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Showing 229 to 231 of 231 entries
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Clinical utility of a personalized and long-term monitoring device for Parkinson's disease in a real clinical practice setting: An expert opinion survey on STAT-ON™.

Neurologia (Barcelona, Spain)

Santos García D, López Ariztegui N, Cubo E, Vinagre Aragón A, García-Ramos R, Borrué C, Fernández-Pajarín G, Caballol N, Cabo I, Barrios-López JM, Hernández Vara J, Ávila Rivera MA, Gasca-Salas C, Escalante S, Manrique de Lara P, Pérez Noguera R, Álvarez Sauco M, Sierra M, Monje MHG, Sánchez Ferro A, Novo Ponte S, Alonso-Frech F, Macías-García D, Legarda I, Rojo A, Álvarez Fernández I, Buongiorno MT, Pastor P, García Ruíz P.
PMID: 33358530
Neurologia (Engl Ed). 2020 Dec 24; doi: 10.1016/j.nrl.2020.10.013. Epub 2020 Dec 24.

BACKGROUND: STAT-ON™ is an objective tool that registers ON-OFF fluctuations making possible to know the state of the patient at every moment of the day in normal life. Our aim was to analyze the opinion of different Parkinson's disease...

Manufacturing Bacteriophages (Part 1 of 2): Cell Line Development, Upstream, and Downstream Considerations.

Pharmaceuticals (Basel, Switzerland)

Tanir T, Orellana M, Escalante A, Moraes de Souza C, Koeris MS.
PMID: 34577634
Pharmaceuticals (Basel). 2021 Sep 17;14(9). doi: 10.3390/ph14090934.

Within this first part of the two-part series on phage manufacturing, we will give an overview of the process leading to bacteriophages as a drug substance, before covering the formulation into a drug product in the second part. The...

A Dictyostelium model for BPAN disease reveals a functional relationship between the WDR45/WIPI4 homolog Wdr45l and Vmp1 in the regulation of autophagy-associated PtdIns3P and ER stress.

Autophagy

Tornero-Écija A, Tábara LC, Bueno-Arribas M, Antón-Esteban L, Navarro-Gómez C, Sánchez I, Vincent O, Escalante R.
PMID: 34328055
Autophagy. 2021 Jul 27;1-17. doi: 10.1080/15548627.2021.1953262. Epub 2021 Jul 27.

PROPPINs are conserved PtdIns3P-binding proteins required for autophagosome biogenesis that fold into a characteristic group of seven-bladed beta-propellers. Mutations in WDR45/WIPI4, a human member of this family, lead to BPAN, a rare form of neurodegeneration. We have generated mutants...

Showing 229 to 231 of 231 entries