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Showing 25 to 36 of 37 entries
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Dietary and Genetic Cholesterol Loading Rather Than Steatosis Promotes Liver Tumorigenesis and NASH-Driven HCC.

Cancers

Ribas V, de la Rosa LC, Robles D, Núñez S, Segalés P, Insausti-Urkia N, Solsona-Vilarrasa E, Fernández-Checa JC, García-Ruiz C.
PMID: 34439245
Cancers (Basel). 2021 Aug 13;13(16). doi: 10.3390/cancers13164091.

The association of nonalcoholic steatohepatitis (NASH) with obesity and type 2 diabetes is a major determinant factor for the continued rise of NASH-driven HCC. Unfortunately, the mechanisms underlying the progression from NASH to HCC are not well-understood. Steatosis is...

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Ribas V, de la Rosa LC, Robles D, et al. Dietary and Genetic Cholesterol Loading Rather Than Steatosis Promotes Liver Tumorigenesis and NASH-Driven HCC. Cancers (Basel). 2021;13(16)doi: 10.3390/cancers13164091.
Ribas, V., de la Rosa, L. C., Robles, D., Núñez, S., Segalés, P., Insausti-Urkia, N., Solsona-Vilarrasa, E., Fernández-Checa, J. C., & García-Ruiz, C. (2021). Dietary and Genetic Cholesterol Loading Rather Than Steatosis Promotes Liver Tumorigenesis and NASH-Driven HCC. Cancers, 13(16), . https://doi.org/10.3390/cancers13164091
Ribas, Vicent, et al. "Dietary and Genetic Cholesterol Loading Rather Than Steatosis Promotes Liver Tumorigenesis and NASH-Driven HCC." Cancers vol. 13,16 (2021). doi: https://doi.org/10.3390/cancers13164091
Ribas V, de la Rosa LC, Robles D, Núñez S, Segalés P, Insausti-Urkia N, Solsona-Vilarrasa E, Fernández-Checa JC, García-Ruiz C. Dietary and Genetic Cholesterol Loading Rather Than Steatosis Promotes Liver Tumorigenesis and NASH-Driven HCC. Cancers (Basel). 2021 Aug 13;13(16). doi: 10.3390/cancers13164091. PMID: 34439245; PMCID: PMC8393403.
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MITOCHONDRIAL CHOLESTEROL AND CANCER.

Seminars in cancer biology

Garcia-Ruiz C, Conde de la Rosa L, Ribas V, Fernandez-Checa JC.
PMID: 32805396
Semin Cancer Biol. 2021 Aug;73:76-85. doi: 10.1016/j.semcancer.2020.07.014. Epub 2020 Aug 14.

Cholesterol is a crucial component of membrane bilayers that determines their physical and functional properties. Cells largely satisfy their need for cholesterol through the novo synthesis from acetyl-CoA and this demand is particularly critical for cancer cells to sustain...

Cite
Garcia-Ruiz C, Conde de la Rosa L, Ribas V, et al. MITOCHONDRIAL CHOLESTEROL AND CANCER. Semin Cancer Biol. 2020;73:76-85doi: 10.1016/j.semcancer.2020.07.014.
Garcia-Ruiz, C., Conde de la Rosa, L., Ribas, V., & Fernandez-Checa, J. C. (2021). MITOCHONDRIAL CHOLESTEROL AND CANCER. Seminars in cancer biology, 7376-85. https://doi.org/10.1016/j.semcancer.2020.07.014
Garcia-Ruiz, Carmen, et al. "MITOCHONDRIAL CHOLESTEROL AND CANCER." Seminars in cancer biology vol. 73 (2021): 76-85. doi: https://doi.org/10.1016/j.semcancer.2020.07.014
Garcia-Ruiz C, Conde de la Rosa L, Ribas V, Fernandez-Checa JC. MITOCHONDRIAL CHOLESTEROL AND CANCER. Semin Cancer Biol. 2021 Aug;73:76-85. doi: 10.1016/j.semcancer.2020.07.014. Epub 2020 Aug 14. PMID: 32805396; PMCID: PMC7882000.
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C-Reactive Protein, a Promising Approach for Acetaminophen Hepatotoxicity.

Cellular and molecular gastroenterology and hepatology

Garcia-Ruiz C, Fernandez-Checa JC.
PMID: 34732318
Cell Mol Gastroenterol Hepatol. 2022;13(1):341-342. doi: 10.1016/j.jcmgh.2021.10.004. Epub 2021 Oct 31.

No abstract available.

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Garcia-Ruiz C, Fernandez-Checa JC. C-Reactive Protein, a Promising Approach for Acetaminophen Hepatotoxicity. Cell Mol Gastroenterol Hepatol. 2021;13(1):341-342doi: 10.1016/j.jcmgh.2021.10.004.
Garcia-Ruiz, C., & Fernandez-Checa, J. C. (2022). C-Reactive Protein, a Promising Approach for Acetaminophen Hepatotoxicity. Cellular and molecular gastroenterology and hepatology, 13(1), 341-342. https://doi.org/10.1016/j.jcmgh.2021.10.004
Garcia-Ruiz, Carmen, and Fernandez-Checa, Jose C. "C-Reactive Protein, a Promising Approach for Acetaminophen Hepatotoxicity." Cellular and molecular gastroenterology and hepatology vol. 13,1 (2022): 341-342. doi: https://doi.org/10.1016/j.jcmgh.2021.10.004
Garcia-Ruiz C, Fernandez-Checa JC. C-Reactive Protein, a Promising Approach for Acetaminophen Hepatotoxicity. Cell Mol Gastroenterol Hepatol. 2022;13(1):341-342. doi: 10.1016/j.jcmgh.2021.10.004. Epub 2021 Oct 31. PMID: 34732318; PMCID: PMC8703118.
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Splicing Factor SLU7 Prevents Oxidative Stress-Mediated Hepatocyte Nuclear Factor 4α Degradation, Preserving Hepatic Differentiation and Protecting From Liver Damage.

Hepatology (Baltimore, Md.)

Gárate-Rascón M, Recalde M, Jimenez M, Elizalde M, Azkona M, Uriarte I, Latasa MU, Urtasun R, Bilbao I, Sangro B, Garcia-Ruiz C, Fernandez-Checa JC, Corrales FJ, Esquivel A, Pineda-Lucena A, Fernández-Barrena MG, Ávila MA, Arechederra M, Berasain C, O'Cathain A, Croot L.
PMID: 34170569
Hepatology. 2021 Nov;74(5):2791-2807. doi: 10.1002/hep.32029. Epub 2021 Sep 25.

BACKGROUND AND AIMS: Hepatocellular dedifferentiation is emerging as an important determinant in liver disease progression. Preservation of mature hepatocyte identity relies on a set of key genes, predominantly the transcription factor hepatocyte nuclear factor 4α (HNF4α) but also splicing...

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Gárate-Rascón M, Recalde M, Jimenez M, et al. Splicing Factor SLU7 Prevents Oxidative Stress-Mediated Hepatocyte Nuclear Factor 4α Degradation, Preserving Hepatic Differentiation and Protecting From Liver Damage. Hepatology. 2021;74(5):2791-2807doi: 10.1002/hep.32029.
Gárate-Rascón, M., Recalde, M., Jimenez, M., Elizalde, M., Azkona, M., Uriarte, I., Latasa, M. U., Urtasun, R., Bilbao, I., Sangro, B., Garcia-Ruiz, C., Fernandez-Checa, J. C., Corrales, F. J., Esquivel, A., Pineda-Lucena, A., Fernández-Barrena, M. G., Ávila, M. A., Arechederra, M., Berasain, C., O'Cathain, A., & Croot, L. (2021). Splicing Factor SLU7 Prevents Oxidative Stress-Mediated Hepatocyte Nuclear Factor 4α Degradation, Preserving Hepatic Differentiation and Protecting From Liver Damage. Hepatology (Baltimore, Md.), 74(5), 2791-2807. https://doi.org/10.1002/hep.32029
Gárate-Rascón, María, et al. "Splicing Factor SLU7 Prevents Oxidative Stress-Mediated Hepatocyte Nuclear Factor 4α Degradation, Preserving Hepatic Differentiation and Protecting From Liver Damage." Hepatology (Baltimore, Md.) vol. 74,5 (2021): 2791-2807. doi: https://doi.org/10.1002/hep.32029
Gárate-Rascón M, Recalde M, Jimenez M, Elizalde M, Azkona M, Uriarte I, Latasa MU, Urtasun R, Bilbao I, Sangro B, Garcia-Ruiz C, Fernandez-Checa JC, Corrales FJ, Esquivel A, Pineda-Lucena A, Fernández-Barrena MG, Ávila MA, Arechederra M, Berasain C, O'Cathain A, Croot L. Splicing Factor SLU7 Prevents Oxidative Stress-Mediated Hepatocyte Nuclear Factor 4α Degradation, Preserving Hepatic Differentiation and Protecting From Liver Damage. Hepatology. 2021 Nov;74(5):2791-2807. doi: 10.1002/hep.32029. Epub 2021 Sep 25. PMID: 34170569.
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GST-Perfringolysin O production for the localization and quantification of membrane cholesterol in human and mouse brain and liver.

STAR protocols

Goicoechea L, Arenas F, Castro F, Nuñez S, Torres S, Garcia-Ruiz C, Fernandez-Checa JC.
PMID: 35024626
STAR Protoc. 2021 Dec 29;3(1):101068. doi: 10.1016/j.xpro.2021.101068. eCollection 2022 Mar 18.

Abnormal cholesterol metabolism is linked to many neurodegenerative disorders. Here, we present a protocol for the production of a recombinant protein consisting of a Glutathione-S-Transferase tag fused with the Perfringolysin O (PFO). The GST-PFO tag enables analysis of the...

Cite
Goicoechea L, Arenas F, Castro F, et al. GST-Perfringolysin O production for the localization and quantification of membrane cholesterol in human and mouse brain and liver. STAR Protoc. 2021;3(1):101068doi: 10.1016/j.xpro.2021.101068.
Goicoechea, L., Arenas, F., Castro, F., Nuñez, S., Torres, S., Garcia-Ruiz, C., & Fernandez-Checa, J. C. (2022). GST-Perfringolysin O production for the localization and quantification of membrane cholesterol in human and mouse brain and liver. STAR protocols, 3(1), 101068. https://doi.org/10.1016/j.xpro.2021.101068
Goicoechea, Leire, et al. "GST-Perfringolysin O production for the localization and quantification of membrane cholesterol in human and mouse brain and liver." STAR protocols vol. 3,1 (2022): 101068. doi: https://doi.org/10.1016/j.xpro.2021.101068
Goicoechea L, Arenas F, Castro F, Nuñez S, Torres S, Garcia-Ruiz C, Fernandez-Checa JC. GST-Perfringolysin O production for the localization and quantification of membrane cholesterol in human and mouse brain and liver. STAR Protoc. 2021 Dec 29;3(1):101068. doi: 10.1016/j.xpro.2021.101068. eCollection 2022 Mar 18. PMID: 35024626; PMCID: PMC8728529.
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STARD1 promotes NASH-driven HCC by sustaining the generation of bile acids through the alternative mitochondrial pathway.

Journal of hepatology

Conde de la Rosa L, Garcia-Ruiz C, Vallejo C, Baulies A, Nuñez S, Monte MJ, Marin JJG, Baila-Rueda L, Cenarro A, Civeira F, Fuster J, Garcia-Valdecasas JC, Ferrer J, Karin M, Ribas V, Fernandez-Checa JC.
PMID: 33515644
J Hepatol. 2021 Jun;74(6):1429-1441. doi: 10.1016/j.jhep.2021.01.028. Epub 2021 Jan 27.

BACKGROUND & AIMS: Besides their physiological role in bile formation and fat digestion, bile acids (BAs) synthesised from cholesterol in hepatocytes act as signalling molecules that modulate hepatocellular carcinoma (HCC). Trafficking of cholesterol to mitochondria through steroidogenic acute regulatory...

Cite
Conde de la Rosa L, Garcia-Ruiz C, Vallejo C, et al. STARD1 promotes NASH-driven HCC by sustaining the generation of bile acids through the alternative mitochondrial pathway. J Hepatol. 2021;74(6):1429-1441doi: 10.1016/j.jhep.2021.01.028.
Conde de la Rosa, L., Garcia-Ruiz, C., Vallejo, C., Baulies, A., Nuñez, S., Monte, M. J., Marin, J. J. G., Baila-Rueda, L., Cenarro, A., Civeira, F., Fuster, J., Garcia-Valdecasas, J. C., Ferrer, J., Karin, M., Ribas, V., & Fernandez-Checa, J. C. (2021). STARD1 promotes NASH-driven HCC by sustaining the generation of bile acids through the alternative mitochondrial pathway. Journal of hepatology, 74(6), 1429-1441. https://doi.org/10.1016/j.jhep.2021.01.028
Conde de la Rosa, Laura, et al. "STARD1 promotes NASH-driven HCC by sustaining the generation of bile acids through the alternative mitochondrial pathway." Journal of hepatology vol. 74,6 (2021): 1429-1441. doi: https://doi.org/10.1016/j.jhep.2021.01.028
Conde de la Rosa L, Garcia-Ruiz C, Vallejo C, Baulies A, Nuñez S, Monte MJ, Marin JJG, Baila-Rueda L, Cenarro A, Civeira F, Fuster J, Garcia-Valdecasas JC, Ferrer J, Karin M, Ribas V, Fernandez-Checa JC. STARD1 promotes NASH-driven HCC by sustaining the generation of bile acids through the alternative mitochondrial pathway. J Hepatol. 2021 Jun;74(6):1429-1441. doi: 10.1016/j.jhep.2021.01.028. Epub 2021 Jan 27. PMID: 33515644; PMCID: PMC8573791.
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MITOCHONDRIAL CHOLESTEROL AND CANCER.

Seminars in cancer biology

Garcia-Ruiz C, Conde de la Rosa L, Ribas V, Fernandez-Checa JC.
PMID: 32805396
Semin Cancer Biol. 2021 Aug;73:76-85. doi: 10.1016/j.semcancer.2020.07.014. Epub 2020 Aug 14.

Cholesterol is a crucial component of membrane bilayers that determines their physical and functional properties. Cells largely satisfy their need for cholesterol through the novo synthesis from acetyl-CoA and this demand is particularly critical for cancer cells to sustain...

Cite
Garcia-Ruiz C, Conde de la Rosa L, Ribas V, et al. MITOCHONDRIAL CHOLESTEROL AND CANCER. Semin Cancer Biol. 2020;73:76-85doi: 10.1016/j.semcancer.2020.07.014.
Garcia-Ruiz, C., Conde de la Rosa, L., Ribas, V., & Fernandez-Checa, J. C. (2021). MITOCHONDRIAL CHOLESTEROL AND CANCER. Seminars in cancer biology, 7376-85. https://doi.org/10.1016/j.semcancer.2020.07.014
Garcia-Ruiz, Carmen, et al. "MITOCHONDRIAL CHOLESTEROL AND CANCER." Seminars in cancer biology vol. 73 (2021): 76-85. doi: https://doi.org/10.1016/j.semcancer.2020.07.014
Garcia-Ruiz C, Conde de la Rosa L, Ribas V, Fernandez-Checa JC. MITOCHONDRIAL CHOLESTEROL AND CANCER. Semin Cancer Biol. 2021 Aug;73:76-85. doi: 10.1016/j.semcancer.2020.07.014. Epub 2020 Aug 14. PMID: 32805396; PMCID: PMC7882000.
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Mitochondrial-Lysosomal Axis in Acetaminophen Hepatotoxicity.

Frontiers in pharmacology

Moles A, Torres S, Baulies A, Garcia-Ruiz C, Fernandez-Checa JC.
PMID: 29867464
Front Pharmacol. 2018 May 15;9:453. doi: 10.3389/fphar.2018.00453. eCollection 2018.

Acetaminophen (APAP) toxicity is the most common cause of acute liver failure and a major indication for liver transplantion in the United States and Europe. Although significant progress has been made in understanding the molecular mechanisms underlying APAP hepatotoxicity,...

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Moles A, Torres S, Baulies A, et al. Mitochondrial-Lysosomal Axis in Acetaminophen Hepatotoxicity. Front Pharmacol. 2018;9:453doi: 10.3389/fphar.2018.00453.
Moles, A., Torres, S., Baulies, A., Garcia-Ruiz, C., & Fernandez-Checa, J. C. (2018). Mitochondrial-Lysosomal Axis in Acetaminophen Hepatotoxicity. Frontiers in pharmacology, 9453. https://doi.org/10.3389/fphar.2018.00453
Moles, Anna, et al. "Mitochondrial-Lysosomal Axis in Acetaminophen Hepatotoxicity." Frontiers in pharmacology vol. 9 (2018): 453. doi: https://doi.org/10.3389/fphar.2018.00453
Moles A, Torres S, Baulies A, Garcia-Ruiz C, Fernandez-Checa JC. Mitochondrial-Lysosomal Axis in Acetaminophen Hepatotoxicity. Front Pharmacol. 2018 May 15;9:453. doi: 10.3389/fphar.2018.00453. eCollection 2018. PMID: 29867464; PMCID: PMC5968389.
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STARD1 promotes NASH-driven HCC by sustaining the generation of bile acids through the alternative mitochondrial pathway.

Journal of hepatology

Conde de la Rosa L, Garcia-Ruiz C, Vallejo C, Baulies A, Nuñez S, Monte MJ, Marin JJG, Baila-Rueda L, Cenarro A, Civeira F, Fuster J, Garcia-Valdecasas JC, Ferrer J, Karin M, Ribas V, Fernandez-Checa JC.
PMID: 33515644
J Hepatol. 2021 Jun;74(6):1429-1441. doi: 10.1016/j.jhep.2021.01.028. Epub 2021 Jan 27.

BACKGROUND & AIMS: Besides their physiological role in bile formation and fat digestion, bile acids (BAs) synthesised from cholesterol in hepatocytes act as signalling molecules that modulate hepatocellular carcinoma (HCC). Trafficking of cholesterol to mitochondria through steroidogenic acute regulatory...

Cite
Conde de la Rosa L, Garcia-Ruiz C, Vallejo C, et al. STARD1 promotes NASH-driven HCC by sustaining the generation of bile acids through the alternative mitochondrial pathway. J Hepatol. 2021;74(6):1429-1441doi: 10.1016/j.jhep.2021.01.028.
Conde de la Rosa, L., Garcia-Ruiz, C., Vallejo, C., Baulies, A., Nuñez, S., Monte, M. J., Marin, J. J. G., Baila-Rueda, L., Cenarro, A., Civeira, F., Fuster, J., Garcia-Valdecasas, J. C., Ferrer, J., Karin, M., Ribas, V., & Fernandez-Checa, J. C. (2021). STARD1 promotes NASH-driven HCC by sustaining the generation of bile acids through the alternative mitochondrial pathway. Journal of hepatology, 74(6), 1429-1441. https://doi.org/10.1016/j.jhep.2021.01.028
Conde de la Rosa, Laura, et al. "STARD1 promotes NASH-driven HCC by sustaining the generation of bile acids through the alternative mitochondrial pathway." Journal of hepatology vol. 74,6 (2021): 1429-1441. doi: https://doi.org/10.1016/j.jhep.2021.01.028
Conde de la Rosa L, Garcia-Ruiz C, Vallejo C, Baulies A, Nuñez S, Monte MJ, Marin JJG, Baila-Rueda L, Cenarro A, Civeira F, Fuster J, Garcia-Valdecasas JC, Ferrer J, Karin M, Ribas V, Fernandez-Checa JC. STARD1 promotes NASH-driven HCC by sustaining the generation of bile acids through the alternative mitochondrial pathway. J Hepatol. 2021 Jun;74(6):1429-1441. doi: 10.1016/j.jhep.2021.01.028. Epub 2021 Jan 27. PMID: 33515644; PMCID: PMC8573791.
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Intracellular Cholesterol Trafficking and Impact in Neurodegeneration.

Frontiers in molecular neuroscience

Arenas F, Garcia-Ruiz C, Fernandez-Checa JC.
PMID: 29204109
Front Mol Neurosci. 2017 Nov 17;10:382. doi: 10.3389/fnmol.2017.00382. eCollection 2017.

Cholesterol is a critical component of membrane bilayers where it plays key structural and functional roles by regulating the activity of diverse signaling platforms and pathways. Particularly enriched in brain, cholesterol homeostasis in this organ is singular with respect...

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Arenas F, Garcia-Ruiz C, Fernandez-Checa JC. Intracellular Cholesterol Trafficking and Impact in Neurodegeneration. Front Mol Neurosci. 2017;10:382doi: 10.3389/fnmol.2017.00382.
Arenas, F., Garcia-Ruiz, C., & Fernandez-Checa, J. C. (2017). Intracellular Cholesterol Trafficking and Impact in Neurodegeneration. Frontiers in molecular neuroscience, 10382. https://doi.org/10.3389/fnmol.2017.00382
Arenas, Fabian, et al. "Intracellular Cholesterol Trafficking and Impact in Neurodegeneration." Frontiers in molecular neuroscience vol. 10 (2017): 382. doi: https://doi.org/10.3389/fnmol.2017.00382
Arenas F, Garcia-Ruiz C, Fernandez-Checa JC. Intracellular Cholesterol Trafficking and Impact in Neurodegeneration. Front Mol Neurosci. 2017 Nov 17;10:382. doi: 10.3389/fnmol.2017.00382. eCollection 2017. PMID: 29204109; PMCID: PMC5698305.
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Sphingomyelin synthase 1 mediates hepatocyte pyroptosis to trigger non-alcoholic steatohepatitis.

Gut

Koh EH, Yoon JE, Ko MS, Leem J, Yun JY, Hong CH, Cho YK, Lee SE, Jang JE, Baek JY, Yoo HJ, Kim SJ, Sung CO, Lim JS, Jeong WI, Back SH, Baek IJ, Torres S, Solsona-Vilarrasa E, Conde de la Rosa L, Garcia-Ruiz C, Feldstein AE, Fernandez-Checa JC, Lee KU.
PMID: 33208407
Gut. 2021 Oct;70(10):1954-1964. doi: 10.1136/gutjnl-2020-322509. Epub 2020 Nov 18.

OBJECTIVE: Lipotoxic hepatocyte injury is a primary event in non-alcoholic steatohepatitis (NASH), but the mechanisms of lipotoxicity are not fully defined. Sphingolipids and free cholesterol (FC) mediate hepatocyte injury, but their link in NASH has not been explored. We...

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Koh EH, Yoon JE, Ko MS, et al. Sphingomyelin synthase 1 mediates hepatocyte pyroptosis to trigger non-alcoholic steatohepatitis. Gut. 2020;70(10):1954-1964doi: 10.1136/gutjnl-2020-322509.
Koh, E. H., Yoon, J. E., Ko, M. S., Leem, J., Yun, J. Y., Hong, C. H., Cho, Y. K., Lee, S. E., Jang, J. E., Baek, J. Y., Yoo, H. J., Kim, S. J., Sung, C. O., Lim, J. S., Jeong, W. I., Back, S. H., Baek, I. J., Torres, S., Solsona-Vilarrasa, E., Conde de la Rosa, L., Garcia-Ruiz, C., Feldstein, A. E., Fernandez-Checa, J. C., & Lee, K. U. (2021). Sphingomyelin synthase 1 mediates hepatocyte pyroptosis to trigger non-alcoholic steatohepatitis. Gut, 70(10), 1954-1964. https://doi.org/10.1136/gutjnl-2020-322509
Koh, Eun Hee, et al. "Sphingomyelin synthase 1 mediates hepatocyte pyroptosis to trigger non-alcoholic steatohepatitis." Gut vol. 70,10 (2021): 1954-1964. doi: https://doi.org/10.1136/gutjnl-2020-322509
Koh EH, Yoon JE, Ko MS, Leem J, Yun JY, Hong CH, Cho YK, Lee SE, Jang JE, Baek JY, Yoo HJ, Kim SJ, Sung CO, Lim JS, Jeong WI, Back SH, Baek IJ, Torres S, Solsona-Vilarrasa E, Conde de la Rosa L, Garcia-Ruiz C, Feldstein AE, Fernandez-Checa JC, Lee KU. Sphingomyelin synthase 1 mediates hepatocyte pyroptosis to trigger non-alcoholic steatohepatitis. Gut. 2021 Oct;70(10):1954-1964. doi: 10.1136/gutjnl-2020-322509. Epub 2020 Nov 18. PMID: 33208407; PMCID: PMC8458090.
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GST-Perfringolysin O production for the localization and quantification of membrane cholesterol in human and mouse brain and liver.

STAR protocols

Goicoechea L, Arenas F, Castro F, Nuñez S, Torres S, Garcia-Ruiz C, Fernandez-Checa JC.
PMID: 35024626
STAR Protoc. 2021 Dec 29;3(1):101068. doi: 10.1016/j.xpro.2021.101068. eCollection 2022 Mar 18.

Abnormal cholesterol metabolism is linked to many neurodegenerative disorders. Here, we present a protocol for the production of a recombinant protein consisting of a Glutathione-S-Transferase tag fused with the Perfringolysin O (PFO). The GST-PFO tag enables analysis of the...

Cite
Goicoechea L, Arenas F, Castro F, et al. GST-Perfringolysin O production for the localization and quantification of membrane cholesterol in human and mouse brain and liver. STAR Protoc. 2021;3(1):101068doi: 10.1016/j.xpro.2021.101068.
Goicoechea, L., Arenas, F., Castro, F., Nuñez, S., Torres, S., Garcia-Ruiz, C., & Fernandez-Checa, J. C. (2022). GST-Perfringolysin O production for the localization and quantification of membrane cholesterol in human and mouse brain and liver. STAR protocols, 3(1), 101068. https://doi.org/10.1016/j.xpro.2021.101068
Goicoechea, Leire, et al. "GST-Perfringolysin O production for the localization and quantification of membrane cholesterol in human and mouse brain and liver." STAR protocols vol. 3,1 (2022): 101068. doi: https://doi.org/10.1016/j.xpro.2021.101068
Goicoechea L, Arenas F, Castro F, Nuñez S, Torres S, Garcia-Ruiz C, Fernandez-Checa JC. GST-Perfringolysin O production for the localization and quantification of membrane cholesterol in human and mouse brain and liver. STAR Protoc. 2021 Dec 29;3(1):101068. doi: 10.1016/j.xpro.2021.101068. eCollection 2022 Mar 18. PMID: 35024626; PMCID: PMC8728529.
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