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Showing 901 to 909 of 909 entries
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Recent fertility declines in Hong Kong: the role of the changing age structure.

Population studies

Freedman R, Adlakha AL.
PMID: 22091609
Popul Stud (Camb). 1968 Jul;22(2):181-98. doi: 10.1080/00324728.1968.10405534.

Abstract The birth rate in Hong Kong fell rapidly from 1961 to 1966: from 35·5 in 1961 to 25·8 in 1966 1 These rates are based on corrected estimates of population and of births made after the 1966 census....

Rare deleterious mutations of HNRNP genes result in shared neurodevelopmental disorders.

Genome medicine

Gillentine MA, Wang T, Hoekzema K, Rosenfeld J, Liu P, Guo H, Kim CN, De Vries BBA, Vissers LELM, Nordenskjold M, Kvarnung M, Lindstrand A, Nordgren A, Gecz J, Iascone M, Cereda A, Scatigno A, Maitz S, Zanni G, Bertini E, Zweier C, Schuhmann S, Wiesener A, Pepper M, Panjwani H, Torti E, Abid F, Anselm I, Srivastava S, Atwal P, Bacino CA, Bhat G, Cobian K, Bird LM, Friedman J, Wright MS, Callewaert B, Petit F, Mathieu S, Afenjar A, Christensen CK, White KM, Elpeleg O, Berger I, Espineli EJ, Fagerberg C, Brasch-Andersen C, Hansen LK, Feyma T, Hughes S, Thiffault I, Sullivan B, Yan S, Keller K, Keren B, Mignot C, Kooy F, Meuwissen M, Basinger A, Kukolich M, Philips M, Ortega L, Drummond-Borg M, Lauridsen M, Sorensen K, Lehman A, Lopez-Rangel E, Levy P, Lessel D, Lotze T, Madan-Khetarpal S, Sebastian J, Vento J, Vats D, Benman LM, Mckee S, Mirzaa GM, Muss C, Pappas J, Peeters H, Romano C, Elia M, Galesi O, Simon MEH, van Gassen KLI, Simpson K, Stratton R, Syed S, Thevenon J, Palafoll IV, Vitobello A, Bournez M, Faivre L, Xia K, Earl RK, Nowakowski T, Bernier RA, Eichler EE.
PMID: 33874999
Genome Med. 2021 Apr 19;13(1):63. doi: 10.1186/s13073-021-00870-6.

BACKGROUND: With the increasing number of genomic sequencing studies, hundreds of genes have been implicated in neurodevelopmental disorders (NDDs). The rate of gene discovery far outpaces our understanding of genotype-phenotype correlations, with clinical characterization remaining a bottleneck for understanding...

Rare deleterious mutations of HNRNP genes result in shared neurodevelopmental disorders.

Genome medicine

Gillentine MA, Wang T, Hoekzema K, Rosenfeld J, Liu P, Guo H, Kim CN, De Vries BBA, Vissers LELM, Nordenskjold M, Kvarnung M, Lindstrand A, Nordgren A, Gecz J, Iascone M, Cereda A, Scatigno A, Maitz S, Zanni G, Bertini E, Zweier C, Schuhmann S, Wiesener A, Pepper M, Panjwani H, Torti E, Abid F, Anselm I, Srivastava S, Atwal P, Bacino CA, Bhat G, Cobian K, Bird LM, Friedman J, Wright MS, Callewaert B, Petit F, Mathieu S, Afenjar A, Christensen CK, White KM, Elpeleg O, Berger I, Espineli EJ, Fagerberg C, Brasch-Andersen C, Hansen LK, Feyma T, Hughes S, Thiffault I, Sullivan B, Yan S, Keller K, Keren B, Mignot C, Kooy F, Meuwissen M, Basinger A, Kukolich M, Philips M, Ortega L, Drummond-Borg M, Lauridsen M, Sorensen K, Lehman A, Lopez-Rangel E, Levy P, Lessel D, Lotze T, Madan-Khetarpal S, Sebastian J, Vento J, Vats D, Benman LM, Mckee S, Mirzaa GM, Muss C, Pappas J, Peeters H, Romano C, Elia M, Galesi O, Simon MEH, van Gassen KLI, Simpson K, Stratton R, Syed S, Thevenon J, Palafoll IV, Vitobello A, Bournez M, Faivre L, Xia K, Earl RK, Nowakowski T, Bernier RA, Eichler EE.
PMID: 33874999
Genome Med. 2021 Apr 19;13(1):63. doi: 10.1186/s13073-021-00870-6.

BACKGROUND: With the increasing number of genomic sequencing studies, hundreds of genes have been implicated in neurodevelopmental disorders (NDDs). The rate of gene discovery far outpaces our understanding of genotype-phenotype correlations, with clinical characterization remaining a bottleneck for understanding...

Fidgetin-like 2 negatively regulates axonal growth and can be targeted to promote functional nerve regeneration.

JCI insight

Baker L, Tar M, Kramer AH, Villegas GA, Charafeddine RA, Vafaeva O, Nacharaju P, Friedman J, Davies KP, Sharp DJ.
PMID: 33872220
JCI Insight. 2021 May 10;6(9). doi: 10.1172/jci.insight.138484.

The microtubule (MT) cytoskeleton plays a critical role in axon growth and guidance. Here, we identify the MT-severing enzyme fidgetin-like 2 (FL2) as a negative regulator of axon regeneration and a therapeutic target for promoting nerve regeneration after injury....

Clinical Utility of SPECT in the Heart Transplant Population: Analysis from a Single Large-Volume Center.

Transplantation

Aguilar J, Miller RJ, Otaki Y, Tamarappoo B, Hayes S, Friedman J, Slomka PJ, Thomson LE, Kittleson M, Patel JK, Kobashigawa JA, Berman DS.
PMID: 33901107
Transplantation. 2021 Apr 21; doi: 10.1097/TP.0000000000003791. Epub 2021 Apr 21.

BACKGROUND: Survival after heart transplant has greatly improved, with median survival now over 12 years. Cardiac allograft vasculopathy (CAV), has become a major source of long-term morbidity and mortality. Single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI)...

Fixes that Fail: A system archetype for examining racialized structures within the food system.

American journal of community psychology

Benninger E, Donley G, Schmidt-Sane M, Clark JK, Lounsbury DW, Rose D, Freedman D.
PMID: 34333787
Am J Community Psychol. 2021 Dec;68(3):455-470. doi: 10.1002/ajcp.12534. Epub 2021 Aug 01.

Access to fresh and healthy food within a neighborhood has been identified as a social mechanism contributing to community health. Grounded in the understanding that challenges related to equity within a food system are both structural and systemic, our...

Accuracy of a Self-Administered Online Cognitive Assessment in Detecting Amnestic Mild Cognitive Impairment.

The journals of gerontology. Series B, Psychological sciences and social sciences

Paterson TSE, Sivajohan B, Gardner S, Binns MA, Stokes KA, Freedman M, Levine B, Troyer AK.
PMID: 34333629
J Gerontol B Psychol Sci Soc Sci. 2021 Aug 01; doi: 10.1093/geronb/gbab097. Epub 2021 Aug 01.

OBJECTIVES: Our aim was to validate the online Brain Health Assessment (BHA) for detection of amnestic mild cognitive impairment (aMCI) compared to gold-standard neuropsychological assessment. We compared the diagnostic accuracy of the BHA to the Montreal Cognitive Assessment (MoCA).METHODS:...

Challenges and opportunities in recruiting and retaining underrepresented populations into health promotion research.

Warren-Findlow J, Prohaska TR, Freedman D.
UIID-AD: 2625
2003;43:37-46.

PURPOSE: To evaluate how recruitment strategies and program characteristics interact with participant characteristics to influence recruitment and retention in an exercise intervention study targeted to African American and White older adults with multiple chronic illnesses. DESIGN AND METHODS: Characteristics...

Improving clinical and translational research training: a qualitative evaluation of the Atlanta Clinical and Translational Science Institute KL2-mentored research scholars program.

Comeau DL, Escoffery C, Freedman A, Ziegler TR, Blumberg HM.
UIID-AD: 3482
2016; doi: 10.1136/jim-2016-000143.

A major impediment to improving the health of communities is the lack of qualified clinical and translational research (CTR) investigators. To address this workforce shortage, the National Institutes of Health (NIH) developed mechanisms to enhance the career development of...

Showing 901 to 909 of 909 entries