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Showing 9985 to 9996 of 36756 entries
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North American terrestrial CO.

Climatic change

Tian H, Chen G, Lu C, Xu X, Hayes DJ, Ren W, Pan S, Huntzinger DN, Wofsy SC.
PMID: 26005232
Clim Change. 2015;129(3):413-426. doi: 10.1007/s10584-014-1072-9. Epub 2014 Mar 14.

The terrestrial ecosystems of North America have been identified as a sink of atmospheric CO

Cobalt fluorocarbenes: cycloaddition reactions with tetrafluoroethylene and reactivity of the perfluorometallacyclic products.

Journal of the American Chemical Society

Harrison DJ, Lee GM, Leclerc MC, Korobkov I, Baker RT.
PMID: 24294941
J Am Chem Soc. 2013 Dec 11;135(49):18296-9. doi: 10.1021/ja411503c. Epub 2013 Dec 02.

Cobalt fluorocarbene complexes CpCo(═CFR(F))(PPh2Me) (Cp = η(5)-C5H5, R(F) = F or CF3) react with tetrafluoroethylene to give the metallacyclobutanes CpCo(κ(2)-CFR(F)CF2CF2-)(PPh2Me) in the first examples of cycloaddition reactions between perfluoroalkenes and metal perfluorocarbenes. The metallacyclic products undergo a variety of...

GLOBAL CHANGE SCIENCE. Stakeholders in climate science: Beyond lip service?.

Science (New York, N.Y.)

Klenk NL, Meehan K, Pinel SL, Mendez F, Lima PT, Kammen DM.
PMID: 26564836
Science. 2015 Nov 13;350(6262):743-4. doi: 10.1126/science.aab1495. Epub 2015 Nov 12.

No abstract available.

The role of fracture reduction and plate position in the aetiology of flexor pollicis longus tendon rupture after volar plate fixation of distal radius fractures.

Hand (New York, N.Y.)

Selvan DR, Machin DG, Perry D, Simpson C, Thorpe P, Brown DJ.
PMID: 26330785
Hand (N Y). 2015 Sep;10(3):497-502. doi: 10.1007/s11552-014-9735-6.

BACKGROUND: Flexor pollicis longus (FPL) rupture has been described as complication following volar plating for distal radius fractures. It has been hypothesised that this is due to plate prominence. The aim of the study was to investigate the relationship...

New capital acquisitions.

Plastic surgery (Oakville, Ont.)

Peters DA, McKay DR.
PMID: 26361631
Plast Surg (Oakv). 2015;23(3):205-6. doi: 10.4172/plastic-surgery.1000930.

No abstract available.

Stretch induced hyperexcitability of mice callosal pathway.

Frontiers in cellular neuroscience

Fan A, Stebbings KA, Llano DA, Saif T.
PMID: 26300729
Front Cell Neurosci. 2015 Aug 05;9:292. doi: 10.3389/fncel.2015.00292. eCollection 2015.

Memory and learning are thought to result from changes in synaptic strength. Previous studies on synaptic physiology in brain slices have traditionally been focused on biochemical processes. Here, we demonstrate with experiments on mouse brain slices that central nervous...

A validated, transitional and translational porcine model of hepatocellular carcinoma.

Oncotarget

Schachtschneider KM, Schwind RM, Darfour-Oduro KA, De AK, Rund LA, Singh K, Principe DR, Guzman G, Ray CE, Ozer H, Gaba RC, Schook LB.
PMID: 28969016
Oncotarget. 2017 Jun 29;8(38):63620-63634. doi: 10.18632/oncotarget.18872. eCollection 2017 Sep 08.

Difficult questions are confronting clinicians attempting to improve hepatocellular carcinoma (HCC) outcomes. A large animal model with genetic, anatomical, and physiological similarities to humans is required to transition from mouse models to human clinical trials to address unmet clinical...

Altered Development of Amygdala-Anterior Cingulate Cortex Connectivity in Anxious Youth and Young Adults.

Biological psychiatry. Cognitive neuroscience and neuroimaging

Kujawa A, Wu M, Klumpp H, Pine DS, Swain JE, Fitzgerald KD, Monk CS, Phan KL.
PMID: 27525316
Biol Psychiatry Cogn Neurosci Neuroimaging. 2016 Jul;1(4):345-352. doi: 10.1016/j.bpsc.2016.01.006.

BACKGROUND: Development of cortico-amygdala circuitry underlies the maturation of emotion processing and regulation, and age-related changes in amygdala connectivity with anterior cingulate cortex (ACC) have been shown to mediate normative developmental decreases in anxiety. It remains unclear whether developmental...

FnrL and Three Dnr Regulators Are Used for the Metabolic Adaptation to Low Oxygen Tension in .

Frontiers in microbiology

Ebert M, Laaß S, Thürmer A, Roselius L, Eckweiler D, Daniel R, Härtig E, Jahn D.
PMID: 28473807
Front Microbiol. 2017 Apr 20;8:642. doi: 10.3389/fmicb.2017.00642. eCollection 2017.

The heterotrophic marine bacterium

Polymeric Materials for Gene Delivery and DNA Vaccination.

Advanced materials (Deerfield Beach, Fla.)

Nguyen DN, Green JJ, Chan JM, Longer R, Anderson DG.
PMID: 28413262
Adv Mater. 2009 Feb 23;21(8):847-867. doi: 10.1002/adma.200801478. Epub 2008 Dec 04.

Gene delivery holds great potential for the treatment of many different diseases. Vaccination with DNA holds particular promise, and may provide a solution to many technical challenges that hinder traditional vaccine systems including rapid development and production and induction...

Kinetic Resolution of 2-Substituted Indolines by N-Sulfonylation using an Atropisomeric 4-DMAP-N-oxide Organocatalyst.

Angewandte Chemie (International ed. in English)

Murray JI, Flodén NJ, Bauer A, Fessner ND, Dunklemann DL, Bob-Egbe O, Rzepa HS, Bürgi T, Richardson J, Spivey AC.
PMID: 28444918
Angew Chem Int Ed Engl. 2017 May 15;56(21):5760-5764. doi: 10.1002/anie.201700977. Epub 2017 Apr 26.

The first catalytic kinetic resolution by N-sulfonylation is described. 2-Substituted indolines are resolved (s=2.6-19) using an atropisomeric 4-dimethylaminopyridine-N-oxide (4-DMAP-N-oxide) organocatalyst. Use of 2-isopropyl-4-nitrophenylsulfonyl chloride is critical to the stereodiscrimination and enables facile deprotection of the sulfonamide products with thioglycolic...

Novel Autotaxin Inhibitors for the Treatment of Osteoarthritis Pain: Lead Optimization via Structure-Based Drug Design.

ACS medicinal chemistry letters

Jones SB, Pfeifer LA, Bleisch TJ, Beauchamp TJ, Durbin JD, Klimkowski VJ, Hughes NE, Rito CJ, Dao Y, Gruber JM, Bui H, Chambers MG, Chandrasekhar S, Lin C, McCann DJ, Mudra DR, Oskins JL, Swearingen CA, Thirunavukkarasu K, Norman BH.
PMID: 27660691
ACS Med Chem Lett. 2016 Aug 02;7(9):857-61. doi: 10.1021/acsmedchemlett.6b00207. eCollection 2016 Sep 08.

In an effort to develop a novel therapeutic agent aimed at addressing the unmet need of patients with osteoarthritis pain, we set out to develop an inhibitor for autotaxin with excellent potency and physical properties to allow for the...

Showing 9985 to 9996 of 36756 entries