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A systems-level analysis highlights microglial activation as a modifying factor in common epilepsies.

Neuropathology and applied neurobiology

Altmann A, Ryten M, Di Nunzio M, Ravizza T, Tolomeo D, Reynolds RH, Somani A, Bacigaluppi M, Iori V, Micotti E, Di Sapia R, Cerovic M, Palma E, Ruffolo G, Botía JA, Absil J, Alhusaini S, Alvim MKM, Auvinen P, Bargallo N, Bartolini E, Bender B, Bergo FPG, Bernardes T, Bernasconi A, Bernasconi N, Bernhardt BC, Blackmon K, Braga B, Caligiuri ME, Calvo A, Carlson C, Carr SJA, Cavalleri GL, Cendes F, Chen J, Chen S, Cherubini A, Concha L, David P, Delanty N, Depondt C, Devinsky O, Doherty CP, Domin M, Focke NK, Foley S, Franca W, Gambardella A, Guerrini R, Hamandi K, Hibar DP, Isaev D, Jackson GD, Jahanshad N, Kälviäinen R, Keller SS, Kochunov P, Kotikalapudi R, Kowalczyk MA, Kuzniecky R, Kwan P, Labate A, Langner S, Lenge M, Liu M, Martin P, Mascalchi M, Meletti S, Morita-Sherman ME, O'Brien TJ, Pariente JC, Richardson MP, Rodriguez-Cruces R, Rummel C, Saavalainen T, Semmelroch MK, Severino M, Striano P, Thesen T, Thomas RH, Tondelli M, Tortora D, Vaudano AE, Vivash L, von Podewils F, Wagner J, Weber B, Wiest R, Yasuda CL, Zhang G, Zhang J, Leu C, Avbersek A, Thom M, Whelan CD, Thompson P, McDonald CR, Vezzani A, Sisodiya SM.
PMID: 34388852
Neuropathol Appl Neurobiol. 2021 Aug 13; doi: 10.1111/nan.12758. Epub 2021 Aug 13.

AIMS: The causes of distinct patterns of reduced cortical thickness in the common human epilepsies, detectable on neuroimaging and with important clinical consequences, are unknown. We investigated the underlying mechanisms of cortical thinning using a systems-level analysis.METHODS: Imaging-based cortical...

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Altmann A, Ryten M, Di Nunzio M, et al. A systems-level analysis highlights microglial activation as a modifying factor in common epilepsies. Neuropathol Appl Neurobiol. 2021;doi: 10.1111/nan.12758.
Altmann, A., Ryten, M., Di Nunzio, M., Ravizza, T., Tolomeo, D., Reynolds, R. H., Somani, A., Bacigaluppi, M., Iori, V., Micotti, E., Di Sapia, R., Cerovic, M., Palma, E., Ruffolo, G., Botía, J. A., Absil, J., Alhusaini, S., Alvim, M. K. M., Auvinen, P., Bargallo, N., Bartolini, E., Bender, B., Bergo, F. P. G., Bernardes, T., Bernasconi, A., Bernasconi, N., Bernhardt, B. C., Blackmon, K., Braga, B., Caligiuri, M. E., Calvo, A., Carlson, C., Carr, S. J. A., Cavalleri, G. L., Cendes, F., Chen, J., Chen, S., Cherubini, A., Concha, L., David, P., Delanty, N., Depondt, C., Devinsky, O., Doherty, C. P., Domin, M., Focke, N. K., Foley, S., Franca, W., Gambardella, A., Guerrini, R., Hamandi, K., Hibar, D. P., Isaev, D., Jackson, G. D., Jahanshad, N., Kälviäinen, R., Keller, S. S., Kochunov, P., Kotikalapudi, R., Kowalczyk, M. A., Kuzniecky, R., Kwan, P., Labate, A., Langner, S., Lenge, M., Liu, M., Martin, P., Mascalchi, M., Meletti, S., Morita-Sherman, M. E., O'Brien, T. J., Pariente, J. C., Richardson, M. P., Rodriguez-Cruces, R., Rummel, C., Saavalainen, T., Semmelroch, M. K., Severino, M., Striano, P., Thesen, T., Thomas, R. H., Tondelli, M., Tortora, D., Vaudano, A. E., Vivash, L., von Podewils, F., Wagner, J., Weber, B., Wiest, R., Yasuda, C. L., Zhang, G., Zhang, J., Leu, C., Avbersek, A., Thom, M., Whelan, C. D., Thompson, P., McDonald, C. R., Vezzani, A., & Sisodiya, S. M. (2021). A systems-level analysis highlights microglial activation as a modifying factor in common epilepsies. Neuropathology and applied neurobiology, . https://doi.org/10.1111/nan.12758
Altmann, Andre, et al. "A systems-level analysis highlights microglial activation as a modifying factor in common epilepsies." Neuropathology and applied neurobiology vol. (2021). doi: https://doi.org/10.1111/nan.12758
Altmann A, Ryten M, Di Nunzio M, Ravizza T, Tolomeo D, Reynolds RH, Somani A, Bacigaluppi M, Iori V, Micotti E, Di Sapia R, Cerovic M, Palma E, Ruffolo G, Botía JA, Absil J, Alhusaini S, Alvim MKM, Auvinen P, Bargallo N, Bartolini E, Bender B, Bergo FPG, Bernardes T, Bernasconi A, Bernasconi N, Bernhardt BC, Blackmon K, Braga B, Caligiuri ME, Calvo A, Carlson C, Carr SJA, Cavalleri GL, Cendes F, Chen J, Chen S, Cherubini A, Concha L, David P, Delanty N, Depondt C, Devinsky O, Doherty CP, Domin M, Focke NK, Foley S, Franca W, Gambardella A, Guerrini R, Hamandi K, Hibar DP, Isaev D, Jackson GD, Jahanshad N, Kälviäinen R, Keller SS, Kochunov P, Kotikalapudi R, Kowalczyk MA, Kuzniecky R, Kwan P, Labate A, Langner S, Lenge M, Liu M, Martin P, Mascalchi M, Meletti S, Morita-Sherman ME, O'Brien TJ, Pariente JC, Richardson MP, Rodriguez-Cruces R, Rummel C, Saavalainen T, Semmelroch MK, Severino M, Striano P, Thesen T, Thomas RH, Tondelli M, Tortora D, Vaudano AE, Vivash L, von Podewils F, Wagner J, Weber B, Wiest R, Yasuda CL, Zhang G, Zhang J, Leu C, Avbersek A, Thom M, Whelan CD, Thompson P, McDonald CR, Vezzani A, Sisodiya SM. A systems-level analysis highlights microglial activation as a modifying factor in common epilepsies. Neuropathol Appl Neurobiol. 2021 Aug 13; doi: 10.1111/nan.12758. Epub 2021 Aug 13. PMID: 34388852.
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Reconstructing the Composition of Per- and Polyfluoroalkyl Substances in Contemporary Aqueous Film-Forming Foams.

Environmental science & technology letters

Ruyle BJ, Thackray CP, McCord JP, Strynar MJ, Mauge-Lewis KA, Fenton SE, Sunderland EM.
PMID: 33628855
Environ Sci Technol Lett. 2021 Jan 12;8(1):59-65. doi: 10.1021/acs.estlett.0c00798.

Hundreds of public water systems across the United States have been contaminated by the use of aqueous film-forming foams (AFFF) containing per- and polyfluoroalkyl substances (PFAS) during firefighting and training activities. Prior work shows AFFF contain hundreds of polyfluoroalkyl...

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Ruyle BJ, Thackray CP, McCord JP, et al. Reconstructing the Composition of Per- and Polyfluoroalkyl Substances in Contemporary Aqueous Film-Forming Foams. Environ Sci Technol Lett. 2021;8(1):59-65doi: 10.1021/acs.estlett.0c00798.
Ruyle, B. J., Thackray, C. P., McCord, J. P., Strynar, M. J., Mauge-Lewis, K. A., Fenton, S. E., & Sunderland, E. M. (2021). Reconstructing the Composition of Per- and Polyfluoroalkyl Substances in Contemporary Aqueous Film-Forming Foams. Environmental science & technology letters, 8(1), 59-65. https://doi.org/10.1021/acs.estlett.0c00798
Ruyle, Bridger J, et al. "Reconstructing the Composition of Per- and Polyfluoroalkyl Substances in Contemporary Aqueous Film-Forming Foams." Environmental science & technology letters vol. 8,1 (2021): 59-65. doi: https://doi.org/10.1021/acs.estlett.0c00798
Ruyle BJ, Thackray CP, McCord JP, Strynar MJ, Mauge-Lewis KA, Fenton SE, Sunderland EM. Reconstructing the Composition of Per- and Polyfluoroalkyl Substances in Contemporary Aqueous Film-Forming Foams. Environ Sci Technol Lett. 2021 Jan 12;8(1):59-65. doi: 10.1021/acs.estlett.0c00798. PMID: 33628855; PMCID: PMC7898139.
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Identifying the Optimal Number of Neoadjuvant Chemotherapy Cycles in Patients with Muscle Invasive Bladder Cancer.

The Journal of urology

D'Andrea D, Black PC, Zargar H, Dinney CP, Soria F, Cookson MS, Montgomery JS, Kassouf W, Dall'Era MA, Sridhar SS, McGrath JS, Wright JL, Thorpe AC, Holzbeierlein JM, Carrión DM, Di Trapani E, Bivalacqua TJ, North S, Barocas DA, Lotan Y, Grivas P, Stephenson AJ, van Rhijn BW, Daneshmand S, Spiess PE, Shariat SF.
PMID: 34445891
J Urol. 2022 Jan;207(1):70-76. doi: 10.1097/JU.0000000000002190. Epub 2021 Aug 27.

PURPOSE: We investigated the pathological response rates and survival associated with 3 vs 4 cycles of cisplatin-based neoadjuvant chemotherapy (NAC) in patients with cT2-4N0M0 muscle invasive bladder cancer.MATERIALS AND METHODS: In this cohort study we analyzed clinical data of...

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D'Andrea D, Black PC, Zargar H, et al. Identifying the Optimal Number of Neoadjuvant Chemotherapy Cycles in Patients with Muscle Invasive Bladder Cancer. J Urol. 2021;207(1):70-76doi: 10.1097/JU.0000000000002190.
D'Andrea, D., Black, P. C., Zargar, H., Dinney, C. P., Soria, F., Cookson, M. S., Montgomery, J. S., Kassouf, W., Dall'Era, M. A., Sridhar, S. S., McGrath, J. S., Wright, J. L., Thorpe, A. C., Holzbeierlein, J. M., Carrión, D. M., Di Trapani, E., Bivalacqua, T. J., North, S., Barocas, D. A., Lotan, Y., Grivas, P., Stephenson, A. J., van Rhijn, B. W., Daneshmand, S., Spiess, P. E., Shariat, S. F. (2022). Identifying the Optimal Number of Neoadjuvant Chemotherapy Cycles in Patients with Muscle Invasive Bladder Cancer. The Journal of urology, 207(1), 70-76. https://doi.org/10.1097/JU.0000000000002190
D'Andrea, David, et al. "Identifying the Optimal Number of Neoadjuvant Chemotherapy Cycles in Patients with Muscle Invasive Bladder Cancer." The Journal of urology vol. 207,1 (2022): 70-76. doi: https://doi.org/10.1097/JU.0000000000002190
D'Andrea D, Black PC, Zargar H, Dinney CP, Soria F, Cookson MS, Montgomery JS, Kassouf W, Dall'Era MA, Sridhar SS, McGrath JS, Wright JL, Thorpe AC, Holzbeierlein JM, Carrión DM, Di Trapani E, Bivalacqua TJ, North S, Barocas DA, Lotan Y, Grivas P, Stephenson AJ, van Rhijn BW, Daneshmand S, Spiess PE, Shariat SF. Identifying the Optimal Number of Neoadjuvant Chemotherapy Cycles in Patients with Muscle Invasive Bladder Cancer. J Urol. 2022 Jan;207(1):70-76. doi: 10.1097/JU.0000000000002190. Epub 2021 Aug 27. PMID: 34445891.
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Disparities among crop species in the evolution of growth rates: the role of distinct origins and domestication histories.

The New phytologist

Gómez-Fernández A, Osborne CP, Rees M, Palomino J, Ingala C, Gómez G, Milla R.
PMID: 34726792
New Phytol. 2022 Jan;233(2):995-1010. doi: 10.1111/nph.17840. Epub 2021 Nov 24.

Growth rates vary widely among plants with different strategies. For crops, evolution under predictable and high-resource environments might favour rapid resource acquisition and growth, but whether this strategy has consistently evolved during domestication and improvement remains unclear. Here we...

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Gómez-Fernández A, Osborne CP, Rees M, et al. Disparities among crop species in the evolution of growth rates: the role of distinct origins and domestication histories. New Phytol. 2021;233(2):995-1010doi: 10.1111/nph.17840.
Gómez-Fernández, A., Osborne, C. P., Rees, M., Palomino, J., Ingala, C., Gómez, G., & Milla, R. (2022). Disparities among crop species in the evolution of growth rates: the role of distinct origins and domestication histories. The New phytologist, 233(2), 995-1010. https://doi.org/10.1111/nph.17840
Gómez-Fernández, Alicia, et al. "Disparities among crop species in the evolution of growth rates: the role of distinct origins and domestication histories." The New phytologist vol. 233,2 (2022): 995-1010. doi: https://doi.org/10.1111/nph.17840
Gómez-Fernández A, Osborne CP, Rees M, Palomino J, Ingala C, Gómez G, Milla R. Disparities among crop species in the evolution of growth rates: the role of distinct origins and domestication histories. New Phytol. 2022 Jan;233(2):995-1010. doi: 10.1111/nph.17840. Epub 2021 Nov 24. PMID: 34726792.
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Racial disparities in treatment and outcomes of children with type 1 diabetes.

Pediatric diabetes

Lipman TH, Smith JA, Patil O, Willi SM, Hawkes CP.
PMID: 33871154
Pediatr Diabetes. 2021 Mar;22(2):241-248. doi: 10.1111/pedi.13139. Epub 2020 Oct 25.

OBJECTIVE: The aim of this study was to assess racial disparities in treatments and outcomes between Non-Hispanic black (NHB), Hispanic and Non-Hispanic white (NHW) children with type 1 diabetes (T1D).METHODS: We reviewed electronic health records of children (

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Lipman TH, Smith JA, Patil O, et al. Racial disparities in treatment and outcomes of children with type 1 diabetes. Pediatr Diabetes. 2020;22(2):241-248doi: 10.1111/pedi.13139.
Lipman, T. H., Smith, J. A., Patil, O., Willi, S. M., & Hawkes, C. P. (2021). Racial disparities in treatment and outcomes of children with type 1 diabetes. Pediatric diabetes, 22(2), 241-248. https://doi.org/10.1111/pedi.13139
Lipman, Terri H, et al. "Racial disparities in treatment and outcomes of children with type 1 diabetes." Pediatric diabetes vol. 22,2 (2021): 241-248. doi: https://doi.org/10.1111/pedi.13139
Lipman TH, Smith JA, Patil O, Willi SM, Hawkes CP. Racial disparities in treatment and outcomes of children with type 1 diabetes. Pediatr Diabetes. 2021 Mar;22(2):241-248. doi: 10.1111/pedi.13139. Epub 2020 Oct 25. PMID: 33871154.
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Unique somatic variants in DNA from urine exosomes of individuals with bladder cancer.

Molecular therapy. Methods & clinical development

Zhou X, Kurywchak P, Wolf-Dennen K, Che SPY, Sulakhe D, D'Souza M, Xie B, Maltsev N, Gilliam TC, Wu CC, McAndrews KM, LeBleu VS, McConkey DJ, Volpert OV, Pretzsch SM, Czerniak BA, Dinney CP, Kalluri R.
PMID: 34514028
Mol Ther Methods Clin Dev. 2021 May 29;22:360-376. doi: 10.1016/j.omtm.2021.05.010. eCollection 2021 Sep 10.

Bladder cancer (BC), a heterogeneous disease characterized by high recurrence rates, is diagnosed and monitored by cystoscopy. Accurate clinical staging based on biopsy remains a challenge, and additional, objective diagnostic tools are needed urgently. We used exosomal DNA (exoDNA)...

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Zhou X, Kurywchak P, Wolf-Dennen K, et al. Unique somatic variants in DNA from urine exosomes of individuals with bladder cancer. Mol Ther Methods Clin Dev. 2021;22:360-376doi: 10.1016/j.omtm.2021.05.010.
Zhou, X., Kurywchak, P., Wolf-Dennen, K., Che, S. P. Y., Sulakhe, D., D'Souza, M., Xie, B., Maltsev, N., Gilliam, T. C., Wu, C. C., McAndrews, K. M., LeBleu, V. S., McConkey, D. J., Volpert, O. V., Pretzsch, S. M., Czerniak, B. A., Dinney, C. P., & Kalluri, R. (2021). Unique somatic variants in DNA from urine exosomes of individuals with bladder cancer. Molecular therapy. Methods & clinical development, 22360-376. https://doi.org/10.1016/j.omtm.2021.05.010
Zhou, Xunian, et al. "Unique somatic variants in DNA from urine exosomes of individuals with bladder cancer." Molecular therapy. Methods & clinical development vol. 22 (2021): 360-376. doi: https://doi.org/10.1016/j.omtm.2021.05.010
Zhou X, Kurywchak P, Wolf-Dennen K, Che SPY, Sulakhe D, D'Souza M, Xie B, Maltsev N, Gilliam TC, Wu CC, McAndrews KM, LeBleu VS, McConkey DJ, Volpert OV, Pretzsch SM, Czerniak BA, Dinney CP, Kalluri R. Unique somatic variants in DNA from urine exosomes of individuals with bladder cancer. Mol Ther Methods Clin Dev. 2021 May 29;22:360-376. doi: 10.1016/j.omtm.2021.05.010. eCollection 2021 Sep 10. PMID: 34514028; PMCID: PMC8408559.
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Associations between clinical characteristics and dual task performance in Multiple Sclerosis depend on the cognitive and motor dual tasks used.

Multiple sclerosis and related disorders

Veldkamp R, Baert I, Kalron A, Romberg A, Tacchino A, Giffroy X, Coninx K, Feys P.
PMID: 34500177
Mult Scler Relat Disord. 2021 Nov;56:103230. doi: 10.1016/j.msard.2021.103230. Epub 2021 Aug 29.

BACKGROUND: In persons with Multiple Sclerosis (pwMS) performing a simultaneous cognitive task while walking often results in slower gait. Clinical characteristics associated with reduced dual task (DT) performance are not yet entirely clear. This multi-centre study aimed to determine...

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Veldkamp R, Baert I, Kalron A, et al. Associations between clinical characteristics and dual task performance in Multiple Sclerosis depend on the cognitive and motor dual tasks used. Mult Scler Relat Disord. 2021;56:103230doi: 10.1016/j.msard.2021.103230.
Veldkamp, R., Baert, I., Kalron, A., Romberg, A., Tacchino, A., Giffroy, X., Coninx, K., & Feys, P. (2021). Associations between clinical characteristics and dual task performance in Multiple Sclerosis depend on the cognitive and motor dual tasks used. Multiple sclerosis and related disorders, 56103230. https://doi.org/10.1016/j.msard.2021.103230
Veldkamp, R, et al. "Associations between clinical characteristics and dual task performance in Multiple Sclerosis depend on the cognitive and motor dual tasks used." Multiple sclerosis and related disorders vol. 56 (2021): 103230. doi: https://doi.org/10.1016/j.msard.2021.103230
Veldkamp R, Baert I, Kalron A, Romberg A, Tacchino A, Giffroy X, Coninx K, Feys P. Associations between clinical characteristics and dual task performance in Multiple Sclerosis depend on the cognitive and motor dual tasks used. Mult Scler Relat Disord. 2021 Nov;56:103230. doi: 10.1016/j.msard.2021.103230. Epub 2021 Aug 29. PMID: 34500177.
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Carriage of Multidrug Resistance Staphylococci in Shelter Dogs in Timisoara, Romania.

Antibiotics (Basel, Switzerland)

János D, Viorel H, Ionica I, Corina P, Tiana F, Roxana D.
PMID: 34356722
Antibiotics (Basel). 2021 Jul 01;10(7). doi: 10.3390/antibiotics10070801.

The present study aimed to determine the prevalence of

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János D, Viorel H, Ionica I, et al. Carriage of Multidrug Resistance Staphylococci in Shelter Dogs in Timisoara, Romania. Antibiotics (Basel). 2021;10(7)doi: 10.3390/antibiotics10070801.
János, D., Viorel, H., Ionica, I., Corina, P., Tiana, F., & Roxana, D. (2021). Carriage of Multidrug Resistance Staphylococci in Shelter Dogs in Timisoara, Romania. Antibiotics (Basel, Switzerland), 10(7), . https://doi.org/10.3390/antibiotics10070801
János, Dégi, et al. "Carriage of Multidrug Resistance Staphylococci in Shelter Dogs in Timisoara, Romania." Antibiotics (Basel, Switzerland) vol. 10,7 (2021). doi: https://doi.org/10.3390/antibiotics10070801
János D, Viorel H, Ionica I, Corina P, Tiana F, Roxana D. Carriage of Multidrug Resistance Staphylococci in Shelter Dogs in Timisoara, Romania. Antibiotics (Basel). 2021 Jul 01;10(7). doi: 10.3390/antibiotics10070801. PMID: 34356722; PMCID: PMC8300769.
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