Advanced Search
Display options
Filter resources
Text Availability
Article type
Publication date
Species
Language
Sex
Age
Showing 13 to 24 of 151 entries
Sorted by: Best Match Show Resources per page
Activated Microglia in Cortical White Matter Across Cognitive Aging Trajectories.

Frontiers in aging neuroscience

Gefen T, Kim G, Bolbolan K, Geoly A, Ohm D, Oboudiyat C, Shahidehpour R, Rademaker A, Weintraub S, Bigio EH, Mesulam MM, Rogalski E, Geula C.
PMID: 31139072
Front Aging Neurosci. 2019 May 14;11:94. doi: 10.3389/fnagi.2019.00094. eCollection 2019.

Activation of microglia, the primary mediators of inflammation in the brain, is a major component of gliosis and neuronal loss in a number of age-related neurodegenerative disorders, such as Alzheimer's disease (AD). The role of activated microglia in white...

Bioorthogonal Swarming: In Situ Generation of Dendrimers.

Journal of the American Chemical Society

Zhang Y, Üçüncü M, Gambardella A, Baibek A, Geng J, Zhang S, Clavadetscher J, Litzen I, Bradley M, Lilienkampf A.
PMID: 33326212
J Am Chem Soc. 2020 Dec 30;142(52):21615-21621. doi: 10.1021/jacs.0c07869. Epub 2020 Dec 16.

With the aid of bioorthogonal chemistry, we demonstrate the fabrication of synthetic dendrimers in situ around living cells. Using tetrazine dienophile and aminooxyl/hydrazide aldehyde chemistries, the density of functional groups on the dendrimers exponentially amplified intensities of fluorescent markers...

FDA Oncology Center of Excellence Project Renewal: Engaging the Oncology Community to Update Product Labeling for Older Oncology Drugs.

Clinical cancer research : an official journal of the American Association for Cancer Research

Kluetz PG, Keegan P, Demetri GD, Thornton K, Sul J, Kim J, Katzen H, Burke LB, Harvey RD, Alebachew E, Agrawal S, Nair A, Donoghue M, Pierce WF, Shord SS, Gao JJ, Pazdur R.
PMID: 33257426
Clin Cancer Res. 2021 Feb 15;27(4):916-921. doi: 10.1158/1078-0432.CCR-20-3213. Epub 2020 Nov 30.

The FDA conducts independent reviews of scientific data obtained with investigational drug products to ensure that they are safe and effective. As a result of this process, FDA-approved product labeling is generated that is considered one of the most...

Fgd5 is a Rac1-specific Rho GEF that is selectively inhibited by aurintricarboxylic acid.

Small GTPases

Park S, Guo Y, Negre J, Preto J, Smithers CC, Azad AK, Overduin M, Murray AG, Eitzen G.
PMID: 31601145
Small GTPases. 2021 Mar;12(2):147-160. doi: 10.1080/21541248.2019.1674765. Epub 2019 Oct 10.

Rho proteins are signalling molecules that control cellular dynamics, movement and morphological changes. They are activated by Rho guanine-nucleotide exchange factors (Rho GEFs) that transduce upstream signals into Rho-mediated activation of downstream processes. Fgd5 is a Rho GEF involved...

Complete Clinical Response in Locally Advanced Metastatic de novo Breast Cancer after Front-Line Treatment with Ribociclib/Letrozole within the RIBANNA Study.

Breast care (Basel, Switzerland)

Rudlowski C, Beermann N, Leitzen L, Nuding B.
PMID: 32774224
Breast Care (Basel). 2020 Jun;15(3):289-293. doi: 10.1159/000502565. Epub 2019 Sep 17.

INTRODUCTION: Ribociclib is an orally bioavailable cyclin-dependent kinase 4/6 inhibitor. In combination with aromatase inhibitor letrozole, it has approval for treatment of hormone receptor positive (HR+) and human epidermal growth factor receptor 2-negative (HER2-) advanced breast cancer. First-line therapy...

Instructed Partnership Appreciation in Depression: Effects on Mood, Momentary Relationship Satisfaction, and Psychobiological Arousal.

Frontiers in psychiatry

Warth M, Stoffel M, Winter F, Jarczok MN, Aguilar-Raab C, Ditzen B.
PMID: 32848903
Front Psychiatry. 2020 Jul 30;11:701. doi: 10.3389/fpsyt.2020.00701. eCollection 2020.

BACKGROUND: Depressive disorders are associated with attentional bias and social anhedonia. There is evidence supporting the hypothesis that depressed individuals participate less in potentially rewarding social situations and exhibit alterations in stress reactivity. With the present study, we aimed...

Oxytocin and social anxiety: Interactions with sex hormones.

Psychoneuroendocrinology

Schneider E, Müller LE, Ditzen B, Herpertz SC, Bertsch K.
PMID: 33878602
Psychoneuroendocrinology. 2021 Jun;128:105224. doi: 10.1016/j.psyneuen.2021.105224. Epub 2021 Apr 18.

Oxytocin has been associated with anxiolytic and stress reducing effects in a number of studies. Less is known about the associations of endogenous oxytocin concentrations and their interaction with other hormones such as sex hormones in relation to self-reported...

Author Correction: Persistent and reversible solid iodine electrodeposition in nanoporous carbons.

Nature communications

Prehal C, Fitzek H, Kothleitner G, Presser V, Gollas B, Freunberger SA, Abbas Q.
PMID: 33159089
Nat Commun. 2020 Nov 06;11(1):5742. doi: 10.1038/s41467-020-19720-x.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Hydrofilm Polyurethane Films Reduce Radiation Dermatitis Severity in Hypofractionated Whole-Breast Irradiation: An Objective, Intra-Patient Randomized Dual-Center Assessment.

Polymers

Schmeel LC, Koch D, Schmeel FC, Bücheler B, Leitzen C, Mahlmann B, Kunze D, Heimann M, Brüser D, Abramian AV, Schoroth F, Müdder T, Röhner F, Garbe S, Baumert BG, Schild HH, Wilhelm-Buchstab TM.
PMID: 31888185
Polymers (Basel). 2019 Dec 16;11(12). doi: 10.3390/polym11122112.

Radiation-induced skin injury represents the most frequent side effect in breast cancer patients undergoing whole-breast irradiation (WBI). Numerous clinical studies on systemic and topical treatments for radiation dermatitis have failed to provide sustainable treatment strategies. While protective skin products...

[Medical Psychology and Medical Sociology in Transition - Review and Perspectives of the two Disciplines in Germany].

Psychotherapie, Psychosomatik, medizinische Psychologie

Härter M, Ditzen B, Dragano N, Fabry G, Kaiser J, Kropp P, Richter M, Schut C, Knesebeck OVD, Bremer D.
PMID: 31952094
Psychother Psychosom Med Psychol. 2020 May;70(5):205-211. doi: 10.1055/a-1075-2851. Epub 2020 Jan 17.

AIM OF THE STUDY: Through the Master Plan for Medical Studies 2020 and the development of the National Competence-Based Learning Target Catalogue Medicine (NKLM), significant changes in university medicine were started. The aim of the study was a systematic...

Changes in Sewage Sludge Chemical Signatures During a COVID-19 Community Lockdown, Part 1: Traffic, Drugs, Mental Health, and Disinfectants.

Environmental toxicology and chemistry

Nason SL, Lin E, Eitzer B, Koelmel J, Peccia J.
PMID: 34668219
Environ Toxicol Chem. 2021 Oct 19; doi: 10.1002/etc.5217. Epub 2021 Oct 19.

The early months of the COVID-19 pandemic and the associated shutdowns disrupted many aspects of daily life and thus caused changes in the use and disposal of many types of chemicals. While records of sales, prescriptions, drug overdoses, and...

Active Living After Cancer: Adaptation and evaluation of a community-based physical activity program for minority and medically underserved breast cancer survivors.

Cancer

Tami-Maury IM, Liao Y, Rangel ML, Gatus LA, Shinn EH, Alexander A, Basen-Engquist K.
PMID: 34554567
Cancer. 2021 Sep 23; doi: 10.1002/cncr.33904. Epub 2021 Sep 23.

BACKGROUND: An expanding body of research documents the benefits of physical activity for cancer survivors' physical functioning and quality of life, but few successful models provide community-based physical activity programs to cancer survivors. This report presents an evaluation of...

Showing 13 to 24 of 151 entries