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Showing 793 to 803 of 803 entries
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Maintenance treatment with rucaparib for recurrent ovarian carcinoma in ARIEL3, a randomized phase 3 trial: The effects of best response to last platinum-based regimen and disease at baseline on efficacy and safety.

Cancer medicine

Oaknin A, Oza AM, Lorusso D, Aghajanian C, Dean A, Colombo N, Weberpals JI, Clamp AR, Scambia G, Leary A, Holloway RW, Amenedo Gancedo M, Fong PC, Goh JC, O'Malley DM, Armstrong DK, Banerjee S, García-Donas J, Swisher EM, Cameron T, Maloney L, Goble S, Ledermann JA, Coleman RL.
PMID: 34549539
Cancer Med. 2021 Oct;10(20):7162-7173. doi: 10.1002/cam4.4260. Epub 2021 Sep 21.

BACKGROUND: The efficacy and safety of rucaparib maintenance treatment in ARIEL3 were evaluated in subgroups based on best response to most recent platinum-based chemotherapy and baseline disease.METHODS: Patients were randomized 2:1 to receive either oral rucaparib at a dosage...

Blood Transfusion and Adverse Graft-related Events in Kidney Transplant Patients.

Kidney international reports

Massicotte-Azarniouch D, Sood MM, Fergusson DA, Chassé M, Tinmouth A, Knoll GA.
PMID: 33912754
Kidney Int Rep. 2021 Feb 02;6(4):1041-1049. doi: 10.1016/j.ekir.2021.01.015. eCollection 2021 Apr.

BACKGROUND: The impact of posttransplant red blood cell transfusion (RBCT) and their potential immunomodulatory effects on kidney transplant recipients are unclear. We examined the risks for adverse graft outcomes associated with post-kidney transplant RBCT.METHODS: We conducted a retrospective cohort...

Toward the diagnosis of rare childhood genetic diseases: what do parents value most?.

European journal of human genetics : EJHG

Pollard S, Weymann D, Dunne J, Mayanloo F, Buckell J, Buchanan J, Wordsworth S, Friedman JM, Stockler-Ipsiroglu S, Dragojlovic N, Elliott AM, Harrison M, Lynd LD, Regier DA.
PMID: 33903739
Eur J Hum Genet. 2021 Oct;29(10):1491-1501. doi: 10.1038/s41431-021-00882-1. Epub 2021 Apr 26.

Genomic testing is becoming routine for diagnosing rare childhood genetic disease. Evidence underlying sustainable implementation is limited, focusing on short-term endpoints such as diagnostic yield, unable to fully characterize patient and family valued outcomes. Although genomic testing is becoming...

The rice blast pathosystem as a case study for the development of new tools and raw materials for genome analysis of fungal plant pathogens.

The New phytologist

K Mitchell T, Thon MR, Jeong JS, Brown D, Deng J, Dean RA.
PMID: 33873673
New Phytol. 2003 Jul;159(1):53-61. doi: 10.1046/j.1469-8137.2003.00787.x.

Fungi have an astounding and diverse impact on this planet. While they are agents of human diseases and the cause of allergic reactions, factories for the conversion of carbon in environmental and industrially adapted systems, and potential biological weapons,...

Design and Evaluation of Hybrid Composite Plates for Ballistic Protection: Experimental and Numerical Investigations.

Polymers

Alkhatib F, Mahdi E, Dean A.
PMID: 33946144
Polymers (Basel). 2021 Apr 30;13(9). doi: 10.3390/polym13091450.

In this paper, hybrid composite plates for ballistic protection were investigated experimentally and numerically, with a target to reduce the weight of currently used body armor inserts and, at the same time, satisfy the requirements of the National Institute...

Early-stage economic analysis of research-based comprehensive genomic sequencing for advanced cancer care.

Journal of community genetics

Weymann D, Laskin J, Jones SJM, Roscoe R, Lim HJ, Renouf DJ, Schrader KA, Sun S, Yip S, Marra MA, Regier DA.
PMID: 34843087
J Community Genet. 2021 Nov 29; doi: 10.1007/s12687-021-00557-w. Epub 2021 Nov 29.

Genomic research is driving discovery for future population benefit. Limited evidence exists on immediate patient and health system impacts of research participation. This study uses real-world data and quasi-experimental matching to examine early-stage cost and health impacts of research-based...

Cancer detection and biopsy classification using concurrent histopathological and metabolomic analysis of core biopsies.

Genome medicine

Brown MV, McDunn JE, Gunst PR, Smith EM, Milburn MV, Troyer DA, Lawton KA.
PMID: 22546470
Genome Med. 2012 Apr 30;4(4):33. doi: 10.1186/gm332.

BACKGROUND: Metabolomics, the non-targeted interrogation of small molecules in a biological sample, is an ideal technology for identifying diagnostic biomarkers. Current tissue extraction protocols involve sample destruction, precluding additional uses of the tissue. This is particularly problematic for high...

Urolithiasis/Endourology.

The Journal of urology

Assimos DG.
PMID: 33858175
J Urol. 2021 Jul;206(1):153-155. doi: 10.1097/JU.0000000000001794. Epub 2021 Apr 16.

No abstract available.

PDGFB RNA in situ hybridization for the diagnosis of dermatofibrosarcoma protuberans.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

Cloutier JM, Allard G, Bean GR, Hornick JL, Charville GW.
PMID: 33762682
Mod Pathol. 2021 Aug;34(8):1521-1529. doi: 10.1038/s41379-021-00800-2. Epub 2021 Mar 24.

Dermatofibrosarcoma protuberans (DFSP) is a spindle cell neoplasm of the skin and superficial soft tissue with a tendency for locally aggressive behavior; metastatic potential coincides with fibrosarcomatous transformation. The vast majority of DFSPs harbor the t(17;22) translocation resulting in...

Costs of Biopsy and Complications in Patients with Lung Cancer.

ClinicoEconomics and outcomes research : CEOR

Chiu YW, Kao YH, Simoff MJ, Ost DE, Wagner O, Lavin J, Culbertson RA, Smith DG.
PMID: 33762834
Clinicoecon Outcomes Res. 2021 Mar 17;13:191-200. doi: 10.2147/CEOR.S295494. eCollection 2021.

PURPOSE: To describe the distribution of diagnostic procedures, rates of complications, and total cost of biopsies for patients with lung cancer.PATIENTS AND METHODS: Observational study using data from IBM MarketscanRESULTS: The database included 22,870 patients who had a total...

Wavelet transform-based photoacoustic time-frequency spectral analysis for bone assessment.

Photoacoustics

Xie W, Feng T, Zhang M, Li J, Ta D, Cheng L, Cheng Q.
PMID: 33777692
Photoacoustics. 2021 Mar 10;22:100259. doi: 10.1016/j.pacs.2021.100259. eCollection 2021 Jun.

In this study, we investigated the feasibility of using photoacoustic time-frequency spectral analysis (PA-TFSA) for evaluating the bone mineral density (BMD) and bone structure. Simulations and

Showing 793 to 803 of 803 entries