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Showing 277 to 281 of 281 entries
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Sensitive and Quantitative Detection of MHC-I Displayed Neoepitopes Using a Semiautomated Workflow and TOMAHAQ Mass Spectrometry.

Molecular & cellular proteomics : MCP

Pollock SB, Rose CM, Darwish M, Bouziat R, Delamarre L, Blanchette C, Lill JR.
PMID: 34129938
Mol Cell Proteomics. 2021;20:100108. doi: 10.1016/j.mcpro.2021.100108. Epub 2021 Jun 12.

Advances in several key technologies, including MHC peptidomics, have helped fuel our understanding of basic immune regulatory mechanisms and the identification of T cell receptor targets for the development of immunotherapeutics. Isolating and accurately quantifying MHC-bound peptides from cells...

High-throughput identification of conditional MHCI ligands and scaled-up production of conditional MHCI complexes.

Protein science : a publication of the Protein Society

Darwish M, Wichner S, Li J, Chang JC, Tam C, Franke Y, Li H, Chan P, Blanchette C.
PMID: 33840137
Protein Sci. 2021 Jun;30(6):1169-1183. doi: 10.1002/pro.4082. Epub 2021 Apr 26.

Despite the need to monitor the impact of Cancer Immunotherapy (CI)/Immuno-Oncology (IO) therapeutics on neoantigen-specific T-cell responses, very few clinical programs incorporate this aspect of immune monitoring due to the challenges in high-throughput (HTP) generation of Major Histocompatibility Complex...

Simvastatin mitigates streptozotocin-induced type 1 diabetes in mice through downregulation of ADAM10 and ADAM17.

Life sciences

Abdel-Bakky MS, Alqasoumi A, Altowayan WM, Amin E, Darwish MA.
PMID: 34896343
Life Sci. 2021 Dec 09;289:120224. doi: 10.1016/j.lfs.2021.120224. Epub 2021 Dec 09.

BACKGROUND: T cell mediates immune response in type 1 diabetes mellitus (T1DM) through its trafficking into pancreatic islets. The role of A Disintigrin And Metalloproteinase 10 (ADAM10) and 17 (ADAM17) in pancreatic T-cells recruitment into the pancreatic islets during...

Antioxidant activity and some quality characteristics of buffalo yoghurt fortified with peanut skin extract powder.

Journal of food science and technology

Hamed AM, Taha SH, Darwish AA, Aly E.
PMID: 33967339
J Food Sci Technol. 2021 Jun;58(6):2431-2440. doi: 10.1007/s13197-020-04835-2. Epub 2020 Oct 10.

Peanut is an important crop grown worldwide. Peanut skin, the byproduct of peanut processing is a valuable byproduct due to its content of many functional components. Therefore, this study aimed to evaluate the effect of fortification of yoghurt with...

Simvastatin mitigates streptozotocin-induced type 1 diabetes in mice through downregulation of ADAM10 and ADAM17.

Life sciences

Abdel-Bakky MS, Alqasoumi A, Altowayan WM, Amin E, Darwish MA.
PMID: 34896343
Life Sci. 2021 Dec 09;289:120224. doi: 10.1016/j.lfs.2021.120224. Epub 2021 Dec 09.

BACKGROUND: T cell mediates immune response in type 1 diabetes mellitus (T1DM) through its trafficking into pancreatic islets. The role of A Disintigrin And Metalloproteinase 10 (ADAM10) and 17 (ADAM17) in pancreatic T-cells recruitment into the pancreatic islets during...

Showing 277 to 281 of 281 entries