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Showing 193 to 203 of 203 entries
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Follicular Lymphoma-associated BTK Mutations are Inactivating Resulting in Augmented AKT Activation.

Clinical cancer research : an official journal of the American Association for Cancer Research

Hu N, Wang F, Sun T, Xu Z, Zhang J, Bernard D, Xu S, Wang S, Kaminski M, Devata S, Phillips T, Malek SN.
PMID: 33419778
Clin Cancer Res. 2021 Apr 15;27(8):2301-2313. doi: 10.1158/1078-0432.CCR-20-3741. Epub 2021 Jan 08.

PURPOSE: On the basis of the recent discovery of mutations in Bruton tyrosine kinase (EXPERIMENTAL DESIGN: We identified novel somatic RESULTS: We uncovered that all BTK mutants destabilized the BTK protein and some created BTK kinase-dead mutants. The phospholipase...

DART takes aim at community editing.

Nature microbiology

Ha CWY, Devkota S.
PMID: 34873294
Nat Microbiol. 2022 Jan;7(1):8-9. doi: 10.1038/s41564-021-01017-4.

No abstract available.

Phenolic Acid Derivatives, Flavonoids and Other Bioactive Compounds from the Leaves of .

Plants (Basel, Switzerland)

Hori K, Watanabe T, Devkota HP.
PMID: 33562289
Plants (Basel). 2021 Feb 07;10(2). doi: 10.3390/plants10020320.

No abstract available.

Probing the SAM Binding Site of SARS-CoV-2 nsp14 in vitro Using SAM Competitive Inhibitors Guides Developing Selective bi-substrate Inhibitors.

bioRxiv : the preprint server for biology

Devkota K, Schapira M, Perveen S, Yazdi AK, Li F, Chau I, Ghiabi P, Hajian T, Loppnau P, Bolotokova A, Satchell KJF, Wang K, Li D, Liu J, Smil D, Luo M, Jin J, Fish PV, Brown PJ, Vedadi M.
PMID: 33619486
bioRxiv. 2021 Feb 19; doi: 10.1101/2021.02.19.424337.

The COVID-19 pandemic has clearly brought the healthcare systems world-wide to a breaking point along with devastating socioeconomic consequences. The SARS-CoV-2 virus which causes the disease uses RNA capping to evade the human immune system. Non-structural protein (nsp) 14...

Evidence-based complementary and alternative medicine : eCAM

Timalsina D, Devkota HP, Bhusal D, Sharma KR.
PMID: 34484388
Evid Based Complement Alternat Med. 2021 Aug 25;2021:3257732. doi: 10.1155/2021/3257732. eCollection 2021.

No abstract available.

Harnessing polyphenol power by targeting eNOS for vascular diseases.

Critical reviews in food science and nutrition

Das M, Devi KP, Belwal T, Devkota HP, Tewari D, Sahebnasagh A, Nabavi SF, Khayat Kashani HR, Rasekhian M, Xu S, Amirizadeh M, Amini K, Banach M, Xiao J, Aghaabdollahian S, Nabavi SM.
PMID: 34553653
Crit Rev Food Sci Nutr. 2021 Sep 23;1-26. doi: 10.1080/10408398.2021.1971153. Epub 2021 Sep 23.

Vascular diseases arise due to vascular endothelium dysfunction in response to several pro-inflammatory stimuli and invading pathogens. Thickening of the vessel wall, formation of atherosclerotic plaques consisting of proliferating smooth muscle cells, macrophages and lymphocytes are the major consequences...

Estimation of Underreported Cases of Infections and Deaths from COVID-19 for Countries with Limited and Scarce Data: Examples from Nepal.

Journal of environmental and public health

Devkota JU.
PMID: 35024047
J Environ Public Health. 2022 Jan 10;2022:3276583. doi: 10.1155/2022/3276583. eCollection 2022.

COVID-19 pandemic has overburdened the public healthcare system around the world. Further, lockdown imposed to curb the spread of pandemic has shown to have an adverse effect on economic and health status of an individual. It has also compelled...

Phosphorus Fertilization Enhances Productivity of Forage Corn (.

Plants (Basel, Switzerland)

Bouras H, Bouaziz A, Choukr-Allah R, Hirich A, Devkota KP, Bouazzama B.
PMID: 34961079
Plants (Basel). 2021 Nov 28;10(12). doi: 10.3390/plants10122608.

Salinity is a major problem affecting crop production in many regions in the world including Morocco. Agricultural practices such as fertilization could be useful to overcome this problem and improve crop productivity. The objective of our study was to...

Reporting guidelines for human microbiome research: the STORMS checklist.

Nature medicine

Mirzayi C, Renson A, Zohra F, Elsafoury S, Geistlinger L, Kasselman LJ, Eckenrode K, van de Wijgert J, Loughman A, Marques FZ, MacIntyre DA, Arumugam M, Azhar R, Beghini F, Bergstrom K, Bhatt A, Bisanz JE, Braun J, Bravo HC, Buck GA, Bushman F, Casero D, Clarke G, Collado MC, Cotter PD, Cryan JF, Demmer RT, Devkota S, Elinav E, Escobar JS, Fettweis J, Finn RD, Fodor AA, Forslund S, Franke A, Furlanello C, Gilbert J, Grice E, Haibe-Kains B, Handley S, Herd P, Holmes S, Jacobs JP, Karstens L, Knight R, Knights D, Koren O, Kwon DS, Langille M, Lindsay B, McGovern D, McHardy AC, McWeeney S, Mueller NT, Nezi L, Olm M, Palm N, Pasolli E, Raes J, Redinbo MR, Rühlemann M, Balfour Sartor R, Schloss PD, Schriml L, Segal E, Shardell M, Sharpton T, Smirnova E, Sokol H, Sonnenburg JL, Srinivasan S, Thingholm LB, Turnbaugh PJ, Upadhyay V, Walls RL, Wilmes P, Yamada T, Zeller G, Zhang M, Zhao N, Zhao L, Bao W, Culhane A, Devanarayan V, Dopazo J, Fan X, Fischer M, Jones W, Kusko R, Mason CE, Mercer TR, Sansone SA, Scherer A, Shi L, Thakkar S, Tong W, Wolfinger R, Hunter C, Segata N, Huttenhower C, Dowd JB, Jones HE, Waldron L.
PMID: 34789871
Nat Med. 2021 Nov;27(11):1885-1892. doi: 10.1038/s41591-021-01552-x. Epub 2021 Nov 17.

The particularly interdisciplinary nature of human microbiome research makes the organization and reporting of results spanning epidemiology, biology, bioinformatics, translational medicine and statistics a challenge. Commonly used reporting guidelines for observational or genetic epidemiology studies lack key features specific...

Genome-wide QTL mapping of yield and agronomic traits in two widely adapted winter wheat cultivars from multiple mega-environments.

PeerJ

Dhakal S, Liu X, Chu C, Yang Y, Rudd JC, Ibrahim AMH, Xue Q, Devkota RN, Baker JA, Baker SA, Simoneaux BE, Opena GB, Sutton R, Jessup KE, Hui K, Wang S, Johnson CD, Metz RP, Liu S.
PMID: 34900409
PeerJ. 2021 Nov 24;9:e12350. doi: 10.7717/peerj.12350. eCollection 2021.

Quantitative trait loci (QTL) analysis could help to identify suitable molecular markers for marker-assisted breeding (MAB). A mapping population of 124 F

A review of chemistry and pharmacology of Piperidine alkaloids of Pinus and related genera.

Current pharmaceutical biotechnology

Singh L, Upadhyay AK, Dixit P, Singh A, Yadav D, Chhavi A, Konar S, Srivastava RP, Pandey S, Devkota HP, Verma PC, Saxena G.
PMID: 34387162
Curr Pharm Biotechnol. 2021 Aug 12; doi: 10.2174/1389201022666210812123815. Epub 2021 Aug 12.

BACKGROUND: Pinus and other related conifers belonging to family pinaceae are most commonly used medicinal plants in Indian North-western Himalayas. Various parts of these plants including needles are source of several well known alkaloids. Of all the alkaloids, piperidine...

Showing 193 to 203 of 203 entries