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Showing 25 to 31 of 31 entries
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Preparing Live Cells for Immunization.

Cold Spring Harbor protocols

Greenfield EA, DeCaprio J, Brahmandam M.
PMID: 34341176
Cold Spring Harb Protoc. 2021 Aug 02;2021(8):pdb.prot100057. doi: 10.1101/pdb.prot100057.

Generating monoclonal antibodies against cell-surface (i.e., membrane) proteins can be challenging because membrane and membrane-associated proteins often lose their native conformation during the purification process. This also makes fusion screening very difficult. One widely used technique to overcome this...

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Greenfield EA, DeCaprio J, Brahmandam M. Preparing Live Cells for Immunization. Cold Spring Harb Protoc. 2021;2021(8):pdb.prot100057doi: 10.1101/pdb.prot100057.
Greenfield, E. A., DeCaprio, J., & Brahmandam, M. (2021). Preparing Live Cells for Immunization. Cold Spring Harbor protocols, 2021(8), pdb.prot100057. https://doi.org/10.1101/pdb.prot100057
Greenfield, Edward A, et al. "Preparing Live Cells for Immunization." Cold Spring Harbor protocols vol. 2021,8 (2021): pdb.prot100057. doi: https://doi.org/10.1101/pdb.prot100057
Greenfield EA, DeCaprio J, Brahmandam M. Preparing Live Cells for Immunization. Cold Spring Harb Protoc. 2021 Aug 02;2021(8):pdb.prot100057. doi: 10.1101/pdb.prot100057. PMID: 34341176.
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An analysis of the use of targeted therapies in patients with advanced Merkel cell carcinoma and an evaluation of genomic correlates of response.

Cancer medicine

Knepper TC, Panchaud RA, Muradova E, Cohen L, DeCaprio JA, Khushalani NI, Tsai KY, Brohl AS.
PMID: 34269527
Cancer Med. 2021 Sep;10(17):5889-5896. doi: 10.1002/cam4.4138. Epub 2021 Jul 16.

BACKGROUND: The use of targeted therapy remains a treatment consideration for some patients with advanced Merkel cell carcinoma (MCC). However, supportive data on the use of targeted therapy approaches are limited. Thus, we sought to evaluate the responsiveness of...

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Knepper TC, Panchaud RA, Muradova E, et al. An analysis of the use of targeted therapies in patients with advanced Merkel cell carcinoma and an evaluation of genomic correlates of response. Cancer Med. 2021;10(17):5889-5896doi: 10.1002/cam4.4138.
Knepper, T. C., Panchaud, R. A., Muradova, E., Cohen, L., DeCaprio, J. A., Khushalani, N. I., Tsai, K. Y., & Brohl, A. S. (2021). An analysis of the use of targeted therapies in patients with advanced Merkel cell carcinoma and an evaluation of genomic correlates of response. Cancer medicine, 10(17), 5889-5896. https://doi.org/10.1002/cam4.4138
Knepper, Todd C, et al. "An analysis of the use of targeted therapies in patients with advanced Merkel cell carcinoma and an evaluation of genomic correlates of response." Cancer medicine vol. 10,17 (2021): 5889-5896. doi: https://doi.org/10.1002/cam4.4138
Knepper TC, Panchaud RA, Muradova E, Cohen L, DeCaprio JA, Khushalani NI, Tsai KY, Brohl AS. An analysis of the use of targeted therapies in patients with advanced Merkel cell carcinoma and an evaluation of genomic correlates of response. Cancer Med. 2021 Sep;10(17):5889-5896. doi: 10.1002/cam4.4138. Epub 2021 Jul 16. PMID: 34269527; PMCID: PMC8419775.
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Correction to "Bioinformatic Mapping of Radical .

Journal of the American Chemical Society

Hudson GA, Burkhart BJ, DiCaprio AJ, Schwalen CJ, Kille B, Pogorelov TV, Mitchell DA.
PMID: 34197098
J Am Chem Soc. 2021 Jul 14;143(27):10479. doi: 10.1021/jacs.1c06285. Epub 2021 Jul 01.

No abstract available.

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Hudson GA, Burkhart BJ, DiCaprio AJ, et al. Correction to "Bioinformatic Mapping of Radical . J Am Chem Soc. 2021;143(27):10479doi: 10.1021/jacs.1c06285.
Hudson, G. A., Burkhart, B. J., DiCaprio, A. J., Schwalen, C. J., Kille, B., Pogorelov, T. V., & Mitchell, D. A. (2021). Correction to "Bioinformatic Mapping of Radical . Journal of the American Chemical Society, 143(27), 10479. https://doi.org/10.1021/jacs.1c06285
Hudson, Graham A, et al. "Correction to "Bioinformatic Mapping of Radical ." Journal of the American Chemical Society vol. 143,27 (2021): 10479. doi: https://doi.org/10.1021/jacs.1c06285
Hudson GA, Burkhart BJ, DiCaprio AJ, Schwalen CJ, Kille B, Pogorelov TV, Mitchell DA. Correction to "Bioinformatic Mapping of Radical . J Am Chem Soc. 2021 Jul 14;143(27):10479. doi: 10.1021/jacs.1c06285. Epub 2021 Jul 01. PMID: 34197098.
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Making Weak Antigens Strong: Preparing Immune Complexes for Injection.

Cold Spring Harbor protocols

Greenfield EA, DeCaprio J, Brahmandam M.
PMID: 34470860
Cold Spring Harb Protoc. 2021 Sep 01;2021(9):pdb.prot099978. doi: 10.1101/pdb.prot099978.

If antibodies against a particular antigen are available, that antigen can be purified and used for further immunizations, and antigens thus purified can show enhanced immunogenicity. Purified immune complexes can be injected directly, or while coupled to beads; the...

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Greenfield EA, DeCaprio J, Brahmandam M. Making Weak Antigens Strong: Preparing Immune Complexes for Injection. Cold Spring Harb Protoc. 2021;2021(9):pdb.prot099978doi: 10.1101/pdb.prot099978.
Greenfield, E. A., DeCaprio, J., & Brahmandam, M. (2021). Making Weak Antigens Strong: Preparing Immune Complexes for Injection. Cold Spring Harbor protocols, 2021(9), pdb.prot099978. https://doi.org/10.1101/pdb.prot099978
Greenfield, Edward A, et al. "Making Weak Antigens Strong: Preparing Immune Complexes for Injection." Cold Spring Harbor protocols vol. 2021,9 (2021): pdb.prot099978. doi: https://doi.org/10.1101/pdb.prot099978
Greenfield EA, DeCaprio J, Brahmandam M. Making Weak Antigens Strong: Preparing Immune Complexes for Injection. Cold Spring Harb Protoc. 2021 Sep 01;2021(9):pdb.prot099978. doi: 10.1101/pdb.prot099978. PMID: 34470860.
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Simultaneous expression of MMB-FOXM1 complex components enables efficient bypass of senescence.

Scientific reports

Kumari R, Hummerich H, Shen X, Fischer M, Litovchick L, Mittnacht S, DeCaprio JA, Jat PS.
PMID: 34728711
Sci Rep. 2021 Nov 02;11(1):21506. doi: 10.1038/s41598-021-01012-z.

Cellular senescence is a stable cell cycle arrest that normal cells undergo after a finite number of divisions, in response to a variety of intrinsic and extrinsic stimuli. Although senescence is largely established and maintained by the p53/p21

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Kumari R, Hummerich H, Shen X, et al. Simultaneous expression of MMB-FOXM1 complex components enables efficient bypass of senescence. Sci Rep. 2021;11(1):21506doi: 10.1038/s41598-021-01012-z.
Kumari, R., Hummerich, H., Shen, X., Fischer, M., Litovchick, L., Mittnacht, S., DeCaprio, J. A., & Jat, P. S. (2021). Simultaneous expression of MMB-FOXM1 complex components enables efficient bypass of senescence. Scientific reports, 11(1), 21506. https://doi.org/10.1038/s41598-021-01012-z
Kumari, Ruchi, et al. "Simultaneous expression of MMB-FOXM1 complex components enables efficient bypass of senescence." Scientific reports vol. 11,1 (2021): 21506. doi: https://doi.org/10.1038/s41598-021-01012-z
Kumari R, Hummerich H, Shen X, Fischer M, Litovchick L, Mittnacht S, DeCaprio JA, Jat PS. Simultaneous expression of MMB-FOXM1 complex components enables efficient bypass of senescence. Sci Rep. 2021 Nov 02;11(1):21506. doi: 10.1038/s41598-021-01012-z. PMID: 34728711; PMCID: PMC8563780.
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Bioinformatics-Guided Expansion and Discovery of Graspetides.

ACS chemical biology

Ramesh S, Guo X, DiCaprio AJ, De Lio AM, Harris LA, Kille BL, Pogorelov TV, Mitchell DA.
PMID: 34766760
ACS Chem Biol. 2021 Dec 17;16(12):2787-2797. doi: 10.1021/acschembio.1c00672. Epub 2021 Nov 12.

Graspetides are a class of ribosomally synthesized and post-translationally modified peptide natural products featuring ATP-grasp ligase-dependent formation of macrolactones/macrolactams. These modifications arise from serine, threonine, or lysine donor residues linked to aspartate or glutamate acceptor residues. Characterized graspetides include...

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Ramesh S, Guo X, DiCaprio AJ, et al. Bioinformatics-Guided Expansion and Discovery of Graspetides. ACS Chem Biol. 2021;16(12):2787-2797doi: 10.1021/acschembio.1c00672.
Ramesh, S., Guo, X., DiCaprio, A. J., De Lio, A. M., Harris, L. A., Kille, B. L., Pogorelov, T. V., & Mitchell, D. A. (2021). Bioinformatics-Guided Expansion and Discovery of Graspetides. ACS chemical biology, 16(12), 2787-2797. https://doi.org/10.1021/acschembio.1c00672
Ramesh, Sangeetha, et al. "Bioinformatics-Guided Expansion and Discovery of Graspetides." ACS chemical biology vol. 16,12 (2021): 2787-2797. doi: https://doi.org/10.1021/acschembio.1c00672
Ramesh S, Guo X, DiCaprio AJ, De Lio AM, Harris LA, Kille BL, Pogorelov TV, Mitchell DA. Bioinformatics-Guided Expansion and Discovery of Graspetides. ACS Chem Biol. 2021 Dec 17;16(12):2787-2797. doi: 10.1021/acschembio.1c00672. Epub 2021 Nov 12. PMID: 34766760; PMCID: PMC8688276.
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MMB-FOXM1-driven premature mitosis is required for CHK1 inhibitor sensitivity.

Cell reports

Branigan TB, Kozono D, Schade AE, Deraska P, Rivas HG, Sambel L, Reavis HD, Shapiro GI, D'Andrea AD, DeCaprio JA.
PMID: 33657372
Cell Rep. 2021 Mar 02;34(9):108808. doi: 10.1016/j.celrep.2021.108808.

To identify genes whose loss confers resistance to CHK1 inhibitors, we perform genome-wide CRISPR-Cas9 screens in non-small-cell lung cancer (NSCLC) cell lines treated with the CHK1 inhibitor prexasertib (CHK1i). Five of the top six hits of the screens, MYBL2...

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Branigan TB, Kozono D, Schade AE, et al. MMB-FOXM1-driven premature mitosis is required for CHK1 inhibitor sensitivity. Cell Rep. 2021;34(9):108808doi: 10.1016/j.celrep.2021.108808.
Branigan, T. B., Kozono, D., Schade, A. E., Deraska, P., Rivas, H. G., Sambel, L., Reavis, H. D., Shapiro, G. I., D'Andrea, A. D., & DeCaprio, J. A. (2021). MMB-FOXM1-driven premature mitosis is required for CHK1 inhibitor sensitivity. Cell reports, 34(9), 108808. https://doi.org/10.1016/j.celrep.2021.108808
Branigan, Timothy B, et al. "MMB-FOXM1-driven premature mitosis is required for CHK1 inhibitor sensitivity." Cell reports vol. 34,9 (2021): 108808. doi: https://doi.org/10.1016/j.celrep.2021.108808
Branigan TB, Kozono D, Schade AE, Deraska P, Rivas HG, Sambel L, Reavis HD, Shapiro GI, D'Andrea AD, DeCaprio JA. MMB-FOXM1-driven premature mitosis is required for CHK1 inhibitor sensitivity. Cell Rep. 2021 Mar 02;34(9):108808. doi: 10.1016/j.celrep.2021.108808. PMID: 33657372; PMCID: PMC7970065.
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Showing 25 to 31 of 31 entries