapeutic advances in respiratory disease, 1517534666211009398. https://doi.org/10.1177/17534666211009398
Detoraki, Aikaterini, et al. "Mepolizumab improves sino-nasal symptoms and asthma control in severe eosinophilic asthma patients with chronic rhinosinusitis and nasal polyps: a 12-month real-life study." Therapeutic advances in respiratory disease vol. 15 (2021): 17534666211009398. doi: https://doi.org/10.1177/17534666211009398
Detoraki A, Tremante E, D'Amato M, Calabrese C, Casella C, Maniscalco M, Poto R, Brancaccio R, Boccia M, Martino M, Imperatore C, Spadaro G. Mepolizumab improves sino-nasal symptoms and asthma control in severe eosinophilic asthma patients with chronic rhinosinusitis and nasal polyps: a 12-month real-life study. Ther Adv Respir Dis. 2021 Jan-Dec;15:17534666211009398. doi: 10.1177/17534666211009398. PMID: 33910399; PMCID: PMC8107661.
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Innovative Silver-Based Capping System for Mesoporous Silica Nanocarriers Able to Exploit a Twofold Anticorrosive Mechanism in Composite Polymer Coatings: Tailoring Benzotriazole Release and Capturing Chloride Ions.

ACS applied materials & interfaces

Olivieri F, Castaldo R, Cocca M, Gentile G, Lavorgna M.
PMID: 34607424
ACS Appl Mater Interfaces. 2021 Oct 13;13(40):48141-48152. doi: 10.1021/acsami.1c15231. Epub 2021 Oct 04.

In this work, engineered stimuli-responsive mesoporous silica nanoparticles (MSNs) were developed and exploited in polymer coatings as multifunctional carriers of a typical corrosion inhibitor, benzotriazole (BTA). In detail, a new capping system based on a BTA-silver coordination complex, able...

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Olivieri F, Castaldo R, Cocca M, et al. Innovative Silver-Based Capping System for Mesoporous Silica Nanocarriers Able to Exploit a Twofold Anticorrosive Mechanism in Composite Polymer Coatings: Tailoring Benzotriazole Release and Capturing Chloride Ions. ACS Appl Mater Interfaces. 2021;13(40):48141-48152doi: 10.1021/acsami.1c15231.
Olivieri, F., Castaldo, R., Cocca, M., Gentile, G., & Lavorgna, M. (2021). Innovative Silver-Based Capping System for Mesoporous Silica Nanocarriers Able to Exploit a Twofold Anticorrosive Mechanism in Composite Polymer Coatings: Tailoring Benzotriazole Release and Capturing Chloride Ions. ACS applied materials & interfaces, 13(40), 48141-48152. https://doi.org/10.1021/acsami.1c15231
Olivieri, Federico, et al. "Innovative Silver-Based Capping System for Mesoporous Silica Nanocarriers Able to Exploit a Twofold Anticorrosive Mechanism in Composite Polymer Coatings: Tailoring Benzotriazole Release and Capturing Chloride Ions." ACS applied materials & interfaces vol. 13,40 (2021): 48141-48152. doi: https://doi.org/10.1021/acsami.1c15231
Olivieri F, Castaldo R, Cocca M, Gentile G, Lavorgna M. Innovative Silver-Based Capping System for Mesoporous Silica Nanocarriers Able to Exploit a Twofold Anticorrosive Mechanism in Composite Polymer Coatings: Tailoring Benzotriazole Release and Capturing Chloride Ions. ACS Appl Mater Interfaces. 2021 Oct 13;13(40):48141-48152. doi: 10.1021/acsami.1c15231. Epub 2021 Oct 04. PMID: 34607424.
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Common bile duct lesions - how cholangioscopy helps rule out intraductal papillary neoplasms of the bile duct: A case report.

World journal of gastrointestinal endoscopy

Cocca S, Grande G, Reggiani Bonetti L, Magistri P, Di Sandro S, Di Benedetto F, Conigliaro R, Bertani H.
PMID: 33362908
World J Gastrointest Endosc. 2020 Dec 16;12(12):555-559. doi: 10.4253/wjge.v12.i12.555.

BACKGROUND: Intraductal papillary neoplasm of the bile duct (IPNB) is a rare variant of bile duct tumors, characterized by an exophytic growth exhibiting a papillary mass within the bile duct lumen and it can be localized anywhere along the...

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Cocca S, Grande G, Reggiani Bonetti L, et al. Common bile duct lesions - how cholangioscopy helps rule out intraductal papillary neoplasms of the bile duct: A case report. World J Gastrointest Endosc. 2020;12(12):555-559doi: 10.4253/wjge.v12.i12.555.
Cocca, S., Grande, G., Reggiani Bonetti, L., Magistri, P., Di Sandro, S., Di Benedetto, F., Conigliaro, R., & Bertani, H. (2020). Common bile duct lesions - how cholangioscopy helps rule out intraductal papillary neoplasms of the bile duct: A case report. World journal of gastrointestinal endoscopy, 12(12), 555-559. https://doi.org/10.4253/wjge.v12.i12.555
Cocca, Silvia, et al. "Common bile duct lesions - how cholangioscopy helps rule out intraductal papillary neoplasms of the bile duct: A case report." World journal of gastrointestinal endoscopy vol. 12,12 (2020): 555-559. doi: https://doi.org/10.4253/wjge.v12.i12.555
Cocca S, Grande G, Reggiani Bonetti L, Magistri P, Di Sandro S, Di Benedetto F, Conigliaro R, Bertani H. Common bile duct lesions - how cholangioscopy helps rule out intraductal papillary neoplasms of the bile duct: A case report. World J Gastrointest Endosc. 2020 Dec 16;12(12):555-559. doi: 10.4253/wjge.v12.i12.555. PMID: 33362908; PMCID: PMC7739144.
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Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target.

Journal of medicinal chemistry

Wilson C, Ray P, Zuccotto F, Hernandez J, Aggarwal A, Mackenzie C, Caldwell N, Taylor M, Huggett M, Mathieson M, Murugesan D, Smith A, Davis S, Cocco M, Parai MK, Acharya A, Tamaki F, Scullion P, Epemolu O, Riley J, Stojanovski L, Lopez-Román EM, Torres-Gómez PA, Toledo AM, Guijarro-Lopez L, Camino I, Engelhart CA, Schnappinger D, Massoudi LM, Lenaerts A, Robertson GT, Walpole C, Matthews D, Floyd D, Sacchettini JC, Read KD, Encinas L, Bates RH, Green SR, Wyatt PG.
PMID: 34910486
J Med Chem. 2022 Jan 13;65(1):409-423. doi: 10.1021/acs.jmedchem.1c01586. Epub 2021 Dec 15.

With increasing drug resistance in tuberculosis (TB) patient populations, there is an urgent need for new drugs. Ideally, new agents should work through novel targets so that they are unencumbered by preexisting clinical resistance to current treatments. Benzofuran

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Wilson C, Ray P, Zuccotto F, et al. Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target. J Med Chem. 2021;65(1):409-423doi: 10.1021/acs.jmedchem.1c01586.
Wilson, C., Ray, P., Zuccotto, F., Hernandez, J., Aggarwal, A., Mackenzie, C., Caldwell, N., Taylor, M., Huggett, M., Mathieson, M., Murugesan, D., Smith, A., Davis, S., Cocco, M., Parai, M. K., Acharya, A., Tamaki, F., Scullion, P., Epemolu, O., Riley, J., Stojanovski, L., Lopez-Román, E. M., Torres-Gómez, P. A., Toledo, A. M., Guijarro-Lopez, L., Camino, I., Engelhart, C. A., Schnappinger, D., Massoudi, L. M., Lenaerts, A., Robertson, G. T., Walpole, C., Matthews, D., Floyd, D., Sacchettini, J. C., Read, K. D., Encinas, L., Bates, R. H., Green, S. R., & Wyatt, P. G. (2022). Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target. Journal of medicinal chemistry, 65(1), 409-423. https://doi.org/10.1021/acs.jmedchem.1c01586
Wilson, Caroline, et al. "Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target." Journal of medicinal chemistry vol. 65,1 (2022): 409-423. doi: https://doi.org/10.1021/acs.jmedchem.1c01586
Wilson C, Ray P, Zuccotto F, Hernandez J, Aggarwal A, Mackenzie C, Caldwell N, Taylor M, Huggett M, Mathieson M, Murugesan D, Smith A, Davis S, Cocco M, Parai MK, Acharya A, Tamaki F, Scullion P, Epemolu O, Riley J, Stojanovski L, Lopez-Román EM, Torres-Gómez PA, Toledo AM, Guijarro-Lopez L, Camino I, Engelhart CA, Schnappinger D, Massoudi LM, Lenaerts A, Robertson GT, Walpole C, Matthews D, Floyd D, Sacchettini JC, Read KD, Encinas L, Bates RH, Green SR, Wyatt PG. Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target. J Med Chem. 2022 Jan 13;65(1):409-423. doi: 10.1021/acs.jmedchem.1c01586. Epub 2021 Dec 15. PMID: 34910486.
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Oxidized Substrates of APEH as a Tool to Study the Endoprotease Activity of the Enzyme.

International journal of molecular sciences

Sandomenico A, Gogliettino M, Iaccarino E, Fusco C, Caporale A, Ruvo M, Palmieri G, Cocca E.
PMID: 35008880
Int J Mol Sci. 2021 Dec 31;23(1). doi: 10.3390/ijms23010443.

APEH is a ubiquitous and cytosolic serine protease belonging to the prolyl oligopeptidase (POP) family, playing a critical role in the processes of degradation of proteins through both exo- and endopeptidase events. Endopeptidase activity has been associated with protein...

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Sandomenico A, Gogliettino M, Iaccarino E, et al. Oxidized Substrates of APEH as a Tool to Study the Endoprotease Activity of the Enzyme. Int J Mol Sci. 2021;23(1)doi: 10.3390/ijms23010443.
Sandomenico, A., Gogliettino, M., Iaccarino, E., Fusco, C., Caporale, A., Ruvo, M., Palmieri, G., & Cocca, E. (2021). Oxidized Substrates of APEH as a Tool to Study the Endoprotease Activity of the Enzyme. International journal of molecular sciences, 23(1), . https://doi.org/10.3390/ijms23010443
Sandomenico, Annamaria, et al. "Oxidized Substrates of APEH as a Tool to Study the Endoprotease Activity of the Enzyme." International journal of molecular sciences vol. 23,1 (2021). doi: https://doi.org/10.3390/ijms23010443
Sandomenico A, Gogliettino M, Iaccarino E, Fusco C, Caporale A, Ruvo M, Palmieri G, Cocca E. Oxidized Substrates of APEH as a Tool to Study the Endoprotease Activity of the Enzyme. Int J Mol Sci. 2021 Dec 31;23(1). doi: 10.3390/ijms23010443. PMID: 35008880.
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Showing 457 to 461 of 461 entries