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HDAC4 inhibition disrupts TET2 function in high-risk MDS and AML.

Aging

Huang F, Sun J, Chen W, He X, Zhu Y, Dong H, Wang H, Li Z, Zhang L, Khaled S, Marcucci G, Huang J, Li L.
PMID: 32726753
Aging (Albany NY). 2020 Jul 29;12(17):16759-16774. doi: 10.18632/aging.103605. Epub 2020 Jul 29.

Aberrant DNA methylation often silences transcription of tumor-suppressor genes and is considered a hallmark of myeloid neoplasms. Similarly, histone deacetylation represses transcription of genes responsible for cell differentiation/death. A previous clinical study suggested potential pharmacodynamic antagonism between histone deacetylase...

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Huang F, Sun J, Chen W, et al. HDAC4 inhibition disrupts TET2 function in high-risk MDS and AML. Aging (Albany NY). 2020;12(17):16759-16774doi: 10.18632/aging.103605.
Huang, F., Sun, J., Chen, W., He, X., Zhu, Y., Dong, H., Wang, H., Li, Z., Zhang, L., Khaled, S., Marcucci, G., Huang, J., & Li, L. (2020). HDAC4 inhibition disrupts TET2 function in high-risk MDS and AML. Aging, 12(17), 16759-16774. https://doi.org/10.18632/aging.103605
Huang, Feiteng, et al. "HDAC4 inhibition disrupts TET2 function in high-risk MDS and AML." Aging vol. 12,17 (2020): 16759-16774. doi: https://doi.org/10.18632/aging.103605
Huang F, Sun J, Chen W, He X, Zhu Y, Dong H, Wang H, Li Z, Zhang L, Khaled S, Marcucci G, Huang J, Li L. HDAC4 inhibition disrupts TET2 function in high-risk MDS and AML. Aging (Albany NY). 2020 Jul 29;12(17):16759-16774. doi: 10.18632/aging.103605. Epub 2020 Jul 29. PMID: 32726753; PMCID: PMC7521497.
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Dexmedetomidine maintains blood-brain barrier integrity by inhibiting Drp1-related endothelial mitochondrial dysfunction in ischemic stroke.

Acta biochimica et biophysica Sinica

Zhou W, Zhang Y, Jiao Y, Yin W, Dong H, Xu S, Tang D, Jiang J, Shao J, Wang Z, Yu W.
PMID: 34244711
Acta Biochim Biophys Sin (Shanghai). 2021 Aug 31;53(9):1177-1188. doi: 10.1093/abbs/gmab092.

Stroke is the second leading cause of death and long-term disability worldwide, which lacks effective treatment. Perioperative stroke is associated with much higher rates of mortality and disability. The neuroprotective role of dexmedetomidine (Dex), a highly selective agonist of...

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Zhou W, Zhang Y, Jiao Y, et al. Dexmedetomidine maintains blood-brain barrier integrity by inhibiting Drp1-related endothelial mitochondrial dysfunction in ischemic stroke. Acta Biochim Biophys Sin (Shanghai). 2021;53(9):1177-1188doi: 10.1093/abbs/gmab092.
Zhou, W., Zhang, Y., Jiao, Y., Yin, W., Dong, H., Xu, S., Tang, D., Jiang, J., Shao, J., Wang, Z., & Yu, W. (2021). Dexmedetomidine maintains blood-brain barrier integrity by inhibiting Drp1-related endothelial mitochondrial dysfunction in ischemic stroke. Acta biochimica et biophysica Sinica, 53(9), 1177-1188. https://doi.org/10.1093/abbs/gmab092
Zhou, Wei, et al. "Dexmedetomidine maintains blood-brain barrier integrity by inhibiting Drp1-related endothelial mitochondrial dysfunction in ischemic stroke." Acta biochimica et biophysica Sinica vol. 53,9 (2021): 1177-1188. doi: https://doi.org/10.1093/abbs/gmab092
Zhou W, Zhang Y, Jiao Y, Yin W, Dong H, Xu S, Tang D, Jiang J, Shao J, Wang Z, Yu W. Dexmedetomidine maintains blood-brain barrier integrity by inhibiting Drp1-related endothelial mitochondrial dysfunction in ischemic stroke. Acta Biochim Biophys Sin (Shanghai). 2021 Aug 31;53(9):1177-1188. doi: 10.1093/abbs/gmab092. PMID: 34244711.
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Residential greenness attenuated associations of long-term exposure to air pollution with biomarkers of advanced fibrosis.

Environmental science and pollution research international

Hou J, Liu X, Zuo T, Tu R, Dong X, Li R, Pan M, Chen R, Yin S, Hu K, Mao Z, Huo W, Guo Y, Li S, Chen G, Wang C.
PMID: 34342826
Environ Sci Pollut Res Int. 2022 Jan;29(1):977-988. doi: 10.1007/s11356-021-15676-7. Epub 2021 Aug 03.

Long-term exposure to air pollutants and residential greenness related to advanced fibrosis have been sparsely studied in low- and middle-income countries. A total of 29883 participants were selected from a cross-sectional survey of the Henan Rural Cohort. Concentrations of...

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Hou J, Liu X, Zuo T, et al. Residential greenness attenuated associations of long-term exposure to air pollution with biomarkers of advanced fibrosis. Environ Sci Pollut Res Int. 2021;29(1):977-988doi: 10.1007/s11356-021-15676-7.
Hou, J., Liu, X., Zuo, T., Tu, R., Dong, X., Li, R., Pan, M., Chen, R., Yin, S., Hu, K., Mao, Z., Huo, W., Guo, Y., Li, S., Chen, G., & Wang, C. (2022). Residential greenness attenuated associations of long-term exposure to air pollution with biomarkers of advanced fibrosis. Environmental science and pollution research international, 29(1), 977-988. https://doi.org/10.1007/s11356-021-15676-7
Hou, Jian, et al. "Residential greenness attenuated associations of long-term exposure to air pollution with biomarkers of advanced fibrosis." Environmental science and pollution research international vol. 29,1 (2022): 977-988. doi: https://doi.org/10.1007/s11356-021-15676-7
Hou J, Liu X, Zuo T, Tu R, Dong X, Li R, Pan M, Chen R, Yin S, Hu K, Mao Z, Huo W, Guo Y, Li S, Chen G, Wang C. Residential greenness attenuated associations of long-term exposure to air pollution with biomarkers of advanced fibrosis. Environ Sci Pollut Res Int. 2022 Jan;29(1):977-988. doi: 10.1007/s11356-021-15676-7. Epub 2021 Aug 03. PMID: 34342826.
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Marine Bromophenol Bis(2,3,6-Tribromo-4,5-Dihydroxybenzyl)ether Inhibits Angiogenesis in Human Umbilical Vein Endothelial Cells and Reduces Vasculogenic Mimicry in Human Lung Cancer A549 Cells.

Marine drugs

Dong S, Chen Z, Wang L, Liu Y, Stagos D, Lin X, Liu M.
PMID: 34822512
Mar Drugs. 2021 Nov 16;19(11). doi: 10.3390/md19110641.

Angiogenesis, including the growth of new capillary blood vessels from existing ones and the malignant tumors cells formed vasculogenic mimicry, is quite important for the tumor metastasis. Anti-angiogenesis is one of the significant therapies in tumor treatment, while the...

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Dong S, Chen Z, Wang L, et al. Marine Bromophenol Bis(2,3,6-Tribromo-4,5-Dihydroxybenzyl)ether Inhibits Angiogenesis in Human Umbilical Vein Endothelial Cells and Reduces Vasculogenic Mimicry in Human Lung Cancer A549 Cells. Mar Drugs. 2021;19(11)doi: 10.3390/md19110641.
Dong, S., Chen, Z., Wang, L., Liu, Y., Stagos, D., Lin, X., & Liu, M. (2021). Marine Bromophenol Bis(2,3,6-Tribromo-4,5-Dihydroxybenzyl)ether Inhibits Angiogenesis in Human Umbilical Vein Endothelial Cells and Reduces Vasculogenic Mimicry in Human Lung Cancer A549 Cells. Marine drugs, 19(11), . https://doi.org/10.3390/md19110641
Dong, Songtao, et al. "Marine Bromophenol Bis(2,3,6-Tribromo-4,5-Dihydroxybenzyl)ether Inhibits Angiogenesis in Human Umbilical Vein Endothelial Cells and Reduces Vasculogenic Mimicry in Human Lung Cancer A549 Cells." Marine drugs vol. 19,11 (2021). doi: https://doi.org/10.3390/md19110641
Dong S, Chen Z, Wang L, Liu Y, Stagos D, Lin X, Liu M. Marine Bromophenol Bis(2,3,6-Tribromo-4,5-Dihydroxybenzyl)ether Inhibits Angiogenesis in Human Umbilical Vein Endothelial Cells and Reduces Vasculogenic Mimicry in Human Lung Cancer A549 Cells. Mar Drugs. 2021 Nov 16;19(11). doi: 10.3390/md19110641. PMID: 34822512; PMCID: PMC8617710.
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Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Attenuate Oxygen-Glucose Deprivation/Reperfusion-Induced Microglial Pyroptosis by Promoting FOXO3a-Dependent Mitophagy.

Oxidative medicine and cellular longevity

Hu Z, Yuan Y, Zhang X, Lu Y, Dong N, Jiang X, Xu J, Zheng D.
PMID: 34765084
Oxid Med Cell Longev. 2021 Nov 02;2021:6219715. doi: 10.1155/2021/6219715. eCollection 2021.

BACKGROUND: Mesenchymal stem cell-derived exosomes (MSC-exos) have been recognized as a promising therapeutic strategy for neonatal hypoxic-ischemic brain damage (HIBD). Recently, microglial pyroptosis was shown to play a vital role in the progression of neonatal HIBD. However, whether MSC-exos...

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Hu Z, Yuan Y, Zhang X, et al. Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Attenuate Oxygen-Glucose Deprivation/Reperfusion-Induced Microglial Pyroptosis by Promoting FOXO3a-Dependent Mitophagy. Oxid Med Cell Longev. 2021;2021:6219715doi: 10.1155/2021/6219715.
Hu, Z., Yuan, Y., Zhang, X., Lu, Y., Dong, N., Jiang, X., Xu, J., & Zheng, D. (2021). Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Attenuate Oxygen-Glucose Deprivation/Reperfusion-Induced Microglial Pyroptosis by Promoting FOXO3a-Dependent Mitophagy. Oxidative medicine and cellular longevity, 20216219715. https://doi.org/10.1155/2021/6219715
Hu, Zhenzhen, et al. "Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Attenuate Oxygen-Glucose Deprivation/Reperfusion-Induced Microglial Pyroptosis by Promoting FOXO3a-Dependent Mitophagy." Oxidative medicine and cellular longevity vol. 2021 (2021): 6219715. doi: https://doi.org/10.1155/2021/6219715
Hu Z, Yuan Y, Zhang X, Lu Y, Dong N, Jiang X, Xu J, Zheng D. Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Attenuate Oxygen-Glucose Deprivation/Reperfusion-Induced Microglial Pyroptosis by Promoting FOXO3a-Dependent Mitophagy. Oxid Med Cell Longev. 2021 Nov 02;2021:6219715. doi: 10.1155/2021/6219715. eCollection 2021. PMID: 34765084; PMCID: PMC8577931.
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Nucleocapsid mutations R203K/G204R increase the infectivity, fitness, and virulence of SARS-CoV-2.

Cell host & microbe

Wu H, Xing N, Meng K, Fu B, Xue W, Dong P, Tang W, Xiao Y, Liu G, Luo H, Zhu W, Lin X, Meng G, Zhu Z.
PMID: 34822776
Cell Host Microbe. 2021 Dec 08;29(12):1788-1801.e6. doi: 10.1016/j.chom.2021.11.005. Epub 2021 Nov 13.

Previous work found that the co-occurring mutations R203K/G204R on the SARS-CoV-2 nucleocapsid (N) protein are increasing in frequency among emerging variants of concern or interest. Through a combination of in silico analyses, this study demonstrates that R203K/G204R are adaptive,...

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Wu H, Xing N, Meng K, et al. Nucleocapsid mutations R203K/G204R increase the infectivity, fitness, and virulence of SARS-CoV-2. Cell Host Microbe. 2021;29(12):1788-1801.e6doi: 10.1016/j.chom.2021.11.005.
Wu, H., Xing, N., Meng, K., Fu, B., Xue, W., Dong, P., Tang, W., Xiao, Y., Liu, G., Luo, H., Zhu, W., Lin, X., Meng, G., & Zhu, Z. (2021). Nucleocapsid mutations R203K/G204R increase the infectivity, fitness, and virulence of SARS-CoV-2. Cell host & microbe, 29(12), 1788-1801.e6. https://doi.org/10.1016/j.chom.2021.11.005
Wu, Haibo, et al. "Nucleocapsid mutations R203K/G204R increase the infectivity, fitness, and virulence of SARS-CoV-2." Cell host & microbe vol. 29,12 (2021): 1788-1801.e6. doi: https://doi.org/10.1016/j.chom.2021.11.005
Wu H, Xing N, Meng K, Fu B, Xue W, Dong P, Tang W, Xiao Y, Liu G, Luo H, Zhu W, Lin X, Meng G, Zhu Z. Nucleocapsid mutations R203K/G204R increase the infectivity, fitness, and virulence of SARS-CoV-2. Cell Host Microbe. 2021 Dec 08;29(12):1788-1801.e6. doi: 10.1016/j.chom.2021.11.005. Epub 2021 Nov 13. PMID: 34822776; PMCID: PMC8590493.
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[No title available]

Frontiers in bioengineering and biotechnology

Li JF, Li HF, Yao SM, Zhao MJ, Dong WX, Liang SK, Xu XY.
PMID: 34765597
Front Bioeng Biotechnol. 2021 Oct 26;9:773104. doi: 10.3389/fbioe.2021.773104. eCollection 2021.

Sophorolipids (SLs) are homologous microbial secondary metabolites produced by

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Li JF, Li HF, Yao SM, et al. . Front Bioeng Biotechnol. 2021;9:773104doi: 10.3389/fbioe.2021.773104.
Li, J. F., Li, H. F., Yao, S. M., Zhao, M. J., Dong, W. X., Liang, S. K., & Xu, X. Y. (2021). . Frontiers in bioengineering and biotechnology, 9773104. https://doi.org/10.3389/fbioe.2021.773104
Li, Jun-Feng, et al. "." Frontiers in bioengineering and biotechnology vol. 9 (2021): 773104. doi: https://doi.org/10.3389/fbioe.2021.773104
Li JF, Li HF, Yao SM, Zhao MJ, Dong WX, Liang SK, Xu XY. . Front Bioeng Biotechnol. 2021 Oct 26;9:773104. doi: 10.3389/fbioe.2021.773104. eCollection 2021. PMID: 34765597; PMCID: PMC8576176.
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Environmental allergens house dust mite-induced asthma is associated with ferroptosis in the lungs.

Experimental and therapeutic medicine

Tang W, Dong M, Teng F, Cui J, Zhu X, Wang W, Wuniqiemu T, Qin J, Yi, Wang S, Dong J, Wei Y.
PMID: 34765024
Exp Ther Med. 2021 Dec;22(6):1483. doi: 10.3892/etm.2021.10918. Epub 2021 Oct 26.

Previous studies have indicated that allergens such as house dust mites (HDM) in the environment can induce allergic asthma. Ferroptosis is a newly discovered form of regulatory cell death characterized by aberrant lipid peroxidation and the accumulation of reactive...

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Tang W, Dong M, Teng F, et al. Environmental allergens house dust mite-induced asthma is associated with ferroptosis in the lungs. Exp Ther Med. 2021;22(6):1483doi: 10.3892/etm.2021.10918.
Tang, W., Dong, M., Teng, F., Cui, J., Zhu, X., Wang, W., Wuniqiemu, T., Qin, J., Yi, Wang, S., Dong, J., & Wei, Y. (2021). Environmental allergens house dust mite-induced asthma is associated with ferroptosis in the lungs. Experimental and therapeutic medicine, 22(6), 1483. https://doi.org/10.3892/etm.2021.10918
Tang, Weifeng, et al. "Environmental allergens house dust mite-induced asthma is associated with ferroptosis in the lungs." Experimental and therapeutic medicine vol. 22,6 (2021): 1483. doi: https://doi.org/10.3892/etm.2021.10918
Tang W, Dong M, Teng F, Cui J, Zhu X, Wang W, Wuniqiemu T, Qin J, Yi, Wang S, Dong J, Wei Y. Environmental allergens house dust mite-induced asthma is associated with ferroptosis in the lungs. Exp Ther Med. 2021 Dec;22(6):1483. doi: 10.3892/etm.2021.10918. Epub 2021 Oct 26. PMID: 34765024; PMCID: PMC8576623.
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NF-κB-dependent IRF1 activation programs cDC1 dendritic cells to drive antitumor immunity.

Science immunology

Ghislat G, Cheema AS, Baudoin E, Verthuy C, Ballester PJ, Crozat K, Attaf N, Dong C, Milpied P, Malissen B, Auphan-Anezin N, Manh TPV, Dalod M, Lawrence T.
PMID: 34244313
Sci Immunol. 2021 Jul 09;6(61). doi: 10.1126/sciimmunol.abg3570.

Conventional type 1 dendritic cells (cDC1s) are critical for antitumor immunity. They acquire antigens from dying tumor cells and cross-present them to CD8

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Ghislat G, Cheema AS, Baudoin E, et al. NF-κB-dependent IRF1 activation programs cDC1 dendritic cells to drive antitumor immunity. Sci Immunol. 2021;6(61)doi: 10.1126/sciimmunol.abg3570.
Ghislat, G., Cheema, A. S., Baudoin, E., Verthuy, C., Ballester, P. J., Crozat, K., Attaf, N., Dong, C., Milpied, P., Malissen, B., Auphan-Anezin, N., Manh, T. P. V., Dalod, M., & Lawrence, T. (2021). NF-κB-dependent IRF1 activation programs cDC1 dendritic cells to drive antitumor immunity. Science immunology, 6(61), . https://doi.org/10.1126/sciimmunol.abg3570
Ghislat, Ghita, et al. "NF-κB-dependent IRF1 activation programs cDC1 dendritic cells to drive antitumor immunity." Science immunology vol. 6,61 (2021). doi: https://doi.org/10.1126/sciimmunol.abg3570
Ghislat G, Cheema AS, Baudoin E, Verthuy C, Ballester PJ, Crozat K, Attaf N, Dong C, Milpied P, Malissen B, Auphan-Anezin N, Manh TPV, Dalod M, Lawrence T. NF-κB-dependent IRF1 activation programs cDC1 dendritic cells to drive antitumor immunity. Sci Immunol. 2021 Jul 09;6(61). doi: 10.1126/sciimmunol.abg3570. PMID: 34244313.
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The Prevalence and Control of Type 2 Diabetes Mellitus in Residents of a Rural Town, Shandong Province, China.

Diabetes, metabolic syndrome and obesity : targets and therapy

Wei M, Dong L, Wang F, Cui K, Ma D, Yang N, Li Y.
PMID: 34795495
Diabetes Metab Syndr Obes. 2021 Nov 11;14:4505-4512. doi: 10.2147/DMSO.S338728. eCollection 2021.

OBJECTIVE: To understand the prevalence and control of type 2 diabetes mellitus (T2DM) in a rural area, a cross-sectional study was carried out.METHODS: Blood glucose was determined in residents over 60 years during the National Basic Public Health Service...

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Wei M, Dong L, Wang F, et al. The Prevalence and Control of Type 2 Diabetes Mellitus in Residents of a Rural Town, Shandong Province, China. Diabetes Metab Syndr Obes. 2021;14:4505-4512doi: 10.2147/DMSO.S338728.
Wei, M., Dong, L., Wang, F., Cui, K., Ma, D., Yang, N., & Li, Y. (2021). The Prevalence and Control of Type 2 Diabetes Mellitus in Residents of a Rural Town, Shandong Province, China. Diabetes, metabolic syndrome and obesity : targets and therapy, 144505-4512. https://doi.org/10.2147/DMSO.S338728
Wei, Maoti, et al. "The Prevalence and Control of Type 2 Diabetes Mellitus in Residents of a Rural Town, Shandong Province, China." Diabetes, metabolic syndrome and obesity : targets and therapy vol. 14 (2021): 4505-4512. doi: https://doi.org/10.2147/DMSO.S338728
Wei M, Dong L, Wang F, Cui K, Ma D, Yang N, Li Y. The Prevalence and Control of Type 2 Diabetes Mellitus in Residents of a Rural Town, Shandong Province, China. Diabetes Metab Syndr Obes. 2021 Nov 11;14:4505-4512. doi: 10.2147/DMSO.S338728. eCollection 2021. PMID: 34795495; PMCID: PMC8593350.
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Effects of respiratory training on ventilation potential and extubation time in patients with tracheotomy: A protocol for systematic review and meta-analysis.

Medicine

Hu T, Jiang J, Deng X, Xiang W, Tan C.
PMID: 34797295
Medicine (Baltimore). 2021 Nov 19;100(46):e27704. doi: 10.1097/MD.0000000000027704.

BACKGROUND: In the early treatment of critical patients, tracheotomy is often performed to improve ventilation. Clinical practices usually start respiratory training after the artificial airway is removed. It is still controversial whether respiratory training during tube occlusion has effects...

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Hu T, Jiang J, Deng X, et al. Effects of respiratory training on ventilation potential and extubation time in patients with tracheotomy: A protocol for systematic review and meta-analysis. Medicine (Baltimore). 2021;100(46):e27704doi: 10.1097/MD.0000000000027704.
Hu, T., Jiang, J., Deng, X., Xiang, W., & Tan, C. (2021). Effects of respiratory training on ventilation potential and extubation time in patients with tracheotomy: A protocol for systematic review and meta-analysis. Medicine, 100(46), e27704. https://doi.org/10.1097/MD.0000000000027704
Hu, Tingting, et al. "Effects of respiratory training on ventilation potential and extubation time in patients with tracheotomy: A protocol for systematic review and meta-analysis." Medicine vol. 100,46 (2021): e27704. doi: https://doi.org/10.1097/MD.0000000000027704
Hu T, Jiang J, Deng X, Xiang W, Tan C. Effects of respiratory training on ventilation potential and extubation time in patients with tracheotomy: A protocol for systematic review and meta-analysis. Medicine (Baltimore). 2021 Nov 19;100(46):e27704. doi: 10.1097/MD.0000000000027704. PMID: 34797295; PMCID: PMC8601331.
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Super-elasticity at 4 K of covalently crosslinked polyimide aerogels with negative Poisson's ratio.

Nature communications

Cheng Y, Zhang X, Qin Y, Dong P, Yao W, Matz J, Ajayan PM, Shen J, Ye M.
PMID: 34215741
Nat Commun. 2021 Jul 02;12(1):4092. doi: 10.1038/s41467-021-24388-y.

The deep cryogenic temperatures encountered in aerospace present significant challenges for the performance of elastic materials in spacecraft and related apparatus. Reported elastic carbon or ceramic aerogels overcome the low-temperature brittleness in conventional elastic polymers. However, complicated fabrication process...

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Cheng Y, Zhang X, Qin Y, et al. Super-elasticity at 4 K of covalently crosslinked polyimide aerogels with negative Poisson's ratio. Nat Commun. 2021;12(1):4092doi: 10.1038/s41467-021-24388-y.
Cheng, Y., Zhang, X., Qin, Y., Dong, P., Yao, W., Matz, J., Ajayan, P. M., Shen, J., & Ye, M. (2021). Super-elasticity at 4 K of covalently crosslinked polyimide aerogels with negative Poisson's ratio. Nature communications, 12(1), 4092. https://doi.org/10.1038/s41467-021-24388-y
Cheng, Yang, et al. "Super-elasticity at 4 K of covalently crosslinked polyimide aerogels with negative Poisson's ratio." Nature communications vol. 12,1 (2021): 4092. doi: https://doi.org/10.1038/s41467-021-24388-y
Cheng Y, Zhang X, Qin Y, Dong P, Yao W, Matz J, Ajayan PM, Shen J, Ye M. Super-elasticity at 4 K of covalently crosslinked polyimide aerogels with negative Poisson's ratio. Nat Commun. 2021 Jul 02;12(1):4092. doi: 10.1038/s41467-021-24388-y. PMID: 34215741; PMCID: PMC8253740.
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