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Risk of anticholinergic burden in adults with intellectual disabilities: a Scottish retrospective cohort study of n = 17 220.

Journal of intellectual disability research : JIDR

Ward LM, Stanley B, Greenlaw N, Cooper SA, Pacitti C, Henderson A, Gibson J, Kinnear D.
PMID: 34169610
J Intellect Disabil Res. 2021 Sep;65(9):813-830. doi: 10.1111/jir.12861. Epub 2021 Jun 25.

BACKGROUND: Several drugs have anticholinergic side effects that are associated with adverse health outcomes. Anticholinergic burden studies in adults with intellectual disabilities (ID) have focused exclusively on older adults. This study investigates anticholinergic burden and its associations in adults...

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Ward LM, Stanley B, Greenlaw N, et al. Risk of anticholinergic burden in adults with intellectual disabilities: a Scottish retrospective cohort study of n = 17 220. J Intellect Disabil Res. 2021;65(9):813-830doi: 10.1111/jir.12861.
Ward, L. M., Stanley, B., Greenlaw, N., Cooper, S. A., Pacitti, C., Henderson, A., Gibson, J., & Kinnear, D. (2021). Risk of anticholinergic burden in adults with intellectual disabilities: a Scottish retrospective cohort study of n = 17 220. Journal of intellectual disability research : JIDR, 65(9), 813-830. https://doi.org/10.1111/jir.12861
Ward, L M, et al. "Risk of anticholinergic burden in adults with intellectual disabilities: a Scottish retrospective cohort study of n = 17 220." Journal of intellectual disability research : JIDR vol. 65,9 (2021): 813-830. doi: https://doi.org/10.1111/jir.12861
Ward LM, Stanley B, Greenlaw N, Cooper SA, Pacitti C, Henderson A, Gibson J, Kinnear D. Risk of anticholinergic burden in adults with intellectual disabilities: a Scottish retrospective cohort study of n = 17 220. J Intellect Disabil Res. 2021 Sep;65(9):813-830. doi: 10.1111/jir.12861. Epub 2021 Jun 25. PMID: 34169610.
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Clonal Hematopoiesis Is Associated With Higher Risk of Stroke.

Stroke

Bhattacharya R, Zekavat SM, Haessler J, Fornage M, Raffield L, Uddin MM, Bick AG, Niroula A, Yu B, Gibson C, Griffin G, Morrison AC, Psaty BM, Longstreth WT, Bis JC, Rich SS, Rotter JI, Tracy RP, Correa A, Seshadri S, Johnson A, Collins JM, Hayden KM, Madsen TE, Ballantyne CM, Jaiswal S, Ebert BL, Kooperberg C, Manson JE, Whitsel EA, Natarajan P, Reiner AP.
PMID: 34743536
Stroke. 2021 Nov 08;STROKEAHA121037388. doi: 10.1161/STROKEAHA.121.037388. Epub 2021 Nov 08.

BACKGROUND AND PURPOSE: Clonal hematopoiesis of indeterminate potential (CHIP) is a novel age-related risk factor for cardiovascular disease-related morbidity and mortality. The association of CHIP with risk of incident ischemic stroke was reported previously in an exploratory analysis including...

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Bhattacharya R, Zekavat SM, Haessler J, et al. Clonal Hematopoiesis Is Associated With Higher Risk of Stroke. Stroke. 2021;STROKEAHA121037388doi: 10.1161/STROKEAHA.121.037388.
Bhattacharya, R., Zekavat, S. M., Haessler, J., Fornage, M., Raffield, L., Uddin, M. M., Bick, A. G., Niroula, A., Yu, B., Gibson, C., Griffin, G., Morrison, A. C., Psaty, B. M., Longstreth, W. T., Bis, J. C., Rich, S. S., Rotter, J. I., Tracy, R. P., Correa, A., Seshadri, S., Johnson, A., Collins, J. M., Hayden, K. M., Madsen, T. E., Ballantyne, C. M., Jaiswal, S., Ebert, B. L., Kooperberg, C., Manson, J. E., Whitsel, E. A., Natarajan, P., & Reiner, A. P. (2021). Clonal Hematopoiesis Is Associated With Higher Risk of Stroke. Stroke, STROKEAHA121037388. https://doi.org/10.1161/STROKEAHA.121.037388
Bhattacharya, Romit, et al. "Clonal Hematopoiesis Is Associated With Higher Risk of Stroke." Stroke vol. (2021): STROKEAHA121037388. doi: https://doi.org/10.1161/STROKEAHA.121.037388
Bhattacharya R, Zekavat SM, Haessler J, Fornage M, Raffield L, Uddin MM, Bick AG, Niroula A, Yu B, Gibson C, Griffin G, Morrison AC, Psaty BM, Longstreth WT, Bis JC, Rich SS, Rotter JI, Tracy RP, Correa A, Seshadri S, Johnson A, Collins JM, Hayden KM, Madsen TE, Ballantyne CM, Jaiswal S, Ebert BL, Kooperberg C, Manson JE, Whitsel EA, Natarajan P, Reiner AP. Clonal Hematopoiesis Is Associated With Higher Risk of Stroke. Stroke. 2021 Nov 08;STROKEAHA121037388. doi: 10.1161/STROKEAHA.121.037388. Epub 2021 Nov 08. PMID: 34743536.
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Creation of an unexpected plane of enhanced covalency in cerium(III) and berkelium(III) terpyridyl complexes.

Nature communications

Gaiser AN, Celis-Barros C, White FD, Beltran-Leiva MJ, Sperling JM, Salpage SR, Poe TN, Gomez Martinez D, Jian T, Wolford NJ, Jones NJ, Ritz AJ, Lazenby RA, Gibson JK, Baumbach RE, Páez-Hernández D, Neidig ML, Albrecht-Schönzart TE.
PMID: 34893651
Nat Commun. 2021 Dec 10;12(1):7230. doi: 10.1038/s41467-021-27576-y.

Controlling the properties of heavy element complexes, such as those containing berkelium, is challenging because relativistic effects, spin-orbit and ligand-field splitting, and complex metal-ligand bonding, all dictate the final electronic states of the molecules. While the first two of...

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Gaiser AN, Celis-Barros C, White FD, et al. Creation of an unexpected plane of enhanced covalency in cerium(III) and berkelium(III) terpyridyl complexes. Nat Commun. 2021;12(1):7230doi: 10.1038/s41467-021-27576-y.
Gaiser, A. N., Celis-Barros, C., White, F. D., Beltran-Leiva, M. J., Sperling, J. M., Salpage, S. R., Poe, T. N., Gomez Martinez, D., Jian, T., Wolford, N. J., Jones, N. J., Ritz, A. J., Lazenby, R. A., Gibson, J. K., Baumbach, R. E., Páez-Hernández, D., Neidig, M. L., & Albrecht-Schönzart, T. E. (2021). Creation of an unexpected plane of enhanced covalency in cerium(III) and berkelium(III) terpyridyl complexes. Nature communications, 12(1), 7230. https://doi.org/10.1038/s41467-021-27576-y
Gaiser, Alyssa N, et al. "Creation of an unexpected plane of enhanced covalency in cerium(III) and berkelium(III) terpyridyl complexes." Nature communications vol. 12,1 (2021): 7230. doi: https://doi.org/10.1038/s41467-021-27576-y
Gaiser AN, Celis-Barros C, White FD, Beltran-Leiva MJ, Sperling JM, Salpage SR, Poe TN, Gomez Martinez D, Jian T, Wolford NJ, Jones NJ, Ritz AJ, Lazenby RA, Gibson JK, Baumbach RE, Páez-Hernández D, Neidig ML, Albrecht-Schönzart TE. Creation of an unexpected plane of enhanced covalency in cerium(III) and berkelium(III) terpyridyl complexes. Nat Commun. 2021 Dec 10;12(1):7230. doi: 10.1038/s41467-021-27576-y. PMID: 34893651.
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Integrating ecosystem markets to co-ordinate landscape-scale public benefits from nature.

PloS one

Reed MS, Curtis T, Gosal A, Kendall H, Andersen SP, Ziv G, Attlee A, Fitton RG, Hay M, Gibson AC, Hume AC, Hill D, Mansfield JL, Martino S, Olesen AS, Prior S, Rodgers C, Rudman H, Tanneberger F.
PMID: 35020743
PLoS One. 2022 Jan 12;17(1):e0258334. doi: 10.1371/journal.pone.0258334. eCollection 2022.

Ecosystem markets are proliferating around the world in response to increasing demand for climate change mitigation and provision of other public goods. However, this may lead to perverse outcomes, for example where public funding crowds out private investment or...

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Reed MS, Curtis T, Gosal A, et al. Integrating ecosystem markets to co-ordinate landscape-scale public benefits from nature. PLoS One. 2022;17(1):e0258334doi: 10.1371/journal.pone.0258334.
Reed, M. S., Curtis, T., Gosal, A., Kendall, H., Andersen, S. P., Ziv, G., Attlee, A., Fitton, R. G., Hay, M., Gibson, A. C., Hume, A. C., Hill, D., Mansfield, J. L., Martino, S., Olesen, A. S., Prior, S., Rodgers, C., Rudman, H., & Tanneberger, F. (2022). Integrating ecosystem markets to co-ordinate landscape-scale public benefits from nature. PloS one, 17(1), e0258334. https://doi.org/10.1371/journal.pone.0258334
Reed, Mark S, et al. "Integrating ecosystem markets to co-ordinate landscape-scale public benefits from nature." PloS one vol. 17,1 (2022): e0258334. doi: https://doi.org/10.1371/journal.pone.0258334
Reed MS, Curtis T, Gosal A, Kendall H, Andersen SP, Ziv G, Attlee A, Fitton RG, Hay M, Gibson AC, Hume AC, Hill D, Mansfield JL, Martino S, Olesen AS, Prior S, Rodgers C, Rudman H, Tanneberger F. Integrating ecosystem markets to co-ordinate landscape-scale public benefits from nature. PLoS One. 2022 Jan 12;17(1):e0258334. doi: 10.1371/journal.pone.0258334. eCollection 2022. PMID: 35020743.
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Dnmt3a-mutated clonal hematopoiesis promotes osteoporosis.

The Journal of experimental medicine

Kim PG, Niroula A, Shkolnik V, McConkey M, Lin AE, Słabicki M, Kemp JP, Bick A, Gibson CJ, Griffin G, Sekar A, Brooks DJ, Wong WJ, Cohen DN, Uddin MM, Shin WJ, Pirruccello J, Tsai JM, Agrawal M, Kiel DP, Bouxsein ML, Richards JB, Evans DM, Wein MN, Charles JF, Jaiswal S, Natarajan P, Ebert BL.
PMID: 34698806
J Exp Med. 2021 Dec 06;218(12). doi: 10.1084/jem.20211872. Epub 2021 Oct 26.

Osteoporosis is caused by an imbalance of osteoclasts and osteoblasts, occurring in close proximity to hematopoietic cells in the bone marrow. Recurrent somatic mutations that lead to an expanded population of mutant blood cells is termed clonal hematopoiesis of...

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Kim PG, Niroula A, Shkolnik V, et al. Dnmt3a-mutated clonal hematopoiesis promotes osteoporosis. J Exp Med. 2021;218(12)doi: 10.1084/jem.20211872.
Kim, P. G., Niroula, A., Shkolnik, V., McConkey, M., Lin, A. E., Słabicki, M., Kemp, J. P., Bick, A., Gibson, C. J., Griffin, G., Sekar, A., Brooks, D. J., Wong, W. J., Cohen, D. N., Uddin, M. M., Shin, W. J., Pirruccello, J., Tsai, J. M., Agrawal, M., Kiel, D. P., Bouxsein, M. L., Richards, J. B., Evans, D. M., Wein, M. N., Charles, J. F., Jaiswal, S., Natarajan, P., & Ebert, B. L. (2021). Dnmt3a-mutated clonal hematopoiesis promotes osteoporosis. The Journal of experimental medicine, 218(12), . https://doi.org/10.1084/jem.20211872
Kim, Peter Geon, et al. "Dnmt3a-mutated clonal hematopoiesis promotes osteoporosis." The Journal of experimental medicine vol. 218,12 (2021). doi: https://doi.org/10.1084/jem.20211872
Kim PG, Niroula A, Shkolnik V, McConkey M, Lin AE, Słabicki M, Kemp JP, Bick A, Gibson CJ, Griffin G, Sekar A, Brooks DJ, Wong WJ, Cohen DN, Uddin MM, Shin WJ, Pirruccello J, Tsai JM, Agrawal M, Kiel DP, Bouxsein ML, Richards JB, Evans DM, Wein MN, Charles JF, Jaiswal S, Natarajan P, Ebert BL. Dnmt3a-mutated clonal hematopoiesis promotes osteoporosis. J Exp Med. 2021 Dec 06;218(12). doi: 10.1084/jem.20211872. Epub 2021 Oct 26. PMID: 34698806; PMCID: PMC8552148.
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Cardiac Implantable Devices Management in Medical Assistance in Dying (MAiD): Review and Recommendations for Cardiac Device Clinics.

The Canadian journal of cardiology

Chakrabarti S, Gibson JA, Bennett MT, Toma M, Verma AT, Chow R, Plewes L, Redpath CJ, Mondésert B, Sterns L, Krahn AD.
PMID: 34010633
Can J Cardiol. 2021 Oct;37(10):1648-1650. doi: 10.1016/j.cjca.2021.05.004. Epub 2021 May 16.

The Medical Assistance in Dying (MAiD) program has been steadily expanding in Canada, and is expected to continue to do so. There are a substantial number of Canadians with pacemakers and defibrillators, many of whom are potential MAiD recipients....

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Chakrabarti S, Gibson JA, Bennett MT, et al. Cardiac Implantable Devices Management in Medical Assistance in Dying (MAiD): Review and Recommendations for Cardiac Device Clinics. Can J Cardiol. 2021;37(10):1648-1650doi: 10.1016/j.cjca.2021.05.004.
Chakrabarti, S., Gibson, J. A., Bennett, M. T., Toma, M., Verma, A. T., Chow, R., Plewes, L., Redpath, C. J., Mondésert, B., Sterns, L., & Krahn, A. D. (2021). Cardiac Implantable Devices Management in Medical Assistance in Dying (MAiD): Review and Recommendations for Cardiac Device Clinics. The Canadian journal of cardiology, 37(10), 1648-1650. https://doi.org/10.1016/j.cjca.2021.05.004
Chakrabarti, Santabhanu, et al. "Cardiac Implantable Devices Management in Medical Assistance in Dying (MAiD): Review and Recommendations for Cardiac Device Clinics." The Canadian journal of cardiology vol. 37,10 (2021): 1648-1650. doi: https://doi.org/10.1016/j.cjca.2021.05.004
Chakrabarti S, Gibson JA, Bennett MT, Toma M, Verma AT, Chow R, Plewes L, Redpath CJ, Mondésert B, Sterns L, Krahn AD. Cardiac Implantable Devices Management in Medical Assistance in Dying (MAiD): Review and Recommendations for Cardiac Device Clinics. Can J Cardiol. 2021 Oct;37(10):1648-1650. doi: 10.1016/j.cjca.2021.05.004. Epub 2021 May 16. PMID: 34010633.
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Health Literacy-Related Safety Events: A Qualitative Study of Health Literacy Failures in Patient Safety Events.

Pediatric quality & safety

Morrison AK, Gibson C, Higgins C, Gutzeit M.
PMID: 34235353
Pediatr Qual Saf. 2021 Jun 23;6(4):e425. doi: 10.1097/pq9.0000000000000425. eCollection 2021.

INTRODUCTION: Communication failures are the leading root cause of safety events. Although much communication research focuses on the healthcare team, there is little focus on communication with patients and families. It is not known what deficits in health literate...

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Morrison AK, Gibson C, Higgins C, et al. Health Literacy-Related Safety Events: A Qualitative Study of Health Literacy Failures in Patient Safety Events. Pediatr Qual Saf. 2021;6(4):e425doi: 10.1097/pq9.0000000000000425.
Morrison, A. K., Gibson, C., Higgins, C., & Gutzeit, M. (2021). Health Literacy-Related Safety Events: A Qualitative Study of Health Literacy Failures in Patient Safety Events. Pediatric quality & safety, 6(4), e425. https://doi.org/10.1097/pq9.0000000000000425
Morrison, Andrea K, et al. "Health Literacy-Related Safety Events: A Qualitative Study of Health Literacy Failures in Patient Safety Events." Pediatric quality & safety vol. 6,4 (2021): e425. doi: https://doi.org/10.1097/pq9.0000000000000425
Morrison AK, Gibson C, Higgins C, Gutzeit M. Health Literacy-Related Safety Events: A Qualitative Study of Health Literacy Failures in Patient Safety Events. Pediatr Qual Saf. 2021 Jun 23;6(4):e425. doi: 10.1097/pq9.0000000000000425. eCollection 2021. PMID: 34235353; PMCID: PMC8225367.
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Creation of an unexpected plane of enhanced covalency in cerium(III) and berkelium(III) terpyridyl complexes.

Nature communications

Gaiser AN, Celis-Barros C, White FD, Beltran-Leiva MJ, Sperling JM, Salpage SR, Poe TN, Gomez Martinez D, Jian T, Wolford NJ, Jones NJ, Ritz AJ, Lazenby RA, Gibson JK, Baumbach RE, Páez-Hernández D, Neidig ML, Albrecht-Schönzart TE.
PMID: 34893651
Nat Commun. 2021 Dec 10;12(1):7230. doi: 10.1038/s41467-021-27576-y.

Controlling the properties of heavy element complexes, such as those containing berkelium, is challenging because relativistic effects, spin-orbit and ligand-field splitting, and complex metal-ligand bonding, all dictate the final electronic states of the molecules. While the first two of...

Cite
Gaiser AN, Celis-Barros C, White FD, et al. Creation of an unexpected plane of enhanced covalency in cerium(III) and berkelium(III) terpyridyl complexes. Nat Commun. 2021;12(1):7230doi: 10.1038/s41467-021-27576-y.
Gaiser, A. N., Celis-Barros, C., White, F. D., Beltran-Leiva, M. J., Sperling, J. M., Salpage, S. R., Poe, T. N., Gomez Martinez, D., Jian, T., Wolford, N. J., Jones, N. J., Ritz, A. J., Lazenby, R. A., Gibson, J. K., Baumbach, R. E., Páez-Hernández, D., Neidig, M. L., & Albrecht-Schönzart, T. E. (2021). Creation of an unexpected plane of enhanced covalency in cerium(III) and berkelium(III) terpyridyl complexes. Nature communications, 12(1), 7230. https://doi.org/10.1038/s41467-021-27576-y
Gaiser, Alyssa N, et al. "Creation of an unexpected plane of enhanced covalency in cerium(III) and berkelium(III) terpyridyl complexes." Nature communications vol. 12,1 (2021): 7230. doi: https://doi.org/10.1038/s41467-021-27576-y
Gaiser AN, Celis-Barros C, White FD, Beltran-Leiva MJ, Sperling JM, Salpage SR, Poe TN, Gomez Martinez D, Jian T, Wolford NJ, Jones NJ, Ritz AJ, Lazenby RA, Gibson JK, Baumbach RE, Páez-Hernández D, Neidig ML, Albrecht-Schönzart TE. Creation of an unexpected plane of enhanced covalency in cerium(III) and berkelium(III) terpyridyl complexes. Nat Commun. 2021 Dec 10;12(1):7230. doi: 10.1038/s41467-021-27576-y. PMID: 34893651.
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Rib Fracture Mortality: Are There Clues in the Core?.

The Journal of surgical research

Kelly-Schuette KA, Prentice A, Orr A, Levine A, Zarnke A, Pardington E, Pounders S, Lypka M, Krech L, Iskander G, Chapman AJ, Gibson CJ, Steensma E, Durling L.
PMID: 34280662
J Surg Res. 2021 Dec;268:25-32. doi: 10.1016/j.jss.2021.06.020. Epub 2021 Jul 17.

BACKGROUND: Sarcopenia is associated with increased morbidity and mortality in the trauma patient. The primary objective of this study was to determine the relationship of psoas cross sectional area with hospital mortality in patients with rib fractures over the...

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Kelly-Schuette KA, Prentice A, Orr A, et al. Rib Fracture Mortality: Are There Clues in the Core?. J Surg Res. 2021;268:25-32doi: 10.1016/j.jss.2021.06.020.
Kelly-Schuette, K. A., Prentice, A., Orr, A., Levine, A., Zarnke, A., Pardington, E., Pounders, S., Lypka, M., Krech, L., Iskander, G., Chapman, A. J., Gibson, C. J., Steensma, E., & Durling, L. (2021). Rib Fracture Mortality: Are There Clues in the Core?. The Journal of surgical research, 26825-32. https://doi.org/10.1016/j.jss.2021.06.020
Kelly-Schuette, Kathrine A, et al. "Rib Fracture Mortality: Are There Clues in the Core?." The Journal of surgical research vol. 268 (2021): 25-32. doi: https://doi.org/10.1016/j.jss.2021.06.020
Kelly-Schuette KA, Prentice A, Orr A, Levine A, Zarnke A, Pardington E, Pounders S, Lypka M, Krech L, Iskander G, Chapman AJ, Gibson CJ, Steensma E, Durling L. Rib Fracture Mortality: Are There Clues in the Core?. J Surg Res. 2021 Dec;268:25-32. doi: 10.1016/j.jss.2021.06.020. Epub 2021 Jul 17. PMID: 34280662.
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Translational Pharmacokinetic-Pharmacodynamic Modeling of NaV1.7 Inhibitor MK-2075 to Inform Human Efficacious Dose.

Frontiers in pharmacology

Ballard JE, Pall PS, Vardigan J, Zhao F, Holahan MA, Zhou X, Jochnowitz N, Kraus RL, Klein RM, Henze DA, Houghton AK, Burgey CS, Gibson C, Struyk A.
PMID: 35002718
Front Pharmacol. 2021 Dec 24;12:786078. doi: 10.3389/fphar.2021.786078. eCollection 2021.

MK-2075 is a small-molecule selective inhibitor of the NaV1.7 channel investigated for the treatment of postoperative pain. A translational strategy was developed for MK-2075 to quantitatively interrelate drug exposure, target modulation, and the desired pharmacological response in preclinical animal...

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Ballard JE, Pall PS, Vardigan J, et al. Translational Pharmacokinetic-Pharmacodynamic Modeling of NaV1.7 Inhibitor MK-2075 to Inform Human Efficacious Dose. Front Pharmacol. 2021;12:786078doi: 10.3389/fphar.2021.786078.
Ballard, J. E., Pall, P. S., Vardigan, J., Zhao, F., Holahan, M. A., Zhou, X., Jochnowitz, N., Kraus, R. L., Klein, R. M., Henze, D. A., Houghton, A. K., Burgey, C. S., Gibson, C., & Struyk, A. (2021). Translational Pharmacokinetic-Pharmacodynamic Modeling of NaV1.7 Inhibitor MK-2075 to Inform Human Efficacious Dose. Frontiers in pharmacology, 12786078. https://doi.org/10.3389/fphar.2021.786078
Ballard, Jeanine E, et al. "Translational Pharmacokinetic-Pharmacodynamic Modeling of NaV1.7 Inhibitor MK-2075 to Inform Human Efficacious Dose." Frontiers in pharmacology vol. 12 (2021): 786078. doi: https://doi.org/10.3389/fphar.2021.786078
Ballard JE, Pall PS, Vardigan J, Zhao F, Holahan MA, Zhou X, Jochnowitz N, Kraus RL, Klein RM, Henze DA, Houghton AK, Burgey CS, Gibson C, Struyk A. Translational Pharmacokinetic-Pharmacodynamic Modeling of NaV1.7 Inhibitor MK-2075 to Inform Human Efficacious Dose. Front Pharmacol. 2021 Dec 24;12:786078. doi: 10.3389/fphar.2021.786078. eCollection 2021. PMID: 35002718; PMCID: PMC8740778.
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