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The histone deacetylase Hdac7 supports LPS-inducible glycolysis and Il-1β production in murine macrophages via distinct mechanisms.

Journal of leukocyte biology

Ramnath D, Das Gupta K, Wang Y, Abrol R, Curson JEB, Lim J, Reid RC, Mansell A, Blumenthal A, Karunakaran D, Fairlie DP, Sweet MJ.
PMID: 34811804
J Leukoc Biol. 2021 Nov 23; doi: 10.1002/JLB.2MR1021-260R. Epub 2021 Nov 23.

TLRs reprogram macrophage metabolism, enhancing glycolysis and promoting flux through the tricarboxylic acid cycle to enable histone acetylation and inflammatory gene expression. The histone deacetylase (HDAC) family of lysine deacetylases regulates both TLR-inducible glycolysis and inflammatory responses. Here, we...

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Ramnath D, Das Gupta K, Wang Y, et al. The histone deacetylase Hdac7 supports LPS-inducible glycolysis and Il-1β production in murine macrophages via distinct mechanisms. J Leukoc Biol. 2021;doi: 10.1002/JLB.2MR1021-260R.
Ramnath, D., Das Gupta, K., Wang, Y., Abrol, R., Curson, J. E. B., Lim, J., Reid, R. C., Mansell, A., Blumenthal, A., Karunakaran, D., Fairlie, D. P., & Sweet, M. J. (2021). The histone deacetylase Hdac7 supports LPS-inducible glycolysis and Il-1β production in murine macrophages via distinct mechanisms. Journal of leukocyte biology, . https://doi.org/10.1002/JLB.2MR1021-260R
Ramnath, Divya, et al. "The histone deacetylase Hdac7 supports LPS-inducible glycolysis and Il-1β production in murine macrophages via distinct mechanisms." Journal of leukocyte biology vol. (2021). doi: https://doi.org/10.1002/JLB.2MR1021-260R
Ramnath D, Das Gupta K, Wang Y, Abrol R, Curson JEB, Lim J, Reid RC, Mansell A, Blumenthal A, Karunakaran D, Fairlie DP, Sweet MJ. The histone deacetylase Hdac7 supports LPS-inducible glycolysis and Il-1β production in murine macrophages via distinct mechanisms. J Leukoc Biol. 2021 Nov 23; doi: 10.1002/JLB.2MR1021-260R. Epub 2021 Nov 23. PMID: 34811804.
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Daily-level effects of alcohol, marijuana, and simultaneous use on young adults' perceived sleep health.

Sleep

Graupensperger S, Fairlie AM, Vitiello MV, Kilmer JR, Larimer ME, Patrick ME, Lee CM.
PMID: 34291803
Sleep. 2021 Dec 10;44(12). doi: 10.1093/sleep/zsab187.

STUDY OBJECTIVES: Simultaneous alcohol and marijuana (SAM) use is increasingly prevalent among young adults but has adverse health consequences. The current study examined daily-level associations between perceived sleep health and SAM use, relative to non-substance-use days and alcohol- or...

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Graupensperger S, Fairlie AM, Vitiello MV, et al. Daily-level effects of alcohol, marijuana, and simultaneous use on young adults' perceived sleep health. Sleep. 2021;44(12)doi: 10.1093/sleep/zsab187.
Graupensperger, S., Fairlie, A. M., Vitiello, M. V., Kilmer, J. R., Larimer, M. E., Patrick, M. E., & Lee, C. M. (2021). Daily-level effects of alcohol, marijuana, and simultaneous use on young adults' perceived sleep health. Sleep, 44(12), . https://doi.org/10.1093/sleep/zsab187
Graupensperger, Scott, et al. "Daily-level effects of alcohol, marijuana, and simultaneous use on young adults' perceived sleep health." Sleep vol. 44,12 (2021). doi: https://doi.org/10.1093/sleep/zsab187
Graupensperger S, Fairlie AM, Vitiello MV, Kilmer JR, Larimer ME, Patrick ME, Lee CM. Daily-level effects of alcohol, marijuana, and simultaneous use on young adults' perceived sleep health. Sleep. 2021 Dec 10;44(12). doi: 10.1093/sleep/zsab187. PMID: 34291803.
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Correction: BCL-XL is an actionable target for treatment of malignant pleural mesothelioma.

Cell death discovery

Arulananda S, O'Brien M, Evangelista M, Harris TJ, Steinohrt NS, Jenkins LJ, Walkiewicz M, O'Donoghue RJJ, Poh AR, Thapa B, Williams DS, Leong T, Mariadason JM, Li X, Cebon J, Lee EF, John T, Fairlie WD.
PMID: 34131107
Cell Death Discov. 2021 Jun 15;7(1):146. doi: 10.1038/s41420-020-00388-7.

No abstract available.

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Arulananda S, O'Brien M, Evangelista M, et al. Correction: BCL-XL is an actionable target for treatment of malignant pleural mesothelioma. Cell Death Discov. 2021;7(1):146doi: 10.1038/s41420-020-00388-7.
Arulananda, S., O'Brien, M., Evangelista, M., Harris, T. J., Steinohrt, N. S., Jenkins, L. J., Walkiewicz, M., O'Donoghue, R. J. J., Poh, A. R., Thapa, B., Williams, D. S., Leong, T., Mariadason, J. M., Li, X., Cebon, J., Lee, E. F., John, T., & Fairlie, W. D. (2021). Correction: BCL-XL is an actionable target for treatment of malignant pleural mesothelioma. Cell death discovery, 7(1), 146. https://doi.org/10.1038/s41420-020-00388-7
Arulananda, Surein, et al. "Correction: BCL-XL is an actionable target for treatment of malignant pleural mesothelioma." Cell death discovery vol. 7,1 (2021): 146. doi: https://doi.org/10.1038/s41420-020-00388-7
Arulananda S, O'Brien M, Evangelista M, Harris TJ, Steinohrt NS, Jenkins LJ, Walkiewicz M, O'Donoghue RJJ, Poh AR, Thapa B, Williams DS, Leong T, Mariadason JM, Li X, Cebon J, Lee EF, John T, Fairlie WD. Correction: BCL-XL is an actionable target for treatment of malignant pleural mesothelioma. Cell Death Discov. 2021 Jun 15;7(1):146. doi: 10.1038/s41420-020-00388-7. PMID: 34131107; PMCID: PMC8206255.
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A novel BH3-mimetic, AZD0466, targeting BCL-XL and BCL-2 is effective in pre-clinical models of malignant pleural mesothelioma.

Cell death discovery

Arulananda S, O'Brien M, Evangelista M, Jenkins LJ, Poh AR, Walkiewicz M, Leong T, Mariadason JM, Cebon J, Balachander SB, Cidado JR, Lee EF, John T, Fairlie WD.
PMID: 34050131
Cell Death Discov. 2021 May 28;7(1):122. doi: 10.1038/s41420-021-00505-0.

Malignant pleural mesothelioma (MPM) is an aggressive cancer with treatment limited to Cisplatin and Pemetrexed chemotherapy. Recently, we showed that drugs targeting the BCL-2-regulated apoptosis pathway could kill MPM cell lines in vitro, and control tumor growth in vivo....

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Arulananda S, O'Brien M, Evangelista M, et al. A novel BH3-mimetic, AZD0466, targeting BCL-XL and BCL-2 is effective in pre-clinical models of malignant pleural mesothelioma. Cell Death Discov. 2021;7(1):122doi: 10.1038/s41420-021-00505-0.
Arulananda, S., O'Brien, M., Evangelista, M., Jenkins, L. J., Poh, A. R., Walkiewicz, M., Leong, T., Mariadason, J. M., Cebon, J., Balachander, S. B., Cidado, J. R., Lee, E. F., John, T., & Fairlie, W. D. (2021). A novel BH3-mimetic, AZD0466, targeting BCL-XL and BCL-2 is effective in pre-clinical models of malignant pleural mesothelioma. Cell death discovery, 7(1), 122. https://doi.org/10.1038/s41420-021-00505-0
Arulananda, Surein, et al. "A novel BH3-mimetic, AZD0466, targeting BCL-XL and BCL-2 is effective in pre-clinical models of malignant pleural mesothelioma." Cell death discovery vol. 7,1 (2021): 122. doi: https://doi.org/10.1038/s41420-021-00505-0
Arulananda S, O'Brien M, Evangelista M, Jenkins LJ, Poh AR, Walkiewicz M, Leong T, Mariadason JM, Cebon J, Balachander SB, Cidado JR, Lee EF, John T, Fairlie WD. A novel BH3-mimetic, AZD0466, targeting BCL-XL and BCL-2 is effective in pre-clinical models of malignant pleural mesothelioma. Cell Death Discov. 2021 May 28;7(1):122. doi: 10.1038/s41420-021-00505-0. PMID: 34050131; PMCID: PMC8163735.
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Schooling and Covid-19: lessons from recent research on EdTech.

NPJ science of learning

Fairlie R, Loyalka P.
PMID: 32821427
NPJ Sci Learn. 2020 Aug 11;5:13. doi: 10.1038/s41539-020-00072-6. eCollection 2020.

The wide-scale global movement of school education to remote instruction due to Covid-19 is unprecedented. The use of educational technology (EdTech) offers an alternative to in-person learning and reinforces social distancing, but there is limited evidence on whether and...

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Fairlie R, Loyalka P. Schooling and Covid-19: lessons from recent research on EdTech. NPJ Sci Learn. 2020;5:13doi: 10.1038/s41539-020-00072-6.
Fairlie, R., & Loyalka, P. (2020). Schooling and Covid-19: lessons from recent research on EdTech. NPJ science of learning, 513. https://doi.org/10.1038/s41539-020-00072-6
Fairlie, Robert, and Loyalka, Prashant. "Schooling and Covid-19: lessons from recent research on EdTech." NPJ science of learning vol. 5 (2020): 13. doi: https://doi.org/10.1038/s41539-020-00072-6
Fairlie R, Loyalka P. Schooling and Covid-19: lessons from recent research on EdTech. NPJ Sci Learn. 2020 Aug 11;5:13. doi: 10.1038/s41539-020-00072-6. eCollection 2020. PMID: 32821427; PMCID: PMC7419293.
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Diagnostic and economic evaluation of a point-of-care test for respiratory syncytial virus.

ERJ open research

Allen AJ, Gonzalez-Ciscar A, Lendrem C, Suklan J, Allen K, Bell A, Baxter F, Crulley S, Fairlie L, Hardy D, Johnston L, McKenna J, Richards N, Shovlin G, Simmister C, Waugh S, Woodsford P, Graziadio S, Power M, Simpson AJ, Kumar P, Eastham K, Brodlie M.
PMID: 32832529
ERJ Open Res. 2020 Aug 17;6(3). doi: 10.1183/23120541.00018-2020. eCollection 2020 Jul.

Respiratory syncytial virus is a common cause of bronchiolitis. Historically, point-of-care tests have involved antigen detection technology with limited sensitivity. The aim of this study was to prospectively evaluate the diagnostic accuracy and model the economic impact of the...

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Allen AJ, Gonzalez-Ciscar A, Lendrem C, et al. Diagnostic and economic evaluation of a point-of-care test for respiratory syncytial virus. ERJ Open Res. 2020;6(3)doi: 10.1183/23120541.00018-2020.
Allen, A. J., Gonzalez-Ciscar, A., Lendrem, C., Suklan, J., Allen, K., Bell, A., Baxter, F., Crulley, S., Fairlie, L., Hardy, D., Johnston, L., McKenna, J., Richards, N., Shovlin, G., Simmister, C., Waugh, S., Woodsford, P., Graziadio, S., Power, M., Simpson, A. J., Kumar, P., Eastham, K., & Brodlie, M. (2020). Diagnostic and economic evaluation of a point-of-care test for respiratory syncytial virus. ERJ open research, 6(3), . https://doi.org/10.1183/23120541.00018-2020
Allen, A Joy, et al. "Diagnostic and economic evaluation of a point-of-care test for respiratory syncytial virus." ERJ open research vol. 6,3 (2020). doi: https://doi.org/10.1183/23120541.00018-2020
Allen AJ, Gonzalez-Ciscar A, Lendrem C, Suklan J, Allen K, Bell A, Baxter F, Crulley S, Fairlie L, Hardy D, Johnston L, McKenna J, Richards N, Shovlin G, Simmister C, Waugh S, Woodsford P, Graziadio S, Power M, Simpson AJ, Kumar P, Eastham K, Brodlie M. Diagnostic and economic evaluation of a point-of-care test for respiratory syncytial virus. ERJ Open Res. 2020 Aug 17;6(3). doi: 10.1183/23120541.00018-2020. eCollection 2020 Jul. PMID: 32832529; PMCID: PMC7430145.
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A Novel Long-Range n to π* Interaction Secures the Smallest known α-Helix in Water.

Angewandte Chemie (International ed. in English)

Hoang HN, Wu C, Hill TA, Dantas de Araujo A, Bernhardt PV, Liu L, Fairlie DP.
PMID: 31625253
Angew Chem Int Ed Engl. 2019 Dec 19;58(52):18873-18877. doi: 10.1002/anie.201911277. Epub 2019 Nov 08.

The introduction of an amide bond linking side chains of the first and fifth amino acids forms a cyclic pentapeptide that optimally stabilizes the smallest known α-helix in water. The origin of the stabilization is unclear. The observed dependence...

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Hoang HN, Wu C, Hill TA, et al. A Novel Long-Range n to π* Interaction Secures the Smallest known α-Helix in Water. Angew Chem Int Ed Engl. 2019;58(52):18873-18877doi: 10.1002/anie.201911277.
Hoang, H. N., Wu, C., Hill, T. A., Dantas de Araujo, A., Bernhardt, P. V., Liu, L., & Fairlie, D. P. (2019). A Novel Long-Range n to π* Interaction Secures the Smallest known α-Helix in Water. Angewandte Chemie (International ed. in English), 58(52), 18873-18877. https://doi.org/10.1002/anie.201911277
Hoang, Huy N, et al. "A Novel Long-Range n to π* Interaction Secures the Smallest known α-Helix in Water." Angewandte Chemie (International ed. in English) vol. 58,52 (2019): 18873-18877. doi: https://doi.org/10.1002/anie.201911277
Hoang HN, Wu C, Hill TA, Dantas de Araujo A, Bernhardt PV, Liu L, Fairlie DP. A Novel Long-Range n to π* Interaction Secures the Smallest known α-Helix in Water. Angew Chem Int Ed Engl. 2019 Dec 19;58(52):18873-18877. doi: 10.1002/anie.201911277. Epub 2019 Nov 08. PMID: 31625253.
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Absence of mucosal-associated invariant T cells in a person with a homozygous point mutation in .

Science immunology

Howson LJ, Awad W, von Borstel A, Lim HJ, McWilliam HEG, Sandoval-Romero ML, Majumdar S, Hamzeh AR, Andrews TD, McDermott DH, Murphy PM, Le Nours J, Mak JYW, Liu L, Fairlie DP, McCluskey J, Villadangos JA, Cook MC, Turner SJ, Davey MS, Ojaimi S, Rossjohn J.
PMID: 32709702
Sci Immunol. 2020 Jul 24;5(49). doi: 10.1126/sciimmunol.abc9492.

The role unconventional T cells play in protective immunity in humans is unclear. Mucosal-associated invariant T (MAIT) cells are an unconventional T cell subset restricted to the antigen-presenting molecule MR1. Here, we report the discovery of a patient homozygous...

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Howson LJ, Awad W, von Borstel A, et al. Absence of mucosal-associated invariant T cells in a person with a homozygous point mutation in . Sci Immunol. 2020;5(49)doi: 10.1126/sciimmunol.abc9492.
Howson, L. J., Awad, W., von Borstel, A., Lim, H. J., McWilliam, H. E. G., Sandoval-Romero, M. L., Majumdar, S., Hamzeh, A. R., Andrews, T. D., McDermott, D. H., Murphy, P. M., Le Nours, J., Mak, J. Y. W., Liu, L., Fairlie, D. P., McCluskey, J., Villadangos, J. A., Cook, M. C., Turner, S. J., Davey, M. S., Ojaimi, S., & Rossjohn, J. (2020). Absence of mucosal-associated invariant T cells in a person with a homozygous point mutation in . Science immunology, 5(49), . https://doi.org/10.1126/sciimmunol.abc9492
Howson, Lauren J, et al. "Absence of mucosal-associated invariant T cells in a person with a homozygous point mutation in ." Science immunology vol. 5,49 (2020). doi: https://doi.org/10.1126/sciimmunol.abc9492
Howson LJ, Awad W, von Borstel A, Lim HJ, McWilliam HEG, Sandoval-Romero ML, Majumdar S, Hamzeh AR, Andrews TD, McDermott DH, Murphy PM, Le Nours J, Mak JYW, Liu L, Fairlie DP, McCluskey J, Villadangos JA, Cook MC, Turner SJ, Davey MS, Ojaimi S, Rossjohn J. Absence of mucosal-associated invariant T cells in a person with a homozygous point mutation in . Sci Immunol. 2020 Jul 24;5(49). doi: 10.1126/sciimmunol.abc9492. PMID: 32709702; PMCID: PMC8581949.
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Cross-fading motives for simultaneous alcohol and marijuana use: Associations with young adults' use and consequences across days.

Drug and alcohol dependence

Patrick ME, Fleming CB, Fairlie AM, Lee CM.
PMID: 32492600
Drug Alcohol Depend. 2020 May 24;213:108077. doi: 10.1016/j.drugalcdep.2020.108077. Epub 2020 May 24.

BACKGROUND: Many young adults engage in simultaneous alcohol and marijuana (SAM) use so that their effects overlap. Little is known about motivations for dual substance use and associations with use and consequences. This study examined daily-level associations between cross-fading...

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Patrick ME, Fleming CB, Fairlie AM, et al. Cross-fading motives for simultaneous alcohol and marijuana use: Associations with young adults' use and consequences across days. Drug Alcohol Depend. 2020;213:108077doi: 10.1016/j.drugalcdep.2020.108077.
Patrick, M. E., Fleming, C. B., Fairlie, A. M., & Lee, C. M. (2020). Cross-fading motives for simultaneous alcohol and marijuana use: Associations with young adults' use and consequences across days. Drug and alcohol dependence, 213108077. https://doi.org/10.1016/j.drugalcdep.2020.108077
Patrick, Megan E, et al. "Cross-fading motives for simultaneous alcohol and marijuana use: Associations with young adults' use and consequences across days." Drug and alcohol dependence vol. 213 (2020): 108077. doi: https://doi.org/10.1016/j.drugalcdep.2020.108077
Patrick ME, Fleming CB, Fairlie AM, Lee CM. Cross-fading motives for simultaneous alcohol and marijuana use: Associations with young adults' use and consequences across days. Drug Alcohol Depend. 2020 May 24;213:108077. doi: 10.1016/j.drugalcdep.2020.108077. Epub 2020 May 24. PMID: 32492600; PMCID: PMC7371509.
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Fortified Coiled Coils: Enhancing Mechanical Stability with Lactam or Metal Staples.

Angewandte Chemie (International ed. in English)

López-García P, de Araujo AD, Bergues-Pupo AE, Tunn I, Fairlie DP, Blank KG.
PMID: 32940968
Angew Chem Int Ed Engl. 2021 Jan 04;60(1):232-236. doi: 10.1002/anie.202006971. Epub 2020 Oct 29.

Coiled coils (CCs) are powerful supramolecular building blocks for biomimetic materials, increasingly used for their mechanical properties. Here, we introduce helix-inducing macrocyclic constraints, so-called staples, to tune thermodynamic and mechanical stability of CCs. We show that thermodynamic stabilization of...

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López-García P, de Araujo AD, Bergues-Pupo AE, et al. Fortified Coiled Coils: Enhancing Mechanical Stability with Lactam or Metal Staples. Angew Chem Int Ed Engl. 2020;60(1):232-236doi: 10.1002/anie.202006971.
López-García, P., de Araujo, A. D., Bergues-Pupo, A. E., Tunn, I., Fairlie, D. P., & Blank, K. G. (2021). Fortified Coiled Coils: Enhancing Mechanical Stability with Lactam or Metal Staples. Angewandte Chemie (International ed. in English), 60(1), 232-236. https://doi.org/10.1002/anie.202006971
López-García, Patricia, et al. "Fortified Coiled Coils: Enhancing Mechanical Stability with Lactam or Metal Staples." Angewandte Chemie (International ed. in English) vol. 60,1 (2021): 232-236. doi: https://doi.org/10.1002/anie.202006971
López-García P, de Araujo AD, Bergues-Pupo AE, Tunn I, Fairlie DP, Blank KG. Fortified Coiled Coils: Enhancing Mechanical Stability with Lactam or Metal Staples. Angew Chem Int Ed Engl. 2021 Jan 04;60(1):232-236. doi: 10.1002/anie.202006971. Epub 2020 Oct 29. PMID: 32940968; PMCID: PMC7821110.
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Activation of protease-activated receptor 2 is associated with blood pressure regulation and proteinuria reduction in metabolic syndrome.

Clinical and experimental pharmacology & physiology

Maruyama-Fumoto K, McGuire JJ, Fairlie DP, Shinozuka K, Kagota S.
PMID: 33124085
Clin Exp Pharmacol Physiol. 2021 Feb;48(2):211-220. doi: 10.1111/1440-1681.13431. Epub 2020 Nov 21.

Metabolic syndrome (MetS) increases the risk of kidney disease. In SHRSP.Z-Lepr

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Maruyama-Fumoto K, McGuire JJ, Fairlie DP, et al. Activation of protease-activated receptor 2 is associated with blood pressure regulation and proteinuria reduction in metabolic syndrome. Clin Exp Pharmacol Physiol. 2020;48(2):211-220doi: 10.1111/1440-1681.13431.
Maruyama-Fumoto, K., McGuire, J. J., Fairlie, D. P., Shinozuka, K., & Kagota, S. (2021). Activation of protease-activated receptor 2 is associated with blood pressure regulation and proteinuria reduction in metabolic syndrome. Clinical and experimental pharmacology & physiology, 48(2), 211-220. https://doi.org/10.1111/1440-1681.13431
Maruyama-Fumoto, Kana, et al. "Activation of protease-activated receptor 2 is associated with blood pressure regulation and proteinuria reduction in metabolic syndrome." Clinical and experimental pharmacology & physiology vol. 48,2 (2021): 211-220. doi: https://doi.org/10.1111/1440-1681.13431
Maruyama-Fumoto K, McGuire JJ, Fairlie DP, Shinozuka K, Kagota S. Activation of protease-activated receptor 2 is associated with blood pressure regulation and proteinuria reduction in metabolic syndrome. Clin Exp Pharmacol Physiol. 2021 Feb;48(2):211-220. doi: 10.1111/1440-1681.13431. Epub 2020 Nov 21. PMID: 33124085.
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Recommended reading.

Nursing management (Harrow, London, England : 1994)

Fairlie S.
PMID: 27736405
Nurs Manag (Harrow). 2009 Jul 09;16(4):9. doi: 10.7748/nm.16.4.9.s15.

If Disney Ran Your Hospital should be mandatory reading for anyone working in healthcare services, whether they are clinicians, managers or ancillary workers.

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Fairlie S. Recommended reading. Nurs Manag (Harrow). 2009;16(4):9doi: 10.7748/nm.16.4.9.s15.
Fairlie, S. (2009). Recommended reading. Nursing management (Harrow, London, England : 1994), 16(4), 9. https://doi.org/10.7748/nm.16.4.9.s15
Fairlie, Susan. "Recommended reading." Nursing management (Harrow, London, England : 1994) vol. 16,4 (2009): 9. doi: https://doi.org/10.7748/nm.16.4.9.s15
Fairlie S. Recommended reading. Nurs Manag (Harrow). 2009 Jul 09;16(4):9. doi: 10.7748/nm.16.4.9.s15. PMID: 27736405.
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