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Addressing Common Challenges in the Implementation of Collaborative Care for Mental Health: The Penn Integrated Care Program.

Annals of family medicine

Wolk CB, Last BS, Livesey C, Oquendo MA, Press MJ, Mandell DS, Ingram E, Futterer AC, Kinkler GP, Oslin DW.
PMID: 33685876
Ann Fam Med. 2021 Mar-Apr;19(2):148-156. doi: 10.1370/afm.2651.

PURPOSE: We developed and implemented a new model of collaborative care that includes a triage and referral management system. We present initial implementation metrics using the Reach, Effectiveness, Adoption, Implementation, Maintenance (RE-AIM) framework.METHODS: Primary care clinicians in 8 practices...

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Wolk CB, Last BS, Livesey C, et al. Addressing Common Challenges in the Implementation of Collaborative Care for Mental Health: The Penn Integrated Care Program. Ann Fam Med. 2021;19(2):148-156doi: 10.1370/afm.2651.
Wolk, C. B., Last, B. S., Livesey, C., Oquendo, M. A., Press, M. J., Mandell, D. S., Ingram, E., Futterer, A. C., Kinkler, G. P., & Oslin, D. W. (2021). Addressing Common Challenges in the Implementation of Collaborative Care for Mental Health: The Penn Integrated Care Program. Annals of family medicine, 19(2), 148-156. https://doi.org/10.1370/afm.2651
Wolk, Courtney Benjamin, et al. "Addressing Common Challenges in the Implementation of Collaborative Care for Mental Health: The Penn Integrated Care Program." Annals of family medicine vol. 19,2 (2021): 148-156. doi: https://doi.org/10.1370/afm.2651
Wolk CB, Last BS, Livesey C, Oquendo MA, Press MJ, Mandell DS, Ingram E, Futterer AC, Kinkler GP, Oslin DW. Addressing Common Challenges in the Implementation of Collaborative Care for Mental Health: The Penn Integrated Care Program. Ann Fam Med. 2021 Mar-Apr;19(2):148-156. doi: 10.1370/afm.2651. PMID: 33685876; PMCID: PMC7939709.
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An outbreak of vancomycin-resistant Enterococcus faecium in an acute care pediatric hospital: Lessons from environmental screening and a case-control study.

The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale

Drews SJ, Richardson SE, Wray R, Freeman R, Goldman C, Streitenberger L, Stevens D, Goia C, Kovach D, Brophy J, Matlow AG.
PMID: 19412380
Can J Infect Dis Med Microbiol. 2008 May;19(3):233-6. doi: 10.1155/2008/727062.

BACKGROUND: The present study describes a vancomycin-resistant enterococci (VRE) outbreak investigation and a case-control study to identify risk factors for VRE acquisition in a tertiary care pediatric hospital.OBJECTIVE: To report an outbreak investigation and a case-control study to identify...

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Drews SJ, Richardson SE, Wray R, et al. An outbreak of vancomycin-resistant Enterococcus faecium in an acute care pediatric hospital: Lessons from environmental screening and a case-control study. Can J Infect Dis Med Microbiol. 2008;19(3):233-6doi: 10.1155/2008/727062.
Drews, S. J., Richardson, S. E., Wray, R., Freeman, R., Goldman, C., Streitenberger, L., Stevens, D., Goia, C., Kovach, D., Brophy, J., & Matlow, A. G. (2008). An outbreak of vancomycin-resistant Enterococcus faecium in an acute care pediatric hospital: Lessons from environmental screening and a case-control study. The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale, 19(3), 233-6. https://doi.org/10.1155/2008/727062
Drews, Steven J, et al. "An outbreak of vancomycin-resistant Enterococcus faecium in an acute care pediatric hospital: Lessons from environmental screening and a case-control study." The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale vol. 19,3 (2008): 233-6. doi: https://doi.org/10.1155/2008/727062
Drews SJ, Richardson SE, Wray R, Freeman R, Goldman C, Streitenberger L, Stevens D, Goia C, Kovach D, Brophy J, Matlow AG. An outbreak of vancomycin-resistant Enterococcus faecium in an acute care pediatric hospital: Lessons from environmental screening and a case-control study. Can J Infect Dis Med Microbiol. 2008 May;19(3):233-6. doi: 10.1155/2008/727062. PMID: 19412380; PMCID: PMC2605870.
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Methane in an open-cage [60]fullerene.

Journal of the American Chemical Society

Whitener KE, Cross RJ, Saunders M, Iwamatsu S, Murata S, Mizorogi N, Nagase S.
PMID: 19368384
J Am Chem Soc. 2009 May 13;131(18):6338-9. doi: 10.1021/ja901383r.

An endohedral methane complex of a fullerene derivative is first synthesized by insertion of a methane molecule through the opening of an open-cage C(60) derivative. The trapped methane is confirmed by NMR spectroscopy and mass spectrometry. Both methane carbon...

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Whitener KE, Cross RJ, Saunders M, et al. Methane in an open-cage [60]fullerene. J Am Chem Soc. 2009;131(18):6338-9doi: 10.1021/ja901383r.
Whitener, K. E., Cross, R. J., Saunders, M., Iwamatsu, S., Murata, S., Mizorogi, N., & Nagase, S. (2009). Methane in an open-cage [60]fullerene. Journal of the American Chemical Society, 131(18), 6338-9. https://doi.org/10.1021/ja901383r
Whitener, Keith E, et al. "Methane in an open-cage [60]fullerene." Journal of the American Chemical Society vol. 131,18 (2009): 6338-9. doi: https://doi.org/10.1021/ja901383r
Whitener KE, Cross RJ, Saunders M, Iwamatsu S, Murata S, Mizorogi N, Nagase S. Methane in an open-cage [60]fullerene. J Am Chem Soc. 2009 May 13;131(18):6338-9. doi: 10.1021/ja901383r. PMID: 19368384.
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Use of intravenous iron and risk of anaphylaxis: A multinational observational post-authorisation safety study in Europe.

Pharmacoepidemiology and drug safety

Fortuny J, von Gersdorff G, Lassalle R, Linder M, Overbeek J, Reinold J, Toft G, Timmer A, Dress J, Blin P, Droz-Perroteau C, Ehrenstein V, Franzoni C, Herings R, Kollhorst B, Moore N, Odsbu I, Perez-Gutthann S, Schink T, Rascher K, Rasouliyan L, Rothman KJ, Saigi-Morgui N, Schaller M, Smits E, Forstner M, Bénichou J, Bircher AJ, Garbe E, Rampton DS, Gutierrez L.
PMID: 34181291
Pharmacoepidemiol Drug Saf. 2021 Oct;30(10):1447-1457. doi: 10.1002/pds.5319. Epub 2021 Jul 12.

PURPOSE: This post-authorisation safety study estimated the risk of anaphylaxis in patients receiving intravenous (IV) iron in Europe, with interest in iron dextran and iron non-dextrans. Studies conducted in the United States have reported risk of anaphylaxis to IV...

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Fortuny J, von Gersdorff G, Lassalle R, et al. Use of intravenous iron and risk of anaphylaxis: A multinational observational post-authorisation safety study in Europe. Pharmacoepidemiol Drug Saf. 2021;30(10):1447-1457doi: 10.1002/pds.5319.
Fortuny, J., von Gersdorff, G., Lassalle, R., Linder, M., Overbeek, J., Reinold, J., Toft, G., Timmer, A., Dress, J., Blin, P., Droz-Perroteau, C., Ehrenstein, V., Franzoni, C., Herings, R., Kollhorst, B., Moore, N., Odsbu, I., Perez-Gutthann, S., Schink, T., Rascher, K., Rasouliyan, L., Rothman, K. J., Saigi-Morgui, N., Schaller, M., Smits, E., Forstner, M., Bénichou, J., Bircher, A. J., Garbe, E., Rampton, D. S., & Gutierrez, L. (2021). Use of intravenous iron and risk of anaphylaxis: A multinational observational post-authorisation safety study in Europe. Pharmacoepidemiology and drug safety, 30(10), 1447-1457. https://doi.org/10.1002/pds.5319
Fortuny, Joan, et al. "Use of intravenous iron and risk of anaphylaxis: A multinational observational post-authorisation safety study in Europe." Pharmacoepidemiology and drug safety vol. 30,10 (2021): 1447-1457. doi: https://doi.org/10.1002/pds.5319
Fortuny J, von Gersdorff G, Lassalle R, Linder M, Overbeek J, Reinold J, Toft G, Timmer A, Dress J, Blin P, Droz-Perroteau C, Ehrenstein V, Franzoni C, Herings R, Kollhorst B, Moore N, Odsbu I, Perez-Gutthann S, Schink T, Rascher K, Rasouliyan L, Rothman KJ, Saigi-Morgui N, Schaller M, Smits E, Forstner M, Bénichou J, Bircher AJ, Garbe E, Rampton DS, Gutierrez L. Use of intravenous iron and risk of anaphylaxis: A multinational observational post-authorisation safety study in Europe. Pharmacoepidemiol Drug Saf. 2021 Oct;30(10):1447-1457. doi: 10.1002/pds.5319. Epub 2021 Jul 12. PMID: 34181291; PMCID: PMC8457074.
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First-Line Systemic Treatments for Stage IV Non-Small Cell Lung Cancer in California: Patterns of Care and Outcomes in a Real-World Setting.

JNCI cancer spectrum

Maguire FB, Morris CR, Parikh-Patel A, Cress RD, Keegan THM, Li CS, Lin PS, Kizer KW.
PMID: 32328551
JNCI Cancer Spectr. 2019 Apr 04;3(3):pkz020. doi: 10.1093/jncics/pkz020. eCollection 2019 Sep.

BACKGROUND: Multiple systemic treatments have been developed for stage IV non-small cell lung cancer (NSCLC), but their use and effect on outcomes at the population level are unknown. This study describes the utilization of first-line systemic treatments among stage...

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Maguire FB, Morris CR, Parikh-Patel A, et al. First-Line Systemic Treatments for Stage IV Non-Small Cell Lung Cancer in California: Patterns of Care and Outcomes in a Real-World Setting. JNCI Cancer Spectr. 2019;3(3):pkz020doi: 10.1093/jncics/pkz020.
Maguire, F. B., Morris, C. R., Parikh-Patel, A., Cress, R. D., Keegan, T. H. M., Li, C. S., Lin, P. S., & Kizer, K. W. (2019). First-Line Systemic Treatments for Stage IV Non-Small Cell Lung Cancer in California: Patterns of Care and Outcomes in a Real-World Setting. JNCI cancer spectrum, 3(3), pkz020. https://doi.org/10.1093/jncics/pkz020
Maguire, Frances B, et al. "First-Line Systemic Treatments for Stage IV Non-Small Cell Lung Cancer in California: Patterns of Care and Outcomes in a Real-World Setting." JNCI cancer spectrum vol. 3,3 (2019): pkz020. doi: https://doi.org/10.1093/jncics/pkz020
Maguire FB, Morris CR, Parikh-Patel A, Cress RD, Keegan THM, Li CS, Lin PS, Kizer KW. First-Line Systemic Treatments for Stage IV Non-Small Cell Lung Cancer in California: Patterns of Care and Outcomes in a Real-World Setting. JNCI Cancer Spectr. 2019 Apr 04;3(3):pkz020. doi: 10.1093/jncics/pkz020. eCollection 2019 Sep. PMID: 32328551; PMCID: PMC7050031.
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Contributions of Social Factors to Disparities in Prostate Cancer Risk Profiles among Black Men and Non-Hispanic White Men with Prostate Cancer in California.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

Press DJ, Shariff-Marco S, Lichtensztajn DY, Lauderdale D, Murphy AB, Inamdar PP, DeRouen MC, Hamilton AS, Yang J, Lin K, Hedeker D, Haiman CA, Cheng I, Gomez SL.
PMID: 34853020
Cancer Epidemiol Biomarkers Prev. 2021 Nov 30; doi: 10.1158/1055-9965.EPI-21-0697. Epub 2021 Nov 30.

BACKGROUND: Black men are more likely than Non-Hispanic White (NHW) men to be diagnosed with high-risk prostate cancer. We examined the extent to which social factors were associated with differences in prostate cancer risk profiles between Black men and...

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Press DJ, Shariff-Marco S, Lichtensztajn DY, et al. Contributions of Social Factors to Disparities in Prostate Cancer Risk Profiles among Black Men and Non-Hispanic White Men with Prostate Cancer in California. Cancer Epidemiol Biomarkers Prev. 2021;doi: 10.1158/1055-9965.EPI-21-0697.
Press, D. J., Shariff-Marco, S., Lichtensztajn, D. Y., Lauderdale, D., Murphy, A. B., Inamdar, P. P., DeRouen, M. C., Hamilton, A. S., Yang, J., Lin, K., Hedeker, D., Haiman, C. A., Cheng, I., & Gomez, S. L. (2021). Contributions of Social Factors to Disparities in Prostate Cancer Risk Profiles among Black Men and Non-Hispanic White Men with Prostate Cancer in California. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, . https://doi.org/10.1158/1055-9965.EPI-21-0697
Press, David J, et al. "Contributions of Social Factors to Disparities in Prostate Cancer Risk Profiles among Black Men and Non-Hispanic White Men with Prostate Cancer in California." Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology vol. (2021). doi: https://doi.org/10.1158/1055-9965.EPI-21-0697
Press DJ, Shariff-Marco S, Lichtensztajn DY, Lauderdale D, Murphy AB, Inamdar PP, DeRouen MC, Hamilton AS, Yang J, Lin K, Hedeker D, Haiman CA, Cheng I, Gomez SL. Contributions of Social Factors to Disparities in Prostate Cancer Risk Profiles among Black Men and Non-Hispanic White Men with Prostate Cancer in California. Cancer Epidemiol Biomarkers Prev. 2021 Nov 30; doi: 10.1158/1055-9965.EPI-21-0697. Epub 2021 Nov 30. PMID: 34853020.
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Direct detection and quantitation of He@C60 by ultrahigh-resolution Fourier transform ion cyclotron resonance mass spectrometry.

Journal of the American Society for Mass Spectrometry

Cooper HJ, Hendrickson CL, Marshall AG, Cross RJ, Saunders M.
PMID: 12443026
J Am Soc Mass Spectrom. 2002 Nov;13(11):1349-55. doi: 10.1016/S1044-0305(02)00650-5.

In this paper, we report negative ion microelectrospray Fourier-transform ion cyclotron resonance (FT-ICR) mass spectrometry of C60 samples containing approximately 1% 3He@C60 or 4He@C60. Resolving He@C60- and 4He@C60- from C60 containing 3 or 4 13C instead of 12C atoms...

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Cooper HJ, Hendrickson CL, Marshall AG, et al. Direct detection and quantitation of He@C60 by ultrahigh-resolution Fourier transform ion cyclotron resonance mass spectrometry. J Am Soc Mass Spectrom. 2002;13(11):1349-55doi: 10.1016/S1044-0305(02)00650-5.
Cooper, H. J., Hendrickson, C. L., Marshall, A. G., Cross, R. J., & Saunders, M. (2002). Direct detection and quantitation of He@C60 by ultrahigh-resolution Fourier transform ion cyclotron resonance mass spectrometry. Journal of the American Society for Mass Spectrometry, 13(11), 1349-55. https://doi.org/10.1016/S1044-0305(02)00650-5
Cooper, Helen J, et al. "Direct detection and quantitation of He@C60 by ultrahigh-resolution Fourier transform ion cyclotron resonance mass spectrometry." Journal of the American Society for Mass Spectrometry vol. 13,11 (2002): 1349-55. doi: https://doi.org/10.1016/S1044-0305(02)00650-5
Cooper HJ, Hendrickson CL, Marshall AG, Cross RJ, Saunders M. Direct detection and quantitation of He@C60 by ultrahigh-resolution Fourier transform ion cyclotron resonance mass spectrometry. J Am Soc Mass Spectrom. 2002 Nov;13(11):1349-55. doi: 10.1016/S1044-0305(02)00650-5. PMID: 12443026.
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Self-assembly in aqueous solution of wheel-shaped Mo154 oxide clusters into vesicles.

Nature

Liu T, Diemann E, Li H, Dress AW, Müller A.
PMID: 14603315
Nature. 2003 Nov 06;426(6962):59-62. doi: 10.1038/nature02036.

Surfactants and membrane lipids readily assemble into complex structures such as micelles, liposomes or hollow vesicles owing to their amphiphilic character-the fact that part of their structure is attracted to polar environments while another part is attracted to non-polar...

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Liu T, Diemann E, Li H, et al. Self-assembly in aqueous solution of wheel-shaped Mo154 oxide clusters into vesicles. Nature. 2003;426(6962):59-62doi: 10.1038/nature02036.
Liu, T., Diemann, E., Li, H., Dress, A. W., & Müller, A. (2003). Self-assembly in aqueous solution of wheel-shaped Mo154 oxide clusters into vesicles. Nature, 426(6962), 59-62. https://doi.org/10.1038/nature02036
Liu, Tianbo, et al. "Self-assembly in aqueous solution of wheel-shaped Mo154 oxide clusters into vesicles." Nature vol. 426,6962 (2003): 59-62. doi: https://doi.org/10.1038/nature02036
Liu T, Diemann E, Li H, Dress AW, Müller A. Self-assembly in aqueous solution of wheel-shaped Mo154 oxide clusters into vesicles. Nature. 2003 Nov 06;426(6962):59-62. doi: 10.1038/nature02036. PMID: 14603315.
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Two helium atoms inside fullerenes: probing the internal magnetic field in C60(6-) and C70(6-).

Journal of the American Chemical Society

Sternfeld T, Hoffman RE, Saunders M, Cross RJ, Syamala MS, Rabinovitz M.
PMID: 12137518
J Am Chem Soc. 2002 Jul 31;124(30):8786-7. doi: 10.1021/ja025990y.

A 3He NMR resonance of C606- containing He is assigned to He2@C606-, thus showing that C60 can also accommodate two helium atoms. The ratio of the di-helium compound relative to the mono- is 1:200, 10 times lower than the...

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Sternfeld T, Hoffman RE, Saunders M, et al. Two helium atoms inside fullerenes: probing the internal magnetic field in C60(6-) and C70(6-). J Am Chem Soc. 2002;124(30):8786-7doi: 10.1021/ja025990y.
Sternfeld, T., Hoffman, R. E., Saunders, M., Cross, R. J., Syamala, M. S., & Rabinovitz, M. (2002). Two helium atoms inside fullerenes: probing the internal magnetic field in C60(6-) and C70(6-). Journal of the American Chemical Society, 124(30), 8786-7. https://doi.org/10.1021/ja025990y
Sternfeld, Tamar, et al. "Two helium atoms inside fullerenes: probing the internal magnetic field in C60(6-) and C70(6-)." Journal of the American Chemical Society vol. 124,30 (2002): 8786-7. doi: https://doi.org/10.1021/ja025990y
Sternfeld T, Hoffman RE, Saunders M, Cross RJ, Syamala MS, Rabinovitz M. Two helium atoms inside fullerenes: probing the internal magnetic field in C60(6-) and C70(6-). J Am Chem Soc. 2002 Jul 31;124(30):8786-7. doi: 10.1021/ja025990y. PMID: 12137518.
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Bed-Sharing in Couples Is Associated With Increased and Stabilized REM Sleep and Sleep-Stage Synchronization.

Frontiers in psychiatry

Drews HJ, Wallot S, Brysch P, Berger-Johannsen H, Weinhold SL, Mitkidis P, Baier PC, Lechinger J, Roepstorff A, Göder R.
PMID: 32670111
Front Psychiatry. 2020 Jun 25;11:583. doi: 10.3389/fpsyt.2020.00583. eCollection 2020.

BACKGROUND/OBJECTIVES: Sharing the bed with a partner is common among adults and impacts sleep quality with potential implications for mental health. However, hitherto findings are contradictory and particularly polysomnographic data on co-sleeping couples are extremely rare. The present study...

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Drews HJ, Wallot S, Brysch P, et al. Bed-Sharing in Couples Is Associated With Increased and Stabilized REM Sleep and Sleep-Stage Synchronization. Front Psychiatry. 2020;11:583doi: 10.3389/fpsyt.2020.00583.
Drews, H. J., Wallot, S., Brysch, P., Berger-Johannsen, H., Weinhold, S. L., Mitkidis, P., Baier, P. C., Lechinger, J., Roepstorff, A., & Göder, R. (2020). Bed-Sharing in Couples Is Associated With Increased and Stabilized REM Sleep and Sleep-Stage Synchronization. Frontiers in psychiatry, 11583. https://doi.org/10.3389/fpsyt.2020.00583
Drews, Henning Johannes, et al. "Bed-Sharing in Couples Is Associated With Increased and Stabilized REM Sleep and Sleep-Stage Synchronization." Frontiers in psychiatry vol. 11 (2020): 583. doi: https://doi.org/10.3389/fpsyt.2020.00583
Drews HJ, Wallot S, Brysch P, Berger-Johannsen H, Weinhold SL, Mitkidis P, Baier PC, Lechinger J, Roepstorff A, Göder R. Bed-Sharing in Couples Is Associated With Increased and Stabilized REM Sleep and Sleep-Stage Synchronization. Front Psychiatry. 2020 Jun 25;11:583. doi: 10.3389/fpsyt.2020.00583. eCollection 2020. PMID: 32670111; PMCID: PMC7330166.
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A delicate balance: Accountability for very high-cost patients in new payment models.

Healthcare (Amsterdam, Netherlands)

Mullangi S, Press MJ, Ryan AM.
PMID: 31558367
Healthc (Amst). 2019 Dec;7(4):100366. doi: 10.1016/j.hjdsi.2019.100366. Epub 2019 Sep 24.

Designing alternative payment models (APMs) to encourage providers to manage the needs of very complex patients while limiting providers' financial risk is a major challenge. Most APMs limit providers' financial risk for complex patients through an annual per-patient expenditure...

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Mullangi S, Press MJ, Ryan AM. A delicate balance: Accountability for very high-cost patients in new payment models. Healthc (Amst). 2019;7(4):100366doi: 10.1016/j.hjdsi.2019.100366.
Mullangi, S., Press, M. J., & Ryan, A. M. (2019). A delicate balance: Accountability for very high-cost patients in new payment models. Healthcare (Amsterdam, Netherlands), 7(4), 100366. https://doi.org/10.1016/j.hjdsi.2019.100366
Mullangi, Samyukta, et al. "A delicate balance: Accountability for very high-cost patients in new payment models." Healthcare (Amsterdam, Netherlands) vol. 7,4 (2019): 100366. doi: https://doi.org/10.1016/j.hjdsi.2019.100366
Mullangi S, Press MJ, Ryan AM. A delicate balance: Accountability for very high-cost patients in new payment models. Healthc (Amst). 2019 Dec;7(4):100366. doi: 10.1016/j.hjdsi.2019.100366. Epub 2019 Sep 24. PMID: 31558367.
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Towards the better understanding of myelopoiesis using single-cell technologies.

Molecular immunology

Dress RJ, Liu Z, Ginhoux F.
PMID: 32388073
Mol Immunol. 2020 May 06;122:186-192. doi: 10.1016/j.molimm.2020.04.020. Epub 2020 May 06.

Myeloid cells and their progenitors have historically been characterized based on their expression of a well-defined set of surface proteins, transcription factors and cytokines they depend on. These traditional analyses on "bulk" myeloid cell populations led to valuable early...

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Dress RJ, Liu Z, Ginhoux F. Towards the better understanding of myelopoiesis using single-cell technologies. Mol Immunol. 2020;122:186-192doi: 10.1016/j.molimm.2020.04.020.
Dress, R. J., Liu, Z., & Ginhoux, F. (2020). Towards the better understanding of myelopoiesis using single-cell technologies. Molecular immunology, 122186-192. https://doi.org/10.1016/j.molimm.2020.04.020
Dress, Regine J, et al. "Towards the better understanding of myelopoiesis using single-cell technologies." Molecular immunology vol. 122 (2020): 186-192. doi: https://doi.org/10.1016/j.molimm.2020.04.020
Dress RJ, Liu Z, Ginhoux F. Towards the better understanding of myelopoiesis using single-cell technologies. Mol Immunol. 2020 May 06;122:186-192. doi: 10.1016/j.molimm.2020.04.020. Epub 2020 May 06. PMID: 32388073.
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