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Showing 13 to 24 of 184 entries
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The Current Status and Future Prospects of Oncolytic Viruses in Clinical Trials against Melanoma, Glioma, Pancreatic, and Breast Cancers.

Cancers

Eissa IR, Bustos-Villalobos I, Ichinose T, Matsumura S, Naoe Y, Miyajima N, Morimoto D, Mukoyama N, Zhiwen W, Tanaka M, Hasegawa H, Sumigama S, Aleksic B, Kodera Y, Kasuya H.
PMID: 30261620
Cancers (Basel). 2018 Sep 26;10(10). doi: 10.3390/cancers10100356.

Oncolytic viral therapy has been accepted as a standard immunotherapy since talimogene laherparepvec (T-VEC, Imlygic

Safety and Efficacy of Mini Open Transforaminal Lumbar Interbody Fusion.

Korean Journal of Spine

Mohi Eldin MM, Eissa EM, Elmorsy HM.
PMID: 28127376
Korean J Spine. 2016 Dec;13(4):190-195. doi: 10.14245/kjs.2016.13.4.190. Epub 2016 Dec 31.

OBJECTIVE: Mini-transforaminal lumbar interbody fusion (Mini-TLIF) and other minimally invasive approaches introduced for the purpose of treating lumbar degenerative disc disease and instability are achieving high success and safety rates as the conventional approaches. Moreover, it has less soft...

Current Enlightenment About Etiology and Pharmacological Treatment of Autism Spectrum Disorder.

Frontiers in neuroscience

Eissa N, Al-Houqani M, Sadeq A, Ojha SK, Sasse A, Sadek B.
PMID: 29867317
Front Neurosci. 2018 May 16;12:304. doi: 10.3389/fnins.2018.00304. eCollection 2018.

Autistic Spectrum Disorder (ASD) is a complex neurodevelopmental brain disorder characterized by two core behavioral symptoms, namely impairments in social communication and restricted/repetitive behavior. The molecular mechanisms underlying ASD are not well understood. Recent genetic as well as non-genetic...

Chandelier-assisted scleral buckling using wide angle viewing contact lens for pseudophakic retinal detachment repair.

International journal of ophthalmology

Nossair AA, Ewais WA, Eissa SA.
PMID: 31024818
Int J Ophthalmol. 2019 Apr 18;12(4):627-633. doi: 10.18240/ijo.2019.04.17. eCollection 2019.

AIM: To evaluate a modified technique for scleral buckling (SB) in pseudophakic retinal detachment (RD).METHODS: A retrospective non-comparative study included 21 consecutive eyes with uncomplicated pseudophakic RD that was repaired by chandelier assisted SB using wide angle viewing (WAV)...

Denosumab Regulates Gut Microbiota Composition and Cytokines in Dinitrobenzene Sulfonic Acid (DNBS)-Experimental Colitis.

Frontiers in microbiology

Khafipour A, Eissa N, Munyaka PM, Rabbi MF, Kapoor K, Kermarrec L, Khafipour E, Bernstein CN, Ghia JE.
PMID: 32670246
Front Microbiol. 2020 Jun 25;11:1405. doi: 10.3389/fmicb.2020.01405. eCollection 2020.

The pro-inflammatory mediator receptor activator of nuclear factor-kappa B ligand (RANKL) plays a significant role in the development of rheumatoid arthritis; however, its role in inflammatory bowel disease is unknown. Genome-wide association meta-analysis for Crohn's disease (CD) identified a...

Low Protein Z Level: A Thrombophilic Risk Biomarker for Acute Coronary Syndrome.

Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion

Ghozlan MF, Mohamed AAE, Eissa DS, Eldawy HS.
PMID: 30988573
Indian J Hematol Blood Transfus. 2019 Apr;35(2):339-346. doi: 10.1007/s12288-018-1002-5. Epub 2018 Aug 13.

Acute coronary syndrome (ACS) encompasses a range of thrombotic coronary artery diseases. Protein Z (PZ)/PZ-dependent protease inhibitor complex is a natural anticoagulant system with a presumptive role for PZ deficiency in the pathogenesis of ACS. We aimed to evaluate...

New benzoxazole derivatives as potential VEGFR-2 inhibitors and apoptosis inducers: design, synthesis, anti-proliferative evaluation, flowcytometric analysis, and .

Journal of enzyme inhibition and medicinal chemistry

Elkady H, Elwan A, El-Mahdy HA, Doghish AS, Ismail A, Taghour MS, Elkaeed EB, Eissa IH, Dahab MA, Mahdy HA, Khalifa MM.
PMID: 34961427
J Enzyme Inhib Med Chem. 2022 Dec;37(1):397-410. doi: 10.1080/14756366.2021.2015343.

A new series of benzoxazole derivatives were designed and synthesised to have the main essential pharmacophoric features of VEGFR-2 inhibitors. Cytotoxic activities were evaluated for all derivatives against two human cancer cell lines, MCF-7 and HepG2. Also, the effect...

Design, synthesis, docking, and anticancer evaluations of phthalazines as VEGFR-2 inhibitors.

Archiv der Pharmazie

El-Adl K, Ibrahim MK, Khedr F, Abulkhair HS, Eissa IH.
PMID: 34596910
Arch Pharm (Weinheim). 2022 Jan;355(1):e2100278. doi: 10.1002/ardp.202100278. Epub 2021 Oct 01.

Twenty new N-substituted-4-phenylphthalazin-1-amine derivatives were designed, synthesized, and evaluated for their anticancer activities against HepG2, HCT-116, and MCF-7 cells as VEGFR-2 inhibitors. HCT-116 was the most sensitive cell line to the influence of the new derivatives. In particular, compound...

Effect of phosphorus-loaded biochar and nitrogen-fertilization on release kinetic of toxic heavy metals and tomato growth.

International journal of phytoremediation

Ding Z, Alharbi S, Ali EF, Ghoneim AM, Hadi Al Fahd M, Wang G, Eissa MA.
PMID: 34081869
Int J Phytoremediation. 2021 Jun 03;1-10. doi: 10.1080/15226514.2021.1929825. Epub 2021 Jun 03.

In this study, we investigate the effect of nitrogen fertilizer application rates with and without phosphorus-loaded biochar (BCP) on the productivity of tomato (

Pancreastatin Reduces Alternatively Activated Macrophages, Disrupts the Epithelial Homeostasis and Aggravates Colonic Inflammation. A Descriptive Analysis.

Biomedicines

Eissa N, Elgazzar O, Hussein H, Hendy GN, Bernstein CN, Ghia JE.
PMID: 33535452
Biomedicines. 2021 Feb 01;9(2). doi: 10.3390/biomedicines9020134.

Ulcerative colitis (UC) is characterized by modifying alternatively activated macrophages (AAM) and epithelial homeostasis. Chromogranin-A (CHGA), released by enterochromaffin cells, is elevated in UC and is implicated in inflammation progression. CHGA can be cleaved into several derived peptides, including...

Synthesis of glycopolymers with specificity for bacterial strains .

Chemical science

Luo Y, Gu Y, Feng R, Brash J, Eissa AM, Haddleton DM, Chen G, Chen H.
PMID: 31191880
Chem Sci. 2019 Apr 18;10(20):5251-5257. doi: 10.1039/c8sc05561k. eCollection 2019 May 28.

Identifying probiotics and pathogens is of great interest to the health of the human body. It is critical to develop microbiota-targeted therapies to have high specificity including strain specificity. In this study, we have utilized

Family, friends, and faith-communities: Intellectual community and the benefits of unofficial networks for marginalized scientists.

History of psychology

Rodkey KL, Rodkey EN.
PMID: 32852966
Hist Psychol. 2020 Nov;23(4):289-311. doi: 10.1037/hop0000172. Epub 2020 Aug 27.

Throughout the 20th century, female scientists faced barriers to participation in scientific communities. Within psychology, the 1st generation of women fought for inclusion in the university and access to laboratories; the 2nd generation officially gained access to such resources...

Showing 13 to 24 of 184 entries