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Showing 9985 to 9996 of 12381 entries
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Author Correction: Comprehensive characterization of 536 patient-derived xenograft models prioritizes candidates for targeted treatment.

Nature communications

Sun H, Cao S, Mashl RJ, Mo CK, Zaccaria S, Wendl MC, Davies SR, Bailey MH, Primeau TM, Hoog J, Mudd JL, Dean DA, Patidar R, Chen L, Wyczalkowski MA, Jayasinghe RG, Rodrigues FM, Terekhanova NV, Li Y, Lim KH, Wang-Gillam A, Van Tine BA, Ma CX, Aft R, Fuh KC, Schwarz JK, Zevallos JP, Puram SV, Dipersio JF, Davis-Dusenbery B, Ellis MJ, Lewis MT, Davies MA, Herlyn M, Fang B, Roth JA, Welm AL, Welm BE, Meric-Bernstam F, Chen F, Fields RC, Li S, Govindan R, Doroshow JH, Moscow JA, Evrard YA, Chuang JH, Raphael BJ, Ding L.
PMID: 34996889
Nat Commun. 2022 Jan 07;13(1):294. doi: 10.1038/s41467-021-27678-7.

No abstract available.

Discovery of cinnoline derivatives as potent PI3K inhibitors with antiproliferative activity.

Bioorganic & medicinal chemistry letters

Tian C, Yang C, Wu T, Lu M, Chen Y, Yang Y, Liu X, Ling Y, Deng M, Jia Y, Zhou Y.
PMID: 34284105
Bioorg Med Chem Lett. 2021 Sep 15;48:128271. doi: 10.1016/j.bmcl.2021.128271. Epub 2021 Jul 17.

Cinnoline is a potential pharmacophore which has rarely been reported for uses as PI3K inhibitors. In this study, a series of cinnoline derivatives were developed as PI3K inhibitors and evaluated for enzymatic and cellular activities. Most compounds displayed nanomolar...

Symptom trajectories for palliative care inpatients with and without hyperactive delirium in the last week of life.

Journal of advanced nursing

Dai Y, Walpole G, Ding J, Scanlon C, Ho L, Khoo RH, Huang C, Cook A, William L, Johnson CE.
PMID: 34252213
J Adv Nurs. 2022 Jan;78(1):142-153. doi: 10.1111/jan.14966. Epub 2021 Jul 12.

AIMS: Hyperactive delirium (HD) is a common and distressing symptom among palliative care patients. This study aimed to describe the characteristics of HD and associated symptoms among palliative care inpatients and evaluate relationships between HD development and symptom trajectories...

Perfluorocarbon Nanoemulsions Enhance Therapeutic siRNA Delivery in the Treatment of Pulmonary Fibrosis.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Ding L, Tang S, Tang W, Mosley DD, Yu A, Sil D, Romanova S, Bailey KL, Knoell DL, Wyatt TA, Oupický D.
PMID: 34994102
Adv Sci (Weinh). 2022 Jan 07;e2103676. doi: 10.1002/advs.202103676. Epub 2022 Jan 07.

Local pulmonary administration of therapeutic siRNA represents a promising approach to the treatment of lung fibrosis, which is currently hampered by inefficient delivery. Development of perfluorooctylbromide (PFOB) nanoemulsions as a way of improving the efficiency of pulmonary polycation-based delivery...

Placental mtDNA copy number and methylation in association with macrosomia in healthy pregnancy.

Placenta

Lin XJ, Xu XX, Zhang HX, Ding MM, Cao WQ, Yu QY, Wang YH, Yan HT, Yang XJ.
PMID: 34972066
Placenta. 2021 Dec 25;118:1-9. doi: 10.1016/j.placenta.2021.12.021. Epub 2021 Dec 25.

INTRODUCTION: Fetal growth and development depend on metabolic energy from placental mitochondria. However, the impact of placental mitochondria on the occurrence of macrosomia remains unclear. We aimed to explore the association between macrosomia without gestational diabetes mellitus (non-GDM) and...

Dual-Specificity Phosphatase 9 Regulates Cellular Proliferation and Predicts Recurrence After Surgery in Hepatocellular Carcinoma.

Hepatology communications

Chen K, Gorgen A, Ding A, Du L, Jiang K, Ding Y, Sapisochin G, Ghanekar A.
PMID: 34278178
Hepatol Commun. 2021 Mar 11;5(7):1310-1328. doi: 10.1002/hep4.1701. eCollection 2021 Jul.

Hepatocellular carcinoma (CC) is a common and deadly cancer with complex molecular pathogenesis. Little is known about dual-specificity phosphatases (DUSPs) in HCC. We investigated DUSP9 expression in human HCC, associations between DUSP9 and patient outcomes, and effects of altered...

Outcomes After Stereotactic Body Radiation Therapy as a Bridging Modality to Liver Transplantation for Hepatocellular Carcinoma.

Advances in radiation oncology

Garg R, Foley K, Movahedi B, Masciocchi MJ, Bledsoe JR, Ding L, Rava P, Fitzgerald TJ, Sioshansi S.
PMID: 33665482
Adv Radiat Oncol. 2020 Sep 14;6(1):100559. doi: 10.1016/j.adro.2020.08.016. eCollection 2021.

PURPOSE: For patients with hepatocellular carcinoma awaiting liver transplantation (LT), stereotactic body radiation therapy (SBRT) has emerged as a bridging treatment to ensure patients maintain priority status and eligibility per Milan criteria. In this study, we aimed to determine...

Paracrine mechanisms of endothelial progenitor cells in vascular repair.

Acta histochemica

Yan F, Liu X, Ding H, Zhang W.
PMID: 34929523
Acta Histochem. 2021 Dec 17;124(1):151833. doi: 10.1016/j.acthis.2021.151833. Epub 2021 Dec 17.

Endothelial progenitor cells (EPCs) play an important role in repairing damaged blood vessels and promoting neovascularization. However, the specific mechanism of EPCs promoting vascular repair is still unclear. Currently, there are two different views on the repair of damaged...

Systematic Approach to the Calcified Mitral Valve Apparatus at Time of Mitral Valve Replacement.

The Annals of thoracic surgery

Rahmouni K, Deng M, Gharibeh L, Elmistekawy E, Grau J, Mesana T, Chan V.
PMID: 33905731
Ann Thorac Surg. 2022 Jan;113(1):e67-e69. doi: 10.1016/j.athoracsur.2021.03.109. Epub 2021 Apr 24.

Mitral annular calcification (MAC) represents a surgical challenge to mitral valve replacement. The presence of MAC at the time of mitral valve replacement is associated with perivalvular leak and atrial-ventricular groove injury. Although percutaneous and hybrid approaches may offer...

Sirt6-mediated Nrf2/HO-1 activation alleviates angiotensin II-induced DNA DSBs and apoptosis in podocytes.

Food & function

Fan Y, Cheng J, Yang Q, Feng J, Hu J, Ren Z, Yang H, Yang D, Ding G.
PMID: 34240732
Food Funct. 2021 Sep 07;12(17):7867-7882. doi: 10.1039/d0fo03467c. Epub 2021 Jul 09.

Recent studies suggested that DNA double-strand breaks (DSBs) were associated with the pathogenesis of chronic kidney disease (CKD). The purpose of this investigation was to determine the role of Sirtuin6 (Sirt6), a histone deacetylase related to DNA damage repair,...

A chiming biological clock?.

Current biology : CB

Ding JM, Chen D, Weber ET, Faiman LE, Rea MA, Gillette MU.
PMID: 9259564
Curr Biol. 1997 Aug 01;7(8):R460. doi: 10.1016/s0960-9822(06)00232-6.
Free Article

No abstract available.

[Determination of inorganic anions and gluconate by two-dimensional ion chromatography].

Se pu = Chinese journal of chromatography

Chen A, Ding H, Fang L, Shi C.
PMID: 27097469
Se Pu. 2015 Dec;33(12):1333-7. doi: 10.3724/sp.j.1123.2015.08036.

A new two-dimensional ion chromatography method was developed to parallelly analyze two different types of samples with the application of valve switching technology-suppressed conductivity and pulsed amperometric analysis system, for concurrent determination of chloride, nitrite, sulfate, nitrate four inorganic...

Showing 9985 to 9996 of 12381 entries