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Item-Level Genome-Wide Association Study of the Alcohol Use Disorders Identification Test in Three Population-Based Cohorts.

The American journal of psychiatry

Mallard TT, Savage JE, Johnson EC, Huang Y, Edwards AC, Hottenga JJ, Grotzinger AD, Gustavson DE, Jennings MV, Anokhin A, Dick DM, Edenberg HJ, Kramer JR, Lai D, Meyers JL, Pandey AK, Harden KP, Nivard MG, de Geus EJC, Boomsma DI, Agrawal A, Davis LK, Clarke TK, Palmer AA, Sanchez-Roige S.
PMID: 33985350
Am J Psychiatry. 2021 May 14;appiajp202020091390. doi: 10.1176/appi.ajp.2020.20091390. Epub 2021 May 14.

OBJECTIVE: Genome-wide association studies (GWASs) of the Alcohol Use Disorders Identification Test (AUDIT), a 10-item screen for alcohol use disorder (AUD), have elucidated novel loci for alcohol consumption and misuse. However, these studies also revealed that GWASs can be...

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Mallard TT, Savage JE, Johnson EC, et al. Item-Level Genome-Wide Association Study of the Alcohol Use Disorders Identification Test in Three Population-Based Cohorts. Am J Psychiatry. 2021;appiajp202020091390doi: 10.1176/appi.ajp.2020.20091390.
Mallard, T. T., Savage, J. E., Johnson, E. C., Huang, Y., Edwards, A. C., Hottenga, J. J., Grotzinger, A. D., Gustavson, D. E., Jennings, M. V., Anokhin, A., Dick, D. M., Edenberg, H. J., Kramer, J. R., Lai, D., Meyers, J. L., Pandey, A. K., Harden, K. P., Nivard, M. G., de Geus, E. J. C., Boomsma, D. I., Agrawal, A., Davis, L. K., Clarke, T. K., Palmer, A. A., & Sanchez-Roige, S. (2021). Item-Level Genome-Wide Association Study of the Alcohol Use Disorders Identification Test in Three Population-Based Cohorts. The American journal of psychiatry, appiajp202020091390. https://doi.org/10.1176/appi.ajp.2020.20091390
Mallard, Travis T, et al. "Item-Level Genome-Wide Association Study of the Alcohol Use Disorders Identification Test in Three Population-Based Cohorts." The American journal of psychiatry vol. (2021): appiajp202020091390. doi: https://doi.org/10.1176/appi.ajp.2020.20091390
Mallard TT, Savage JE, Johnson EC, Huang Y, Edwards AC, Hottenga JJ, Grotzinger AD, Gustavson DE, Jennings MV, Anokhin A, Dick DM, Edenberg HJ, Kramer JR, Lai D, Meyers JL, Pandey AK, Harden KP, Nivard MG, de Geus EJC, Boomsma DI, Agrawal A, Davis LK, Clarke TK, Palmer AA, Sanchez-Roige S. Item-Level Genome-Wide Association Study of the Alcohol Use Disorders Identification Test in Three Population-Based Cohorts. Am J Psychiatry. 2021 May 14;appiajp202020091390. doi: 10.1176/appi.ajp.2020.20091390. Epub 2021 May 14. PMID: 33985350.
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Discovery of GSK251: A Highly Potent, Highly Selective, Orally Bioavailable Inhibitor of PI3Kδ with a Novel Binding Mode.

Journal of medicinal chemistry

Down K, Amour A, Anderson NA, Barton N, Campos S, Cannons EP, Clissold C, Convery MA, Coward JJ, Doyle K, Duempelfeld B, Edwards CD, Goldsmith MD, Krause J, Mallett DN, McGonagle GA, Patel VK, Rowedder J, Rowland P, Sharpe A, Sriskantharajah S, Thomas DA, Thomson DW, Uddin S, Hamblin JN, Hessel EM.
PMID: 34510892
J Med Chem. 2021 Sep 23;64(18):13780-13792. doi: 10.1021/acs.jmedchem.1c01102. Epub 2021 Sep 11.

Optimization of a previously reported lead series of PI3Kδ inhibitors with a novel binding mode led to the identification of a clinical candidate compound

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Down K, Amour A, Anderson NA, et al. Discovery of GSK251: A Highly Potent, Highly Selective, Orally Bioavailable Inhibitor of PI3Kδ with a Novel Binding Mode. J Med Chem. 2021;64(18):13780-13792doi: 10.1021/acs.jmedchem.1c01102.
Down, K., Amour, A., Anderson, N. A., Barton, N., Campos, S., Cannons, E. P., Clissold, C., Convery, M. A., Coward, J. J., Doyle, K., Duempelfeld, B., Edwards, C. D., Goldsmith, M. D., Krause, J., Mallett, D. N., McGonagle, G. A., Patel, V. K., Rowedder, J., Rowland, P., Sharpe, A., Sriskantharajah, S., Thomas, D. A., Thomson, D. W., Uddin, S., Hamblin, J. N., & Hessel, E. M. (2021). Discovery of GSK251: A Highly Potent, Highly Selective, Orally Bioavailable Inhibitor of PI3Kδ with a Novel Binding Mode. Journal of medicinal chemistry, 64(18), 13780-13792. https://doi.org/10.1021/acs.jmedchem.1c01102
Down, Kenneth, et al. "Discovery of GSK251: A Highly Potent, Highly Selective, Orally Bioavailable Inhibitor of PI3Kδ with a Novel Binding Mode." Journal of medicinal chemistry vol. 64,18 (2021): 13780-13792. doi: https://doi.org/10.1021/acs.jmedchem.1c01102
Down K, Amour A, Anderson NA, Barton N, Campos S, Cannons EP, Clissold C, Convery MA, Coward JJ, Doyle K, Duempelfeld B, Edwards CD, Goldsmith MD, Krause J, Mallett DN, McGonagle GA, Patel VK, Rowedder J, Rowland P, Sharpe A, Sriskantharajah S, Thomas DA, Thomson DW, Uddin S, Hamblin JN, Hessel EM. Discovery of GSK251: A Highly Potent, Highly Selective, Orally Bioavailable Inhibitor of PI3Kδ with a Novel Binding Mode. J Med Chem. 2021 Sep 23;64(18):13780-13792. doi: 10.1021/acs.jmedchem.1c01102. Epub 2021 Sep 11. PMID: 34510892.
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A chickpea genetic variation map based on the sequencing of 3,366 genomes.

Nature

Varshney RK, Roorkiwal M, Sun S, Bajaj P, Chitikineni A, Thudi M, Singh NP, Du X, Upadhyaya HD, Khan AW, Wang Y, Garg V, Fan G, Cowling WA, Crossa J, Gentzbittel L, Voss-Fels KP, Valluri VK, Sinha P, Singh VK, Ben C, Rathore A, Punna R, Singh MK, Tar'an B, Bharadwaj C, Yasin M, Pithia MS, Singh S, Soren KR, Kudapa H, Jarquín D, Cubry P, Hickey LT, Dixit GP, Thuillet AC, Hamwieh A, Kumar S, Deokar AA, Chaturvedi SK, Francis A, Howard R, Chattopadhyay D, Edwards D, Lyons E, Vigouroux Y, Hayes BJ, von Wettberg E, Datta SK, Yang H, Nguyen HT, Wang J, Siddique KHM, Mohapatra T, Bennetzen JL, Xu X, Liu X.
PMID: 34759320
Nature. 2021 Nov;599(7886):622-627. doi: 10.1038/s41586-021-04066-1. Epub 2021 Nov 10.

Zero hunger and good health could be realized by 2030 through effective conservation, characterization and utilization of germplasm resources

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Varshney RK, Roorkiwal M, Sun S, et al. A chickpea genetic variation map based on the sequencing of 3,366 genomes. Nature. 2021;599(7886):622-627doi: 10.1038/s41586-021-04066-1.
Varshney, R. K., Roorkiwal, M., Sun, S., Bajaj, P., Chitikineni, A., Thudi, M., Singh, N. P., Du, X., Upadhyaya, H. D., Khan, A. W., Wang, Y., Garg, V., Fan, G., Cowling, W. A., Crossa, J., Gentzbittel, L., Voss-Fels, K. P., Valluri, V. K., Sinha, P., Singh, V. K., Ben, C., Rathore, A., Punna, R., Singh, M. K., Tar'an, B., Bharadwaj, C., Yasin, M., Pithia, M. S., Singh, S., Soren, K. R., Kudapa, H., Jarquín, D., Cubry, P., Hickey, L. T., Dixit, G. P., Thuillet, A. C., Hamwieh, A., Kumar, S., Deokar, A. A., Chaturvedi, S. K., Francis, A., Howard, R., Chattopadhyay, D., Edwards, D., Lyons, E., Vigouroux, Y., Hayes, B. J., von Wettberg, E., Datta, S. K., Yang, H., Nguyen, H. T., Wang, J., Siddique, K. H. M., Mohapatra, T., Bennetzen, J. L., Xu, X., & Liu, X. (2021). A chickpea genetic variation map based on the sequencing of 3,366 genomes. Nature, 599(7886), 622-627. https://doi.org/10.1038/s41586-021-04066-1
Varshney, Rajeev K, et al. "A chickpea genetic variation map based on the sequencing of 3,366 genomes." Nature vol. 599,7886 (2021): 622-627. doi: https://doi.org/10.1038/s41586-021-04066-1
Varshney RK, Roorkiwal M, Sun S, Bajaj P, Chitikineni A, Thudi M, Singh NP, Du X, Upadhyaya HD, Khan AW, Wang Y, Garg V, Fan G, Cowling WA, Crossa J, Gentzbittel L, Voss-Fels KP, Valluri VK, Sinha P, Singh VK, Ben C, Rathore A, Punna R, Singh MK, Tar'an B, Bharadwaj C, Yasin M, Pithia MS, Singh S, Soren KR, Kudapa H, Jarquín D, Cubry P, Hickey LT, Dixit GP, Thuillet AC, Hamwieh A, Kumar S, Deokar AA, Chaturvedi SK, Francis A, Howard R, Chattopadhyay D, Edwards D, Lyons E, Vigouroux Y, Hayes BJ, von Wettberg E, Datta SK, Yang H, Nguyen HT, Wang J, Siddique KHM, Mohapatra T, Bennetzen JL, Xu X, Liu X. A chickpea genetic variation map based on the sequencing of 3,366 genomes. Nature. 2021 Nov;599(7886):622-627. doi: 10.1038/s41586-021-04066-1. Epub 2021 Nov 10. PMID: 34759320; PMCID: PMC8612933.
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Undergraduate nursing students' education and training in aseptic technique: A mixed methods systematic review.

Journal of advanced nursing

Hawker C, Gould D, Courtenay M, Edwards D.
PMID: 34258782
J Adv Nurs. 2022 Jan;78(1):63-77. doi: 10.1111/jan.14974. Epub 2021 Jul 14.

AIM: To appraise and synthesize empirical studies exploring undergraduate nursing students' education and training in aseptic technique.DESIGN: Mixed methods, systematic literature review adopting Joanna Briggs Institute methodology.DATA SOURCES: Thirteen electronic databases were searched 1996-2020, followed by searches with a...

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Hawker C, Gould D, Courtenay M, et al. Undergraduate nursing students' education and training in aseptic technique: A mixed methods systematic review. J Adv Nurs. 2021;78(1):63-77doi: 10.1111/jan.14974.
Hawker, C., Gould, D., Courtenay, M., & Edwards, D. (2022). Undergraduate nursing students' education and training in aseptic technique: A mixed methods systematic review. Journal of advanced nursing, 78(1), 63-77. https://doi.org/10.1111/jan.14974
Hawker, Clare, et al. "Undergraduate nursing students' education and training in aseptic technique: A mixed methods systematic review." Journal of advanced nursing vol. 78,1 (2022): 63-77. doi: https://doi.org/10.1111/jan.14974
Hawker C, Gould D, Courtenay M, Edwards D. Undergraduate nursing students' education and training in aseptic technique: A mixed methods systematic review. J Adv Nurs. 2022 Jan;78(1):63-77. doi: 10.1111/jan.14974. Epub 2021 Jul 14. PMID: 34258782.
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Internal Tibial Forces and Moments During Graded Running.

Journal of biomechanical engineering

Baggaley M, Derrick TR, Vernillo G, Millet GY, Edwards WB.
PMID: 34318310
J Biomech Eng. 2022 Jan 01;144(1). doi: 10.1115/1.4051924.

The stress experienced by the tibia has contributions from the forces and moments acting on the tibia. We sought to quantify the influence of running grade on internal tibial forces and moments. Seventeen participants ran at 3.33 m/s on...

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Baggaley M, Derrick TR, Vernillo G, et al. Internal Tibial Forces and Moments During Graded Running. J Biomech Eng. 2022;144(1)doi: 10.1115/1.4051924.
Baggaley, M., Derrick, T. R., Vernillo, G., Millet, G. Y., & Edwards, W. B. (2022). Internal Tibial Forces and Moments During Graded Running. Journal of biomechanical engineering, 144(1), . https://doi.org/10.1115/1.4051924
Baggaley, Michael, et al. "Internal Tibial Forces and Moments During Graded Running." Journal of biomechanical engineering vol. 144,1 (2022). doi: https://doi.org/10.1115/1.4051924
Baggaley M, Derrick TR, Vernillo G, Millet GY, Edwards WB. Internal Tibial Forces and Moments During Graded Running. J Biomech Eng. 2022 Jan 01;144(1). doi: 10.1115/1.4051924. PMID: 34318310.
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Queen Pregnancy Increases Group Estradiol Levels in Cooperatively Breeding Naked Mole-Rats.

Integrative and comparative biology

Edwards PD, Arguelles DA, Mastromonaco GF, Holmes MM.
PMID: 34048558
Integr Comp Biol. 2021 Nov 17;61(5):1841-1851. doi: 10.1093/icb/icab106.

For cooperative species, there can be great value in the synchronization of physiological states to coordinate group behavioral states. This is evident in naked mole-rats (Heterocephalus glaber), which have the most extreme form of cooperative breeding in mammals. Colonies...

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Edwards PD, Arguelles DA, Mastromonaco GF, et al. Queen Pregnancy Increases Group Estradiol Levels in Cooperatively Breeding Naked Mole-Rats. Integr Comp Biol. 2021;61(5):1841-1851doi: 10.1093/icb/icab106.
Edwards, P. D., Arguelles, D. A., Mastromonaco, G. F., & Holmes, M. M. (2021). Queen Pregnancy Increases Group Estradiol Levels in Cooperatively Breeding Naked Mole-Rats. Integrative and comparative biology, 61(5), 1841-1851. https://doi.org/10.1093/icb/icab106
Edwards, Phoebe D, et al. "Queen Pregnancy Increases Group Estradiol Levels in Cooperatively Breeding Naked Mole-Rats." Integrative and comparative biology vol. 61,5 (2021): 1841-1851. doi: https://doi.org/10.1093/icb/icab106
Edwards PD, Arguelles DA, Mastromonaco GF, Holmes MM. Queen Pregnancy Increases Group Estradiol Levels in Cooperatively Breeding Naked Mole-Rats. Integr Comp Biol. 2021 Nov 17;61(5):1841-1851. doi: 10.1093/icb/icab106. PMID: 34048558.
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Transcranial Random Noise Stimulation Modulates Neural Processing of Sensory and Motor Circuits, from Potential Cellular Mechanisms to Behavior: A Scoping Review.

eNeuro

Potok W, van der Groen O, Bächinger M, Edwards D, Wenderoth N.
PMID: 34921057
eNeuro. 2022 Jan 07;9(1). doi: 10.1523/ENEURO.0248-21.2021. Print 2022.

Noise introduced in the human nervous system from cellular to systems levels can have a major impact on signal processing. Using transcranial stimulation, electrical noise can be added to cortical circuits to modulate neuronal activity and enhance function in...

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Potok W, van der Groen O, Bächinger M, et al. Transcranial Random Noise Stimulation Modulates Neural Processing of Sensory and Motor Circuits, from Potential Cellular Mechanisms to Behavior: A Scoping Review. eNeuro. 2022;9(1)doi: 10.1523/ENEURO.0248-21.2021.
Potok, W., van der Groen, O., Bächinger, M., Edwards, D., & Wenderoth, N. (2022). Transcranial Random Noise Stimulation Modulates Neural Processing of Sensory and Motor Circuits, from Potential Cellular Mechanisms to Behavior: A Scoping Review. eNeuro, 9(1), . https://doi.org/10.1523/ENEURO.0248-21.2021
Potok, Weronika, et al. "Transcranial Random Noise Stimulation Modulates Neural Processing of Sensory and Motor Circuits, from Potential Cellular Mechanisms to Behavior: A Scoping Review." eNeuro vol. 9,1 (2022). doi: https://doi.org/10.1523/ENEURO.0248-21.2021
Potok W, van der Groen O, Bächinger M, Edwards D, Wenderoth N. Transcranial Random Noise Stimulation Modulates Neural Processing of Sensory and Motor Circuits, from Potential Cellular Mechanisms to Behavior: A Scoping Review. eNeuro. 2022 Jan 07;9(1). doi: 10.1523/ENEURO.0248-21.2021. Print 2022. PMID: 34921057.
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Influence of clinical experience on accuracy and safety of obliquus capitus inferior dry needling in unembalmed cadavers.

Physiotherapy theory and practice

Kearns GA, Hooper TL, Brismée JM, Allen B, Lierly M, Gilbert KK, Pendergrass TJ, Edwards D.
PMID: 33719823
Physiother Theory Pract. 2021 Mar 15;1-10. doi: 10.1080/09593985.2021.1901326. Epub 2021 Mar 15.

No abstract available.

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Kearns GA, Hooper TL, Brismée JM, et al. Influence of clinical experience on accuracy and safety of obliquus capitus inferior dry needling in unembalmed cadavers. Physiother Theory Pract. 2021;1-10doi: 10.1080/09593985.2021.1901326.
Kearns, G. A., Hooper, T. L., Brismée, J. M., Allen, B., Lierly, M., Gilbert, K. K., Pendergrass, T. J., & Edwards, D. (2021). Influence of clinical experience on accuracy and safety of obliquus capitus inferior dry needling in unembalmed cadavers. Physiotherapy theory and practice, 1-10. https://doi.org/10.1080/09593985.2021.1901326
Kearns, Gary A, et al. "Influence of clinical experience on accuracy and safety of obliquus capitus inferior dry needling in unembalmed cadavers." Physiotherapy theory and practice vol. (2021): 1-10. doi: https://doi.org/10.1080/09593985.2021.1901326
Kearns GA, Hooper TL, Brismée JM, Allen B, Lierly M, Gilbert KK, Pendergrass TJ, Edwards D. Influence of clinical experience on accuracy and safety of obliquus capitus inferior dry needling in unembalmed cadavers. Physiother Theory Pract. 2021 Mar 15;1-10. doi: 10.1080/09593985.2021.1901326. Epub 2021 Mar 15. PMID: 33719823.
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Further observations on the Lower Devonian Plant, Gosslingia breconensis Heard.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences

Edwards D.
PMID: 22408827
Philos Trans R Soc Lond B Biol Sci. 1970 Apr 28;258(821):225-43. doi: 10.1098/rstb.1970.0034.

The first description of this plant was published by Heard (1927). The present writer has collected more material from the type locality and has used a comparatively new technique on the petrified axes present. This involved sawing the axes...

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Edwards D. Further observations on the Lower Devonian Plant, Gosslingia breconensis Heard. Philos Trans R Soc Lond B Biol Sci. 1970;258(821):225-43doi: 10.1098/rstb.1970.0034.
Edwards, D. (1970). Further observations on the Lower Devonian Plant, Gosslingia breconensis Heard. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 258(821), 225-43. https://doi.org/10.1098/rstb.1970.0034
Edwards, D. "Further observations on the Lower Devonian Plant, Gosslingia breconensis Heard." Philosophical transactions of the Royal Society of London. Series B, Biological sciences vol. 258,821 (1970): 225-43. doi: https://doi.org/10.1098/rstb.1970.0034
Edwards D. Further observations on the Lower Devonian Plant, Gosslingia breconensis Heard. Philos Trans R Soc Lond B Biol Sci. 1970 Apr 28;258(821):225-43. doi: 10.1098/rstb.1970.0034. PMID: 22408827.
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Amborella gene presence/absence variation is associated with abiotic stress responses that may contribute to environmental adaptation.

The New phytologist

Hu H, Scheben A, Verpaalen B, Tirnaz S, Bayer PE, Hodel RGJ, Batley J, Soltis DE, Soltis PS, Edwards D.
PMID: 34328223
New Phytol. 2021 Jul 30; doi: 10.1111/nph.17658. Epub 2021 Jul 30.

No abstract available.

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Hu H, Scheben A, Verpaalen B, et al. Amborella gene presence/absence variation is associated with abiotic stress responses that may contribute to environmental adaptation. New Phytol. 2021;doi: 10.1111/nph.17658.
Hu, H., Scheben, A., Verpaalen, B., Tirnaz, S., Bayer, P. E., Hodel, R. G. J., Batley, J., Soltis, D. E., Soltis, P. S., & Edwards, D. (2021). Amborella gene presence/absence variation is associated with abiotic stress responses that may contribute to environmental adaptation. The New phytologist, . https://doi.org/10.1111/nph.17658
Hu, Haifei, et al. "Amborella gene presence/absence variation is associated with abiotic stress responses that may contribute to environmental adaptation." The New phytologist vol. (2021). doi: https://doi.org/10.1111/nph.17658
Hu H, Scheben A, Verpaalen B, Tirnaz S, Bayer PE, Hodel RGJ, Batley J, Soltis DE, Soltis PS, Edwards D. Amborella gene presence/absence variation is associated with abiotic stress responses that may contribute to environmental adaptation. New Phytol. 2021 Jul 30; doi: 10.1111/nph.17658. Epub 2021 Jul 30. PMID: 34328223.
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Genomics Armed With Diversity Leads the Way in .

Frontiers in genetics

Mohd Saad NS, Severn-Ellis AA, Pradhan A, Edwards D, Batley J.
PMID: 33679880
Front Genet. 2021 Feb 18;12:600789. doi: 10.3389/fgene.2021.600789. eCollection 2021.

Meeting the needs of a growing world population in the face of imminent climate change is a challenge; breeding of vegetable and oilseed

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Mohd Saad NS, Severn-Ellis AA, Pradhan A, et al. Genomics Armed With Diversity Leads the Way in . Front Genet. 2021;12:600789doi: 10.3389/fgene.2021.600789.
Mohd Saad, N. S., Severn-Ellis, A. A., Pradhan, A., Edwards, D., & Batley, J. (2021). Genomics Armed With Diversity Leads the Way in . Frontiers in genetics, 12600789. https://doi.org/10.3389/fgene.2021.600789
Mohd Saad, Nur Shuhadah, et al. "Genomics Armed With Diversity Leads the Way in ." Frontiers in genetics vol. 12 (2021): 600789. doi: https://doi.org/10.3389/fgene.2021.600789
Mohd Saad NS, Severn-Ellis AA, Pradhan A, Edwards D, Batley J. Genomics Armed With Diversity Leads the Way in . Front Genet. 2021 Feb 18;12:600789. doi: 10.3389/fgene.2021.600789. eCollection 2021. PMID: 33679880; PMCID: PMC7930750.
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