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KDM6B promotes activation of the oncogenic CDK4/6-pRB-E2F pathway by maintaining enhancer activity in MYCN-amplified neuroblastoma.

Nature communications

D'Oto A, Fang J, Jin H, Xu B, Singh S, Mullasseril A, Jones V, Abu-Zaid A, von Buttlar X, Cooke B, Hu D, Shohet J, Murphy AJ, Davidoff AM, Yang J.
PMID: 34893606
Nat Commun. 2021 Dec 10;12(1):7204. doi: 10.1038/s41467-021-27502-2.

The H3K27me2/me3 histone demethylase KDM6B is essential to neuroblastoma cell survival. However, the mechanism of KDM6B action remains poorly defined. We demonstrate that inhibition of KDM6B activity 1) reduces the chromatin accessibility of E2F target genes and MYCN, 2)...

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D'Oto A, Fang J, Jin H, et al. KDM6B promotes activation of the oncogenic CDK4/6-pRB-E2F pathway by maintaining enhancer activity in MYCN-amplified neuroblastoma. Nat Commun. 2021;12(1):7204doi: 10.1038/s41467-021-27502-2.
D'Oto, A., Fang, J., Jin, H., Xu, B., Singh, S., Mullasseril, A., Jones, V., Abu-Zaid, A., von Buttlar, X., Cooke, B., Hu, D., Shohet, J., Murphy, A. J., Davidoff, A. M., & Yang, J. (2021). KDM6B promotes activation of the oncogenic CDK4/6-pRB-E2F pathway by maintaining enhancer activity in MYCN-amplified neuroblastoma. Nature communications, 12(1), 7204. https://doi.org/10.1038/s41467-021-27502-2
D'Oto, Alexandra, et al. "KDM6B promotes activation of the oncogenic CDK4/6-pRB-E2F pathway by maintaining enhancer activity in MYCN-amplified neuroblastoma." Nature communications vol. 12,1 (2021): 7204. doi: https://doi.org/10.1038/s41467-021-27502-2
D'Oto A, Fang J, Jin H, Xu B, Singh S, Mullasseril A, Jones V, Abu-Zaid A, von Buttlar X, Cooke B, Hu D, Shohet J, Murphy AJ, Davidoff AM, Yang J. KDM6B promotes activation of the oncogenic CDK4/6-pRB-E2F pathway by maintaining enhancer activity in MYCN-amplified neuroblastoma. Nat Commun. 2021 Dec 10;12(1):7204. doi: 10.1038/s41467-021-27502-2. PMID: 34893606.
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Efficient assessment of efficacy in post-traumatic peripheral neuropathic pain patients: pregabalin in a randomized, placebo-controlled, crossover study.

Journal of pain research

Jenkins TM, Smart TS, Hackman F, Cooke C, Tan KK.
PMID: 22888270
J Pain Res. 2012;5:243-50. doi: 10.2147/JPR.S34098. Epub 2012 Jul 27.

BACKGROUND: Detecting the efficacy of novel analgesic agents in neuropathic pain is challenging. There is a critical need for study designs with the desirable characteristics of assay sensitivity, low placebo response, reliable pain recordings, low cost, short duration of...

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Jenkins TM, Smart TS, Hackman F, et al. Efficient assessment of efficacy in post-traumatic peripheral neuropathic pain patients: pregabalin in a randomized, placebo-controlled, crossover study. J Pain Res. 2012;5:243-50doi: 10.2147/JPR.S34098.
Jenkins, T. M., Smart, T. S., Hackman, F., Cooke, C., & Tan, K. K. (2012). Efficient assessment of efficacy in post-traumatic peripheral neuropathic pain patients: pregabalin in a randomized, placebo-controlled, crossover study. Journal of pain research, 5243-50. https://doi.org/10.2147/JPR.S34098
Jenkins, Tim M, et al. "Efficient assessment of efficacy in post-traumatic peripheral neuropathic pain patients: pregabalin in a randomized, placebo-controlled, crossover study." Journal of pain research vol. 5 (2012): 243-50. doi: https://doi.org/10.2147/JPR.S34098
Jenkins TM, Smart TS, Hackman F, Cooke C, Tan KK. Efficient assessment of efficacy in post-traumatic peripheral neuropathic pain patients: pregabalin in a randomized, placebo-controlled, crossover study. J Pain Res. 2012;5:243-50. doi: 10.2147/JPR.S34098. Epub 2012 Jul 27. PMID: 22888270; PMCID: PMC3413398.
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Harmonious Integration: Tuning STEM Education with Generative Justice.

Ieee, Drazan JF, Eglash R, Cooke L.
UIID-AD: 3851
2016;58-64.

STEM educational practices not only have limited success in engaging students from underrepresented groups, but also often fail to prepare future scientists and engineers with an appreciation for the social and environmental concerns that underpin their work. Rather than...

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Ieee, Drazan JF, Eglash R, et al. Harmonious Integration: Tuning STEM Education with Generative Justice. 2016;58-64
Ieee, Drazan, J. F., Eglash, R., & Cooke, L. (2016). Harmonious Integration: Tuning STEM Education with Generative Justice. 58-64.
Ieee, et al. "Harmonious Integration: Tuning STEM Education with Generative Justice." vol. (2016): 58-64.
Ieee, Drazan JF, Eglash R, Cooke L. Harmonious Integration: Tuning STEM Education with Generative Justice. 2016;58-64. UIID-AD: 3851.
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Showing 1297 to 1299 of 1299 entries