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Targeted Mass Spectrometry Enables Quantification of Novel Pharmacodynamic Biomarkers of ATM Kinase Inhibition.

Cancers

Whiteaker JR, Wang T, Zhao L, Schoenherr RM, Kennedy JJ, Voytovich U, Ivey RG, Huang D, Lin C, Colantonio S, Caceres TW, Roberts RR, Knotts JG, Kaczmarczyk JA, Blonder J, Reading JJ, Richardson CW, Hewitt SM, Garcia-Buntley SS, Bocik W, Hiltke T, Rodriguez H, Harrington EA, Barrett JC, Lombardi B, Marco-Casanova P, Pierce AJ, Paulovich AG.
PMID: 34359745
Cancers (Basel). 2021 Jul 30;13(15). doi: 10.3390/cancers13153843.

The ATM serine/threonine kinase (HGNC: ATM) is involved in initiation of repair of DNA double-stranded breaks, and ATM inhibitors are currently being tested as anti-cancer agents in clinical trials, where pharmacodynamic (PD) assays are crucial to help guide dose...

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Whiteaker JR, Wang T, Zhao L, et al. Targeted Mass Spectrometry Enables Quantification of Novel Pharmacodynamic Biomarkers of ATM Kinase Inhibition. Cancers (Basel). 2021;13(15)doi: 10.3390/cancers13153843.
Whiteaker, J. R., Wang, T., Zhao, L., Schoenherr, R. M., Kennedy, J. J., Voytovich, U., Ivey, R. G., Huang, D., Lin, C., Colantonio, S., Caceres, T. W., Roberts, R. R., Knotts, J. G., Kaczmarczyk, J. A., Blonder, J., Reading, J. J., Richardson, C. W., Hewitt, S. M., Garcia-Buntley, S. S., Bocik, W., Hiltke, T., Rodriguez, H., Harrington, E. A., Barrett, J. C., Lombardi, B., Marco-Casanova, P., Pierce, A. J., & Paulovich, A. G. (2021). Targeted Mass Spectrometry Enables Quantification of Novel Pharmacodynamic Biomarkers of ATM Kinase Inhibition. Cancers, 13(15), . https://doi.org/10.3390/cancers13153843
Whiteaker, Jeffrey R, et al. "Targeted Mass Spectrometry Enables Quantification of Novel Pharmacodynamic Biomarkers of ATM Kinase Inhibition." Cancers vol. 13,15 (2021). doi: https://doi.org/10.3390/cancers13153843
Whiteaker JR, Wang T, Zhao L, Schoenherr RM, Kennedy JJ, Voytovich U, Ivey RG, Huang D, Lin C, Colantonio S, Caceres TW, Roberts RR, Knotts JG, Kaczmarczyk JA, Blonder J, Reading JJ, Richardson CW, Hewitt SM, Garcia-Buntley SS, Bocik W, Hiltke T, Rodriguez H, Harrington EA, Barrett JC, Lombardi B, Marco-Casanova P, Pierce AJ, Paulovich AG. Targeted Mass Spectrometry Enables Quantification of Novel Pharmacodynamic Biomarkers of ATM Kinase Inhibition. Cancers (Basel). 2021 Jul 30;13(15). doi: 10.3390/cancers13153843. PMID: 34359745; PMCID: PMC8345163.
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Instantaneous microwave-photonic spatial-spectral channelization via k-space imaging.

Optics express

Ryan CJ, Beardell WL, Murakowski J, Schneider GJ, Prather DW.
PMID: 34266093
Opt Express. 2021 Jun 21;29(13):19928-19944. doi: 10.1364/OE.427280.

The ability to both spatially and spectrally demultiplex wireless transmitters enables communication networks with higher spectral and energy efficiency. In practice, demultiplexing requires sub-millisecond latency to map the dynamics of the user space in real-time. Here, we present a...

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Ryan CJ, Beardell WL, Murakowski J, et al. Instantaneous microwave-photonic spatial-spectral channelization via k-space imaging. Opt Express. 2021;29(13):19928-19944doi: 10.1364/OE.427280.
Ryan, C. J., Beardell, W. L., Murakowski, J., Schneider, G. J., & Prather, D. W. (2021). Instantaneous microwave-photonic spatial-spectral channelization via k-space imaging. Optics express, 29(13), 19928-19944. https://doi.org/10.1364/OE.427280
Ryan, Conor J, et al. "Instantaneous microwave-photonic spatial-spectral channelization via k-space imaging." Optics express vol. 29,13 (2021): 19928-19944. doi: https://doi.org/10.1364/OE.427280
Ryan CJ, Beardell WL, Murakowski J, Schneider GJ, Prather DW. Instantaneous microwave-photonic spatial-spectral channelization via k-space imaging. Opt Express. 2021 Jun 21;29(13):19928-19944. doi: 10.1364/OE.427280. PMID: 34266093.
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Retrospective analysis of Schlafen11 (SLFN11) to predict the outcomes to therapies affecting the DNA damage response.

British journal of cancer

Willis SE, Winkler C, Roudier MP, Baird T, Marco-Casanova P, Jones EV, Rowe P, Rodriguez-Canales J, Angell HK, Ng FSL, Waring PM, Hodgson D, Ledermann JA, Weberpals JI, Dean E, Harrington EA, Barrett JC, Pierce AJ, Leo E, Jones GN.
PMID: 34663950
Br J Cancer. 2021 Dec;125(12):1666-1676. doi: 10.1038/s41416-021-01560-1. Epub 2021 Oct 18.

BACKGROUND: The absence of the putative DNA/RNA helicase Schlafen11 (SLFN11) is thought to cause resistance to DNA-damaging agents (DDAs) and PARP inhibitors.METHODS: We developed and validated a clinically applicable SLFN11 immunohistochemistry assay and retrospectively correlated SLFN11 tumour levels to...

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Willis SE, Winkler C, Roudier MP, et al. Retrospective analysis of Schlafen11 (SLFN11) to predict the outcomes to therapies affecting the DNA damage response. Br J Cancer. 2021;125(12):1666-1676doi: 10.1038/s41416-021-01560-1.
Willis, S. E., Winkler, C., Roudier, M. P., Baird, T., Marco-Casanova, P., Jones, E. V., Rowe, P., Rodriguez-Canales, J., Angell, H. K., Ng, F. S. L., Waring, P. M., Hodgson, D., Ledermann, J. A., Weberpals, J. I., Dean, E., Harrington, E. A., Barrett, J. C., Pierce, A. J., Leo, E., & Jones, G. N. (2021). Retrospective analysis of Schlafen11 (SLFN11) to predict the outcomes to therapies affecting the DNA damage response. British journal of cancer, 125(12), 1666-1676. https://doi.org/10.1038/s41416-021-01560-1
Willis, Sophie E, et al. "Retrospective analysis of Schlafen11 (SLFN11) to predict the outcomes to therapies affecting the DNA damage response." British journal of cancer vol. 125,12 (2021): 1666-1676. doi: https://doi.org/10.1038/s41416-021-01560-1
Willis SE, Winkler C, Roudier MP, Baird T, Marco-Casanova P, Jones EV, Rowe P, Rodriguez-Canales J, Angell HK, Ng FSL, Waring PM, Hodgson D, Ledermann JA, Weberpals JI, Dean E, Harrington EA, Barrett JC, Pierce AJ, Leo E, Jones GN. Retrospective analysis of Schlafen11 (SLFN11) to predict the outcomes to therapies affecting the DNA damage response. Br J Cancer. 2021 Dec;125(12):1666-1676. doi: 10.1038/s41416-021-01560-1. Epub 2021 Oct 18. PMID: 34663950.
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The TGF-β/HDAC7 axis suppresses TCA cycle metabolism in renal cancer.

JCI insight

Nam H, Kundu A, Karki S, Brinkley GJ, Chandrashekar DS, Kirkman RL, Liu J, Liberti MV, Locasale JW, Mitchell T, Varambally S, Sudarshan S.
PMID: 34609963
JCI Insight. 2021 Nov 22;6(22). doi: 10.1172/jci.insight.148438.

Mounting evidence points to alterations in mitochondrial metabolism in renal cell carcinoma (RCC). However, the mechanisms that regulate the TCA cycle in RCC remain uncharacterized. Here, we demonstrate that loss of TCA cycle enzyme expression is retained in RCC...

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Nam H, Kundu A, Karki S, et al. The TGF-β/HDAC7 axis suppresses TCA cycle metabolism in renal cancer. JCI Insight. 2021;6(22)doi: 10.1172/jci.insight.148438.
Nam, H., Kundu, A., Karki, S., Brinkley, G. J., Chandrashekar, D. S., Kirkman, R. L., Liu, J., Liberti, M. V., Locasale, J. W., Mitchell, T., Varambally, S., & Sudarshan, S. (2021). The TGF-β/HDAC7 axis suppresses TCA cycle metabolism in renal cancer. JCI insight, 6(22), . https://doi.org/10.1172/jci.insight.148438
Nam, Hyeyoung, et al. "The TGF-β/HDAC7 axis suppresses TCA cycle metabolism in renal cancer." JCI insight vol. 6,22 (2021). doi: https://doi.org/10.1172/jci.insight.148438
Nam H, Kundu A, Karki S, Brinkley GJ, Chandrashekar DS, Kirkman RL, Liu J, Liberti MV, Locasale JW, Mitchell T, Varambally S, Sudarshan S. The TGF-β/HDAC7 axis suppresses TCA cycle metabolism in renal cancer. JCI Insight. 2021 Nov 22;6(22). doi: 10.1172/jci.insight.148438. PMID: 34609963.
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Controlled human malaria infection with a clone of Plasmodium vivax with high-quality genome assembly.

JCI insight

Minassian AM, Themistocleous Y, Silk SE, Barrett JR, Kemp A, Quinkert D, Nielsen CM, Edwards NJ, Rawlinson TA, Ramos Lopez F, Roobsoong W, Ellis KJ, Cho JS, Aunin E, Otto TD, Reid AJ, Bach FA, Labbé GM, Poulton ID, Marini A, Zaric M, Mulatier M, Lopez Ramon R, Baker M, Mitton CH, Sousa JC, Rachaphaew N, Kumpitak C, Maneechai N, Suansomjit C, Piteekan T, Hou MM, Khozoee B, McHugh K, Roberts DJ, Lawrie AM, Blagborough AM, Nugent FL, Taylor IJ, Johnson KJ, Spence PJ, Sattabongkot J, Biswas S, Rayner JC, Draper SJ.
PMID: 34609964
JCI Insight. 2021 Dec 08;6(23). doi: 10.1172/jci.insight.152465.

Controlled human malaria infection (CHMI) provides a highly informative means to investigate host-pathogen interactions and enable in vivo proof-of-concept efficacy testing of new drugs and vaccines. However, unlike Plasmodium falciparum, well-characterized P. vivax parasites that are safe and suitable...

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Minassian AM, Themistocleous Y, Silk SE, et al. Controlled human malaria infection with a clone of Plasmodium vivax with high-quality genome assembly. JCI Insight. 2021;6(23)doi: 10.1172/jci.insight.152465.
Minassian, A. M., Themistocleous, Y., Silk, S. E., Barrett, J. R., Kemp, A., Quinkert, D., Nielsen, C. M., Edwards, N. J., Rawlinson, T. A., Ramos Lopez, F., Roobsoong, W., Ellis, K. J., Cho, J. S., Aunin, E., Otto, T. D., Reid, A. J., Bach, F. A., Labbé, G. M., Poulton, I. D., Marini, A., Zaric, M., Mulatier, M., Lopez Ramon, R., Baker, M., Mitton, C. H., Sousa, J. C., Rachaphaew, N., Kumpitak, C., Maneechai, N., Suansomjit, C., Piteekan, T., Hou, M. M., Khozoee, B., McHugh, K., Roberts, D. J., Lawrie, A. M., Blagborough, A. M., Nugent, F. L., Taylor, I. J., Johnson, K. J., Spence, P. J., Sattabongkot, J., Biswas, S., Rayner, J. C., & Draper, S. J. (2021). Controlled human malaria infection with a clone of Plasmodium vivax with high-quality genome assembly. JCI insight, 6(23), . https://doi.org/10.1172/jci.insight.152465
Minassian, Angela M, et al. "Controlled human malaria infection with a clone of Plasmodium vivax with high-quality genome assembly." JCI insight vol. 6,23 (2021). doi: https://doi.org/10.1172/jci.insight.152465
Minassian AM, Themistocleous Y, Silk SE, Barrett JR, Kemp A, Quinkert D, Nielsen CM, Edwards NJ, Rawlinson TA, Ramos Lopez F, Roobsoong W, Ellis KJ, Cho JS, Aunin E, Otto TD, Reid AJ, Bach FA, Labbé GM, Poulton ID, Marini A, Zaric M, Mulatier M, Lopez Ramon R, Baker M, Mitton CH, Sousa JC, Rachaphaew N, Kumpitak C, Maneechai N, Suansomjit C, Piteekan T, Hou MM, Khozoee B, McHugh K, Roberts DJ, Lawrie AM, Blagborough AM, Nugent FL, Taylor IJ, Johnson KJ, Spence PJ, Sattabongkot J, Biswas S, Rayner JC, Draper SJ. Controlled human malaria infection with a clone of Plasmodium vivax with high-quality genome assembly. JCI Insight. 2021 Dec 08;6(23). doi: 10.1172/jci.insight.152465. PMID: 34609964.
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Showing 517 to 521 of 521 entries