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Showing 109 to 115 of 115 entries
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Efficient stimulation of retinal regeneration from Müller glia in adult mice using combinations of proneural bHLH transcription factors.

Cell reports

Todd L, Hooper MJ, Haugan AK, Finkbeiner C, Jorstad N, Radulovich N, Wong CK, Donaldson PC, Jenkins W, Chen Q, Rieke F, Reh TA.
PMID: 34686336
Cell Rep. 2021 Oct 19;37(3):109857. doi: 10.1016/j.celrep.2021.109857.

Regenerative neuroscience aims to stimulate endogenous repair in the nervous system to replace neurons lost from degenerative diseases. Recently, we reported that overexpressing the transcription factor Ascl1 in Müller glia (MG) is sufficient to stimulate MG to regenerate functional...

Generation of two human induced pluripotent stem cell lines from fibroblasts of unrelated Parkinson's patients carrying the G2019S mutation in the LRRK2 gene (LCSBi005, LCSBi006).

Stem cell research

Novak G, Finkbeiner S, Skibinski G, Skupin A.
PMID: 34736041
Stem Cell Res. 2021 Oct 12;57:102569. doi: 10.1016/j.scr.2021.102569. Epub 2021 Oct 12.

Mutations in the LRRK2 gene are known to mediate predisposition to Parkinson disease. Fibroblasts heterozygous for the G2019S LRRK2 mutation were obtained from a 53-year-old male patient with disease onset at 34 years (LCSBi005, ND29542), and from a 63-year-old...

Epithelial miR-141 regulates IL-13-induced airway mucus production.

JCI insight

Siddiqui S, Johansson K, Joo A, Bonser LR, Koh KD, Le Tonqueze O, Bolourchi S, Bautista RA, Zlock L, Roth TL, Marson A, Bhakta NR, Ansel KM, Finkbeiner WE, Erle DJ, Woodruff PG.
PMID: 33682796
JCI Insight. 2021 Mar 08;6(5). doi: 10.1172/jci.insight.139019.

IL-13-induced goblet cell metaplasia contributes to airway remodeling and pathological mucus hypersecretion in asthma. miRNAs are potent modulators of cellular responses, but their role in mucus regulation is largely unexplored. We hypothesized that airway epithelial miRNAs play roles in...

Generation of two human induced pluripotent stem cell lines from fibroblasts of unrelated Parkinson's patients carrying the G2019S mutation in the LRRK2 gene (LCSBi005, LCSBi006).

Stem cell research

Novak G, Finkbeiner S, Skibinski G, Skupin A.
PMID: 34736041
Stem Cell Res. 2021 Oct 12;57:102569. doi: 10.1016/j.scr.2021.102569. Epub 2021 Oct 12.

Mutations in the LRRK2 gene are known to mediate predisposition to Parkinson disease. Fibroblasts heterozygous for the G2019S LRRK2 mutation were obtained from a 53-year-old male patient with disease onset at 34 years (LCSBi005, ND29542), and from a 63-year-old...

Superhuman cell death detection with biomarker-optimized neural networks.

Science advances

Linsley JW, Linsley DA, Lamstein J, Ryan G, Shah K, Castello NA, Oza V, Kalra J, Wang S, Tokuno Z, Javaherian A, Serre T, Finkbeiner S.
PMID: 34878844
Sci Adv. 2021 Dec 10;7(50):eabf8142. doi: 10.1126/sciadv.abf8142. Epub 2021 Dec 08.

[Figure: see text].

Long-Term Safety and Efficacy of Deutetrabenazine in Younger and Older Patients With Tardive Dyskinesia.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Sajatovic M, Finkbeiner S, Wilhelm A, Barkay H, Chaijale N, Gross N, Gordon MF.
PMID: 34511333
Am J Geriatr Psychiatry. 2021 Aug 16; doi: 10.1016/j.jagp.2021.08.003. Epub 2021 Aug 16.

OBJECTIVES: To assess long-term safety and efficacy of deutetrabenazine in younger (

The Communication between Ocular Surface and Nasal Epithelia in 3D Cell Culture Technology for Translational Research: A Narrative Review.

International journal of molecular sciences

Aydin M, Dietrich J, Witt J, Finkbeiner MSC, Park JJ, Wirth S, Engeland CE, Paulsen F, Ehrhardt A.
PMID: 34884799
Int J Mol Sci. 2021 Nov 30;22(23). doi: 10.3390/ijms222312994.

There is a lack of knowledge regarding the connection between the ocular and nasal epithelia. This narrative review focuses on conjunctival, corneal, ultrastructural corneal stroma, and nasal epithelia as well as an introduction into their interconnections. We describe in...

Showing 109 to 115 of 115 entries