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Showing 265 to 272 of 272 entries
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Patterns of brachyury expression in chordomas.

Annals of diagnostic pathology

Dridi M, Boutonnat J, Dumollard JM, Peoc'h M, Karpathiou G.
PMID: 33989961
Ann Diagn Pathol. 2021 Aug;53:151760. doi: 10.1016/j.anndiagpath.2021.151760. Epub 2021 May 10.

INTRODUCTION: Chordomas are rare malignant midline tumors, presumed to arise from notochordal remnants. This was further suggested by the discovery of the brachyury in chordomas pathogenesis. Its immunohistochemical expression has become the principal adjunct in the diagnosis of chordomas....

New Insights Into Osteoclast Biology.

JBMR plus

McDonald MM, Kim AS, Mulholland BS, Rauner M.
PMID: 34532619
JBMR Plus. 2021 Aug 30;5(9):e10539. doi: 10.1002/jbm4.10539. eCollection 2021 Sep.

Osteoclasts are multinucleated cells that are characterized by their unique ability to resorb large quantities of bone. Therefore, they are frequently the target of therapeutic interventions to ameliorate bone loss. In an adult organism, osteoclasts derive from hematopoietic stem...

Autophagic Markers in Chordomas: Immunohistochemical Analysis and Comparison with the Immune Microenvironment of Chordoma Tissues.

Cancers

Karpathiou G, Dridi M, Krebs-Drouot L, Vassal F, Jouanneau E, Jacquesson T, Barrey C, Prades JM, Dumollard JM, Meyronet D, Boutonnat J, Péoc'h M.
PMID: 33946484
Cancers (Basel). 2021 Apr 30;13(9). doi: 10.3390/cancers13092169.

Chordomas are notably resistant to chemotherapy. One of the cytoprotective mechanisms implicated in chemoresistance is autophagy. There are indirect data that autophagy could be implicated in chordomas, but its presence has not been studied in chordoma tissues. Sixty-one (61)...

Attenuating persistent sodium current-induced atrial myopathy and fibrillation by preventing mitochondrial oxidative stress.

JCI insight

Avula UMR, Dridi H, Chen BX, Yuan Q, Katchman AN, Reiken SR, Desai AD, Parsons S, Baksh H, Ma E, Dasrat P, Ji R, Lin Y, Sison C, Lederer WJ, Joca HC, Ward CW, Greiser M, Marks AR, Marx SO, Wan EY.
PMID: 34710060
JCI Insight. 2021 Oct 28;6(23). doi: 10.1172/jci.insight.147371.

Mechanistically driven therapies for atrial fibrillation (AF), the most common cardiac arrhythmia, are urgently needed, the development of which requires improved understanding of the cellular signaling pathways that facilitate the structural and electrophysiological remodeling that occurs in the atria....

Autophagy in cardiac myxoma: An important puzzle piece in understanding its inflammatory environment.

Pathology, research and practice

Sramek V, Dridi M, Papoudou-Bai A, Dumollard JM, Péoc'h M, Karpathiou G.
PMID: 34537518
Pathol Res Pract. 2021 Oct;226:153609. doi: 10.1016/j.prp.2021.153609. Epub 2021 Sep 04.

BACKGROUND: Cardiac myxomas are rare, predominantly sporadic tumors that can cause heart failure and systematic inflammatory symptoms, and increase the risk of emboli. Their pathophysiology remains poorly understood, but intra-tumoral inflammation and senescence seem to be implicated in it....

Global immune characterization of HBV/HCV-related hepatocellular carcinoma identifies macrophage and T-cell subsets associated with disease progression.

Cell discovery

Song G, Shi Y, Zhang M, Goswami S, Afridi S, Meng L, Ma J, Chen Y, Lin Y, Zhang J, Liu Y, Jin Z, Yang S, Rao D, Zhang S, Ke A, Wang X, Cao Y, Zhou J, Fan J, Zhang X, Xi R, Gao Q.
PMID: 33298893
Cell Discov. 2020 Dec 08;6(1):90. doi: 10.1038/s41421-020-00214-5.

Diverse immune cells in the tumor microenvironment form a complex ecosystem, but our knowledge of their heterogeneity and dynamics within hepatocellular carcinoma (HCC) still remains limited. To assess the plasticity and phenotypes of immune cells within HBV/HCV-related HCC microenvironment...

Autophagy and immune microenvironment in craniopharyngioma and ameloblastoma.

Experimental and molecular pathology

Karpathiou G, Hamlat M, Dridi M, Forest F, Papoudou-Bai A, Dumollard JM, Peoc'h M.
PMID: 34655574
Exp Mol Pathol. 2021 Dec;123:104712. doi: 10.1016/j.yexmp.2021.104712. Epub 2021 Oct 13.

BACKGROUND: Craniopharyngiomas and ameloblastomas show remarkable histologic and molecular similarities. The immune microenvironment of craniopharyngiomas has been recently studied showing interesting findings, while its composition in ameloblastomas is unknown. Similarly, some evidence of autophagic activity, a process of cellular...

Green fabrication of Co and Co.

Open life sciences

Waris A, Din M, Ali A, Afridi S, Baset A, Khan AU, Ali M.
PMID: 33817294
Open Life Sci. 2021 Jan 20;16(1):14-30. doi: 10.1515/biol-2021-0003. eCollection 2021.

Nanotechnology is the fabrication, characterization, and potential application of various materials at the nanoscale. Over the past few decades, nanomaterials have attracted researchers from different fields because of their high surface-to-volume ratio and other unique and remarkable properties. Cobalt...

Showing 265 to 272 of 272 entries