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Identification, Synthesis, and Biological Evaluation of the Major Human Metabolite of NLRP3 Inflammasome Inhibitor MCC950.

ACS medicinal chemistry letters

Salla M, Butler MS, Pelingon R, Kaeslin G, Croker DE, Reid JC, Baek JM, Bernhardt PV, Gillam EM, Cooper MA, Robertson AA.
PMID: 27994733
ACS Med Chem Lett. 2016 Sep 27;7(12):1034-1038. doi: 10.1021/acsmedchemlett.6b00198. eCollection 2016 Dec 08.

MCC950 is an orally bioavailable small molecule inhibitor of the NOD-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasome that exhibits remarkable activity in multiple models of inflammatory disease. Incubation of MCC950 with human liver microsomes, and subsequent analysis by...

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Salla M, Butler MS, Pelingon R, et al. Identification, Synthesis, and Biological Evaluation of the Major Human Metabolite of NLRP3 Inflammasome Inhibitor MCC950. ACS Med Chem Lett. 2016;7(12):1034-1038doi: 10.1021/acsmedchemlett.6b00198.
Salla, M., Butler, M. S., Pelingon, R., Kaeslin, G., Croker, D. E., Reid, J. C., Baek, J. M., Bernhardt, P. V., Gillam, E. M., Cooper, M. A., & Robertson, A. A. (2016). Identification, Synthesis, and Biological Evaluation of the Major Human Metabolite of NLRP3 Inflammasome Inhibitor MCC950. ACS medicinal chemistry letters, 7(12), 1034-1038. https://doi.org/10.1021/acsmedchemlett.6b00198
Salla, Manohar, et al. "Identification, Synthesis, and Biological Evaluation of the Major Human Metabolite of NLRP3 Inflammasome Inhibitor MCC950." ACS medicinal chemistry letters vol. 7,12 (2016): 1034-1038. doi: https://doi.org/10.1021/acsmedchemlett.6b00198
Salla M, Butler MS, Pelingon R, Kaeslin G, Croker DE, Reid JC, Baek JM, Bernhardt PV, Gillam EM, Cooper MA, Robertson AA. Identification, Synthesis, and Biological Evaluation of the Major Human Metabolite of NLRP3 Inflammasome Inhibitor MCC950. ACS Med Chem Lett. 2016 Sep 27;7(12):1034-1038. doi: 10.1021/acsmedchemlett.6b00198. eCollection 2016 Dec 08. PMID: 27994733; PMCID: PMC5150672.
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Endocrine responses and acute mTOR pathway phosphorylation to resistance exercise with leucine and whey.

Biology of sport

Lane MT, Herda TJ, Fry AC, Cooper MA, Andre MJ, Gallagher PM.
PMID: 28566814
Biol Sport. 2017 Jun;34(2):197-203. doi: 10.5114/biolsport.2017.65339. Epub 2017 Jan 20.

Leucine ingestion reportedly activates the mTOR pathway in skeletal muscle, contributing to a hypertrophy response. The purpose of the study was to compare the post-resistance exercise effects of leucine and whey protein supplementation on endocrine responses and muscle mTOR...

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Lane MT, Herda TJ, Fry AC, et al. Endocrine responses and acute mTOR pathway phosphorylation to resistance exercise with leucine and whey. Biol Sport. 2017;34(2):197-203doi: 10.5114/biolsport.2017.65339.
Lane, M. T., Herda, T. J., Fry, A. C., Cooper, M. A., Andre, M. J., & Gallagher, P. M. (2017). Endocrine responses and acute mTOR pathway phosphorylation to resistance exercise with leucine and whey. Biology of sport, 34(2), 197-203. https://doi.org/10.5114/biolsport.2017.65339
Lane, M T, et al. "Endocrine responses and acute mTOR pathway phosphorylation to resistance exercise with leucine and whey." Biology of sport vol. 34,2 (2017): 197-203. doi: https://doi.org/10.5114/biolsport.2017.65339
Lane MT, Herda TJ, Fry AC, Cooper MA, Andre MJ, Gallagher PM. Endocrine responses and acute mTOR pathway phosphorylation to resistance exercise with leucine and whey. Biol Sport. 2017 Jun;34(2):197-203. doi: 10.5114/biolsport.2017.65339. Epub 2017 Jan 20. PMID: 28566814; PMCID: PMC5424460.
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Automatic detection of cone photoreceptors in split detector adaptive optics scanning light ophthalmoscope images.

Biomedical optics express

Cunefare D, Cooper RF, Higgins B, Katz DF, Dubra A, Carroll J, Farsiu S.
PMID: 27231641
Biomed Opt Express. 2016 Apr 27;7(5):2036-50. doi: 10.1364/BOE.7.002036. eCollection 2016 May 01.

Quantitative analysis of the cone photoreceptor mosaic in the living retina is potentially useful for early diagnosis and prognosis of many ocular diseases. Non-confocal split detector based adaptive optics scanning light ophthalmoscope (AOSLO) imaging reveals the cone photoreceptor inner...

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Cunefare D, Cooper RF, Higgins B, et al. Automatic detection of cone photoreceptors in split detector adaptive optics scanning light ophthalmoscope images. Biomed Opt Express. 2016;7(5):2036-50doi: 10.1364/BOE.7.002036.
Cunefare, D., Cooper, R. F., Higgins, B., Katz, D. F., Dubra, A., Carroll, J., & Farsiu, S. (2016). Automatic detection of cone photoreceptors in split detector adaptive optics scanning light ophthalmoscope images. Biomedical optics express, 7(5), 2036-50. https://doi.org/10.1364/BOE.7.002036
Cunefare, David, et al. "Automatic detection of cone photoreceptors in split detector adaptive optics scanning light ophthalmoscope images." Biomedical optics express vol. 7,5 (2016): 2036-50. doi: https://doi.org/10.1364/BOE.7.002036
Cunefare D, Cooper RF, Higgins B, Katz DF, Dubra A, Carroll J, Farsiu S. Automatic detection of cone photoreceptors in split detector adaptive optics scanning light ophthalmoscope images. Biomed Opt Express. 2016 Apr 27;7(5):2036-50. doi: 10.1364/BOE.7.002036. eCollection 2016 May 01. PMID: 27231641; PMCID: PMC4871101.
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Perception of Perspective Distortions in Image-Based Rendering.

ACM transactions on graphics

Vangorp P, Richardt C, Cooper EA, Chaurasia G, Banks MS, Drettakis G.
PMID: 24273376
ACM Trans Graph. 2013 Jul 04;32(4). doi: 10.1145/2461912.2461971.

Image-based rendering (IBR) creates realistic images by enriching simple geometries with photographs, e.g., mapping the photograph of a building façade onto a plane. However, as soon as the viewer moves away from the correct viewpoint, the image in the...

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Vangorp P, Richardt C, Cooper EA, et al. Perception of Perspective Distortions in Image-Based Rendering. ACM Trans Graph. 2013;32(4)doi: 10.1145/2461912.2461971.
Vangorp, P., Richardt, C., Cooper, E. A., Chaurasia, G., Banks, M. S., & Drettakis, G. (2013). Perception of Perspective Distortions in Image-Based Rendering. ACM transactions on graphics, 32(4), . https://doi.org/10.1145/2461912.2461971
Vangorp, Peter, et al. "Perception of Perspective Distortions in Image-Based Rendering." ACM transactions on graphics vol. 32,4 (2013). doi: https://doi.org/10.1145/2461912.2461971
Vangorp P, Richardt C, Cooper EA, Chaurasia G, Banks MS, Drettakis G. Perception of Perspective Distortions in Image-Based Rendering. ACM Trans Graph. 2013 Jul 04;32(4). doi: 10.1145/2461912.2461971. PMID: 24273376; PMCID: PMC3833453.
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Crystal structures of increasingly large molecules: meeting the challenges with CRYSTALS software.

Chemistry Central journal

Parois P, Cooper RI, Thompson AL.
PMID: 26029252
Chem Cent J. 2015 May 24;9:30. doi: 10.1186/s13065-015-0105-4. eCollection 2015.

BACKGROUND: The size and complexity of molecules being studied by single crystal diffraction is growing year by year, resulting in an increase in the difficulties encountered during structure determination. From the crystallisation itself and sample handling, to structure solution...

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Parois P, Cooper RI, Thompson AL. Crystal structures of increasingly large molecules: meeting the challenges with CRYSTALS software. Chem Cent J. 2015;9:30doi: 10.1186/s13065-015-0105-4.
Parois, P., Cooper, R. I., & Thompson, A. L. (2015). Crystal structures of increasingly large molecules: meeting the challenges with CRYSTALS software. Chemistry Central journal, 930. https://doi.org/10.1186/s13065-015-0105-4
Parois, Pascal, et al. "Crystal structures of increasingly large molecules: meeting the challenges with CRYSTALS software." Chemistry Central journal vol. 9 (2015): 30. doi: https://doi.org/10.1186/s13065-015-0105-4
Parois P, Cooper RI, Thompson AL. Crystal structures of increasingly large molecules: meeting the challenges with CRYSTALS software. Chem Cent J. 2015 May 24;9:30. doi: 10.1186/s13065-015-0105-4. eCollection 2015. PMID: 26029252; PMCID: PMC4448882.
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A Systematic Review and Network Meta-Analysis of Pharmacological Therapies Used for Patients with Advanced Parkinson's Disease.

Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research

Ren S, Cooper K, Cooper JA, Smith HT, Shaikh S.
PMID: 27200898
Value Health. 2014 Nov;17(7):A390. doi: 10.1016/j.jval.2014.08.856. Epub 2014 Oct 26.

No abstract available.

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Ren S, Cooper K, Cooper JA, et al. A Systematic Review and Network Meta-Analysis of Pharmacological Therapies Used for Patients with Advanced Parkinson's Disease. Value Health. 2014;17(7):A390doi: 10.1016/j.jval.2014.08.856.
Ren, S., Cooper, K., Cooper, J. A., Smith, H. T., & Shaikh, S. (2014). A Systematic Review and Network Meta-Analysis of Pharmacological Therapies Used for Patients with Advanced Parkinson's Disease. Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research, 17(7), A390. https://doi.org/10.1016/j.jval.2014.08.856
Ren, S, et al. "A Systematic Review and Network Meta-Analysis of Pharmacological Therapies Used for Patients with Advanced Parkinson's Disease." Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research vol. 17,7 (2014): A390. doi: https://doi.org/10.1016/j.jval.2014.08.856
Ren S, Cooper K, Cooper JA, Smith HT, Shaikh S. A Systematic Review and Network Meta-Analysis of Pharmacological Therapies Used for Patients with Advanced Parkinson's Disease. Value Health. 2014 Nov;17(7):A390. doi: 10.1016/j.jval.2014.08.856. Epub 2014 Oct 26. PMID: 27200898.
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A novel method for assessing postoperative femoral head reduction in developmental dysplasia of the hip.

Journal of children's orthopaedics

Cooper A, Evans O, Ali F, Flowers M.
PMID: 24993902
J Child Orthop. 2014 Aug;8(4):319-24. doi: 10.1007/s11832-014-0600-5. Epub 2014 Jul 04.

PURPOSE: Developmental dysplasia of the hip (DDH) affects approximately 1 % of live births. Dislocated hips require reduction and stabilisation in a spica cast, and reduction efficacy is assessed radiologically. Numerous measurements are used to ascertain the adequacy of...

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Cooper A, Evans O, Ali F, et al. A novel method for assessing postoperative femoral head reduction in developmental dysplasia of the hip. J Child Orthop. 2014;8(4):319-24doi: 10.1007/s11832-014-0600-5.
Cooper, A., Evans, O., Ali, F., & Flowers, M. (2014). A novel method for assessing postoperative femoral head reduction in developmental dysplasia of the hip. Journal of children's orthopaedics, 8(4), 319-24. https://doi.org/10.1007/s11832-014-0600-5
Cooper, Anthony, et al. "A novel method for assessing postoperative femoral head reduction in developmental dysplasia of the hip." Journal of children's orthopaedics vol. 8,4 (2014): 319-24. doi: https://doi.org/10.1007/s11832-014-0600-5
Cooper A, Evans O, Ali F, Flowers M. A novel method for assessing postoperative femoral head reduction in developmental dysplasia of the hip. J Child Orthop. 2014 Aug;8(4):319-24. doi: 10.1007/s11832-014-0600-5. Epub 2014 Jul 04. PMID: 24993902; PMCID: PMC4128942.
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The Association of Patient Chronic Disease Burden and Self-Management Requirements With Shared Decision Making in Primary Care Visits.

Health services research and managerial epidemiology

Peek ME, Drum M, Cooper LA.
PMID: 26640812
Health Serv Res Manag Epidemiol. 2014 Jan;1. doi: 10.1177/2333392814538775. Epub 2014 Jun 17.

BACKGROUND: Shared decision making (SDM) is associated with positive health outcomes and may be particularly relevant for patients with chronic disease.OBJECTIVES: To investigate whether (1) patients with chronic diseases, particularly those requiring self-management, are more likely to engage in...

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Peek ME, Drum M, Cooper LA. The Association of Patient Chronic Disease Burden and Self-Management Requirements With Shared Decision Making in Primary Care Visits. Health Serv Res Manag Epidemiol. 2014;1doi: 10.1177/2333392814538775.
Peek, M. E., Drum, M., & Cooper, L. A. (2014). The Association of Patient Chronic Disease Burden and Self-Management Requirements With Shared Decision Making in Primary Care Visits. Health services research and managerial epidemiology, 1. https://doi.org/10.1177/2333392814538775
Peek, Monica E, et al. "The Association of Patient Chronic Disease Burden and Self-Management Requirements With Shared Decision Making in Primary Care Visits." Health services research and managerial epidemiology vol. 1 (2014). doi: https://doi.org/10.1177/2333392814538775
Peek ME, Drum M, Cooper LA. The Association of Patient Chronic Disease Burden and Self-Management Requirements With Shared Decision Making in Primary Care Visits. Health Serv Res Manag Epidemiol. 2014 Jan;1. doi: 10.1177/2333392814538775. Epub 2014 Jun 17. PMID: 26640812; PMCID: PMC4670035.
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Discovery of 8-Amino-imidazo[1,5-a]pyrazines as Reversible BTK Inhibitors for the Treatment of Rheumatoid Arthritis.

ACS medicinal chemistry letters

Liu J, Guiadeen D, Krikorian A, Gao X, Wang J, Boga SB, Alhassan AB, Yu Y, Vaccaro H, Liu S, Yang C, Wu H, Cooper A, de Man J, Kaptein A, Maloney K, Hornak V, Gao YD, Fischmann TO, Raaijmakers H, Vu-Pham D, Presland J, Mansueto M, Xu Z, Leccese E, Zhang-Hoover J, Knemeyer I, Garlisi CG, Bays N, Stivers P, Brandish PE, Hicks A, Kim R, Kozlowski JA.
PMID: 26985298
ACS Med Chem Lett. 2015 Dec 19;7(2):198-203. doi: 10.1021/acsmedchemlett.5b00463. eCollection 2016 Feb 11.

Bruton's tyrosine kinase (BTK) is a Tec family kinase with a well-defined role in the B cell receptor (BCR) pathway. It has become an attractive kinase target for selective B cell inhibition and for the treatment of B cell...

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Liu J, Guiadeen D, Krikorian A, et al. Discovery of 8-Amino-imidazo[1,5-a]pyrazines as Reversible BTK Inhibitors for the Treatment of Rheumatoid Arthritis. ACS Med Chem Lett. 2015;7(2):198-203doi: 10.1021/acsmedchemlett.5b00463.
Liu, J., Guiadeen, D., Krikorian, A., Gao, X., Wang, J., Boga, S. B., Alhassan, A. B., Yu, Y., Vaccaro, H., Liu, S., Yang, C., Wu, H., Cooper, A., de Man, J., Kaptein, A., Maloney, K., Hornak, V., Gao, Y. D., Fischmann, T. O., Raaijmakers, H., Vu-Pham, D., Presland, J., Mansueto, M., Xu, Z., Leccese, E., Zhang-Hoover, J., Knemeyer, I., Garlisi, C. G., Bays, N., Stivers, P., Brandish, P. E., Hicks, A., Kim, R., & Kozlowski, J. A. (2016). Discovery of 8-Amino-imidazo[1,5-a]pyrazines as Reversible BTK Inhibitors for the Treatment of Rheumatoid Arthritis. ACS medicinal chemistry letters, 7(2), 198-203. https://doi.org/10.1021/acsmedchemlett.5b00463
Liu, Jian, et al. "Discovery of 8-Amino-imidazo[1,5-a]pyrazines as Reversible BTK Inhibitors for the Treatment of Rheumatoid Arthritis." ACS medicinal chemistry letters vol. 7,2 (2016): 198-203. doi: https://doi.org/10.1021/acsmedchemlett.5b00463
Liu J, Guiadeen D, Krikorian A, Gao X, Wang J, Boga SB, Alhassan AB, Yu Y, Vaccaro H, Liu S, Yang C, Wu H, Cooper A, de Man J, Kaptein A, Maloney K, Hornak V, Gao YD, Fischmann TO, Raaijmakers H, Vu-Pham D, Presland J, Mansueto M, Xu Z, Leccese E, Zhang-Hoover J, Knemeyer I, Garlisi CG, Bays N, Stivers P, Brandish PE, Hicks A, Kim R, Kozlowski JA. Discovery of 8-Amino-imidazo[1,5-a]pyrazines as Reversible BTK Inhibitors for the Treatment of Rheumatoid Arthritis. ACS Med Chem Lett. 2015 Dec 19;7(2):198-203. doi: 10.1021/acsmedchemlett.5b00463. eCollection 2016 Feb 11. PMID: 26985298; PMCID: PMC4753550.
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Inside information on xenon adsorption in porous organic cages by NMR.

Chemical science

Komulainen S, Roukala J, Zhivonitko VV, Javed MA, Chen L, Holden D, Hasell T, Cooper A, Lantto P, Telkki VV.
PMID: 28989612
Chem Sci. 2017 Aug 01;8(8):5721-5727. doi: 10.1039/c7sc01990d. Epub 2017 Jun 14.

A solid porous molecular crystal formed from an organic cage, CC3, has unprecedented performance for the separation of rare gases. Here, xenon was used as an internal reporter providing extraordinarily versatile information about the gas adsorption phenomena in the...

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Komulainen S, Roukala J, Zhivonitko VV, et al. Inside information on xenon adsorption in porous organic cages by NMR. Chem Sci. 2017;8(8):5721-5727doi: 10.1039/c7sc01990d.
Komulainen, S., Roukala, J., Zhivonitko, V. V., Javed, M. A., Chen, L., Holden, D., Hasell, T., Cooper, A., Lantto, P., & Telkki, V. V. (2017). Inside information on xenon adsorption in porous organic cages by NMR. Chemical science, 8(8), 5721-5727. https://doi.org/10.1039/c7sc01990d
Komulainen, Sanna, et al. "Inside information on xenon adsorption in porous organic cages by NMR." Chemical science vol. 8,8 (2017): 5721-5727. doi: https://doi.org/10.1039/c7sc01990d
Komulainen S, Roukala J, Zhivonitko VV, Javed MA, Chen L, Holden D, Hasell T, Cooper A, Lantto P, Telkki VV. Inside information on xenon adsorption in porous organic cages by NMR. Chem Sci. 2017 Aug 01;8(8):5721-5727. doi: 10.1039/c7sc01990d. Epub 2017 Jun 14. PMID: 28989612; PMCID: PMC5621166.
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Barriers and facilitators of a near real-time feedback approach for measuring patient experiences of hospital care.

Health policy and technology

Käsbauer S, Cooper R, Kelly L, King J.
PMID: 28367401
Health Policy Technol. 2017 Mar;6(1):51-58. doi: 10.1016/j.hlpt.2016.09.003.

OBJECTIVES: To contribute towards the current policy directive and recommendations outlined in the Francis Report (1) to strengthen relational aspects of hospital care and increase the use of a near real-time feedback (RTF) approach. This article offers insight into...

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Käsbauer S, Cooper R, Kelly L, et al. Barriers and facilitators of a near real-time feedback approach for measuring patient experiences of hospital care. Health Policy Technol. 2017;6(1):51-58doi: 10.1016/j.hlpt.2016.09.003.
Käsbauer, S., Cooper, R., Kelly, L., & King, J. (2017). Barriers and facilitators of a near real-time feedback approach for measuring patient experiences of hospital care. Health policy and technology, 6(1), 51-58. https://doi.org/10.1016/j.hlpt.2016.09.003
Käsbauer, Susanne, et al. "Barriers and facilitators of a near real-time feedback approach for measuring patient experiences of hospital care." Health policy and technology vol. 6,1 (2017): 51-58. doi: https://doi.org/10.1016/j.hlpt.2016.09.003
Käsbauer S, Cooper R, Kelly L, King J. Barriers and facilitators of a near real-time feedback approach for measuring patient experiences of hospital care. Health Policy Technol. 2017 Mar;6(1):51-58. doi: 10.1016/j.hlpt.2016.09.003. PMID: 28367401; PMCID: PMC5364923.
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A systematic pipeline for the objective comparison of whole-brain spectroscopic MRI with histology in biopsy specimens from grade III glioma.

Tomography (Ann Arbor, Mich.)

Cordova JS, Gurbani SS, Olson JJ, Liang Z, Cooper LA, Shu HG, Schreibmann E, Neill SG, Hadjipanayis CG, Holder CA, Shim H.
PMID: 27489883
Tomography. 2016 Jun;2(2):106-116. doi: 10.18383/j.tom.2016.00136.

The diagnosis, prognosis, and management of patients with gliomas are largely dictated by the pathological analysis of tissue biopsied from a selected region within the lesion. However, due to the heterogeneous and infiltrative nature of gliomas, identifying the optimal...

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Cordova JS, Gurbani SS, Olson JJ, et al. A systematic pipeline for the objective comparison of whole-brain spectroscopic MRI with histology in biopsy specimens from grade III glioma. Tomography. 2016;2(2):106-116doi: 10.18383/j.tom.2016.00136.
Cordova, J. S., Gurbani, S. S., Olson, J. J., Liang, Z., Cooper, L. A., Shu, H. G., Schreibmann, E., Neill, S. G., Hadjipanayis, C. G., Holder, C. A., & Shim, H. (2016). A systematic pipeline for the objective comparison of whole-brain spectroscopic MRI with histology in biopsy specimens from grade III glioma. Tomography (Ann Arbor, Mich.), 2(2), 106-116. https://doi.org/10.18383/j.tom.2016.00136
Cordova, J Scott, et al. "A systematic pipeline for the objective comparison of whole-brain spectroscopic MRI with histology in biopsy specimens from grade III glioma." Tomography (Ann Arbor, Mich.) vol. 2,2 (2016): 106-116. doi: https://doi.org/10.18383/j.tom.2016.00136
Cordova JS, Gurbani SS, Olson JJ, Liang Z, Cooper LA, Shu HG, Schreibmann E, Neill SG, Hadjipanayis CG, Holder CA, Shim H. A systematic pipeline for the objective comparison of whole-brain spectroscopic MRI with histology in biopsy specimens from grade III glioma. Tomography. 2016 Jun;2(2):106-116. doi: 10.18383/j.tom.2016.00136. PMID: 27489883; PMCID: PMC4968944.
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Showing 25 to 36 of 1297 entries