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The SUMO E3 ligase CBX4 is identified as a poor prognostic marker of gastric cancer through multipronged OMIC analyses.

Genes & diseases

Pan Y, Li Q, Cao Z, Zhao S.
PMID: 34522711
Genes Dis. 2020 Sep 01;8(6):827-837. doi: 10.1016/j.gendis.2020.08.010. eCollection 2021 Nov.

Gastric cancer (GC) is one of the most common malignancies, with an ever-increasing incidence and high mortality rate. Chromobox4 (CBX4), also named hPC2, is a small ubiquitin-related modifier (SUMO) E3 ligase. Previous studies have found that high CBX4 expression...

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Pan Y, Li Q, Cao Z, et al. The SUMO E3 ligase CBX4 is identified as a poor prognostic marker of gastric cancer through multipronged OMIC analyses. Genes Dis. 2020;8(6):827-837doi: 10.1016/j.gendis.2020.08.010.
Pan, Y., Li, Q., Cao, Z., & Zhao, S. (2021). The SUMO E3 ligase CBX4 is identified as a poor prognostic marker of gastric cancer through multipronged OMIC analyses. Genes & diseases, 8(6), 827-837. https://doi.org/10.1016/j.gendis.2020.08.010
Pan, Yi, et al. "The SUMO E3 ligase CBX4 is identified as a poor prognostic marker of gastric cancer through multipronged OMIC analyses." Genes & diseases vol. 8,6 (2021): 827-837. doi: https://doi.org/10.1016/j.gendis.2020.08.010
Pan Y, Li Q, Cao Z, Zhao S. The SUMO E3 ligase CBX4 is identified as a poor prognostic marker of gastric cancer through multipronged OMIC analyses. Genes Dis. 2020 Sep 01;8(6):827-837. doi: 10.1016/j.gendis.2020.08.010. eCollection 2021 Nov. PMID: 34522711; PMCID: PMC8427259.
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A panel of platelet-associated circulating long non-coding RNAs as potential biomarkers for colorectal cancer.

Genomics

Ye B, Li F, Chen M, Weng Y, Qi C, Xie Y, Zhang Q, Ding H, Zhang J, Gao X.
PMID: 34843904
Genomics. 2021 Nov 27;114(1):31-37. doi: 10.1016/j.ygeno.2021.11.026. Epub 2021 Nov 27.

Evidence has suggested the potential of tumor-educated platelets as a biomarker trove for cancer diagnostics, but the difficulty in isolation limits its application. Since most of the circulating RNAs are derived from platelets, the change of RNA profile in...

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Ye B, Li F, Chen M, et al. A panel of platelet-associated circulating long non-coding RNAs as potential biomarkers for colorectal cancer. Genomics. 2021;114(1):31-37doi: 10.1016/j.ygeno.2021.11.026.
Ye, B., Li, F., Chen, M., Weng, Y., Qi, C., Xie, Y., Zhang, Q., Ding, H., Zhang, J., & Gao, X. (2021). A panel of platelet-associated circulating long non-coding RNAs as potential biomarkers for colorectal cancer. Genomics, 114(1), 31-37. https://doi.org/10.1016/j.ygeno.2021.11.026
Ye, Bingqi, et al. "A panel of platelet-associated circulating long non-coding RNAs as potential biomarkers for colorectal cancer." Genomics vol. 114,1 (2021): 31-37. doi: https://doi.org/10.1016/j.ygeno.2021.11.026
Ye B, Li F, Chen M, Weng Y, Qi C, Xie Y, Zhang Q, Ding H, Zhang J, Gao X. A panel of platelet-associated circulating long non-coding RNAs as potential biomarkers for colorectal cancer. Genomics. 2021 Nov 27;114(1):31-37. doi: 10.1016/j.ygeno.2021.11.026. Epub 2021 Nov 27. PMID: 34843904.
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Progressive Damage Numerical Modelling and Simulation of Aircraft Composite Bolted Joints Bearing Response.

Materials (Basel, Switzerland)

Gao G, An L, Giannopoulos IK, Han N, Ge E, Hu G.
PMID: 33302590
Materials (Basel). 2020 Dec 08;13(24). doi: 10.3390/ma13245606.

Finite element numerical progressive damage modelling and simulations applied to the strength prediction of airframe bolted joints on composite laminates can lead to shorter and more efficient product cycles in terms of design, analysis and certification, while benefiting the...

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Gao G, An L, Giannopoulos IK, et al. Progressive Damage Numerical Modelling and Simulation of Aircraft Composite Bolted Joints Bearing Response. Materials (Basel). 2020;13(24)doi: 10.3390/ma13245606.
Gao, G., An, L., Giannopoulos, I. K., Han, N., Ge, E., & Hu, G. (2020). Progressive Damage Numerical Modelling and Simulation of Aircraft Composite Bolted Joints Bearing Response. Materials (Basel, Switzerland), 13(24), . https://doi.org/10.3390/ma13245606
Gao, Guoqiang, et al. "Progressive Damage Numerical Modelling and Simulation of Aircraft Composite Bolted Joints Bearing Response." Materials (Basel, Switzerland) vol. 13,24 (2020). doi: https://doi.org/10.3390/ma13245606
Gao G, An L, Giannopoulos IK, Han N, Ge E, Hu G. Progressive Damage Numerical Modelling and Simulation of Aircraft Composite Bolted Joints Bearing Response. Materials (Basel). 2020 Dec 08;13(24). doi: 10.3390/ma13245606. PMID: 33302590; PMCID: PMC7763887.
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Baicalin ameliorates APEC-induced intestinal injury in chicks by inhibiting the PI3K/AKT-mediated NF-κB signaling pathway.

Poultry science

Cheng X, Cao Z, Luo J, Hu R, Cao H, Guo X, Xing C, Yang F, Zhuang Y, Hu G.
PMID: 34844111
Poult Sci. 2022 Jan;101(1):101572. doi: 10.1016/j.psj.2021.101572. Epub 2021 Oct 29.

Avian pathogenic Escherichia coli (APEC) is the causative agent of avian colibacillosis. Baicalin (BA) possesses multiple pharmacological effects, but the mechanism underlying its activity in APEC-induced intestinal injury remains unknown. This study aims to investigate the protective effects and...

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Cheng X, Cao Z, Luo J, et al. Baicalin ameliorates APEC-induced intestinal injury in chicks by inhibiting the PI3K/AKT-mediated NF-κB signaling pathway. Poult Sci. 2021;101(1):101572doi: 10.1016/j.psj.2021.101572.
Cheng, X., Cao, Z., Luo, J., Hu, R., Cao, H., Guo, X., Xing, C., Yang, F., Zhuang, Y., & Hu, G. (2022). Baicalin ameliorates APEC-induced intestinal injury in chicks by inhibiting the PI3K/AKT-mediated NF-κB signaling pathway. Poultry science, 101(1), 101572. https://doi.org/10.1016/j.psj.2021.101572
Cheng, Xinyi, et al. "Baicalin ameliorates APEC-induced intestinal injury in chicks by inhibiting the PI3K/AKT-mediated NF-κB signaling pathway." Poultry science vol. 101,1 (2022): 101572. doi: https://doi.org/10.1016/j.psj.2021.101572
Cheng X, Cao Z, Luo J, Hu R, Cao H, Guo X, Xing C, Yang F, Zhuang Y, Hu G. Baicalin ameliorates APEC-induced intestinal injury in chicks by inhibiting the PI3K/AKT-mediated NF-κB signaling pathway. Poult Sci. 2022 Jan;101(1):101572. doi: 10.1016/j.psj.2021.101572. Epub 2021 Oct 29. PMID: 34844111; PMCID: PMC8633683.
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Evidence-based Chinese Medicine Clinical Practice Guideline for Stroke in Hong Kong.

Chinese medicine

Zhong LLD, Kun W, Shi N, Ziea TC, Ng BFL, Gao Y, Bian Z, Lu A.
PMID: 33292342
Chin Med. 2020 Nov 03;15(1):116. doi: 10.1186/s13020-020-00397-9.

BACKGROUND: Stroke in Chinese Medicine (CM) includes the concepts of ischemic and hemorrhagic strokes from Western Medicine and is a common disease in Hong Kong. This clinical practice guideline (CPG) aims to evaluate and demonstrate CM treatment options for...

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Zhong LLD, Kun W, Shi N, et al. Evidence-based Chinese Medicine Clinical Practice Guideline for Stroke in Hong Kong. Chin Med. 2020;15(1):116doi: 10.1186/s13020-020-00397-9.
Zhong, L. L. D., Kun, W., Shi, N., Ziea, T. C., Ng, B. F. L., Gao, Y., Bian, Z., & Lu, A. (2020). Evidence-based Chinese Medicine Clinical Practice Guideline for Stroke in Hong Kong. Chinese medicine, 15(1), 116. https://doi.org/10.1186/s13020-020-00397-9
Zhong, Linda L D, et al. "Evidence-based Chinese Medicine Clinical Practice Guideline for Stroke in Hong Kong." Chinese medicine vol. 15,1 (2020): 116. doi: https://doi.org/10.1186/s13020-020-00397-9
Zhong LLD, Kun W, Shi N, Ziea TC, Ng BFL, Gao Y, Bian Z, Lu A. Evidence-based Chinese Medicine Clinical Practice Guideline for Stroke in Hong Kong. Chin Med. 2020 Nov 03;15(1):116. doi: 10.1186/s13020-020-00397-9. PMID: 33292342; PMCID: PMC7607854.
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HDV Seroprevalence in HBsAg-Positive Patients in China Occurs in Hotspots and Is Not Associated with HCV Mono-Infection.

Viruses

Roggenbach I, Chi X, Lempp FA, Qu B, Walter L, Wu R, Gao X, Schnitzler P, Ding Y, Urban S, Niu J.
PMID: 34578380
Viruses. 2021 Sep 10;13(9). doi: 10.3390/v13091799.

HDV infection causes severe liver disease, the global health burden of which may be underestimated due to limited epidemiological data. HDV depends on HBV for infection, but recent studies indicated that dissemination can also be supported by other helper...

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Roggenbach I, Chi X, Lempp FA, et al. HDV Seroprevalence in HBsAg-Positive Patients in China Occurs in Hotspots and Is Not Associated with HCV Mono-Infection. Viruses. 2021;13(9)doi: 10.3390/v13091799.
Roggenbach, I., Chi, X., Lempp, F. A., Qu, B., Walter, L., Wu, R., Gao, X., Schnitzler, P., Ding, Y., Urban, S., & Niu, J. (2021). HDV Seroprevalence in HBsAg-Positive Patients in China Occurs in Hotspots and Is Not Associated with HCV Mono-Infection. Viruses, 13(9), . https://doi.org/10.3390/v13091799
Roggenbach, Imme, et al. "HDV Seroprevalence in HBsAg-Positive Patients in China Occurs in Hotspots and Is Not Associated with HCV Mono-Infection." Viruses vol. 13,9 (2021). doi: https://doi.org/10.3390/v13091799
Roggenbach I, Chi X, Lempp FA, Qu B, Walter L, Wu R, Gao X, Schnitzler P, Ding Y, Urban S, Niu J. HDV Seroprevalence in HBsAg-Positive Patients in China Occurs in Hotspots and Is Not Associated with HCV Mono-Infection. Viruses. 2021 Sep 10;13(9). doi: 10.3390/v13091799. PMID: 34578380; PMCID: PMC8473203.
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Computed Tomography Measurement and Evaluation of the Subarachnoid Space Over Cerebral Convexities in Infants Aged 1-24 Months.

Journal of child neurology

Yu K, Yi M, Cui R, Gong T, Dong C, Gao X, Zhao J, Li M.
PMID: 33331188
J Child Neurol. 2021 May;36(6):447-452. doi: 10.1177/0883073820977998. Epub 2020 Dec 17.

A widened subarachnoid space might be pathologic, potentially pathologic, or simply a normal developmental variant. However, the definition of a normal subarachnoid space width in infants remains unclear, especially on computed tomography (CT) images. To determine the physiological subarachnoid...

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Yu K, Yi M, Cui R, et al. Computed Tomography Measurement and Evaluation of the Subarachnoid Space Over Cerebral Convexities in Infants Aged 1-24 Months. J Child Neurol. 2020;36(6):447-452doi: 10.1177/0883073820977998.
Yu, K., Yi, M., Cui, R., Gong, T., Dong, C., Gao, X., Zhao, J., & Li, M. (2021). Computed Tomography Measurement and Evaluation of the Subarachnoid Space Over Cerebral Convexities in Infants Aged 1-24 Months. Journal of child neurology, 36(6), 447-452. https://doi.org/10.1177/0883073820977998
Yu, Ke, et al. "Computed Tomography Measurement and Evaluation of the Subarachnoid Space Over Cerebral Convexities in Infants Aged 1-24 Months." Journal of child neurology vol. 36,6 (2021): 447-452. doi: https://doi.org/10.1177/0883073820977998
Yu K, Yi M, Cui R, Gong T, Dong C, Gao X, Zhao J, Li M. Computed Tomography Measurement and Evaluation of the Subarachnoid Space Over Cerebral Convexities in Infants Aged 1-24 Months. J Child Neurol. 2021 May;36(6):447-452. doi: 10.1177/0883073820977998. Epub 2020 Dec 17. PMID: 33331188.
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Single-atom catalysis in advanced oxidation processes for environmental remediation.

Chemical Society reviews

Shang Y, Xu X, Gao B, Wang S, Duan X.
PMID: 33904567
Chem Soc Rev. 2021 Apr 26;50(8):5281-5322. doi: 10.1039/d0cs01032d.

Emerging single atom catalysts (SACs), especially carbon-based SACs are appealing materials in environmental catalysis because of their ultrahigh performances, environmental friendliness, structural/chemical robustness, and the maximum utilization of active metal sites. The metal centres, carbon matrixes, and coordination characteristics...

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Shang Y, Xu X, Gao B, et al. Single-atom catalysis in advanced oxidation processes for environmental remediation. Chem Soc Rev. 2021;50(8):5281-5322doi: 10.1039/d0cs01032d.
Shang, Y., Xu, X., Gao, B., Wang, S., & Duan, X. (2021). Single-atom catalysis in advanced oxidation processes for environmental remediation. Chemical Society reviews, 50(8), 5281-5322. https://doi.org/10.1039/d0cs01032d
Shang, Yanan, et al. "Single-atom catalysis in advanced oxidation processes for environmental remediation." Chemical Society reviews vol. 50,8 (2021): 5281-5322. doi: https://doi.org/10.1039/d0cs01032d
Shang Y, Xu X, Gao B, Wang S, Duan X. Single-atom catalysis in advanced oxidation processes for environmental remediation. Chem Soc Rev. 2021 Apr 26;50(8):5281-5322. doi: 10.1039/d0cs01032d. PMID: 33904567.
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Bell's palsy following vaccination with mRNA (BNT162b2) and inactivated (CoronaVac) SARS-CoV-2 vaccines: a case series and nested case-control study.

The Lancet. Infectious diseases

Wan EYF, Chui CSL, Lai FTT, Chan EWY, Li X, Yan VKC, Gao L, Yu Q, Lam ICH, Chun RKC, Cowling BJ, Fong WC, Lau AYL, Mok VCT, Chan FLF, Lee CK, Chan LST, Lo D, Lau KK, Hung IFN, Leung GM, Wong ICK.
PMID: 34411532
Lancet Infect Dis. 2021 Aug 16; doi: 10.1016/S1473-3099(21)00451-5. Epub 2021 Aug 16.

BACKGROUND: Bell's palsy is a rare adverse event reported in clinical trials of COVID-19 vaccines. However, to our knowledge no population-based study has assessed the association between the inactivated SARS-CoV-2 vaccines and Bell's palsy. The aim of this study...

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Wan EYF, Chui CSL, Lai FTT, et al. Bell's palsy following vaccination with mRNA (BNT162b2) and inactivated (CoronaVac) SARS-CoV-2 vaccines: a case series and nested case-control study. Lancet Infect Dis. 2021;doi: 10.1016/S1473-3099(21)00451-5.
Wan, E. Y. F., Chui, C. S. L., Lai, F. T. T., Chan, E. W. Y., Li, X., Yan, V. K. C., Gao, L., Yu, Q., Lam, I. C. H., Chun, R. K. C., Cowling, B. J., Fong, W. C., Lau, A. Y. L., Mok, V. C. T., Chan, F. L. F., Lee, C. K., Chan, L. S. T., Lo, D., Lau, K. K., Hung, I. F. N., Leung, G. M., & Wong, I. C. K. (2021). Bell's palsy following vaccination with mRNA (BNT162b2) and inactivated (CoronaVac) SARS-CoV-2 vaccines: a case series and nested case-control study. The Lancet. Infectious diseases, . https://doi.org/10.1016/S1473-3099(21)00451-5
Wan, Eric Yuk Fai, et al. "Bell's palsy following vaccination with mRNA (BNT162b2) and inactivated (CoronaVac) SARS-CoV-2 vaccines: a case series and nested case-control study." The Lancet. Infectious diseases vol. (2021). doi: https://doi.org/10.1016/S1473-3099(21)00451-5
Wan EYF, Chui CSL, Lai FTT, Chan EWY, Li X, Yan VKC, Gao L, Yu Q, Lam ICH, Chun RKC, Cowling BJ, Fong WC, Lau AYL, Mok VCT, Chan FLF, Lee CK, Chan LST, Lo D, Lau KK, Hung IFN, Leung GM, Wong ICK. Bell's palsy following vaccination with mRNA (BNT162b2) and inactivated (CoronaVac) SARS-CoV-2 vaccines: a case series and nested case-control study. Lancet Infect Dis. 2021 Aug 16; doi: 10.1016/S1473-3099(21)00451-5. Epub 2021 Aug 16. PMID: 34411532; PMCID: PMC8367195.
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Graphene nanoribbon-based supramolecular ensembles with dual-receptor targeting function for targeted photothermal tumor therapy.

Chemical science

Dou WT, Xu F, Xu CX, Gao J, Ru HB, Luan X, Zhang J, Zhu L, Sedgwick AC, Chen GR, Zang Y, James TD, Tian H, Li J, Mai Y, He XP.
PMID: 34522306
Chem Sci. 2021 Jul 15;12(33):11089-11097. doi: 10.1039/d1sc02154k. eCollection 2021 Aug 25.

Triple negative breast cancer (TNBC) is one of the most malignant subtypes of breast cancer. Here, we report the construction of graphene nanoribbon (GNR)-based supramolecular ensembles with dual-receptor (mannose and α

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Dou WT, Xu F, Xu CX, et al. Graphene nanoribbon-based supramolecular ensembles with dual-receptor targeting function for targeted photothermal tumor therapy. Chem Sci. 2021;12(33):11089-11097doi: 10.1039/d1sc02154k.
Dou, W. T., Xu, F., Xu, C. X., Gao, J., Ru, H. B., Luan, X., Zhang, J., Zhu, L., Sedgwick, A. C., Chen, G. R., Zang, Y., James, T. D., Tian, H., Li, J., Mai, Y., & He, X. P. (2021). Graphene nanoribbon-based supramolecular ensembles with dual-receptor targeting function for targeted photothermal tumor therapy. Chemical science, 12(33), 11089-11097. https://doi.org/10.1039/d1sc02154k
Dou, Wei-Tao, et al. "Graphene nanoribbon-based supramolecular ensembles with dual-receptor targeting function for targeted photothermal tumor therapy." Chemical science vol. 12,33 (2021): 11089-11097. doi: https://doi.org/10.1039/d1sc02154k
Dou WT, Xu F, Xu CX, Gao J, Ru HB, Luan X, Zhang J, Zhu L, Sedgwick AC, Chen GR, Zang Y, James TD, Tian H, Li J, Mai Y, He XP. Graphene nanoribbon-based supramolecular ensembles with dual-receptor targeting function for targeted photothermal tumor therapy. Chem Sci. 2021 Jul 15;12(33):11089-11097. doi: 10.1039/d1sc02154k. eCollection 2021 Aug 25. PMID: 34522306; PMCID: PMC8386659.
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Single-cell RNA sequencing reveals cell heterogeneity and transcriptome profile of breast cancer lymph node metastasis.

Oncogenesis

Xu K, Wang R, Xie H, Hu L, Wang C, Xu J, Zhu C, Liu Y, Gao F, Li X, Wang C, Huang J, Zhou W, Zhou G, Shu Y, Guan X.
PMID: 34611125
Oncogenesis. 2021 Oct 05;10(10):66. doi: 10.1038/s41389-021-00355-6.

Molecular mechanisms underlying breast cancer lymph node metastasis remain unclear. Using single-cell sequencing, we investigated the transcriptome profile of 96,796 single cells from 15 paired samples of primary tumors and axillary lymph nodes. We identified nine cancer cell subclusters...

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Xu K, Wang R, Xie H, et al. Single-cell RNA sequencing reveals cell heterogeneity and transcriptome profile of breast cancer lymph node metastasis. Oncogenesis. 2021;10(10):66doi: 10.1038/s41389-021-00355-6.
Xu, K., Wang, R., Xie, H., Hu, L., Wang, C., Xu, J., Zhu, C., Liu, Y., Gao, F., Li, X., Wang, C., Huang, J., Zhou, W., Zhou, G., Shu, Y., & Guan, X. (2021). Single-cell RNA sequencing reveals cell heterogeneity and transcriptome profile of breast cancer lymph node metastasis. Oncogenesis, 10(10), 66. https://doi.org/10.1038/s41389-021-00355-6
Xu, Kun, et al. "Single-cell RNA sequencing reveals cell heterogeneity and transcriptome profile of breast cancer lymph node metastasis." Oncogenesis vol. 10,10 (2021): 66. doi: https://doi.org/10.1038/s41389-021-00355-6
Xu K, Wang R, Xie H, Hu L, Wang C, Xu J, Zhu C, Liu Y, Gao F, Li X, Wang C, Huang J, Zhou W, Zhou G, Shu Y, Guan X. Single-cell RNA sequencing reveals cell heterogeneity and transcriptome profile of breast cancer lymph node metastasis. Oncogenesis. 2021 Oct 05;10(10):66. doi: 10.1038/s41389-021-00355-6. PMID: 34611125; PMCID: PMC8492772.
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Pan-cancer single-cell landscape of tumor-infiltrating T cells.

Science (New York, N.Y.)

Zheng L, Qin S, Si W, Wang A, Xing B, Gao R, Ren X, Wang L, Wu X, Zhang J, Wu N, Zhang N, Zheng H, Ouyang H, Chen K, Bu Z, Hu X, Ji J, Zhang Z.
PMID: 34914499
Science. 2021 Dec 17;374(6574):abe6474. doi: 10.1126/science.abe6474. Epub 2021 Dec 17.

[Figure: see text].

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Zheng L, Qin S, Si W, et al. Pan-cancer single-cell landscape of tumor-infiltrating T cells. Science. 2021;374(6574):abe6474doi: 10.1126/science.abe6474.
Zheng, L., Qin, S., Si, W., Wang, A., Xing, B., Gao, R., Ren, X., Wang, L., Wu, X., Zhang, J., Wu, N., Zhang, N., Zheng, H., Ouyang, H., Chen, K., Bu, Z., Hu, X., Ji, J., & Zhang, Z. (2021). Pan-cancer single-cell landscape of tumor-infiltrating T cells. Science (New York, N.Y.), 374(6574), abe6474. https://doi.org/10.1126/science.abe6474
Zheng, Liangtao, et al. "Pan-cancer single-cell landscape of tumor-infiltrating T cells." Science (New York, N.Y.) vol. 374,6574 (2021): abe6474. doi: https://doi.org/10.1126/science.abe6474
Zheng L, Qin S, Si W, Wang A, Xing B, Gao R, Ren X, Wang L, Wu X, Zhang J, Wu N, Zhang N, Zheng H, Ouyang H, Chen K, Bu Z, Hu X, Ji J, Zhang Z. Pan-cancer single-cell landscape of tumor-infiltrating T cells. Science. 2021 Dec 17;374(6574):abe6474. doi: 10.1126/science.abe6474. Epub 2021 Dec 17. PMID: 34914499.
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