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Showing 709 to 715 of 715 entries
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Sex Differences in End-Stage Ankle Arthritis and Following Total Ankle Replacement or Ankle Arthrodesis.

The Journal of bone and joint surgery. American volume

Dodd A, Pinsker E, Younger ASE, Penner MJ, Wing KJ, Dryden PJ, Glazebrook M, Daniels TR.
PMID: 35007215
J Bone Joint Surg Am. 2021 Nov 01; doi: 10.2106/JBJS.21.00287. Epub 2021 Nov 01.

BACKGROUND: We investigated the influence of sex on patient-reported outcomes preoperatively and following total ankle replacement and ankle arthrodesis.METHODS: Patients who had undergone total ankle replacement or ankle arthrodesis for the treatment of end-stage ankle arthritis and who had...

Conjugation to PEG as a Strategy to Limit the Uptake of Drugs by the Placenta: Potential Applications for Drug Administration in Pregnancy.

Molecular pharmaceutics

Dodd A, Natfji AA, Evangelinos A, Grigoletto A, Pasut G, Beards F, Renshall L, Osborn HMI, Greco F, Harris LK.
PMID: 34842438
Mol Pharm. 2021 Nov 29; doi: 10.1021/acs.molpharmaceut.1c00498. Epub 2021 Nov 29.

Here, we evaluated the feasibility of non-prodrug PEG-drug conjugates to decrease the accumulation of drugs within the placental tissues. The results showed that PEG was biocompatible with the human placenta with no alteration of the basal rate of proliferation...

Oxidative ornithine metabolism supports non-inflammatory C. difficile colonization.

Nature metabolism

Pruss KM, Enam F, Battaglioli E, DeFeo M, Diaz OR, Higginbottom SK, Fischer CR, Hryckowian AJ, Van Treuren W, Dodd D, Kashyap P, Sonnenburg JL.
PMID: 34992297
Nat Metab. 2022 Jan 06; doi: 10.1038/s42255-021-00506-4. Epub 2022 Jan 06.

The enteric pathogen Clostridioides difficile (Cd) is responsible for a toxin-mediated infection that causes more than 200,000 recorded hospitalizations and 13,000 deaths in the United States every year

Clinical and genomic characterisation of mismatch repair deficient pancreatic adenocarcinoma.

Gut

Grant RC, Denroche R, Jang GH, Nowak KM, Zhang A, Borgida A, Holter S, Topham JT, Wilson J, Dodd A, Jang R, Prince R, Karasinska JM, Schaeffer DF, Wang Y, Zogopoulos G, Berry S, Simeone D, Renouf DJ, Notta F, O'Kane G, Knox J, Fischer S, Gallinger S.
PMID: 32933947
Gut. 2021 Oct;70(10):1894-1903. doi: 10.1136/gutjnl-2020-320730. Epub 2020 Sep 15.

OBJECTIVE: To describe the clinical, pathological and genomic characteristics of pancreatic cancer with DNA mismatch repair deficiency (MMRD) and proficiency (MMRP).DESIGN: We identified patients with MMRD and MMRP pancreatic cancer in a clinical cohort (N=1213, 519 with genetic testing,...

Evidence update for the treatment of anaphylaxis.

Resuscitation

Dodd A, Hughes A, Sargant N, Whyte AF, Soar J, Turner PJ.
PMID: 33895231
Resuscitation. 2021 Apr 23;163:86-96. doi: 10.1016/j.resuscitation.2021.04.010. Epub 2021 Apr 23.

The Resuscitation Council UK has updated its Guideline for healthcare providers on the Emergency treatment of anaphylaxis. As part of this process, an evidence review was undertaken by the Guideline Working Group, using an internationally-accepted approach for adoption, adaptation,...

Nanotransfection-based vasculogenic cell reprogramming drives functional recovery in a mouse model of ischemic stroke.

Science advances

Lemmerman LR, Balch MHH, Moore JT, Alzate-Correa D, Rincon-Benavides MA, Salazar-Puerta A, Gnyawali S, Harris HN, Lawrence W, Ortega-Pineda L, Wilch L, Risser IB, Maxwell AJ, Duarte-Sanmiguel S, Dodd D, Guio-Vega GP, McTigue DM, Arnold WD, Nimjee SM, Sen CK, Khanna S, Rink C, Higuita-Castro N, Gallego-Perez D.
PMID: 33741587
Sci Adv. 2021 Mar 19;7(12). doi: 10.1126/sciadv.abd4735. Print 2021 Mar.

Ischemic stroke causes vascular and neuronal tissue deficiencies that could lead to substantial functional impairment and/or death. Although progenitor-based vasculogenic cell therapies have shown promise as a potential rescue strategy following ischemic stroke, current approaches face major hurdles. Here,...

Comparison of five-year clinical outcomes of 524 cemented and cementless medial unicompartmental knee replacements.

The Knee

Martin B, Rahman A, Jenkins C, Mohammad H, Barker K, Dodd C, Jackson W, Price A, Mellon S, Murray D.
PMID: 34883332
Knee. 2021 Dec 06;34:89-97. doi: 10.1016/j.knee.2021.08.015. Epub 2021 Dec 06.

AIM: To compare the outcomes of cemented and cementless Unicompartmental Knee Replacements (UKR) at 5 years after surgery.METHODS: 262 cemented and 262 cementless medial mobile-bearing UKR, implanted by four high-volume surgeons using identical indications and surgical techniques, were reviewed...

Showing 709 to 715 of 715 entries