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Showing 409 to 418 of 418 entries
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Structural and Mechanistic Insight into CRISPR-Cas9 Inhibition by Anti-CRISPR Protein AcrIIC4.

Journal of molecular biology

Hwang S, Pan C, Garcia B, Davidson AR, Moraes TF, Maxwell KL.
PMID: 34954237
J Mol Biol. 2021 Dec 23;434(5):167420. doi: 10.1016/j.jmb.2021.167420. Epub 2021 Dec 23.

Phages, plasmids, and other mobile genetic elements express inhibitors of CRISPR-Cas immune systems, known as anti-CRISPR proteins, to protect themselves from targeted destruction. These anti-CRISPR proteins have been shown to function through very diverse mechanisms. In this work we...

From crypts to enteroids: establishment and characterization of avian intestinal organoids.

Poultry science

Zhao D, Farnell MB, Kogut MH, Genovese KJ, Chapkin RS, Davidson LA, Berghman LR, Farnell YZ.
PMID: 35016046
Poult Sci. 2021 Dec 04;101(3):101642. doi: 10.1016/j.psj.2021.101642. Epub 2021 Dec 04.

Intestinal organoids (IO), known as "mini-guts", derived from intestinal crypts, are self-organizing three-dimensional (3D) multicellular ex vivo models that recapitulate intestine epithelial structure and function and have been widely used for studying intestinal physiology, pathophysiology, molecular mechanisms of host-pathogen...

Single-cell RNA Sequencing Reveals How the Aryl Hydrocarbon Receptor Shapes Cellular Differentiation Potency in the Mouse Colon.

Cancer prevention research (Philadelphia, Pa.)

Yang Y, Osorio D, Davidson LA, Han H, Mullens DA, Jayaraman A, Safe S, Ivanov I, Cai JJ, Chapkin RS.
PMID: 34815312
Cancer Prev Res (Phila). 2022 Jan;15(1):17-28. doi: 10.1158/1940-6207.CAPR-21-0378. Epub 2021 Nov 22.

Despite recent progress recognizing the importance of aryl hydrocarbon receptor (Ahr)-dependent signaling in suppressing colon tumorigenesis, its role in regulating colonic crypt homeostasis remains unclear. To assess the effects of Ahr on intestinal epithelial cell heterogeneity and functional phenotypes,...

Effective Peer Employment Within Multidisciplinary Organizations: Model for Best Practice.

Administration and policy in mental health

Byrne L, Roennfeldt H, Wolf J, Linfoot A, Foglesong D, Davidson L, Bellamy C.
PMID: 34478040
Adm Policy Ment Health. 2021 Sep 03; doi: 10.1007/s10488-021-01162-2. Epub 2021 Sep 03.

This study sought a clearer understanding of organizational mechanisms reinforcing effective peer employment and organizational change from the perspectives of peer workers, non-peer staff and management in multidisciplinary mental health and substance use recovery services. Findings were used to...

Mavis Agbandje-McKenna's Lifelong Commitment to Teaching and Research.

Human gene therapy

Byrne BJ, McCall AL, Davidson BL, Samulski RJ.
PMID: 33891506
Hum Gene Ther. 2021 Apr;32(7):319-320. doi: 10.1089/hum.2021.29157.alm.

No abstract available.

Quantitative Proteomic Profiling Identifies a Potential Novel Chaperone Marker in Resistant Breast Cancer.

Frontiers in oncology

Gallegos KM, Patel JR, Llopis SD, Walker RR, Davidson AM, Zhang W, Zhang K, Tilghman SL.
PMID: 33718123
Front Oncol. 2021 Feb 25;11:540134. doi: 10.3389/fonc.2021.540134. eCollection 2021.

Development of aromatase inhibitor resistant breast cancer among postmenopausal women continues to be a major clinical obstacle. Previously, our group demonstrated that as breast cancer cells transition from hormone-dependent to hormone-independent, they are associated with increased growth factor signaling,...

Gene therapy for ALS: A review.

Molecular therapy : the journal of the American Society of Gene Therapy

Amado DA, Davidson BL.
PMID: 33839324
Mol Ther. 2021 Dec 01;29(12):3345-3358. doi: 10.1016/j.ymthe.2021.04.008. Epub 2021 Apr 09.

Amyotrophic lateral sclerosis (ALS) has historically posed unique challenges for gene-therapy-based approaches, due to a paucity of therapeutic targets as well as the difficulty of accessing both the brain and spinal cord. Recent advances in our understanding of disease...

A Review of Reported Adverse Events in MRI-Safe and MRI-Conditional Cochlear Implants.

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology

Bestourous DE, Davidson L, Reilly BK.
PMID: 34510115
Otol Neurotol. 2022 Jan 01;43(1):42-47. doi: 10.1097/MAO.0000000000003339.

OBJECTIVES: This study looks to examine how the development of diametric magnet cochlear implant devices (CIDs) has affected observed magnetic resonance imaging (MRI)-related adverse events and MRI safety measures.METHODS: A search of the Food and Drug Administration (FDA) Manufacturer...

PTPN21/Pez Is a Novel and Evolutionarily Conserved Key Regulator of Inflammation In Vivo.

Current biology : CB

Campbell JS, Davidson AJ, Todd H, Rodrigues FSLM, Elliot AM, Early JJ, Lyons DA, Feng Y, Wood W.
PMID: 33296680
Curr Biol. 2021 Feb 22;31(4):875-883.e5. doi: 10.1016/j.cub.2020.11.014. Epub 2020 Dec 08.

Drosophila provides a powerful model in which to study inflammation in vivo, and previous studies have revealed many of the key signaling events critical for recruitment of immune cells to tissue damage. In the fly, wounding stimulates the rapid...

An empirical perspective on cigarette use in substance use recovery.

Psychological medicine

Goodwin RD, Wu M, Davidson L.
PMID: 34261564
Psychol Med. 2021 Oct;51(14):2299-2306. doi: 10.1017/S0033291721002300. Epub 2021 Jul 15.

No abstract available.

Showing 409 to 418 of 418 entries