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Showing 49 to 57 of 57 entries
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GAPDH controls extracellular vesicle biogenesis and enhances the therapeutic potential of EV mediated siRNA delivery to the brain.

Nature communications

Dar GH, Mendes CC, Kuan WL, Speciale AA, Conceição M, Görgens A, Uliyakina I, Lobo MJ, Lim WF, El Andaloussi S, Mäger I, Roberts TC, Barker RA, Goberdhan DCI, Wilson C, Wood MJA.
PMID: 34795295
Nat Commun. 2021 Nov 18;12(1):6666. doi: 10.1038/s41467-021-27056-3.

Extracellular vesicles (EVs) are biological nanoparticles with important roles in intercellular communication, and potential as drug delivery vehicles. Here we demonstrate a role for the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in EV assembly and secretion. We observe high levels...

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Dar GH, Mendes CC, Kuan WL, et al. GAPDH controls extracellular vesicle biogenesis and enhances the therapeutic potential of EV mediated siRNA delivery to the brain. Nat Commun. 2021;12(1):6666doi: 10.1038/s41467-021-27056-3.
Dar, G. H., Mendes, C. C., Kuan, W. L., Speciale, A. A., Conceição, M., Görgens, A., Uliyakina, I., Lobo, M. J., Lim, W. F., El Andaloussi, S., Mäger, I., Roberts, T. C., Barker, R. A., Goberdhan, D. C. I., Wilson, C., & Wood, M. J. A. (2021). GAPDH controls extracellular vesicle biogenesis and enhances the therapeutic potential of EV mediated siRNA delivery to the brain. Nature communications, 12(1), 6666. https://doi.org/10.1038/s41467-021-27056-3
Dar, Ghulam Hassan, et al. "GAPDH controls extracellular vesicle biogenesis and enhances the therapeutic potential of EV mediated siRNA delivery to the brain." Nature communications vol. 12,1 (2021): 6666. doi: https://doi.org/10.1038/s41467-021-27056-3
Dar GH, Mendes CC, Kuan WL, Speciale AA, Conceição M, Görgens A, Uliyakina I, Lobo MJ, Lim WF, El Andaloussi S, Mäger I, Roberts TC, Barker RA, Goberdhan DCI, Wilson C, Wood MJA. GAPDH controls extracellular vesicle biogenesis and enhances the therapeutic potential of EV mediated siRNA delivery to the brain. Nat Commun. 2021 Nov 18;12(1):6666. doi: 10.1038/s41467-021-27056-3. PMID: 34795295; PMCID: PMC8602309.
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Influence of short term storage conditions, concentration methodsand excipients on extracellular vesicle recovery and function.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

van de Wakker SI, van Oudheusden J, Mol EA, Roefs MT, Zheng W, Görgens A, El Andaloussi S, Sluijter JPG, Vader P.
PMID: 34864197
Eur J Pharm Biopharm. 2022 Jan;170:59-69. doi: 10.1016/j.ejpb.2021.11.012. Epub 2021 Dec 02.

Extracellular vesicles (EVs) are phospholipid bilayer enclosed vesicles which play an important role in intercellular communication. To date, many studies have focused on therapeutic application of EVs. However, to progress EV applications faster towards the clinic, more information about...

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van de Wakker SI, van Oudheusden J, Mol EA, et al. Influence of short term storage conditions, concentration methodsand excipients on extracellular vesicle recovery and function. Eur J Pharm Biopharm. 2021;170:59-69doi: 10.1016/j.ejpb.2021.11.012.
van de Wakker, S. I., van Oudheusden, J., Mol, E. A., Roefs, M. T., Zheng, W., Görgens, A., El Andaloussi, S., Sluijter, J. P. G., & Vader, P. (2022). Influence of short term storage conditions, concentration methodsand excipients on extracellular vesicle recovery and function. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 17059-69. https://doi.org/10.1016/j.ejpb.2021.11.012
van de Wakker, S I, et al. "Influence of short term storage conditions, concentration methodsand excipients on extracellular vesicle recovery and function." European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V vol. 170 (2022): 59-69. doi: https://doi.org/10.1016/j.ejpb.2021.11.012
van de Wakker SI, van Oudheusden J, Mol EA, Roefs MT, Zheng W, Görgens A, El Andaloussi S, Sluijter JPG, Vader P. Influence of short term storage conditions, concentration methodsand excipients on extracellular vesicle recovery and function. Eur J Pharm Biopharm. 2022 Jan;170:59-69. doi: 10.1016/j.ejpb.2021.11.012. Epub 2021 Dec 02. PMID: 34864197.
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Claudin-7, -16, and -19 during mouse kidney development.

Tissue barriers

Khairallah H, El Andalousi J, Simard A, Haddad N, Chen YH, Hou J, Ryan AK, Gupta IR.
PMID: 25610756
Tissue Barriers. 2014 Aug 08;2(4):e964547. doi: 10.4161/21688362.2014.964547. eCollection 2014.

Members of the claudin family of tight junction proteins are critical for establishing epithelial barriers and for the regulation of paracellular transport. To understand their roles during kidney development, we first performed RT-PCR analyses and determined that 23 claudin...

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Khairallah H, El Andalousi J, Simard A, et al. Claudin-7, -16, and -19 during mouse kidney development. Tissue Barriers. 2014;2(4):e964547doi: 10.4161/21688362.2014.964547.
Khairallah, H., El Andalousi, J., Simard, A., Haddad, N., Chen, Y. H., Hou, J., Ryan, A. K., & Gupta, I. R. (2014). Claudin-7, -16, and -19 during mouse kidney development. Tissue barriers, 2(4), e964547. https://doi.org/10.4161/21688362.2014.964547
Khairallah, Halim, et al. "Claudin-7, -16, and -19 during mouse kidney development." Tissue barriers vol. 2,4 (2014): e964547. doi: https://doi.org/10.4161/21688362.2014.964547
Khairallah H, El Andalousi J, Simard A, Haddad N, Chen YH, Hou J, Ryan AK, Gupta IR. Claudin-7, -16, and -19 during mouse kidney development. Tissue Barriers. 2014 Aug 08;2(4):e964547. doi: 10.4161/21688362.2014.964547. eCollection 2014. PMID: 25610756; PMCID: PMC4292044.
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mRNA and microRNA transcriptomics analyses in a murine model of dystrophin loss and therapeutic restoration.

Genomics data

Roberts TC, Blomberg KE, Smith CI, El Andaloussi S, Wood MJ.
PMID: 26981371
Genom Data. 2015 Dec 02;7:88-9. doi: 10.1016/j.gdata.2015.11.025. eCollection 2016 Mar.

Duchenne muscular dystrophy (DMD) is a pediatric, X-linked, progressive muscle-wasting disorder caused by loss of function mutations affecting the gene encoding the dystrophin protein. While the primary genetic insult in DMD is well described, many details of the molecular...

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Roberts TC, Blomberg KE, Smith CI, et al. mRNA and microRNA transcriptomics analyses in a murine model of dystrophin loss and therapeutic restoration. Genom Data. 2015;7:88-9doi: 10.1016/j.gdata.2015.11.025.
Roberts, T. C., Blomberg, K. E., Smith, C. I., El Andaloussi, S., & Wood, M. J. (2016). mRNA and microRNA transcriptomics analyses in a murine model of dystrophin loss and therapeutic restoration. Genomics data, 788-9. https://doi.org/10.1016/j.gdata.2015.11.025
Roberts, Thomas C, et al. "mRNA and microRNA transcriptomics analyses in a murine model of dystrophin loss and therapeutic restoration." Genomics data vol. 7 (2016): 88-9. doi: https://doi.org/10.1016/j.gdata.2015.11.025
Roberts TC, Blomberg KE, Smith CI, El Andaloussi S, Wood MJ. mRNA and microRNA transcriptomics analyses in a murine model of dystrophin loss and therapeutic restoration. Genom Data. 2015 Dec 02;7:88-9. doi: 10.1016/j.gdata.2015.11.025. eCollection 2016 Mar. PMID: 26981371; PMCID: PMC4778658.
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Systematic Methodological Evaluation of a Multiplex Bead-Based Flow Cytometry Assay for Detection of Extracellular Vesicle Surface Signatures.

Frontiers in immunology

Wiklander OPB, Bostancioglu RB, Welsh JA, Zickler AM, Murke F, Corso G, Felldin U, Hagey DW, Evertsson B, Liang XM, Gustafsson MO, Mohammad DK, Wiek C, Hanenberg H, Bremer M, Gupta D, Björnstedt M, Giebel B, Nordin JZ, Jones JC, El Andaloussi S, Görgens A.
PMID: 29951064
Front Immunol. 2018 Jun 13;9:1326. doi: 10.3389/fimmu.2018.01326. eCollection 2018.

Extracellular vesicles (EVs) can be harvested from cell culture supernatants and from all body fluids. EVs can be conceptually classified based on their size and biogenesis as exosomes and microvesicles. Nowadays, it is however commonly accepted in the field...

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Wiklander OPB, Bostancioglu RB, Welsh JA, et al. Systematic Methodological Evaluation of a Multiplex Bead-Based Flow Cytometry Assay for Detection of Extracellular Vesicle Surface Signatures. Front Immunol. 2018;9:1326doi: 10.3389/fimmu.2018.01326.
Wiklander, O. P. B., Bostancioglu, R. B., Welsh, J. A., Zickler, A. M., Murke, F., Corso, G., Felldin, U., Hagey, D. W., Evertsson, B., Liang, X. M., Gustafsson, M. O., Mohammad, D. K., Wiek, C., Hanenberg, H., Bremer, M., Gupta, D., Björnstedt, M., Giebel, B., Nordin, J. Z., Jones, J. C., El Andaloussi, S., & Görgens, A. (2018). Systematic Methodological Evaluation of a Multiplex Bead-Based Flow Cytometry Assay for Detection of Extracellular Vesicle Surface Signatures. Frontiers in immunology, 91326. https://doi.org/10.3389/fimmu.2018.01326
Wiklander, Oscar P B, et al. "Systematic Methodological Evaluation of a Multiplex Bead-Based Flow Cytometry Assay for Detection of Extracellular Vesicle Surface Signatures." Frontiers in immunology vol. 9 (2018): 1326. doi: https://doi.org/10.3389/fimmu.2018.01326
Wiklander OPB, Bostancioglu RB, Welsh JA, Zickler AM, Murke F, Corso G, Felldin U, Hagey DW, Evertsson B, Liang XM, Gustafsson MO, Mohammad DK, Wiek C, Hanenberg H, Bremer M, Gupta D, Björnstedt M, Giebel B, Nordin JZ, Jones JC, El Andaloussi S, Görgens A. Systematic Methodological Evaluation of a Multiplex Bead-Based Flow Cytometry Assay for Detection of Extracellular Vesicle Surface Signatures. Front Immunol. 2018 Jun 13;9:1326. doi: 10.3389/fimmu.2018.01326. eCollection 2018. PMID: 29951064; PMCID: PMC6008374.
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Systematic characterization of extracellular vesicle sorting domains and quantification at the single molecule - single vesicle level by fluorescence correlation spectroscopy and single particle imaging.

Journal of extracellular vesicles

Corso G, Heusermann W, Trojer D, Görgens A, Steib E, Voshol J, Graff A, Genoud C, Lee Y, Hean J, Nordin JZ, Wiklander OPB, El Andaloussi S, Meisner-Kober N.
PMID: 31579435
J Extracell Vesicles. 2019 Sep 18;8(1):1663043. doi: 10.1080/20013078.2019.1663043. eCollection 2019.

Extracellular vesicles (EV) convey biological information by transmitting macromolecules between cells and tissues and are of great promise as pharmaceutical nanocarriers, and as therapeutic per se. Strategies for customizing the EV surface and cargo are being developed to enable...

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Corso G, Heusermann W, Trojer D, et al. Systematic characterization of extracellular vesicle sorting domains and quantification at the single molecule - single vesicle level by fluorescence correlation spectroscopy and single particle imaging. J Extracell Vesicles. 2019;8(1):1663043doi: 10.1080/20013078.2019.1663043.
Corso, G., Heusermann, W., Trojer, D., Görgens, A., Steib, E., Voshol, J., Graff, A., Genoud, C., Lee, Y., Hean, J., Nordin, J. Z., Wiklander, O. P. B., El Andaloussi, S., & Meisner-Kober, N. (2019). Systematic characterization of extracellular vesicle sorting domains and quantification at the single molecule - single vesicle level by fluorescence correlation spectroscopy and single particle imaging. Journal of extracellular vesicles, 8(1), 1663043. https://doi.org/10.1080/20013078.2019.1663043
Corso, Giulia, et al. "Systematic characterization of extracellular vesicle sorting domains and quantification at the single molecule - single vesicle level by fluorescence correlation spectroscopy and single particle imaging." Journal of extracellular vesicles vol. 8,1 (2019): 1663043. doi: https://doi.org/10.1080/20013078.2019.1663043
Corso G, Heusermann W, Trojer D, Görgens A, Steib E, Voshol J, Graff A, Genoud C, Lee Y, Hean J, Nordin JZ, Wiklander OPB, El Andaloussi S, Meisner-Kober N. Systematic characterization of extracellular vesicle sorting domains and quantification at the single molecule - single vesicle level by fluorescence correlation spectroscopy and single particle imaging. J Extracell Vesicles. 2019 Sep 18;8(1):1663043. doi: 10.1080/20013078.2019.1663043. eCollection 2019. PMID: 31579435; PMCID: PMC6758720.
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The Role of Gene Therapy in Premature Ovarian Insufficiency Management.

Biomedicines

Atabiekov I, Hobeika E, Sheikh U, El Andaloussi A, Al-Hendy A.
PMID: 30388808
Biomedicines. 2018 Nov 01;6(4). doi: 10.3390/biomedicines6040102.

Premature ovarian insufficiency (POI) is a highly prevalent disorder, characterized by the development of menopause before the age of 40. Most cases are idiopathic; however, in some women the cause of this condition (e.g.; anticancer treatment, genetic disorders, and...

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Atabiekov I, Hobeika E, Sheikh U, et al. The Role of Gene Therapy in Premature Ovarian Insufficiency Management. Biomedicines. 2018;6(4)doi: 10.3390/biomedicines6040102.
Atabiekov, I., Hobeika, E., Sheikh, U., El Andaloussi, A., & Al-Hendy, A. (2018). The Role of Gene Therapy in Premature Ovarian Insufficiency Management. Biomedicines, 6(4), . https://doi.org/10.3390/biomedicines6040102
Atabiekov, Ihor, et al. "The Role of Gene Therapy in Premature Ovarian Insufficiency Management." Biomedicines vol. 6,4 (2018). doi: https://doi.org/10.3390/biomedicines6040102
Atabiekov I, Hobeika E, Sheikh U, El Andaloussi A, Al-Hendy A. The Role of Gene Therapy in Premature Ovarian Insufficiency Management. Biomedicines. 2018 Nov 01;6(4). doi: 10.3390/biomedicines6040102. PMID: 30388808; PMCID: PMC6316312.
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Author Correction: GAPDH controls extracellular vesicle biogenesis and enhances the therapeutic potential of EV mediated siRNA delivery to the brain.

Nature communications

Dar GH, Mendes CC, Kuan WL, Speciale AA, Conceição M, Görgens A, Uliyakina I, Lobo MJ, Lim WF, El Andaloussi S, Mäger I, Roberts TC, Barker RA, Goberdhan DCI, Wilson C, Wood MJA.
PMID: 34916508
Nat Commun. 2021 Dec 16;12(1):7357. doi: 10.1038/s41467-021-27700-y.

No abstract available.

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Dar GH, Mendes CC, Kuan WL, et al. Author Correction: GAPDH controls extracellular vesicle biogenesis and enhances the therapeutic potential of EV mediated siRNA delivery to the brain. Nat Commun. 2021;12(1):7357doi: 10.1038/s41467-021-27700-y.
Dar, G. H., Mendes, C. C., Kuan, W. L., Speciale, A. A., Conceição, M., Görgens, A., Uliyakina, I., Lobo, M. J., Lim, W. F., El Andaloussi, S., Mäger, I., Roberts, T. C., Barker, R. A., Goberdhan, D. C. I., Wilson, C., & Wood, M. J. A. (2021). Author Correction: GAPDH controls extracellular vesicle biogenesis and enhances the therapeutic potential of EV mediated siRNA delivery to the brain. Nature communications, 12(1), 7357. https://doi.org/10.1038/s41467-021-27700-y
Dar, Ghulam Hassan, et al. "Author Correction: GAPDH controls extracellular vesicle biogenesis and enhances the therapeutic potential of EV mediated siRNA delivery to the brain." Nature communications vol. 12,1 (2021): 7357. doi: https://doi.org/10.1038/s41467-021-27700-y
Dar GH, Mendes CC, Kuan WL, Speciale AA, Conceição M, Görgens A, Uliyakina I, Lobo MJ, Lim WF, El Andaloussi S, Mäger I, Roberts TC, Barker RA, Goberdhan DCI, Wilson C, Wood MJA. Author Correction: GAPDH controls extracellular vesicle biogenesis and enhances the therapeutic potential of EV mediated siRNA delivery to the brain. Nat Commun. 2021 Dec 16;12(1):7357. doi: 10.1038/s41467-021-27700-y. PMID: 34916508.
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Human BM-MSC secretome enhances human granulosa cell proliferation and steroidogenesis and restores ovarian function in primary ovarian insufficiency mouse model.

Scientific reports

Park HS, Chugh RM, El Andaloussi A, Hobeika E, Esfandyari S, Elsharoud A, Ulin M, Garcia N, Bilal M, Al-Hendy A.
PMID: 33633319
Sci Rep. 2021 Feb 25;11(1):4525. doi: 10.1038/s41598-021-84216-7.

Primary ovarian insufficiency (POI) is defined as the loss of ovarian function before 40 years of age. It clinically manifests as amenorrhea, infertility, and signs of estrogen insufficiency. POI is frequently induced by chemotherapy. Gonadotoxic chemotherapy reagents damage granulosa...

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Park HS, Chugh RM, El Andaloussi A, et al. Human BM-MSC secretome enhances human granulosa cell proliferation and steroidogenesis and restores ovarian function in primary ovarian insufficiency mouse model. Sci Rep. 2021;11(1):4525doi: 10.1038/s41598-021-84216-7.
Park, H. S., Chugh, R. M., El Andaloussi, A., Hobeika, E., Esfandyari, S., Elsharoud, A., Ulin, M., Garcia, N., Bilal, M., & Al-Hendy, A. (2021). Human BM-MSC secretome enhances human granulosa cell proliferation and steroidogenesis and restores ovarian function in primary ovarian insufficiency mouse model. Scientific reports, 11(1), 4525. https://doi.org/10.1038/s41598-021-84216-7
Park, Hang-Soo, et al. "Human BM-MSC secretome enhances human granulosa cell proliferation and steroidogenesis and restores ovarian function in primary ovarian insufficiency mouse model." Scientific reports vol. 11,1 (2021): 4525. doi: https://doi.org/10.1038/s41598-021-84216-7
Park HS, Chugh RM, El Andaloussi A, Hobeika E, Esfandyari S, Elsharoud A, Ulin M, Garcia N, Bilal M, Al-Hendy A. Human BM-MSC secretome enhances human granulosa cell proliferation and steroidogenesis and restores ovarian function in primary ovarian insufficiency mouse model. Sci Rep. 2021 Feb 25;11(1):4525. doi: 10.1038/s41598-021-84216-7. PMID: 33633319; PMCID: PMC7907146.
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Showing 49 to 57 of 57 entries