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Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2).

Cellular and molecular gastroenterology and hepatology

Sharma RS, Harrison DJ, Kisielewski D, Cassidy DM, McNeilly AD, Gallagher JR, Walsh SV, Honda T, McCrimmon RJ, Dinkova-Kostova AT, Ashford MLJ, Dillon JF, Hayes JD.
PMID: 29552625
Cell Mol Gastroenterol Hepatol. 2017 Dec 13;5(3):367-398. doi: 10.1016/j.jcmgh.2017.11.016. eCollection 2018 Mar.

RESULTS: TBE-31 treatment reversed insulin resistance in HFFr-fed wild-type mice, but not in HFFr-fed Nrf2-null mice. TBE-31 treatment of HFFr-fed wild-type mice substantially decreased liver steatosis and expression of lipid synthesis genes, while increasing hepatic expression of fatty acid...

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Sharma RS, Harrison DJ, Kisielewski D, et al. Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2). Cell Mol Gastroenterol Hepatol. 2017;5(3):367-398doi: 10.1016/j.jcmgh.2017.11.016.
Sharma, R. S., Harrison, D. J., Kisielewski, D., Cassidy, D. M., McNeilly, A. D., Gallagher, J. R., Walsh, S. V., Honda, T., McCrimmon, R. J., Dinkova-Kostova, A. T., Ashford, M. L. J., Dillon, J. F., & Hayes, J. D. (2018). Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2). Cellular and molecular gastroenterology and hepatology, 5(3), 367-398. https://doi.org/10.1016/j.jcmgh.2017.11.016
Sharma, Ritu S, et al. "Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2)." Cellular and molecular gastroenterology and hepatology vol. 5,3 (2018): 367-398. doi: https://doi.org/10.1016/j.jcmgh.2017.11.016
Sharma RS, Harrison DJ, Kisielewski D, Cassidy DM, McNeilly AD, Gallagher JR, Walsh SV, Honda T, McCrimmon RJ, Dinkova-Kostova AT, Ashford MLJ, Dillon JF, Hayes JD. Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2). Cell Mol Gastroenterol Hepatol. 2017 Dec 13;5(3):367-398. doi: 10.1016/j.jcmgh.2017.11.016. eCollection 2018 Mar. PMID: 29552625; PMCID: PMC5852394.
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KEAP1 and Done? Targeting the NRF2 Pathway with Sulforaphane.

Trends in food science & technology

Dinkova-Kostova AT, Fahey JW, Kostov RV, Kensler TW.
PMID: 29242678
Trends Food Sci Technol. 2017 Nov;69:257-269. doi: 10.1016/j.tifs.2017.02.002. Epub 2017 Feb 16.

BACKGROUND: Since the re-discovery of sulforaphane in 1992 and the recognition of the bioactivity of this phytochemical, many studies have examined its mode of action in cells, animals and humans. Broccoli, especially as young sprouts, is a rich source...

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Dinkova-Kostova AT, Fahey JW, Kostov RV, et al. KEAP1 and Done? Targeting the NRF2 Pathway with Sulforaphane. Trends Food Sci Technol. 2017;69:257-269doi: 10.1016/j.tifs.2017.02.002.
Dinkova-Kostova, A. T., Fahey, J. W., Kostov, R. V., & Kensler, T. W. (2017). KEAP1 and Done? Targeting the NRF2 Pathway with Sulforaphane. Trends in food science & technology, 69257-269. https://doi.org/10.1016/j.tifs.2017.02.002
Dinkova-Kostova, Albena T, et al. "KEAP1 and Done? Targeting the NRF2 Pathway with Sulforaphane." Trends in food science & technology vol. 69 (2017): 257-269. doi: https://doi.org/10.1016/j.tifs.2017.02.002
Dinkova-Kostova AT, Fahey JW, Kostov RV, Kensler TW. KEAP1 and Done? Targeting the NRF2 Pathway with Sulforaphane. Trends Food Sci Technol. 2017 Nov;69:257-269. doi: 10.1016/j.tifs.2017.02.002. Epub 2017 Feb 16. PMID: 29242678; PMCID: PMC5725197.
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The isoquinoline PRL-295 increases the thermostability of Keap1 and disrupts its interaction with Nrf2.

iScience

Dayalan Naidu S, Suzuki T, Dikovskaya D, Knatko EV, Higgins M, Sato M, Novak M, Villegas JA, Moore TW, Yamamoto M, Dinkova-Kostova AT, Patterson E.
PMID: 35036882
iScience. 2021 Dec 27;25(1):103703. doi: 10.1016/j.isci.2021.103703. eCollection 2022 Jan 21.

Transcription factor Nrf2 and its negative regulator Keap1 orchestrate a cytoprotective response against oxidative, metabolic, and inflammatory stress. Keap1 is a drug target, with several small molecules in drug development. Here, we show that the isoquinoline PRL-295 increased Keap1...

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Dayalan Naidu S, Suzuki T, Dikovskaya D, et al. The isoquinoline PRL-295 increases the thermostability of Keap1 and disrupts its interaction with Nrf2. iScience. 2021;25(1):103703doi: 10.1016/j.isci.2021.103703.
Dayalan Naidu, S., Suzuki, T., Dikovskaya, D., Knatko, E. V., Higgins, M., Sato, M., Novak, M., Villegas, J. A., Moore, T. W., Yamamoto, M., Dinkova-Kostova, A. T., & Patterson, E. (2022). The isoquinoline PRL-295 increases the thermostability of Keap1 and disrupts its interaction with Nrf2. iScience, 25(1), 103703. https://doi.org/10.1016/j.isci.2021.103703
Dayalan Naidu, Sharadha, et al. "The isoquinoline PRL-295 increases the thermostability of Keap1 and disrupts its interaction with Nrf2." iScience vol. 25,1 (2022): 103703. doi: https://doi.org/10.1016/j.isci.2021.103703
Dayalan Naidu S, Suzuki T, Dikovskaya D, Knatko EV, Higgins M, Sato M, Novak M, Villegas JA, Moore TW, Yamamoto M, Dinkova-Kostova AT, Patterson E. The isoquinoline PRL-295 increases the thermostability of Keap1 and disrupts its interaction with Nrf2. iScience. 2021 Dec 27;25(1):103703. doi: 10.1016/j.isci.2021.103703. eCollection 2022 Jan 21. PMID: 35036882; PMCID: PMC8749459.
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Nrf2 activation does not affect adenoma development in a mouse model of colorectal cancer.

Communications biology

Knatko EV, Castro C, Higgins M, Zhang Y, Honda T, Henderson CJ, Wolf CR, Griffin JL, Dinkova-Kostova AT.
PMID: 34526660
Commun Biol. 2021 Sep 15;4(1):1081. doi: 10.1038/s42003-021-02552-w.

Transcription factor nuclear factor erythroid 2 p45-related factor 2 (Nrf2) and its main negative regulator, Kelch-like ECH associated protein 1 (Keap1), are at the interface between redox and intermediary metabolism. Nrf2 activation is protective in models of human disease...

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Knatko EV, Castro C, Higgins M, et al. Nrf2 activation does not affect adenoma development in a mouse model of colorectal cancer. Commun Biol. 2021;4(1):1081doi: 10.1038/s42003-021-02552-w.
Knatko, E. V., Castro, C., Higgins, M., Zhang, Y., Honda, T., Henderson, C. J., Wolf, C. R., Griffin, J. L., & Dinkova-Kostova, A. T. (2021). Nrf2 activation does not affect adenoma development in a mouse model of colorectal cancer. Communications biology, 4(1), 1081. https://doi.org/10.1038/s42003-021-02552-w
Knatko, Elena V, et al. "Nrf2 activation does not affect adenoma development in a mouse model of colorectal cancer." Communications biology vol. 4,1 (2021): 1081. doi: https://doi.org/10.1038/s42003-021-02552-w
Knatko EV, Castro C, Higgins M, Zhang Y, Honda T, Henderson CJ, Wolf CR, Griffin JL, Dinkova-Kostova AT. Nrf2 activation does not affect adenoma development in a mouse model of colorectal cancer. Commun Biol. 2021 Sep 15;4(1):1081. doi: 10.1038/s42003-021-02552-w. PMID: 34526660; PMCID: PMC8443638.
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Showing 13 to 16 of 16 entries