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Showing 13 to 24 of 119 entries
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Dence for a gene in rats affecting lymphocyte responsiveness to PHA.

Immunogenetics

Gasser DL, Winters BA, Balaban-Malenbaum G.
PMID: 21302068
Immunogenetics. 1978 Dec;7(1):149-54. doi: 10.1007/BF01844000.

A gene controlling high responsiveness of lymphocytes to in vitro stimulation by PHA was transferred from the Lewis strain of rats to the BN background by ten generations of backcrossing. The high-responder phenotype was initially defined on the basis...

Application of PCR-Based Tools to Explore Strongyloides Infection in People in Parts of Northern Australia.

Tropical medicine and infectious disease

Robertson GJ, Koehler AV, Gasser RB, Watts M, Norton R, Bradbury RS.
PMID: 30270919
Trop Med Infect Dis. 2017 Dec 08;2(4). doi: 10.3390/tropicalmed2040062.

Strongyloidiasis, which is caused by infection with the nematode

The Importance of Satellite Sequence Repression for Genome Stability.

Cold Spring Harbor symposia on quantitative biology

Zeller P, Gasser SM.
PMID: 29133300
Cold Spring Harb Symp Quant Biol. 2017;82:15-24. doi: 10.1101/sqb.2017.82.033662. Epub 2017 Nov 13.

Up to two-thirds of eukaryotic genomes consist of repetitive sequences, which include both transposable elements and tandemly arranged simple or satellite repeats. Whereas extensive progress has been made toward understanding the danger of and control over transposon expression, only...

Therapy for musculoskeletal disorders.

Journal of orthopaedic translation

Gasser JA.
PMID: 30035067
J Orthop Translat. 2016 Jan 04;4:71-74. doi: 10.1016/j.jot.2015.12.001. eCollection 2016 Jan.

No abstract available.

Exploration of extracellular vesicles from .

Journal of extracellular vesicles

Hansen EP, Fromm B, Andersen SD, Marcilla A, Andersen KL, Borup A, Williams AR, Jex AR, Gasser RB, Young ND, Hall RS, Stensballe A, Ovchinnikov V, Yan Y, Fredholm M, Thamsborg SM, Nejsum P.
PMID: 30815237
J Extracell Vesicles. 2019 Feb 14;8(1):1578116. doi: 10.1080/20013078.2019.1578116. eCollection 2019.

The prevalent porcine helminth,

Safety, pharmacokinetics and pharmacodynamics of idarucizumab, a specific dabigatran reversal agent in healthy Japanese volunteers: a randomized study.

Research and practice in thrombosis and haemostasis

Yasaka M, Ikushima I, Harada A, Imazu S, Taniguchi A, Norris S, Gansser D, Stangier J, Schmohl M, Reilly PA.
PMID: 30046691
Res Pract Thromb Haemost. 2017 Aug 05;1(2):202-215. doi: 10.1002/rth2.12029. eCollection 2017 Oct.

BACKGROUND: Idarucizumab is a humanized monoclonal antibody fragment that specifically binds with high affinity to dabigatran.OBJECTIVES: This study investigated the safety, tolerability and pharmacokinetics of idarucizumab alone and with dabigatran at steady state, and the effects of idarucizumab on...

The study of protein recruitment to UV-induced DNA lesions can be distorted by photoconversion of DNA dyes like Hoechst or DAPI.

F1000Research

Hurst V, Gasser SM.
PMID: 30828443
F1000Res. 2019 Jan 25;8:104. doi: 10.12688/f1000research.17865.1. eCollection 2019.

A common approach used to assess DNA repair factor binding in mammalian cells is to induce DNA damage with a UV laser and follow the movement of GFP-tagged proteins to the site of damage. Often these measurements are performed...

Steroid Metabolites Support Evidence of Autism as a Spectrum.

Behavioral sciences (Basel, Switzerland)

Gasser BA, Kurz J, Dick B, Mohaupt MG.
PMID: 31075898
Behav Sci (Basel). 2019 May 09;9(5). doi: 10.3390/bs9050052.

No abstract available.

First Evidence of Function for .

Pathogens (Basel, Switzerland)

Mughal MN, Ye Q, Zhao L, Grevelding CG, Li Y, Di W, He X, Li X, Gasser RB, Hu M.
PMID: 34358012
Pathogens. 2021 Jul 08;10(7). doi: 10.3390/pathogens10070862.

Protein kinases are known as key molecules that regulate many biological processes in animals. The right open reading frame protein kinase (

H3K9me selectively blocks transcription factor activity and ensures differentiated tissue integrity.

Nature cell biology

Methot SP, Padeken J, Brancati G, Zeller P, Delaney CE, Gaidatzis D, Kohler H, van Oudenaarden A, Großhans H, Gasser SM.
PMID: 34737442
Nat Cell Biol. 2021 Nov;23(11):1163-1175. doi: 10.1038/s41556-021-00776-w. Epub 2021 Nov 04.

The developmental role of histone H3K9 methylation (H3K9me), which typifies heterochromatin, remains unclear. In Caenorhabditis elegans, loss of H3K9me leads to a highly divergent upregulation of genes with tissue and developmental-stage specificity. During development H3K9me is lost from differentiated...

Prospects of Using High-Throughput Proteomics to Underpin the Discovery of Animal Host-Nematode Interactions.

Pathogens (Basel, Switzerland)

Wang T, Gasser RB.
PMID: 34209223
Pathogens. 2021 Jun 30;10(7). doi: 10.3390/pathogens10070825.

Parasitic nematodes impose a significant public health burden, and cause major economic losses to agriculture worldwide. Due to the widespread of anthelmintic resistance and lack of effective vaccines for most nematode species, there is an urgent need to discover...

Sucrose gradient chromatin enrichment for quantitative proteomics analysis in budding yeast.

STAR protocols

Challa K, Seebacher J, Gasser SM.
PMID: 34568845
STAR Protoc. 2021 Sep 14;2(4):100825. doi: 10.1016/j.xpro.2021.100825. eCollection 2021 Dec 17.

Here, we describe a fractionation protocol optimized to quantify changes in relative abundance of the chromatin-bound proteome (chromatome) by tandem mass tag multiplexing-based tandem mass spectrometry. It has been applied to yeast cells before and after exposure to DNA-damaging...

Showing 13 to 24 of 119 entries