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Predictors of change in depressive symptoms in older and multimorbid patients: a longitudinal analysis of the multicare cohort.

Aging & mental health

Wicke FS, Dinh TS, Riedel-Heller S, Weyerer S, König HH, Gensichen J, Schön G, Wegscheider K, Bickel H, Fuchs A, Schäfer I, van den Bussche H, Scherer M, Mergenthal K.
PMID: 33764211
Aging Ment Health. 2021 Mar 25;1-10. doi: 10.1080/13607863.2021.1902470. Epub 2021 Mar 25.

BACKGROUND: Depression in older adults is becoming an increasing concern. As depressive symptoms change over time, it is important to understand the determinants of change in depressive symptoms. The aim of our study is to use a longitudinal study...

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Wicke FS, Dinh TS, Riedel-Heller S, et al. Predictors of change in depressive symptoms in older and multimorbid patients: a longitudinal analysis of the multicare cohort. Aging Ment Health. 2021;1-10doi: 10.1080/13607863.2021.1902470.
Wicke, F. S., Dinh, T. S., Riedel-Heller, S., Weyerer, S., König, H. H., Gensichen, J., Schön, G., Wegscheider, K., Bickel, H., Fuchs, A., Schäfer, I., van den Bussche, H., Scherer, M., Mergenthal, K. (2021). Predictors of change in depressive symptoms in older and multimorbid patients: a longitudinal analysis of the multicare cohort. Aging & mental health, 1-10. https://doi.org/10.1080/13607863.2021.1902470
Wicke, Felix Sebastian, et al. "Predictors of change in depressive symptoms in older and multimorbid patients: a longitudinal analysis of the multicare cohort." Aging & mental health vol. (2021): 1-10. doi: https://doi.org/10.1080/13607863.2021.1902470
Wicke FS, Dinh TS, Riedel-Heller S, Weyerer S, König HH, Gensichen J, Schön G, Wegscheider K, Bickel H, Fuchs A, Schäfer I, van den Bussche H, Scherer M, Mergenthal K. Predictors of change in depressive symptoms in older and multimorbid patients: a longitudinal analysis of the multicare cohort. Aging Ment Health. 2021 Mar 25;1-10. doi: 10.1080/13607863.2021.1902470. Epub 2021 Mar 25. PMID: 33764211.
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Incidence of Anxiety in Latest Life and Risk Factors. Results of the AgeCoDe/AgeQualiDe Study.

International journal of environmental research and public health

Welzel FD, Luppa M, Pabst A, Pentzek M, Fuchs A, Weeg D, Bickel H, Weyerer S, Werle J, Wiese B, Oey A, Brettschneider C, König HH, Heser K, van den Bussche H, Eisele M, Maier W, Scherer M, Wagner M, Riedel-Heller SG.
PMID: 34886512
Int J Environ Res Public Health. 2021 Dec 03;18(23). doi: 10.3390/ijerph182312786.

Research on anxiety in oldest-old individuals is scarce. Specifically, incidence studies based on large community samples are lacking. The objective of this study is to assess age- and gender-specific incidence rates in a large sample of oldest-old individuals and...

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Welzel FD, Luppa M, Pabst A, et al. Incidence of Anxiety in Latest Life and Risk Factors. Results of the AgeCoDe/AgeQualiDe Study. Int J Environ Res Public Health. 2021;18(23)doi: 10.3390/ijerph182312786.
Welzel, F. D., Luppa, M., Pabst, A., Pentzek, M., Fuchs, A., Weeg, D., Bickel, H., Weyerer, S., Werle, J., Wiese, B., Oey, A., Brettschneider, C., König, H. H., Heser, K., van den Bussche, H., Eisele, M., Maier, W., Scherer, M., Wagner, M., & Riedel-Heller, S. G. (2021). Incidence of Anxiety in Latest Life and Risk Factors. Results of the AgeCoDe/AgeQualiDe Study. International journal of environmental research and public health, 18(23), . https://doi.org/10.3390/ijerph182312786
Welzel, Franziska Dinah, et al. "Incidence of Anxiety in Latest Life and Risk Factors. Results of the AgeCoDe/AgeQualiDe Study." International journal of environmental research and public health vol. 18,23 (2021). doi: https://doi.org/10.3390/ijerph182312786
Welzel FD, Luppa M, Pabst A, Pentzek M, Fuchs A, Weeg D, Bickel H, Weyerer S, Werle J, Wiese B, Oey A, Brettschneider C, König HH, Heser K, van den Bussche H, Eisele M, Maier W, Scherer M, Wagner M, Riedel-Heller SG. Incidence of Anxiety in Latest Life and Risk Factors. Results of the AgeCoDe/AgeQualiDe Study. Int J Environ Res Public Health. 2021 Dec 03;18(23). doi: 10.3390/ijerph182312786. PMID: 34886512; PMCID: PMC8657712.
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Hepatocyte-specific deletion of adipose triglyceride lipase (adipose triglyceride lipase/patatin-like phospholipase domain containing 2) ameliorates dietary induced steatohepatitis in mice.

Hepatology (Baltimore, Md.)

Fuchs CD, Radun R, Dixon ED, Mlitz V, Timelthaler G, Halilbasic E, Herac M, Jonker JW, Ronda OAHO, Tardelli M, Haemmerle G, Zimmermann R, Scharnagl H, Stojakovic T, Verkade HJ, Trauner M.
PMID: 34387896
Hepatology. 2021 Aug 13; doi: 10.1002/hep.32112. Epub 2021 Aug 13.

BACKGROUND AND AIMS: Increased fatty acid (FA) flux from adipose tissue to the liver contributes to the development of NAFLD. Because free FAs are key lipotoxic triggers accelerating disease progression, inhibiting adipose triglyceride lipase (ATGL)/patatin-like phospholipase domain containing 2...

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Fuchs CD, Radun R, Dixon ED, et al. Hepatocyte-specific deletion of adipose triglyceride lipase (adipose triglyceride lipase/patatin-like phospholipase domain containing 2) ameliorates dietary induced steatohepatitis in mice. Hepatology. 2021;doi: 10.1002/hep.32112.
Fuchs, C. D., Radun, R., Dixon, E. D., Mlitz, V., Timelthaler, G., Halilbasic, E., Herac, M., Jonker, J. W., Ronda, O. A. H. O., Tardelli, M., Haemmerle, G., Zimmermann, R., Scharnagl, H., Stojakovic, T., Verkade, H. J., & Trauner, M. (2021). Hepatocyte-specific deletion of adipose triglyceride lipase (adipose triglyceride lipase/patatin-like phospholipase domain containing 2) ameliorates dietary induced steatohepatitis in mice. Hepatology (Baltimore, Md.), . https://doi.org/10.1002/hep.32112
Fuchs, Claudia D, et al. "Hepatocyte-specific deletion of adipose triglyceride lipase (adipose triglyceride lipase/patatin-like phospholipase domain containing 2) ameliorates dietary induced steatohepatitis in mice." Hepatology (Baltimore, Md.) vol. (2021). doi: https://doi.org/10.1002/hep.32112
Fuchs CD, Radun R, Dixon ED, Mlitz V, Timelthaler G, Halilbasic E, Herac M, Jonker JW, Ronda OAHO, Tardelli M, Haemmerle G, Zimmermann R, Scharnagl H, Stojakovic T, Verkade HJ, Trauner M. Hepatocyte-specific deletion of adipose triglyceride lipase (adipose triglyceride lipase/patatin-like phospholipase domain containing 2) ameliorates dietary induced steatohepatitis in mice. Hepatology. 2021 Aug 13; doi: 10.1002/hep.32112. Epub 2021 Aug 13. PMID: 34387896.
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Construction of functional biliary epithelial branched networks with predefined geometry using digital light stereolithography.

Biomaterials

Mazari-Arrighi E, Ayollo D, Farhat W, Marret A, Gontran E, Dupuis-Williams P, Larghero J, Chatelain F, Fuchs A.
PMID: 34741977
Biomaterials. 2021 Dec;279:121207. doi: 10.1016/j.biomaterials.2021.121207. Epub 2021 Oct 28.

Cholangiocytes, biliary epithelial cells, are known to spontaneously self-organize into spherical cysts with a central lumen. In this work, we explore a promising biocompatible stereolithographic approach to encapsulate cholangiocytes into geometrically controlled 3D hydrogel structures to guide them towards...

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Mazari-Arrighi E, Ayollo D, Farhat W, et al. Construction of functional biliary epithelial branched networks with predefined geometry using digital light stereolithography. Biomaterials. 2021;279:121207doi: 10.1016/j.biomaterials.2021.121207.
Mazari-Arrighi, E., Ayollo, D., Farhat, W., Marret, A., Gontran, E., Dupuis-Williams, P., Larghero, J., Chatelain, F., & Fuchs, A. (2021). Construction of functional biliary epithelial branched networks with predefined geometry using digital light stereolithography. Biomaterials, 279121207. https://doi.org/10.1016/j.biomaterials.2021.121207
Mazari-Arrighi, Elsa, et al. "Construction of functional biliary epithelial branched networks with predefined geometry using digital light stereolithography." Biomaterials vol. 279 (2021): 121207. doi: https://doi.org/10.1016/j.biomaterials.2021.121207
Mazari-Arrighi E, Ayollo D, Farhat W, Marret A, Gontran E, Dupuis-Williams P, Larghero J, Chatelain F, Fuchs A. Construction of functional biliary epithelial branched networks with predefined geometry using digital light stereolithography. Biomaterials. 2021 Dec;279:121207. doi: 10.1016/j.biomaterials.2021.121207. Epub 2021 Oct 28. PMID: 34741977.
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Effects of Gender-Affirming Hormone Therapy on Progression Along the HIV Care Continuum in Transgender Women.

Open forum infectious diseases

Summers NA, Huynh TT, Dunn RC, Cross SL, Fuchs CJ.
PMID: 34514019
Open Forum Infect Dis. 2021 Jul 30;8(9):ofab404. doi: 10.1093/ofid/ofab404. eCollection 2021 Sep.

BACKGROUND: Progression along the HIV care continuum has been a key focus for improving outcomes for people with HIV (PWH). Transgender women with HIV (TGWWH) have not made the same progress as their cisgender counterparts.METHODS: All PWH identifying as...

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Summers NA, Huynh TT, Dunn RC, et al. Effects of Gender-Affirming Hormone Therapy on Progression Along the HIV Care Continuum in Transgender Women. Open Forum Infect Dis. 2021;8(9):ofab404doi: 10.1093/ofid/ofab404.
Summers, N. A., Huynh, T. T., Dunn, R. C., Cross, S. L., & Fuchs, C. J. (2021). Effects of Gender-Affirming Hormone Therapy on Progression Along the HIV Care Continuum in Transgender Women. Open forum infectious diseases, 8(9), ofab404. https://doi.org/10.1093/ofid/ofab404
Summers, Nathan A, et al. "Effects of Gender-Affirming Hormone Therapy on Progression Along the HIV Care Continuum in Transgender Women." Open forum infectious diseases vol. 8,9 (2021): ofab404. doi: https://doi.org/10.1093/ofid/ofab404
Summers NA, Huynh TT, Dunn RC, Cross SL, Fuchs CJ. Effects of Gender-Affirming Hormone Therapy on Progression Along the HIV Care Continuum in Transgender Women. Open Forum Infect Dis. 2021 Jul 30;8(9):ofab404. doi: 10.1093/ofid/ofab404. eCollection 2021 Sep. PMID: 34514019; PMCID: PMC8415531.
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Loss of bile salt export pump aggravates lipopolysaccharide-induced liver injury in mice due to impaired hepatic endotoxin clearance.

Hepatology (Baltimore, Md.)

Remetic J, Ghallab A, Hobloss Z, Brackhagen L, Hassan R, Myllys M, Radun R, Mlitz V, Zhu C, Baumgartner M, Schrottmaier WC, Mussbacher M, Timelthaler G, Scharnagl H, Stojakovic T, Assinger A, Fuchs CD, Hengstler JG, Trauner M.
PMID: 34927748
Hepatology. 2021 Dec 20; doi: 10.1002/hep.32289. Epub 2021 Dec 20.

BACKGROUND AND AIMS: LPS clearance is delayed in cholestatic liver diseases. While compromised clearance by Kupffer cells (KCs) is involved, the role of LPS uptake into hepatocytes and canalicular excretion remains unclear.APPROACH AND RESULTS: Wild-type (WT) and Bsep knockout...

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Remetic J, Ghallab A, Hobloss Z, et al. Loss of bile salt export pump aggravates lipopolysaccharide-induced liver injury in mice due to impaired hepatic endotoxin clearance. Hepatology. 2021;doi: 10.1002/hep.32289.
Remetic, J., Ghallab, A., Hobloss, Z., Brackhagen, L., Hassan, R., Myllys, M., Radun, R., Mlitz, V., Zhu, C., Baumgartner, M., Schrottmaier, W. C., Mussbacher, M., Timelthaler, G., Scharnagl, H., Stojakovic, T., Assinger, A., Fuchs, C. D., Hengstler, J. G., & Trauner, M. (2021). Loss of bile salt export pump aggravates lipopolysaccharide-induced liver injury in mice due to impaired hepatic endotoxin clearance. Hepatology (Baltimore, Md.), . https://doi.org/10.1002/hep.32289
Remetic, Jelena, et al. "Loss of bile salt export pump aggravates lipopolysaccharide-induced liver injury in mice due to impaired hepatic endotoxin clearance." Hepatology (Baltimore, Md.) vol. (2021). doi: https://doi.org/10.1002/hep.32289
Remetic J, Ghallab A, Hobloss Z, Brackhagen L, Hassan R, Myllys M, Radun R, Mlitz V, Zhu C, Baumgartner M, Schrottmaier WC, Mussbacher M, Timelthaler G, Scharnagl H, Stojakovic T, Assinger A, Fuchs CD, Hengstler JG, Trauner M. Loss of bile salt export pump aggravates lipopolysaccharide-induced liver injury in mice due to impaired hepatic endotoxin clearance. Hepatology. 2021 Dec 20; doi: 10.1002/hep.32289. Epub 2021 Dec 20. PMID: 34927748.
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Prior Acoustic Trauma Alters Type II Afferent Activity in the Mouse Cochlea.

eNeuro

Nowak N, Wood MB, Glowatzki E, Fuchs PA.
PMID: 34607806
eNeuro. 2021 Nov 11;8(6). doi: 10.1523/ENEURO.0383-21.2021. Print 2021.

Auditory stimuli travel from the cochlea to the brainstem through type I and type II cochlear afferents. While type I afferents convey information about the frequency, intensity, and timing of sounds, the role of type II afferents remains unresolved....

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Nowak N, Wood MB, Glowatzki E, et al. Prior Acoustic Trauma Alters Type II Afferent Activity in the Mouse Cochlea. eNeuro. 2021;8(6)doi: 10.1523/ENEURO.0383-21.2021.
Nowak, N., Wood, M. B., Glowatzki, E., & Fuchs, P. A. (2021). Prior Acoustic Trauma Alters Type II Afferent Activity in the Mouse Cochlea. eNeuro, 8(6), . https://doi.org/10.1523/ENEURO.0383-21.2021
Nowak, Nathaniel, et al. "Prior Acoustic Trauma Alters Type II Afferent Activity in the Mouse Cochlea." eNeuro vol. 8,6 (2021). doi: https://doi.org/10.1523/ENEURO.0383-21.2021
Nowak N, Wood MB, Glowatzki E, Fuchs PA. Prior Acoustic Trauma Alters Type II Afferent Activity in the Mouse Cochlea. eNeuro. 2021 Nov 11;8(6). doi: 10.1523/ENEURO.0383-21.2021. Print 2021. PMID: 34607806; PMCID: PMC8589282.
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Novel therapeutic targets for cholestatic and fatty liver disease.

Gut

Trauner M, Fuchs CD.
PMID: 34615727
Gut. 2022 Jan;71(1):194-209. doi: 10.1136/gutjnl-2021-324305. Epub 2021 Oct 06.

Cholestatic and non-alcoholic fatty liver disease (NAFLD) share several key pathophysiological mechanisms which can be targeted by novel therapeutic concepts that are currently developed for both areas. Nuclear receptors (NRs) are ligand-activated transcriptional regulators of key metabolic processes including...

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Trauner M, Fuchs CD. Novel therapeutic targets for cholestatic and fatty liver disease. Gut. 2021;71(1):194-209doi: 10.1136/gutjnl-2021-324305.
Trauner, M., & Fuchs, C. D. (2022). Novel therapeutic targets for cholestatic and fatty liver disease. Gut, 71(1), 194-209. https://doi.org/10.1136/gutjnl-2021-324305
Trauner, Michael, and Fuchs, Claudia Daniela. "Novel therapeutic targets for cholestatic and fatty liver disease." Gut vol. 71,1 (2022): 194-209. doi: https://doi.org/10.1136/gutjnl-2021-324305
Trauner M, Fuchs CD. Novel therapeutic targets for cholestatic and fatty liver disease. Gut. 2022 Jan;71(1):194-209. doi: 10.1136/gutjnl-2021-324305. Epub 2021 Oct 06. PMID: 34615727.
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Evaluation of atelectasis using electrical impedance tomography during procedural deep sedation for MRI in small children: A prospective observational trial.

Journal of clinical anesthesia

Riva T, Pascolo F, Huber M, Theiler L, Greif R, Disma N, Fuchs A, Berger-Estilita J, Riedel T.
PMID: 34902800
J Clin Anesth. 2021 Dec 10;77:110626. doi: 10.1016/j.jclinane.2021.110626. Epub 2021 Dec 10.

STUDY OBJECTIVE: To investigate the variation of poorly ventilated lung units (i.e., silent spaces) in children undergoing procedural sedation in a day-hospital setting, until discharge home from the Post-Anesthesia Care Unit (PACU).DESIGN: Prospective, single-center, observational cohort trial.SETTING: This study...

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Riva T, Pascolo F, Huber M, et al. Evaluation of atelectasis using electrical impedance tomography during procedural deep sedation for MRI in small children: A prospective observational trial. J Clin Anesth. 2021;77:110626doi: 10.1016/j.jclinane.2021.110626.
Riva, T., Pascolo, F., Huber, M., Theiler, L., Greif, R., Disma, N., Fuchs, A., Berger-Estilita, J., & Riedel, T. (2021). Evaluation of atelectasis using electrical impedance tomography during procedural deep sedation for MRI in small children: A prospective observational trial. Journal of clinical anesthesia, 77110626. https://doi.org/10.1016/j.jclinane.2021.110626
Riva, Thomas, et al. "Evaluation of atelectasis using electrical impedance tomography during procedural deep sedation for MRI in small children: A prospective observational trial." Journal of clinical anesthesia vol. 77 (2021): 110626. doi: https://doi.org/10.1016/j.jclinane.2021.110626
Riva T, Pascolo F, Huber M, Theiler L, Greif R, Disma N, Fuchs A, Berger-Estilita J, Riedel T. Evaluation of atelectasis using electrical impedance tomography during procedural deep sedation for MRI in small children: A prospective observational trial. J Clin Anesth. 2021 Dec 10;77:110626. doi: 10.1016/j.jclinane.2021.110626. Epub 2021 Dec 10. PMID: 34902800.
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Differences in transport function of the human and rat orthologue of the Organic Anion Transporting Polypeptide 2B1 (OATP2B1).

Drug metabolism and pharmacokinetics

Hussner J, Foletti A, Seibert I, Fuchs A, Schuler E, Malagnino V, Grube M, Meyer Zu Schwabedissen HE.
PMID: 34628357
Drug Metab Pharmacokinet. 2021 Dec;41:100418. doi: 10.1016/j.dmpk.2021.100418. Epub 2021 Aug 30.

The human drug transporter Organic Anion Transporting Polypeptide (hOATP)2B1 facilitates cellular uptake of its substrates. Various studies suggest that hOATP2B1 is involved in intestinal absorption, but preclinical evaluations performed in rodents do not support this. Thus, our study aimed...

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Hussner J, Foletti A, Seibert I, et al. Differences in transport function of the human and rat orthologue of the Organic Anion Transporting Polypeptide 2B1 (OATP2B1). Drug Metab Pharmacokinet. 2021;41:100418doi: 10.1016/j.dmpk.2021.100418.
Hussner, J., Foletti, A., Seibert, I., Fuchs, A., Schuler, E., Malagnino, V., Grube, M., & Meyer Zu Schwabedissen, H. E. (2021). Differences in transport function of the human and rat orthologue of the Organic Anion Transporting Polypeptide 2B1 (OATP2B1). Drug metabolism and pharmacokinetics, 41100418. https://doi.org/10.1016/j.dmpk.2021.100418
Hussner, Janine, et al. "Differences in transport function of the human and rat orthologue of the Organic Anion Transporting Polypeptide 2B1 (OATP2B1)." Drug metabolism and pharmacokinetics vol. 41 (2021): 100418. doi: https://doi.org/10.1016/j.dmpk.2021.100418
Hussner J, Foletti A, Seibert I, Fuchs A, Schuler E, Malagnino V, Grube M, Meyer Zu Schwabedissen HE. Differences in transport function of the human and rat orthologue of the Organic Anion Transporting Polypeptide 2B1 (OATP2B1). Drug Metab Pharmacokinet. 2021 Dec;41:100418. doi: 10.1016/j.dmpk.2021.100418. Epub 2021 Aug 30. PMID: 34628357.
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Elevated lipoprotein(a) in mitral and aortic valve calcification and disease: The Copenhagen General Population Study.

Atherosclerosis

Kaltoft M, Sigvardsen PE, Afzal S, Langsted A, Fuchs A, Kühl JT, Køber L, Kamstrup PR, Kofoed KF, Nordestgaard BG.
PMID: 34903381
Atherosclerosis. 2021 Dec 03; doi: 10.1016/j.atherosclerosis.2021.11.029. Epub 2021 Dec 03.

BACKGROUND AND AIMS: We tested the hypotheses (i) that elevated lipoprotein(a) is causally associated with both mitral and aortic valve calcification and disease, and (ii) that aortic valve calcification mediates the effect of elevated lipoprotein(a) on aortic valve stenosis.METHODS:...

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Kaltoft M, Sigvardsen PE, Afzal S, et al. Elevated lipoprotein(a) in mitral and aortic valve calcification and disease: The Copenhagen General Population Study. Atherosclerosis. 2021;doi: 10.1016/j.atherosclerosis.2021.11.029.
Kaltoft, M., Sigvardsen, P. E., Afzal, S., Langsted, A., Fuchs, A., Kühl, J. T., Køber, L., Kamstrup, P. R., Kofoed, K. F., & Nordestgaard, B. G. (2021). Elevated lipoprotein(a) in mitral and aortic valve calcification and disease: The Copenhagen General Population Study. Atherosclerosis, . https://doi.org/10.1016/j.atherosclerosis.2021.11.029
Kaltoft, Morten, et al. "Elevated lipoprotein(a) in mitral and aortic valve calcification and disease: The Copenhagen General Population Study." Atherosclerosis vol. (2021). doi: https://doi.org/10.1016/j.atherosclerosis.2021.11.029
Kaltoft M, Sigvardsen PE, Afzal S, Langsted A, Fuchs A, Kühl JT, Køber L, Kamstrup PR, Kofoed KF, Nordestgaard BG. Elevated lipoprotein(a) in mitral and aortic valve calcification and disease: The Copenhagen General Population Study. Atherosclerosis. 2021 Dec 03; doi: 10.1016/j.atherosclerosis.2021.11.029. Epub 2021 Dec 03. PMID: 34903381.
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